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The map label for this gene is aroC

Identifier: 15835262

GI number: 15835262

Start: 773766

End: 774839

Strand: Direct

Name: aroC

Synonym: TC0647

Alternate gene names: 15835262

Gene position: 773766-774839 (Clockwise)

Preceding gene: 15835261

Following gene: 15835263

Centisome position: 72.12

GC content: 45.34

Gene sequence:

>1074_bases
ATGCATAATCAATATGGATCCCTATTTTCTATTACTACCTGGGGAGAATCTCACGGTCCCTCTATCGGAGTCGTTATTGA
TGGTTGTCCCGCTGGACTTCCTTTAGCACCAGAAGATTTTCTTCCCGCTATGAAAAGAAGAAGACCTGGACAACTCCACA
CCTCTCCTCGCCAAGAAACAGACTCGGTGACCATTTTATCTGGTGTCTACCAACAAAAAACAACGGGAACCCCCATTTCT
CTTCTTATTCAAAACGAGGATGCATCCAGTACTTCTTACGAGCAACTAAATGACTGCTACCGCCCAGGACATGCACAATT
TGCTTACGAAGGTAAATACGGTTTTGCAGATAACCGCGGAGGAGGACGATCCTCCGCTAGAGAAACAGCTGCTCGAGTAG
CAGCAGGCGTGGTTGCTAAAAAAATTCTCTCATCTCAGGGAATCAAAACACTCGCCTTCCTTTCTGGATTCGGTCCCTTA
GAAAATAAAACCTACCCAAAACTCACCGATCCTCTAATACGAAAGGTCTATTCATCTCCCTTTTATACCATCCTCTCTCA
AGAGGAAATTCAAAATCTTCTTCTCCATGATCCAGAAGATTCCTTCGGAGGGATCGTTTCTTTTATCACTTCTCCCCTAC
CTATAGGCCTAGGAGAGCCCGTGTTTGGGAAACTCCCAGCTCTTTTAGCGGCTGGTATGATGAGCATCCCCGCAACCAAG
GGATTTGAAATAGGAGAAGGGTTTGCTTCAGCACATATGACAGGCTCTACTTATCTAGATTCTTTTATTGCTAAGGAAGG
AGAGATATCTTTCCAAACGAATCGATGCGGAGGAACTTTAGGAGGCATTAGCATCGGACAACCTCTTGAAGGCCGAGTAG
CCTTTAAACCCACTTCATCTATTCGAAAACCTTGTCCCTCCGTATCAAAGGATGGAGAGCCCATCACATATAAAACCCCT
AAACAAGGGCGTCATGATCCCTGCGTGGCAATTCGAGCTGTTACCGTTGTTGAAGCCATGCTTGATCTCACTTTAGTAGA
CCTTCTCCTTCAACACCGCTGTGCTAAATTATGA

Upstream 100 bases:

>100_bases
CCCCATATTTTCTCTTTACAAGCAGCTACCTCTCTTCATGAGATAGGAGAAGTTTGTCAAAGTTTTTGCTTGCAATTCTT
GACTGCACAAGAGATTCCTT

Downstream 100 bases:

>100_bases
TAGAACTCATCACAGATAAACCCCACCCTATGCACTTAGTAGATTCCCTGTGCGATCCCCAGCTATTTGCTACCTTAGCA
AAAACTTCTCCTTTGATTTT

Product: chorismate synthase

Products: NA

Alternate protein names: 5-enolpyruvylshikimate-3-phosphate phospholyase

Number of amino acids: Translated: 357; Mature: 357

Protein sequence:

>357_residues
MHNQYGSLFSITTWGESHGPSIGVVIDGCPAGLPLAPEDFLPAMKRRRPGQLHTSPRQETDSVTILSGVYQQKTTGTPIS
LLIQNEDASSTSYEQLNDCYRPGHAQFAYEGKYGFADNRGGGRSSARETAARVAAGVVAKKILSSQGIKTLAFLSGFGPL
ENKTYPKLTDPLIRKVYSSPFYTILSQEEIQNLLLHDPEDSFGGIVSFITSPLPIGLGEPVFGKLPALLAAGMMSIPATK
GFEIGEGFASAHMTGSTYLDSFIAKEGEISFQTNRCGGTLGGISIGQPLEGRVAFKPTSSIRKPCPSVSKDGEPITYKTP
KQGRHDPCVAIRAVTVVEAMLDLTLVDLLLQHRCAKL

Sequences:

>Translated_357_residues
MHNQYGSLFSITTWGESHGPSIGVVIDGCPAGLPLAPEDFLPAMKRRRPGQLHTSPRQETDSVTILSGVYQQKTTGTPIS
LLIQNEDASSTSYEQLNDCYRPGHAQFAYEGKYGFADNRGGGRSSARETAARVAAGVVAKKILSSQGIKTLAFLSGFGPL
ENKTYPKLTDPLIRKVYSSPFYTILSQEEIQNLLLHDPEDSFGGIVSFITSPLPIGLGEPVFGKLPALLAAGMMSIPATK
GFEIGEGFASAHMTGSTYLDSFIAKEGEISFQTNRCGGTLGGISIGQPLEGRVAFKPTSSIRKPCPSVSKDGEPITYKTP
KQGRHDPCVAIRAVTVVEAMLDLTLVDLLLQHRCAKL
>Mature_357_residues
MHNQYGSLFSITTWGESHGPSIGVVIDGCPAGLPLAPEDFLPAMKRRRPGQLHTSPRQETDSVTILSGVYQQKTTGTPIS
LLIQNEDASSTSYEQLNDCYRPGHAQFAYEGKYGFADNRGGGRSSARETAARVAAGVVAKKILSSQGIKTLAFLSGFGPL
ENKTYPKLTDPLIRKVYSSPFYTILSQEEIQNLLLHDPEDSFGGIVSFITSPLPIGLGEPVFGKLPALLAAGMMSIPATK
GFEIGEGFASAHMTGSTYLDSFIAKEGEISFQTNRCGGTLGGISIGQPLEGRVAFKPTSSIRKPCPSVSKDGEPITYKTP
KQGRHDPCVAIRAVTVVEAMLDLTLVDLLLQHRCAKL

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; seventh step. [C]

COG id: COG0082

COG function: function code E; Chorismate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chorismate synthase family

Homologues:

Organism=Escherichia coli, GI1788669, Length=361, Percent_Identity=46.5373961218837, Blast_Score=272, Evalue=3e-74,
Organism=Saccharomyces cerevisiae, GI6321290, Length=362, Percent_Identity=40.6077348066298, Blast_Score=250, Evalue=2e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROC_CHLMU (Q9PK26)

Other databases:

- EMBL:   AE002160
- PIR:   F81679
- RefSeq:   NP_297021.1
- ProteinModelPortal:   Q9PK26
- GeneID:   1246008
- GenomeReviews:   AE002160_GR
- KEGG:   cmu:TC0647
- TIGR:   TC_0647
- HOGENOM:   HBG292336
- OMA:   SRFTTQR
- PhylomeDB:   Q9PK26
- ProtClustDB:   PRK05382
- BioCyc:   CMUR243161:TC_0647-MONOMER
- BRENDA:   4.2.3.5
- HAMAP:   MF_00300_B
- InterPro:   IPR000453
- InterPro:   IPR020541
- PANTHER:   PTHR21085
- PIRSF:   PIRSF001456
- TIGRFAMs:   TIGR00033

Pfam domain/function: PF01264 Chorismate_synt; SSF103263 Chorismate_synth

EC number: =4.2.3.5

Molecular weight: Translated: 38292; Mature: 38292

Theoretical pI: Translated: 7.86; Mature: 7.86

Prosite motif: PS00787 CHORISMATE_SYNTHASE_1; PS00788 CHORISMATE_SYNTHASE_2; PS00789 CHORISMATE_SYNTHASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHNQYGSLFSITTWGESHGPSIGVVIDGCPAGLPLAPEDFLPAMKRRRPGQLHTSPRQET
CCCCCCCEEEEEECCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCC
DSVTILSGVYQQKTTGTPISLLIQNEDASSTSYEQLNDCYRPGHAQFAYEGKYGFADNRG
CCEEEHHHHHHHCCCCCCEEEEEECCCCCCCCHHHHHHHHCCCCCCEEECCCCCCCCCCC
GGRSSARETAARVAAGVVAKKILSSQGIKTLAFLSGFGPLENKTYPKLTDPLIRKVYSSP
CCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCC
FYTILSQEEIQNLLLHDPEDSFGGIVSFITSPLPIGLGEPVFGKLPALLAAGMMSIPATK
HHHHHCHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCC
GFEIGEGFASAHMTGSTYLDSFIAKEGEISFQTNRCGGTLGGISIGQPLEGRVAFKPTSS
CCCCCCCHHHHHCCCHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCEEECCCHH
IRKPCPSVSKDGEPITYKTPKQGRHDPCVAIRAVTVVEAMLDLTLVDLLLQHRCAKL
HHCCCCCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MHNQYGSLFSITTWGESHGPSIGVVIDGCPAGLPLAPEDFLPAMKRRRPGQLHTSPRQET
CCCCCCCEEEEEECCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCC
DSVTILSGVYQQKTTGTPISLLIQNEDASSTSYEQLNDCYRPGHAQFAYEGKYGFADNRG
CCEEEHHHHHHHCCCCCCEEEEEECCCCCCCCHHHHHHHHCCCCCCEEECCCCCCCCCCC
GGRSSARETAARVAAGVVAKKILSSQGIKTLAFLSGFGPLENKTYPKLTDPLIRKVYSSP
CCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCC
FYTILSQEEIQNLLLHDPEDSFGGIVSFITSPLPIGLGEPVFGKLPALLAAGMMSIPATK
HHHHHCHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCC
GFEIGEGFASAHMTGSTYLDSFIAKEGEISFQTNRCGGTLGGISIGQPLEGRVAFKPTSS
CCCCCCCHHHHHCCCHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCEEECCCHH
IRKPCPSVSKDGEPITYKTPKQGRHDPCVAIRAVTVVEAMLDLTLVDLLLQHRCAKL
HHCCCCCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10684935