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The map label for this gene is aroB

Identifier: 15835263

GI number: 15835263

Start: 774836

End: 775957

Strand: Direct

Name: aroB

Synonym: TC0648

Alternate gene names: 15835263

Gene position: 774836-775957 (Clockwise)

Preceding gene: 15835262

Following gene: 15835264

Centisome position: 72.22

GC content: 40.2

Gene sequence:

>1122_bases
ATGATAGAACTCATCACAGATAAACCCCACCCTATGCACTTAGTAGATTCCCTGTGCGATCCCCAGCTATTTGCTACCTT
AGCAAAAACTTCTCCTTTGATTTTTATCACCAATTCTACGCTAGAAATACTCGTACTCCCGCCTTTATTAGAAACGGCTC
GCTCATTAGGATTTTCTGTAGAAATCCTTATCATTCCAGAAGGAGAACAGGCAAAAACAGAAACCACCTTCCTCTATTTG
CATAAACAGCTAGCAACTCTTACTATCCCTAGGCAAGCTACTCTTATTGGTGTTGGAGGTGGCGTTGTTTTGGATATTGT
AGGATTTGTAGCCTCTACACATTGTCGAGGCATGCCTTTCATTGCCGTACCCACAACCCTAGTTGCTATGATCGATGCCA
GTATTGGGGGGAAAAATGGAATCAATTTGGATCATATTAAAAATCGCATTGGCTCTTTTTATTTACCTAAAGATGTATGG
ATTTGCCCCTCTGTGCTCTCTTCTCTTCCTGAACAAGAATTTTATCATGGAATAGCTGAGTGCATCAAACATGCCTATAT
AGCGGATGCTTCTATTCTCCCTATCCTTCAAAATCCAGCTTCTTTACGCTCCACGAAACAACTGTCTCTTCTCATCAAAC
GCAACTGTCTTTGTAAGGCCTCTATAGTGGGAAAAGATATTAGAGATCATGGAATACGTCAGATTTTAAATTTTGGGCAT
ACGTTAGGACATGCTTTGGAAATGCTATTTACAGGGAAAATTTCTCATGGTTTTGCTATAAGCGTGGGAATGGTTCTGGA
AACGAAACTTTCTCTAGCCATGGGAGTCGCTCGCAACCCAAATATCTTACATTTTTTAGTTCAGGATCTCCTGAGATACC
AACTTCCTACTTCTTTGAAAGATCTGTACGCACAAGCTCAAATTCCTATTCACAGTTGTAGTCAAATTCTTTCTGCTCTC
AGCTATGATAAGAAAAAACAAAATGCCTCTTTACCTCCTTTCGTTATGATAGAAGAGATCGGACTCGCAGCCTCTTGTAA
TGGTAGTTTCTGCCAACCTGCATCTAATCATTTTCTTACACACATTTTAAAGGAAGATCTCCATGCTATGCACGATCATT
AG

Upstream 100 bases:

>100_bases
GTCATGATCCCTGCGTGGCAATTCGAGCTGTTACCGTTGTTGAAGCCATGCTTGATCTCACTTTAGTAGACCTTCTCCTT
CAACACCGCTGTGCTAAATT

Downstream 100 bases:

>100_bases
AGGCCCTTCTTTCCTTGAAGCCAGAAATCAGCTATTGCGCTCTTTAAAAAAATGCCGTTGCTTTGAAATGCGTGCAGATC
TTCTTACTGTATCCGATGCA

Product: 3-dehydroquinate synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 373; Mature: 373

Protein sequence:

>373_residues
MIELITDKPHPMHLVDSLCDPQLFATLAKTSPLIFITNSTLEILVLPPLLETARSLGFSVEILIIPEGEQAKTETTFLYL
HKQLATLTIPRQATLIGVGGGVVLDIVGFVASTHCRGMPFIAVPTTLVAMIDASIGGKNGINLDHIKNRIGSFYLPKDVW
ICPSVLSSLPEQEFYHGIAECIKHAYIADASILPILQNPASLRSTKQLSLLIKRNCLCKASIVGKDIRDHGIRQILNFGH
TLGHALEMLFTGKISHGFAISVGMVLETKLSLAMGVARNPNILHFLVQDLLRYQLPTSLKDLYAQAQIPIHSCSQILSAL
SYDKKKQNASLPPFVMIEEIGLAASCNGSFCQPASNHFLTHILKEDLHAMHDH

Sequences:

>Translated_373_residues
MIELITDKPHPMHLVDSLCDPQLFATLAKTSPLIFITNSTLEILVLPPLLETARSLGFSVEILIIPEGEQAKTETTFLYL
HKQLATLTIPRQATLIGVGGGVVLDIVGFVASTHCRGMPFIAVPTTLVAMIDASIGGKNGINLDHIKNRIGSFYLPKDVW
ICPSVLSSLPEQEFYHGIAECIKHAYIADASILPILQNPASLRSTKQLSLLIKRNCLCKASIVGKDIRDHGIRQILNFGH
TLGHALEMLFTGKISHGFAISVGMVLETKLSLAMGVARNPNILHFLVQDLLRYQLPTSLKDLYAQAQIPIHSCSQILSAL
SYDKKKQNASLPPFVMIEEIGLAASCNGSFCQPASNHFLTHILKEDLHAMHDH
>Mature_373_residues
MIELITDKPHPMHLVDSLCDPQLFATLAKTSPLIFITNSTLEILVLPPLLETARSLGFSVEILIIPEGEQAKTETTFLYL
HKQLATLTIPRQATLIGVGGGVVLDIVGFVASTHCRGMPFIAVPTTLVAMIDASIGGKNGINLDHIKNRIGSFYLPKDVW
ICPSVLSSLPEQEFYHGIAECIKHAYIADASILPILQNPASLRSTKQLSLLIKRNCLCKASIVGKDIRDHGIRQILNFGH
TLGHALEMLFTGKISHGFAISVGMVLETKLSLAMGVARNPNILHFLVQDLLRYQLPTSLKDLYAQAQIPIHSCSQILSAL
SYDKKKQNASLPPFVMIEEIGLAASCNGSFCQPASNHFLTHILKEDLHAMHDH

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; second step. [C]

COG id: COG0337

COG function: function code E; 3-dehydroquinate synthetase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dehydroquinate synthase family

Homologues:

Organism=Escherichia coli, GI1789791, Length=311, Percent_Identity=34.0836012861736, Blast_Score=155, Evalue=3e-39,
Organism=Saccharomyces cerevisiae, GI6320332, Length=338, Percent_Identity=33.7278106508876, Blast_Score=164, Evalue=1e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROB_CHLMU (Q9PK25)

Other databases:

- EMBL:   AE002160
- RefSeq:   NP_297022.1
- ProteinModelPortal:   Q9PK25
- SMR:   Q9PK25
- GeneID:   1246009
- GenomeReviews:   AE002160_GR
- KEGG:   cmu:TC0648
- TIGR:   TC_0648
- HOGENOM:   HBG632303
- ProtClustDB:   PRK00002
- BioCyc:   CMUR243161:TC_0648-MONOMER
- BRENDA:   4.2.3.4
- GO:   GO:0005737
- HAMAP:   MF_00110
- InterPro:   IPR016303
- InterPro:   IPR002658
- InterPro:   IPR016037
- PANTHER:   PTHR21090:SF1
- PIRSF:   PIRSF001455
- TIGRFAMs:   TIGR01357

Pfam domain/function: PF01761 DHQ_synthase

EC number: =4.2.3.4

Molecular weight: Translated: 40842; Mature: 40842

Theoretical pI: Translated: 7.45; Mature: 7.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIELITDKPHPMHLVDSLCDPQLFATLAKTSPLIFITNSTLEILVLPPLLETARSLGFSV
CEEEECCCCCCHHHHHHHCCHHHHHHHHHCCCEEEEECCCEEEEEECHHHHHHHHCCCEE
EILIIPEGEQAKTETTFLYLHKQLATLTIPRQATLIGVGGGVVLDIVGFVASTHCRGMPF
EEEEEECCCCCCHHHHHHHHHHHHHHEECCCCEEEEEECCHHHHHHHHHHHHHCCCCCCE
IAVPTTLVAMIDASIGGKNGINLDHIKNRIGSFYLPKDVWICPSVLSSLPEQEFYHGIAE
EHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCEECCCCCEECHHHHHHCCHHHHHHHHHH
CIKHAYIADASILPILQNPASLRSTKQLSLLIKRNCLCKASIVGKDIRDHGIRQILNFGH
HHHHHHHCCCCCHHHHCCCHHHHHHHHHHHHHHHCCCEEHHHHCCCHHHHHHHHHHHHHH
TLGHALEMLFTGKISHGFAISVGMVLETKLSLAMGVARNPNILHFLVQDLLRYQLPTSLK
HHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCHHHH
DLYAQAQIPIHSCSQILSALSYDKKKQNASLPPFVMIEEIGLAASCNGSFCQPASNHFLT
HHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHCCCEECCCCCCCCCCHHHHHH
HILKEDLHAMHDH
HHHHHHHHHHCCC
>Mature Secondary Structure
MIELITDKPHPMHLVDSLCDPQLFATLAKTSPLIFITNSTLEILVLPPLLETARSLGFSV
CEEEECCCCCCHHHHHHHCCHHHHHHHHHCCCEEEEECCCEEEEEECHHHHHHHHCCCEE
EILIIPEGEQAKTETTFLYLHKQLATLTIPRQATLIGVGGGVVLDIVGFVASTHCRGMPF
EEEEEECCCCCCHHHHHHHHHHHHHHEECCCCEEEEEECCHHHHHHHHHHHHHCCCCCCE
IAVPTTLVAMIDASIGGKNGINLDHIKNRIGSFYLPKDVWICPSVLSSLPEQEFYHGIAE
EHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCEECCCCCEECHHHHHHCCHHHHHHHHHH
CIKHAYIADASILPILQNPASLRSTKQLSLLIKRNCLCKASIVGKDIRDHGIRQILNFGH
HHHHHHHCCCCCHHHHCCCHHHHHHHHHHHHHHHCCCEEHHHHCCCHHHHHHHHHHHHHH
TLGHALEMLFTGKISHGFAISVGMVLETKLSLAMGVARNPNILHFLVQDLLRYQLPTSLK
HHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCHHHH
DLYAQAQIPIHSCSQILSALSYDKKKQNASLPPFVMIEEIGLAASCNGSFCQPASNHFLT
HHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHCCCEECCCCCCCCCCHHHHHH
HILKEDLHAMHDH
HHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10684935