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The map label for this gene is clpP-2

Identifier: 15835330

GI number: 15835330

Start: 853019

End: 853609

Strand: Reverse

Name: clpP-2

Synonym: TC0715

Alternate gene names: 15835330

Gene position: 853609-853019 (Counterclockwise)

Preceding gene: 15835331

Following gene: 15835329

Centisome position: 79.56

GC content: 43.32

Gene sequence:

>591_bases
GTGGGAGACTCTATGCCTGAAGGGGAAATGATGCATAAGTTACAAGATATCATAGATAGAAAGTTGTTAGATTCTCGGCG
TATTTTTTTCTCTGAGCCTGTAACAGAGAAGAGCGCTGCAGAGGCTATCAAAAAGCTTTGGTATTTGGAACTCACAAGTC
CGGGACAGCCAATTGTATTCGTTATTAACAGTCCAGGGGGATCTGTTGACGCGGGATTTGCTGTTTGGGACCAAATTAAG
ATGATCTCTTCTCCTGTAACAACAGTAGTTACAGGGTTAGCAGCATCTATGGGATCTGTGTTAAGTTTATGCGCTGCTCC
AGGAAGACGGTTTGCTACACCTCATGCGCGTATTATGATCCATCAACCTTCTATTGGAGGCACCATTACTGGCCAGGCCA
CTGATTTGGATATTCATGCGCGGGAGATTTTAAAAACTAAGGCTCGCATTATTGATGTGTATGTTGAAGCAACAGGGCAG
TCTCGAGAGGTGATAGAGAAAGCTATTGATCGAGATATGTGGATGAGTGCCAATGAAGCTATGGAGTTTGGTCTATTAGA
TGGGATCCTTTTCTCCTTTAATGACTTATAG

Upstream 100 bases:

>100_bases
TGCTATCGGAGGAGATCGCTCAAGAAGCGAGACAACGAGTAGCTGATTTATTAGGAAGATTCCCTCTTTACCCTGAAATC
GATCTGGAAACGCTAGTTTA

Downstream 100 bases:

>100_bases
GTATCATCTATATTCTGGAACTGGTAATAGTTTTATTTTAGGGGAGTTCATACCTCCCCTCCAACATATTGTGTTTCTAT
GCCAGAAAGAGAAGGTCGAT

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp 1 [H]

Number of amino acids: Translated: 196; Mature: 195

Protein sequence:

>196_residues
MGDSMPEGEMMHKLQDIIDRKLLDSRRIFFSEPVTEKSAAEAIKKLWYLELTSPGQPIVFVINSPGGSVDAGFAVWDQIK
MISSPVTTVVTGLAASMGSVLSLCAAPGRRFATPHARIMIHQPSIGGTITGQATDLDIHAREILKTKARIIDVYVEATGQ
SREVIEKAIDRDMWMSANEAMEFGLLDGILFSFNDL

Sequences:

>Translated_196_residues
MGDSMPEGEMMHKLQDIIDRKLLDSRRIFFSEPVTEKSAAEAIKKLWYLELTSPGQPIVFVINSPGGSVDAGFAVWDQIK
MISSPVTTVVTGLAASMGSVLSLCAAPGRRFATPHARIMIHQPSIGGTITGQATDLDIHAREILKTKARIIDVYVEATGQ
SREVIEKAIDRDMWMSANEAMEFGLLDGILFSFNDL
>Mature_195_residues
GDSMPEGEMMHKLQDIIDRKLLDSRRIFFSEPVTEKSAAEAIKKLWYLELTSPGQPIVFVINSPGGSVDAGFAVWDQIKM
ISSPVTTVVTGLAASMGSVLSLCAAPGRRFATPHARIMIHQPSIGGTITGQATDLDIHAREILKTKARIIDVYVEATGQS
REVIEKAIDRDMWMSANEAMEFGLLDGILFSFNDL

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins [H]

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family [H]

Homologues:

Organism=Homo sapiens, GI5174419, Length=175, Percent_Identity=45.7142857142857, Blast_Score=148, Evalue=3e-36,
Organism=Escherichia coli, GI1786641, Length=179, Percent_Identity=45.2513966480447, Blast_Score=152, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI17538017, Length=187, Percent_Identity=45.9893048128342, Blast_Score=150, Evalue=4e-37,
Organism=Drosophila melanogaster, GI20129427, Length=175, Percent_Identity=40, Blast_Score=134, Evalue=3e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001907
- InterPro:   IPR018215 [H]

Pfam domain/function: PF00574 CLP_protease [H]

EC number: =3.4.21.92 [H]

Molecular weight: Translated: 21468; Mature: 21337

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: PS00382 CLP_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGDSMPEGEMMHKLQDIIDRKLLDSRRIFFSEPVTEKSAAEAIKKLWYLELTSPGQPIVF
CCCCCCCHHHHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHEEEECCCCCCEEE
VINSPGGSVDAGFAVWDQIKMISSPVTTVVTGLAASMGSVLSLCAAPGRRFATPHARIMI
EEECCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEE
HQPSIGGTITGQATDLDIHAREILKTKARIIDVYVEATGQSREVIEKAIDRDMWMSANEA
ECCCCCCEECCCCCCCHHHHHHHHHHHHHHEEEEEECCCCHHHHHHHHHHHHHCCCHHHH
MEFGLLDGILFSFNDL
HHHHHHHHHHHHCCCC
>Mature Secondary Structure 
GDSMPEGEMMHKLQDIIDRKLLDSRRIFFSEPVTEKSAAEAIKKLWYLELTSPGQPIVF
CCCCCCHHHHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHEEEECCCCCCEEE
VINSPGGSVDAGFAVWDQIKMISSPVTTVVTGLAASMGSVLSLCAAPGRRFATPHARIMI
EEECCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEE
HQPSIGGTITGQATDLDIHAREILKTKARIIDVYVEATGQSREVIEKAIDRDMWMSANEA
ECCCCCCEECCCCCCCHHHHHHHHHHHHHHEEEEEECCCCHHHHHHHHHHHHHCCCHHHH
MEFGLLDGILFSFNDL
HHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10684935 [H]