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Identifier: 15835321

GI number: 15835321

Start: 844723

End: 845847

Strand: Direct

Name: Not Available

Synonym: TC0706

Alternate gene names: 15835321

Gene position: 844723-845847 (Clockwise)

Preceding gene: 15835320

Following gene: 15835322

Centisome position: 78.73

GC content: 41.33

Gene sequence:

>1125_bases
ATGCTGTATATTCTGCTGGCTACCATTATTCTTTTCCTTTTTCTCGGCTCAGCAATAAATCGCAGGGTCACTACCTTAGC
GTATGGAACTGATGGGATCCCAGTTCCCCCCTCCTCTTCTAGATTACTTCCTCTGCTTTGCCTACTTTATGGGATACTCG
GAGCACCTATTTATCAGTATATCAATACTTTCTTCTCTATTCCCTTGCCTATTTTTTGGGGTACTTTCCTATTTTTAATC
CTAGTAGCCTGTAAATTTTTACCCTCCTTTTATGGTTGTTCGAAAAACTGGTGGGGTTCCCAGATCCCAATTTCTACAGT
TAAAGCTCTAGAAAAATGTCTGATGGGATTAAAAAAATCCTCATCAACTACAATTCCACAACTTCCTGCCCCAACACCAT
CCAACGAGCTATCCGCAAATATCTCTTGCCTTGAAGATATGATTGCTCGAGAAATTATGACCCCGAAAGCCGATATTTTC
GCTTTACCAAGCGAAATCCCTATTTCTCAAGCTTTCCCCCTAATCATAGATGAGGGATATAGTCGCGTTCCTTTATTCAC
TAAAAATATCGATGACATTACAGGAATGGTTCTTGTGAAAGACCTACTCCCTGTGTATTATAAGGATCCACATACCACCC
AACCACTATCATCCATCGCTTATCCTCCCTTGTATACTCCCGAAATCCGTCGCGTCTCTCTGCTTTTACAAGAATTTCGA
CAGAAACGTTGCCACTTAGCCATTGTTGTAAATGAATACGGATTCACAGAGGGTCTGGTTTCCATGGAAGACATTGTTGA
AGAAATTTTCGGGGAAATTGCAGACGAATACGATGACCAAGAAGATGTTCACTACAAAAAAGTAGGTAATGCTTGGATTG
TGGATGGACGAATGAACATTTCCGATGCCGAAGAATATTTTGGGCTGCGCATAGCACATGAGAGCAGTTACGACACTCTT
GGCGGTTATGTTTTTCATAAGTTAGGCGCCGTCCCCGAGAAAGGAATGAAAATCTACTATGAAGATTTTGCTATCGATAT
TTTATCCTGCTCTGACCGCAGCGTAGAAAAGATGAAAATTACACCAAGAAAGCGAAAGCCTTTATCACGGAACAACCGAT
TCTAA

Upstream 100 bases:

>100_bases
AAATTTTTATCATAACATGTGAAGAGGCTATAAGTTCTTTCTTGAATATAGTCCTGAAATAATTTCTTTTTTTACGGAGA
AGATCATTTCATTTCTCATC

Downstream 100 bases:

>100_bases
ATGAAACATTAGTAAATTCTGTTCTCTCTATCCGTTGTCCTAAAATGTATCACCATAGTAGAAAGAAAATTACAAAAAGG
TCCCTCTAATCAGAATATTC

Product: hemolysin, putative

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 374; Mature: 374

Protein sequence:

>374_residues
MLYILLATIILFLFLGSAINRRVTTLAYGTDGIPVPPSSSRLLPLLCLLYGILGAPIYQYINTFFSIPLPIFWGTFLFLI
LVACKFLPSFYGCSKNWWGSQIPISTVKALEKCLMGLKKSSSTTIPQLPAPTPSNELSANISCLEDMIAREIMTPKADIF
ALPSEIPISQAFPLIIDEGYSRVPLFTKNIDDITGMVLVKDLLPVYYKDPHTTQPLSSIAYPPLYTPEIRRVSLLLQEFR
QKRCHLAIVVNEYGFTEGLVSMEDIVEEIFGEIADEYDDQEDVHYKKVGNAWIVDGRMNISDAEEYFGLRIAHESSYDTL
GGYVFHKLGAVPEKGMKIYYEDFAIDILSCSDRSVEKMKITPRKRKPLSRNNRF

Sequences:

>Translated_374_residues
MLYILLATIILFLFLGSAINRRVTTLAYGTDGIPVPPSSSRLLPLLCLLYGILGAPIYQYINTFFSIPLPIFWGTFLFLI
LVACKFLPSFYGCSKNWWGSQIPISTVKALEKCLMGLKKSSSTTIPQLPAPTPSNELSANISCLEDMIAREIMTPKADIF
ALPSEIPISQAFPLIIDEGYSRVPLFTKNIDDITGMVLVKDLLPVYYKDPHTTQPLSSIAYPPLYTPEIRRVSLLLQEFR
QKRCHLAIVVNEYGFTEGLVSMEDIVEEIFGEIADEYDDQEDVHYKKVGNAWIVDGRMNISDAEEYFGLRIAHESSYDTL
GGYVFHKLGAVPEKGMKIYYEDFAIDILSCSDRSVEKMKITPRKRKPLSRNNRF
>Mature_374_residues
MLYILLATIILFLFLGSAINRRVTTLAYGTDGIPVPPSSSRLLPLLCLLYGILGAPIYQYINTFFSIPLPIFWGTFLFLI
LVACKFLPSFYGCSKNWWGSQIPISTVKALEKCLMGLKKSSSTTIPQLPAPTPSNELSANISCLEDMIAREIMTPKADIF
ALPSEIPISQAFPLIIDEGYSRVPLFTKNIDDITGMVLVKDLLPVYYKDPHTTQPLSSIAYPPLYTPEIRRVSLLLQEFR
QKRCHLAIVVNEYGFTEGLVSMEDIVEEIFGEIADEYDDQEDVHYKKVGNAWIVDGRMNISDAEEYFGLRIAHESSYDTL
GGYVFHKLGAVPEKGMKIYYEDFAIDILSCSDRSVEKMKITPRKRKPLSRNNRF

Specific function: Unknown

COG id: COG1253

COG function: function code R; Hemolysins and related proteins containing CBS domains

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI310128564, Length=190, Percent_Identity=28.9473684210526, Blast_Score=89, Evalue=7e-18,
Organism=Homo sapiens, GI40068053, Length=158, Percent_Identity=32.9113924050633, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI40068055, Length=158, Percent_Identity=32.9113924050633, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI40068049, Length=169, Percent_Identity=31.3609467455621, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI94681046, Length=158, Percent_Identity=32.9113924050633, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1786879, Length=211, Percent_Identity=32.7014218009479, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI87082033, Length=219, Percent_Identity=26.9406392694064, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI145693175, Length=371, Percent_Identity=22.6415094339623, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1788119, Length=265, Percent_Identity=24.1509433962264, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1790664, Length=228, Percent_Identity=19.2982456140351, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17539402, Length=216, Percent_Identity=30.0925925925926, Blast_Score=66, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6324512, Length=155, Percent_Identity=31.6129032258064, Blast_Score=64, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016169
- InterPro:   IPR000644
- InterPro:   IPR002550
- InterPro:   IPR005170 [H]

Pfam domain/function: PF00571 CBS; PF03471 CorC_HlyC; PF01595 DUF21 [H]

EC number: NA

Molecular weight: Translated: 42243; Mature: 42243

Theoretical pI: Translated: 5.74; Mature: 5.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLYILLATIILFLFLGSAINRRVTTLAYGTDGIPVPPSSSRLLPLLCLLYGILGAPIYQY
CHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
INTFFSIPLPIFWGTFLFLILVACKFLPSFYGCSKNWWGSQIPISTVKALEKCLMGLKKS
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCC
SSTTIPQLPAPTPSNELSANISCLEDMIAREIMTPKADIFALPSEIPISQAFPLIIDEGY
CCCCCCCCCCCCCCHHHHCCHHHHHHHHHHHHCCCCHHEEECCCCCCHHHCCCCEEECCC
SRVPLFTKNIDDITGMVLVKDLLPVYYKDPHTTQPLSSIAYPPLYTPEIRRVSLLLQEFR
CCCCEEECCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHH
QKRCHLAIVVNEYGFTEGLVSMEDIVEEIFGEIADEYDDQEDVHYKKVGNAWIVDGRMNI
HCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCEEEECCCCCC
SDAEEYFGLRIAHESSYDTLGGYVFHKLGAVPEKGMKIYYEDFAIDILSCSDRSVEKMKI
CCHHHHHCEEEECCCCCCHHHHHHHHHHCCCCCCCCEEEEEHHEEEEECCCCCCCHHEEC
TPRKRKPLSRNNRF
CCHHCCCCCCCCCC
>Mature Secondary Structure
MLYILLATIILFLFLGSAINRRVTTLAYGTDGIPVPPSSSRLLPLLCLLYGILGAPIYQY
CHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
INTFFSIPLPIFWGTFLFLILVACKFLPSFYGCSKNWWGSQIPISTVKALEKCLMGLKKS
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCC
SSTTIPQLPAPTPSNELSANISCLEDMIAREIMTPKADIFALPSEIPISQAFPLIIDEGY
CCCCCCCCCCCCCCHHHHCCHHHHHHHHHHHHCCCCHHEEECCCCCCHHHCCCCEEECCC
SRVPLFTKNIDDITGMVLVKDLLPVYYKDPHTTQPLSSIAYPPLYTPEIRRVSLLLQEFR
CCCCEEECCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHH
QKRCHLAIVVNEYGFTEGLVSMEDIVEEIFGEIADEYDDQEDVHYKKVGNAWIVDGRMNI
HCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCEEEECCCCCC
SDAEEYFGLRIAHESSYDTLGGYVFHKLGAVPEKGMKIYYEDFAIDILSCSDRSVEKMKI
CCHHHHHCEEEECCCCCCHHHHHHHHHHCCCCCCCCEEEEEHHEEEEECCCCCCCHHEEC
TPRKRKPLSRNNRF
CCHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]