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The map label for this gene is dxs

Identifier: 15835225

GI number: 15835225

Start: 726440

End: 728338

Strand: Direct

Name: dxs

Synonym: TC0608

Alternate gene names: 15835225

Gene position: 726440-728338 (Clockwise)

Preceding gene: 15835224

Following gene: 15835226

Centisome position: 67.7

GC content: 41.55

Gene sequence:

>1899_bases
ATGATCTCCCCTCTTCTACAACATATTAGCTCCCCTCAAAAGCTGCGTTCCTTATCTCTAGATCAACTTCCTTTGTTATG
CGATGAAATCCGTAACAGAATTATTGCGACCCTTTCTTTAACAGGAGGCCATTTAGCTTCCAATTTAGGCATAGTTGAGC
TCACTGTTGCTTTACATTATGTTTTCGCTTCTCCTGAGGATCAATTCATTTTTGACGTTGGACACCAAGCTTATGTACAC
AAACTACTAACAGGACGTAATACAGAAGCCTTCTCTAATATACGACATGATAATGGACTAAGTGGATTTACAAGCCCCCA
GGAATCCAATCATGACATTTTTTTTTCTGGACATGCTGGAAATGCTCTTTCTTTAGCATTGGGGTTAGCTAAGGGAGCAT
CCCACGGCTCTTCGCATATTCTTCCTATACTCGGAGATGCTGCTTTTTCTTGTGGGCTCACCCTAGAGGCTCTGAATAAT
GTTCCCTCTGACTTATCGAAATTTATTATTGTCCTTAACGACAACCAAATGTCGATCTCTGAGAATGTAGGCAATATCCC
TCAGGGAATCTCTCAGTGGATTCAGCCCCCAAAGTTCGATAAAATATTCCAGAAAATACATTCCTGGATGAGAAAAATTC
CTGGTTTTTCACGACAAAAAAGCGAACTGTTGCACAAGGTGGATATTGCTCTAAAATCTTTATCTCATCCTTTATTTGAA
CAATTTGGCATCCATTATGTAGGTCCTTTCGACGGACATAACATTAAAAAACTCATTCCTGCTTTAGAAGCAGTCAAAGG
GCTCCCCTACCCCGTTCTTTTTCATGTATGCACAGCTAAGGGCAATGGTTTGGCTGAGGCCGAAAAAGACCCAGCTCTCT
ATCACGGAGTAAAAGCTTATTTCAAAAATCATTCCCCCAAGAAAAAACCTCTTAGTTCTGAAGTAAAAACACCCTCTTCT
TTCCCTCAGCATGTAGGCCATATCCTATGCCAATTAGGGGAAAAACATCCTCGCTTGCAAGTCGTGACTCCTGCCATGTC
CTTGGGATCTTGTTTAGAAGATTTCCGTAAACAATTCCCTGATCGCTTCACTGATGTAGGGATAGCAGAAGGCCATGCCG
TGACTTTTTCGGCAGGAATAGCTCGAAGCGGCACTCCTGTAGTCTGTTCTATCTATTCCACATTTTTAAACCGAGCTATG
GATAACGTATTTCACGATGTCTGCATGCAAGAACTCCCCGTGATTTTTGCTATTGACCGAGCAGGGTTAGCCTTCCATGA
TGGGCGAAGCCATCATGGAATTTATGACTTAGGGTTCCTATGTTCTATGCCTAATATGGTAGTTTGCCAGCCGAGAAACG
CCAGCGTTCTTGAAAGACTGCTATTCTCTTCTTTACTTTGGAAGTCCCCTTGCGCGATTCGATACCCCAACCTCTCTACT
CGTAAAGAAGTCTCCAATCCTTCTTTTAGTCCTATTTTCCCTGGAGAAGCAGAAGTTCTTTGCCAAGGAGACGATCTATT
ATTAATAGCCCTTGGACACATGTGTGATACTGCTCTAGCAGTCAAAGAACAACTTCTTGATCATGGGATCTCTACCACTG
TTGTTGATCCCATTTTTATTAAACCTTTAGATACAGAACTTCTGCAAACACTGCTTTCCCATCACTCAAAAGTAGTCGTT
TTAGAAGAGCACTCTATTCATGGGGGATTATCCGCAGAATTCCTTCTCTTCTTAAATAACCACAATCTTAAAACCGATGT
TCTCTCTTTAGGTATTCCTGATATATTTATTCCTCATGGGAATCCTGAAACGATTTTAAATATGATTGGGTTAACTAGCG
ATCAGATCACCCTGAAGATTCTCGCGCATTTTAATTTTTCAGCACCTATTCCCATCTAG

Upstream 100 bases:

>100_bases
AGCAGCACAGTTTTCAACTACAATTAAACTCCGATGGTTCTATCGTTAAAGATGCTTCAGGCAACCCTATTAAGCATCCC
TTTATCCCTGGGGAGCCTGC

Downstream 100 bases:

>100_bases
CACTTTTTCAAAGTTTACCCCTCCCCATCGCTAAATATTTTGTATAGTTGAAGGCTTCTTTCATTTTGGATATCCTAAGA
AAATATTCCTCTTACTAATA

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS

Number of amino acids: Translated: 632; Mature: 632

Protein sequence:

>632_residues
MISPLLQHISSPQKLRSLSLDQLPLLCDEIRNRIIATLSLTGGHLASNLGIVELTVALHYVFASPEDQFIFDVGHQAYVH
KLLTGRNTEAFSNIRHDNGLSGFTSPQESNHDIFFSGHAGNALSLALGLAKGASHGSSHILPILGDAAFSCGLTLEALNN
VPSDLSKFIIVLNDNQMSISENVGNIPQGISQWIQPPKFDKIFQKIHSWMRKIPGFSRQKSELLHKVDIALKSLSHPLFE
QFGIHYVGPFDGHNIKKLIPALEAVKGLPYPVLFHVCTAKGNGLAEAEKDPALYHGVKAYFKNHSPKKKPLSSEVKTPSS
FPQHVGHILCQLGEKHPRLQVVTPAMSLGSCLEDFRKQFPDRFTDVGIAEGHAVTFSAGIARSGTPVVCSIYSTFLNRAM
DNVFHDVCMQELPVIFAIDRAGLAFHDGRSHHGIYDLGFLCSMPNMVVCQPRNASVLERLLFSSLLWKSPCAIRYPNLST
RKEVSNPSFSPIFPGEAEVLCQGDDLLLIALGHMCDTALAVKEQLLDHGISTTVVDPIFIKPLDTELLQTLLSHHSKVVV
LEEHSIHGGLSAEFLLFLNNHNLKTDVLSLGIPDIFIPHGNPETILNMIGLTSDQITLKILAHFNFSAPIPI

Sequences:

>Translated_632_residues
MISPLLQHISSPQKLRSLSLDQLPLLCDEIRNRIIATLSLTGGHLASNLGIVELTVALHYVFASPEDQFIFDVGHQAYVH
KLLTGRNTEAFSNIRHDNGLSGFTSPQESNHDIFFSGHAGNALSLALGLAKGASHGSSHILPILGDAAFSCGLTLEALNN
VPSDLSKFIIVLNDNQMSISENVGNIPQGISQWIQPPKFDKIFQKIHSWMRKIPGFSRQKSELLHKVDIALKSLSHPLFE
QFGIHYVGPFDGHNIKKLIPALEAVKGLPYPVLFHVCTAKGNGLAEAEKDPALYHGVKAYFKNHSPKKKPLSSEVKTPSS
FPQHVGHILCQLGEKHPRLQVVTPAMSLGSCLEDFRKQFPDRFTDVGIAEGHAVTFSAGIARSGTPVVCSIYSTFLNRAM
DNVFHDVCMQELPVIFAIDRAGLAFHDGRSHHGIYDLGFLCSMPNMVVCQPRNASVLERLLFSSLLWKSPCAIRYPNLST
RKEVSNPSFSPIFPGEAEVLCQGDDLLLIALGHMCDTALAVKEQLLDHGISTTVVDPIFIKPLDTELLQTLLSHHSKVVV
LEEHSIHGGLSAEFLLFLNNHNLKTDVLSLGIPDIFIPHGNPETILNMIGLTSDQITLKILAHFNFSAPIPI
>Mature_632_residues
MISPLLQHISSPQKLRSLSLDQLPLLCDEIRNRIIATLSLTGGHLASNLGIVELTVALHYVFASPEDQFIFDVGHQAYVH
KLLTGRNTEAFSNIRHDNGLSGFTSPQESNHDIFFSGHAGNALSLALGLAKGASHGSSHILPILGDAAFSCGLTLEALNN
VPSDLSKFIIVLNDNQMSISENVGNIPQGISQWIQPPKFDKIFQKIHSWMRKIPGFSRQKSELLHKVDIALKSLSHPLFE
QFGIHYVGPFDGHNIKKLIPALEAVKGLPYPVLFHVCTAKGNGLAEAEKDPALYHGVKAYFKNHSPKKKPLSSEVKTPSS
FPQHVGHILCQLGEKHPRLQVVTPAMSLGSCLEDFRKQFPDRFTDVGIAEGHAVTFSAGIARSGTPVVCSIYSTFLNRAM
DNVFHDVCMQELPVIFAIDRAGLAFHDGRSHHGIYDLGFLCSMPNMVVCQPRNASVLERLLFSSLLWKSPCAIRYPNLST
RKEVSNPSFSPIFPGEAEVLCQGDDLLLIALGHMCDTALAVKEQLLDHGISTTVVDPIFIKPLDTELLQTLLSHHSKVVV
LEEHSIHGGLSAEFLLFLNNHNLKTDVLSLGIPDIFIPHGNPETILNMIGLTSDQITLKILAHFNFSAPIPI

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily

Homologues:

Organism=Homo sapiens, GI205277463, Length=685, Percent_Identity=23.5036496350365, Blast_Score=111, Evalue=3e-24,
Organism=Homo sapiens, GI4507521, Length=685, Percent_Identity=23.5036496350365, Blast_Score=111, Evalue=3e-24,
Organism=Homo sapiens, GI133778974, Length=328, Percent_Identity=23.780487804878, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI225637463, Length=305, Percent_Identity=24.5901639344262, Blast_Score=79, Evalue=9e-15,
Organism=Homo sapiens, GI225637461, Length=305, Percent_Identity=24.5901639344262, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI225637459, Length=305, Percent_Identity=24.5901639344262, Blast_Score=79, Evalue=1e-14,
Organism=Escherichia coli, GI1786622, Length=627, Percent_Identity=37.4800637958533, Blast_Score=416, Evalue=1e-117,
Organism=Caenorhabditis elegans, GI17539652, Length=670, Percent_Identity=22.8358208955224, Blast_Score=89, Evalue=9e-18,
Organism=Drosophila melanogaster, GI24666278, Length=643, Percent_Identity=23.0171073094868, Blast_Score=96, Evalue=7e-20,
Organism=Drosophila melanogaster, GI45551847, Length=324, Percent_Identity=25.6172839506173, Blast_Score=88, Evalue=2e-17,
Organism=Drosophila melanogaster, GI45550715, Length=324, Percent_Identity=25.6172839506173, Blast_Score=88, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24645119, Length=327, Percent_Identity=25.3822629969419, Blast_Score=88, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXS_CHLMU (Q9PK62)

Other databases:

- EMBL:   AE002160
- PIR:   E81684
- RefSeq:   NP_296984.1
- ProteinModelPortal:   Q9PK62
- SMR:   Q9PK62
- GeneID:   1245970
- GenomeReviews:   AE002160_GR
- KEGG:   cmu:TC0608
- TIGR:   TC_0608
- HOGENOM:   HBG571647
- OMA:   QRFPDRY
- ProtClustDB:   PRK05444
- BioCyc:   CMUR243161:TC_0608-MONOMER
- BRENDA:   2.2.1.7
- HAMAP:   MF_00315
- InterPro:   IPR005477
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476
- Gene3D:   G3DSA:3.40.50.920
- SMART:   SM00861
- TIGRFAMs:   TIGR00204

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; SSF52922 Transketo_C_like

EC number: =2.2.1.7

Molecular weight: Translated: 69340; Mature: 69340

Theoretical pI: Translated: 7.00; Mature: 7.00

Prosite motif: PS00801 TRANSKETOLASE_1; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISPLLQHISSPQKLRSLSLDQLPLLCDEIRNRIIATLSLTGGHLASNLGIVELTVALHY
CCCHHHHHCCCHHHHHHCCCHHHHHHHHHHHHHEEEEEEECCCHHHHCCCCEEHEEHHHH
VFASPEDQFIFDVGHQAYVHKLLTGRNTEAFSNIRHDNGLSGFTSPQESNHDIFFSGHAG
HCCCCCCCEEEECCHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCCC
NALSLALGLAKGASHGSSHILPILGDAAFSCGLTLEALNNVPSDLSKFIIVLNDNQMSIS
CHHHHHHHHHHCCCCCCCCEEEEECCHHHHCCCCHHHHHCCCCCCCCEEEEECCCCEEHH
ENVGNIPQGISQWIQPPKFDKIFQKIHSWMRKIPGFSRQKSELLHKVDIALKSLSHPLFE
HCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCHHHH
QFGIHYVGPFDGHNIKKLIPALEAVKGLPYPVLFHVCTAKGNGLAEAEKDPALYHGVKAY
HCCCEEECCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHH
FKNHSPKKKPLSSEVKTPSSFPQHVGHILCQLGEKHPRLQVVTPAMSLGSCLEDFRKQFP
HCCCCCCCCCCCHHCCCCCCHHHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHCC
DRFTDVGIAEGHAVTFSAGIARSGTPVVCSIYSTFLNRAMDNVFHDVCMQELPVIFAIDR
HHHHCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEC
AGLAFHDGRSHHGIYDLGFLCSMPNMVVCQPRNASVLERLLFSSLLWKSPCAIRYPNLST
CCCEEECCCCCCCEEHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHCCCCEEECCCCCC
RKEVSNPSFSPIFPGEAEVLCQGDDLLLIALGHMCDTALAVKEQLLDHGISTTVVDPIFI
HHHCCCCCCCCCCCCCCEEEECCCCEEEEEHHHHHHHHHHHHHHHHHCCCCHHEECCEEE
KPLDTELLQTLLSHHSKVVVLEEHSIHGGLSAEFLLFLNNHNLKTDVLSLGIPDIFIPHG
CCCCHHHHHHHHHCCCEEEEEECCCCCCCCCEEEEEEEECCCCHHHHHHCCCCEEEECCC
NPETILNMIGLTSDQITLKILAHFNFSAPIPI
CHHHHHHHHCCCCCCEEEEEEEECCCCCCCCC
>Mature Secondary Structure
MISPLLQHISSPQKLRSLSLDQLPLLCDEIRNRIIATLSLTGGHLASNLGIVELTVALHY
CCCHHHHHCCCHHHHHHCCCHHHHHHHHHHHHHEEEEEEECCCHHHHCCCCEEHEEHHHH
VFASPEDQFIFDVGHQAYVHKLLTGRNTEAFSNIRHDNGLSGFTSPQESNHDIFFSGHAG
HCCCCCCCEEEECCHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCCC
NALSLALGLAKGASHGSSHILPILGDAAFSCGLTLEALNNVPSDLSKFIIVLNDNQMSIS
CHHHHHHHHHHCCCCCCCCEEEEECCHHHHCCCCHHHHHCCCCCCCCEEEEECCCCEEHH
ENVGNIPQGISQWIQPPKFDKIFQKIHSWMRKIPGFSRQKSELLHKVDIALKSLSHPLFE
HCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCHHHH
QFGIHYVGPFDGHNIKKLIPALEAVKGLPYPVLFHVCTAKGNGLAEAEKDPALYHGVKAY
HCCCEEECCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHH
FKNHSPKKKPLSSEVKTPSSFPQHVGHILCQLGEKHPRLQVVTPAMSLGSCLEDFRKQFP
HCCCCCCCCCCCHHCCCCCCHHHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHCC
DRFTDVGIAEGHAVTFSAGIARSGTPVVCSIYSTFLNRAMDNVFHDVCMQELPVIFAIDR
HHHHCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEC
AGLAFHDGRSHHGIYDLGFLCSMPNMVVCQPRNASVLERLLFSSLLWKSPCAIRYPNLST
CCCEEECCCCCCCEEHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHCCCCEEECCCCCC
RKEVSNPSFSPIFPGEAEVLCQGDDLLLIALGHMCDTALAVKEQLLDHGISTTVVDPIFI
HHHCCCCCCCCCCCCCCEEEECCCCEEEEEHHHHHHHHHHHHHHHHHCCCCHHEECCEEE
KPLDTELLQTLLSHHSKVVVLEEHSIHGGLSAEFLLFLNNHNLKTDVLSLGIPDIFIPHG
CCCCHHHHHHHHHCCCEEEEEECCCCCCCCCEEEEEEEECCCCHHHHHHCCCCEEEECCC
NPETILNMIGLTSDQITLKILAHFNFSAPIPI
CHHHHHHHHCCCCCCEEEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10684935