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Identifier: 15835325

GI number: 15835325

Start: 848610

End: 849719

Strand: Direct

Name: Not Available

Synonym: TC0710

Alternate gene names: 15835325

Gene position: 848610-849719 (Clockwise)

Preceding gene: 15835324

Following gene: 15835326

Centisome position: 79.09

GC content: 41.35

Gene sequence:

>1110_bases
ATGACGACCTCGACAACTCGCATTCTTCCTAAAAGTGCTTGGCTTAAAACTTTGTTTAACGACTATTTATCTGGAGCTCG
TCTTTCTGAAGAACAGGCTTTGCAGTTGCTTCTTATTGATGATGAAGATCAGCAGGCGTTATGGAGTTTTGCTGATCAGA
TTCGCGCAAATCGTGTTGGCGATACCGTTTACTACTCTTCCACTCTCTATCTTTATCCCACAAACTTCTGCCAATTTAAC
TGCACTTTTTGTTCTTTCTACGCTAAACCAGGTAATCCTTCAGGCTGGTTCTTCACTCCTGATCAACTCATTCGTTCCAT
AAAAGAAACTACTTCCCCCATTACTGAAACCCATATCGTAGCAGGTTGCTATCCATCATGTAATCTTGCTTACTATGAAG
AGCTGTTCACGAAAATTAAACAAAATTTTCCAGACCTACATATCAAAGCGCTTTCTGCTATTGAATATGCCTATCTAGCA
AAACTGGAAAACCTTTCTGTCAGAGAGGTCATGGAACGACTACGTATTGCAGGCCTGGATTCTATTCCTGGGGGTGGTGC
AGAGATTCTAGTTGATGAAGTGCGAGAAACCCTTTCTCGAGGAAGACTATCTTCCCAAGGTTTTTTAGATATCCATCGAA
CCGCACATTCTTTGGGAATTCCTAGTAATGCTACCATGCTTTGTTACCATCGAGAAACTCCAGAAGATATGGTAACACAT
CTGAGCAAGCTACGTTCTCTCCAGGATGAAACGTTGGGATTTAAAAATTTTATTCTCTTGAAGTTTGCCTCAGAAAATAA
TGCTTTAGGCAAACGATTACATAAAATGACTGCAAGACATTCTATTCCCCCCGCGACCATCATTGCAGTTGCTCGGCTGT
TTTTAGATAATTTTTCCAATATTAAGGCTTTGTGGAATTATCTAGGGCTTGATGTTGCTCTGCACCTACTTTCTTGTGGA
GCTAACGACTTTTCTTCCACACATCTAGGAGAAAAGGTTTTTCAAATGTCCTCTTCCAAAGAGCCCATCCGAATGGACAT
TGAAGGGATGGCTAAGCTGATTACGCAACAAGGTCGTATCCCATGTCTCGTCAGTTCCGCTCTTGTTTAA

Upstream 100 bases:

>100_bases
CTAGGAAGACCTTTATCTAAAGGTTGCGGCCGAAGTGATTGCTGTCAGAAAAAGAAGTCTTGCCCTTATGGAAACAAAAA
CTCGCAACCCGACAACGATT

Downstream 100 bases:

>100_bases
CTGTTGGGTGTGTATGCTACGTTAACGCCCTACCTTTTTCTATTGGGTTGTCCCAAGCTCCAGGAGTTTCTCTCCAGACG
GATACGCCATCTAATCTGGT

Product: hypothetical protein

Products: NA

Alternate protein names: 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase subunit 2 [H]

Number of amino acids: Translated: 369; Mature: 368

Protein sequence:

>369_residues
MTTSTTRILPKSAWLKTLFNDYLSGARLSEEQALQLLLIDDEDQQALWSFADQIRANRVGDTVYYSSTLYLYPTNFCQFN
CTFCSFYAKPGNPSGWFFTPDQLIRSIKETTSPITETHIVAGCYPSCNLAYYEELFTKIKQNFPDLHIKALSAIEYAYLA
KLENLSVREVMERLRIAGLDSIPGGGAEILVDEVRETLSRGRLSSQGFLDIHRTAHSLGIPSNATMLCYHRETPEDMVTH
LSKLRSLQDETLGFKNFILLKFASENNALGKRLHKMTARHSIPPATIIAVARLFLDNFSNIKALWNYLGLDVALHLLSCG
ANDFSSTHLGEKVFQMSSSKEPIRMDIEGMAKLITQQGRIPCLVSSALV

Sequences:

>Translated_369_residues
MTTSTTRILPKSAWLKTLFNDYLSGARLSEEQALQLLLIDDEDQQALWSFADQIRANRVGDTVYYSSTLYLYPTNFCQFN
CTFCSFYAKPGNPSGWFFTPDQLIRSIKETTSPITETHIVAGCYPSCNLAYYEELFTKIKQNFPDLHIKALSAIEYAYLA
KLENLSVREVMERLRIAGLDSIPGGGAEILVDEVRETLSRGRLSSQGFLDIHRTAHSLGIPSNATMLCYHRETPEDMVTH
LSKLRSLQDETLGFKNFILLKFASENNALGKRLHKMTARHSIPPATIIAVARLFLDNFSNIKALWNYLGLDVALHLLSCG
ANDFSSTHLGEKVFQMSSSKEPIRMDIEGMAKLITQQGRIPCLVSSALV
>Mature_368_residues
TTSTTRILPKSAWLKTLFNDYLSGARLSEEQALQLLLIDDEDQQALWSFADQIRANRVGDTVYYSSTLYLYPTNFCQFNC
TFCSFYAKPGNPSGWFFTPDQLIRSIKETTSPITETHIVAGCYPSCNLAYYEELFTKIKQNFPDLHIKALSAIEYAYLAK
LENLSVREVMERLRIAGLDSIPGGGAEILVDEVRETLSRGRLSSQGFLDIHRTAHSLGIPSNATMLCYHRETPEDMVTHL
SKLRSLQDETLGFKNFILLKFASENNALGKRLHKMTARHSIPPATIIAVARLFLDNFSNIKALWNYLGLDVALHLLSCGA
NDFSSTHLGEKVFQMSSSKEPIRMDIEGMAKLITQQGRIPCLVSSALV

Specific function: Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) [H]

COG id: COG1060

COG function: function code HR; Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. CofH family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR019940
- InterPro:   IPR006638
- InterPro:   IPR020050
- InterPro:   IPR005244
- InterPro:   IPR007197 [H]

Pfam domain/function: PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 41454; Mature: 41323

Theoretical pI: Translated: 7.03; Mature: 7.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTSTTRILPKSAWLKTLFNDYLSGARLSEEQALQLLLIDDEDQQALWSFADQIRANRVG
CCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHCEEEEEECCCCHHHHHHHHHHHHHHCCC
DTVYYSSTLYLYPTNFCQFNCTFCSFYAKPGNPSGWFFTPDQLIRSIKETTSPITETHIV
CEEEEEEEEEEEECCCEEEEEEEEEEECCCCCCCCCEECHHHHHHHHHHHCCCCHHHHEE
AGCYPSCNLAYYEELFTKIKQNFPDLHIKALSAIEYAYLAKLENLSVREVMERLRIAGLD
EECCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCC
SIPGGGAEILVDEVRETLSRGRLSSQGFLDIHRTAHSLGIPSNATMLCYHRETPEDMVTH
CCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHH
LSKLRSLQDETLGFKNFILLKFASENNALGKRLHKMTARHSIPPATIIAVARLFLDNFSN
HHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCHH
IKALWNYLGLDVALHLLSCGANDFSSTHLGEKVFQMSSSKEPIRMDIEGMAKLITQQGRI
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCEECHHHHHHHHHHCCCC
PCLVSSALV
CCHHHCCCC
>Mature Secondary Structure 
TTSTTRILPKSAWLKTLFNDYLSGARLSEEQALQLLLIDDEDQQALWSFADQIRANRVG
CCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHCEEEEEECCCCHHHHHHHHHHHHHHCCC
DTVYYSSTLYLYPTNFCQFNCTFCSFYAKPGNPSGWFFTPDQLIRSIKETTSPITETHIV
CEEEEEEEEEEEECCCEEEEEEEEEEECCCCCCCCCEECHHHHHHHHHHHCCCCHHHHEE
AGCYPSCNLAYYEELFTKIKQNFPDLHIKALSAIEYAYLAKLENLSVREVMERLRIAGLD
EECCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCC
SIPGGGAEILVDEVRETLSRGRLSSQGFLDIHRTAHSLGIPSNATMLCYHRETPEDMVTH
CCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHH
LSKLRSLQDETLGFKNFILLKFASENNALGKRLHKMTARHSIPPATIIAVARLFLDNFSN
HHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCHH
IKALWNYLGLDVALHLLSCGANDFSSTHLGEKVFQMSSSKEPIRMDIEGMAKLITQQGRI
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCEECHHHHHHHHHHCCCC
PCLVSSALV
CCHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA