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The map label for this gene is atpA

Identifier: 15835199

GI number: 15835199

Start: 695157

End: 696932

Strand: Reverse

Name: atpA

Synonym: TC0582

Alternate gene names: 15835199

Gene position: 696932-695157 (Counterclockwise)

Preceding gene: 15835200

Following gene: 15835198

Centisome position: 64.95

GC content: 42.12

Gene sequence:

>1776_bases
ATGGTAGCAACTTCAAAACAAACGACGCAGGGCTATGTCGTAGAAGCTTACGGAAATTTATTGCGGGTGCATTTTGATGG
GCATGTGCGTCAAGGAGAAGTGGCCTATGTCAGCGTGGATGATACTTGGTTGAAAGCGGAAATTATAGAAGTTGTGGGAG
ATGAGGTTAAAGTCCAAGTTTTTGAGGAAACTCAAGGAATTTCTCGAGGCGCTTTGGTAACTTTTTCCGGGCATTTATTA
GAAGCGGAACTTGGGCCCGGTCTATTGCAAGGTATTTTTGACGGACTTCAGAATCGCTTAGAGGTATTGGCAGATACAAG
CTTGTTCTTGAAAAGAGGGGAGTATGTTAATGCCATTTGTCGGGAAACTGTATGGGCTTATACGCAAAAGGCTTCTGTCG
GGGATGTTCTATCTCGGGGAGATGTGCTTGGTACAGTAAAGGAAGGGCGGTTTGATCATAAAATCATGGTTCCTTTCTCT
TGTTTTGAGGAAGTGACTATCACTTGGGTCATTTCTTCAGGAGATTACACTGTTGATACCGTTATTGCTAAAGGACGTAC
TGCTTCAGGAGCCGAGCTTGAATTTACAATGGTTCAGAAATGGCCCATTAAACAGGCTTTTTTAGAAGGGGAAAAGGTAC
CGTCTCATGAAATTATGGATGTTGGGTTACGAGTATTAGATACTCAGATCCCCGTCTTAAAGGGAGGAACTTTTTGTACT
CCAGGGCCTTTTGGTGCAGGAAAGACCGTTTTACAGCACCATTTATCTAAGTATGCAGCTGTAGATATCGTAGTTTTGTG
TGCTTGTGGAGAGCGAGCTGGAGAGGTTGTAGAAATTCTTCAGGAGTTCCCGCATTTGACAGATCCTCATACGGGGCAGT
CTTTGATGCATAGGACCTGTATTATTTGTAATACATCTTCCATGCCTGTAGCAGCTAGAGAGTCCTCCATTTATTTGGGT
ATTACTATAGCAGAATATTACCGTCAAATGGGGTTGCATGTTTTGTTATTGGCTGACTCGACATCTAGATGGGCTCAAGC
TTTAAGGGAAATTTCAGGGCGATTAGAAGAAATCCCTGGAGAAGAAGCTTTCCCAGCCTATTTGGCGTCTCGAATAGCAG
CTTTTTATGAGCGAGGCGGGGCTGTGAAAATGAAAGATGGATCGGAAGGCTCCTTGACTATCTGTGGAGCGGTTTCTCCC
GCAGGAGGAAATTTTGAAGAGCCTGTTACACAAGCAACTTTATCTGTTGTTGGGGCTTTCTGTGGGCTTTCTAAGGCTAG
AGCAGATGCTAGACGGTATCCTTCTATTGATCCGATGATTTCATGGTCTAAGTACTTGGATTCTGTGGCGGAGATTTTAG
AGAAAAAAGTTCCAGGATGGGGAGATTCCGTTAAAAAAGCTTCTCGTTTCTTAGAAGAAGGAGCAGAAATTGGTAAGCGA
ATAGAAGTTGTTGGGGAAGAAGGGATTTCTATGGAAGATATAGAAATCTTTTTGAAATCAGAGTTGTATGATTTCTGTTA
CTTACAGCAAAACGCTTTCGATGCAGAGGACTGTTATTGTCCTTTTGATCGTCAAATAGAGCTTTTTTCTTTAATGAGTC
ATATTTTTAGCTCTAGATTCTGTTTTGATTGTCCAGATAATGCTCGGAGTTTCTTTTTAGAGCTTCAAAGTAAAATTAAA
ACGCTGAATGGTCAAAAATTCCTTTCTGAAGACTATCAGAAGGGGCTAGAAGTGATCTATAAACTATTAGAAAGCAAAAT
GGTGCAGACGGCGTAG

Upstream 100 bases:

>100_bases
TTCTTTCTCGTGTAACTACCTATTTAATGGCTATTCGTAATAGCTATGTGAGCGTTCAAAAAGGGAAAGAACTGATTAAT
TTGATGGAGAAAGGAATCAA

Downstream 100 bases:

>100_bases
GTATGCAAACAATATATACAAGAATTACGGATATCAAGGGGAACTTGATTACTGTAGAGGCCGAAGGAGCCTCTTTAGGT
GAATTAGTGCAGATTGAGCG

Product: V-type ATP synthase subunit A

Products: NA

Alternate protein names: V-ATPase subunit A

Number of amino acids: Translated: 591; Mature: 591

Protein sequence:

>591_residues
MVATSKQTTQGYVVEAYGNLLRVHFDGHVRQGEVAYVSVDDTWLKAEIIEVVGDEVKVQVFEETQGISRGALVTFSGHLL
EAELGPGLLQGIFDGLQNRLEVLADTSLFLKRGEYVNAICRETVWAYTQKASVGDVLSRGDVLGTVKEGRFDHKIMVPFS
CFEEVTITWVISSGDYTVDTVIAKGRTASGAELEFTMVQKWPIKQAFLEGEKVPSHEIMDVGLRVLDTQIPVLKGGTFCT
PGPFGAGKTVLQHHLSKYAAVDIVVLCACGERAGEVVEILQEFPHLTDPHTGQSLMHRTCIICNTSSMPVAARESSIYLG
ITIAEYYRQMGLHVLLLADSTSRWAQALREISGRLEEIPGEEAFPAYLASRIAAFYERGGAVKMKDGSEGSLTICGAVSP
AGGNFEEPVTQATLSVVGAFCGLSKARADARRYPSIDPMISWSKYLDSVAEILEKKVPGWGDSVKKASRFLEEGAEIGKR
IEVVGEEGISMEDIEIFLKSELYDFCYLQQNAFDAEDCYCPFDRQIELFSLMSHIFSSRFCFDCPDNARSFFLELQSKIK
TLNGQKFLSEDYQKGLEVIYKLLESKMVQTA

Sequences:

>Translated_591_residues
MVATSKQTTQGYVVEAYGNLLRVHFDGHVRQGEVAYVSVDDTWLKAEIIEVVGDEVKVQVFEETQGISRGALVTFSGHLL
EAELGPGLLQGIFDGLQNRLEVLADTSLFLKRGEYVNAICRETVWAYTQKASVGDVLSRGDVLGTVKEGRFDHKIMVPFS
CFEEVTITWVISSGDYTVDTVIAKGRTASGAELEFTMVQKWPIKQAFLEGEKVPSHEIMDVGLRVLDTQIPVLKGGTFCT
PGPFGAGKTVLQHHLSKYAAVDIVVLCACGERAGEVVEILQEFPHLTDPHTGQSLMHRTCIICNTSSMPVAARESSIYLG
ITIAEYYRQMGLHVLLLADSTSRWAQALREISGRLEEIPGEEAFPAYLASRIAAFYERGGAVKMKDGSEGSLTICGAVSP
AGGNFEEPVTQATLSVVGAFCGLSKARADARRYPSIDPMISWSKYLDSVAEILEKKVPGWGDSVKKASRFLEEGAEIGKR
IEVVGEEGISMEDIEIFLKSELYDFCYLQQNAFDAEDCYCPFDRQIELFSLMSHIFSSRFCFDCPDNARSFFLELQSKIK
TLNGQKFLSEDYQKGLEVIYKLLESKMVQTA
>Mature_591_residues
MVATSKQTTQGYVVEAYGNLLRVHFDGHVRQGEVAYVSVDDTWLKAEIIEVVGDEVKVQVFEETQGISRGALVTFSGHLL
EAELGPGLLQGIFDGLQNRLEVLADTSLFLKRGEYVNAICRETVWAYTQKASVGDVLSRGDVLGTVKEGRFDHKIMVPFS
CFEEVTITWVISSGDYTVDTVIAKGRTASGAELEFTMVQKWPIKQAFLEGEKVPSHEIMDVGLRVLDTQIPVLKGGTFCT
PGPFGAGKTVLQHHLSKYAAVDIVVLCACGERAGEVVEILQEFPHLTDPHTGQSLMHRTCIICNTSSMPVAARESSIYLG
ITIAEYYRQMGLHVLLLADSTSRWAQALREISGRLEEIPGEEAFPAYLASRIAAFYERGGAVKMKDGSEGSLTICGAVSP
AGGNFEEPVTQATLSVVGAFCGLSKARADARRYPSIDPMISWSKYLDSVAEILEKKVPGWGDSVKKASRFLEEGAEIGKR
IEVVGEEGISMEDIEIFLKSELYDFCYLQQNAFDAEDCYCPFDRQIELFSLMSHIFSSRFCFDCPDNARSFFLELQSKIK
TLNGQKFLSEDYQKGLEVIYKLLESKMVQTA

Specific function: Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit

COG id: COG1155

COG function: function code C; Archaeal/vacuolar-type H+-ATPase subunit A

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase alpha/beta chains family

Homologues:

Organism=Homo sapiens, GI19913424, Length=505, Percent_Identity=41.7821782178218, Blast_Score=395, Evalue=1e-110,
Organism=Homo sapiens, GI32189394, Length=289, Percent_Identity=28.0276816608997, Blast_Score=87, Evalue=6e-17,
Organism=Homo sapiens, GI19913426, Length=230, Percent_Identity=25.6521739130435, Blast_Score=84, Evalue=4e-16,
Organism=Homo sapiens, GI19913428, Length=230, Percent_Identity=24.7826086956522, Blast_Score=81, Evalue=3e-15,
Organism=Escherichia coli, GI1790170, Length=299, Percent_Identity=26.4214046822742, Blast_Score=93, Evalue=4e-20,
Organism=Escherichia coli, GI1788251, Length=247, Percent_Identity=26.3157894736842, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1790172, Length=272, Percent_Identity=24.2647058823529, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17565854, Length=505, Percent_Identity=42.5742574257426, Blast_Score=395, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI25144756, Length=286, Percent_Identity=28.3216783216783, Blast_Score=89, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI17510931, Length=201, Percent_Identity=29.3532338308458, Blast_Score=85, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17570191, Length=205, Percent_Identity=27.8048780487805, Blast_Score=78, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6320016, Length=270, Percent_Identity=42.2222222222222, Blast_Score=225, Evalue=1e-59,
Organism=Saccharomyces cerevisiae, GI6322581, Length=243, Percent_Identity=29.6296296296296, Blast_Score=86, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6319603, Length=238, Percent_Identity=26.0504201680672, Blast_Score=84, Evalue=8e-17,
Organism=Saccharomyces cerevisiae, GI6319370, Length=214, Percent_Identity=25.2336448598131, Blast_Score=64, Evalue=6e-11,
Organism=Drosophila melanogaster, GI20129479, Length=512, Percent_Identity=39.84375, Blast_Score=382, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24583988, Length=494, Percent_Identity=40.2834008097166, Blast_Score=378, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24583986, Length=494, Percent_Identity=40.2834008097166, Blast_Score=378, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24583984, Length=494, Percent_Identity=40.2834008097166, Blast_Score=378, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24583992, Length=509, Percent_Identity=38.7033398821218, Blast_Score=373, Evalue=1e-103,
Organism=Drosophila melanogaster, GI28574560, Length=235, Percent_Identity=30.2127659574468, Blast_Score=89, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24638766, Length=241, Percent_Identity=29.8755186721992, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI281361666, Length=254, Percent_Identity=26.7716535433071, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24646341, Length=254, Percent_Identity=26.7716535433071, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI17136796, Length=254, Percent_Identity=26.7716535433071, Blast_Score=84, Evalue=2e-16,

Paralogues:

None

Copy number: 10836 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 8,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): VATA_CHLMU (Q9PK85)

Other databases:

- EMBL:   AE002160
- PIR:   E81687
- RefSeq:   NP_296958.1
- ProteinModelPortal:   Q9PK85
- SMR:   Q9PK85
- GeneID:   1245941
- GenomeReviews:   AE002160_GR
- KEGG:   cmu:TC0582
- TIGR:   TC_0582
- HOGENOM:   HBG288114
- OMA:   QMGLDIL
- ProtClustDB:   PRK04192
- BioCyc:   CMUR243161:TC_0582-MONOMER
- BRENDA:   3.6.3.14
- HAMAP:   MF_00309
- InterPro:   IPR020003
- InterPro:   IPR000194
- InterPro:   IPR018118
- InterPro:   IPR000793
- InterPro:   IPR004100
- InterPro:   IPR022878

Pfam domain/function: PF00006 ATP-synt_ab; PF00306 ATP-synt_ab_C; PF02874 ATP-synt_ab_N; SSF50615 ATPase_a/b_N

EC number: =3.6.3.14

Molecular weight: Translated: 65302; Mature: 65302

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: PS00152 ATPASE_ALPHA_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVATSKQTTQGYVVEAYGNLLRVHFDGHVRQGEVAYVSVDDTWLKAEIIEVVGDEVKVQV
CCCCCCCCCCCEEEEECCCEEEEEECCCCCCCCEEEEEECCCHHHHHHHHHCCCCEEEEE
FEETQGISRGALVTFSGHLLEAELGPGLLQGIFDGLQNRLEVLADTSLFLKRGEYVNAIC
EHHCCCCCCCEEEEEECCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
RETVWAYTQKASVGDVLSRGDVLGTVKEGRFDHKIMVPFSCFEEVTITWVISSGDYTVDT
HHHHHHHHHCCCHHHHHHCCCEEEECCCCCCCCEEECCHHHCCCEEEEEEEECCCEEEEE
VIAKGRTASGAELEFTMVQKWPIKQAFLEGEKVPSHEIMDVGLRVLDTQIPVLKGGTFCT
EEECCCCCCCCEEEEEEEECCCHHHHHHCCCCCCCHHHHHHHHHHHHCCCCEEECCCCCC
PGPFGAGKTVLQHHLSKYAAVDIVVLCACGERAGEVVEILQEFPHLTDPHTGQSLMHRTC
CCCCCCCHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHCCCCCCCCCCHHHHHCEE
IICNTSSMPVAARESSIYLGITIAEYYRQMGLHVLLLADSTSRWAQALREISGRLEEIPG
EEECCCCCCCEECCCCEEEEEEHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHCCC
EEAFPAYLASRIAAFYERGGAVKMKDGSEGSLTICGAVSPAGGNFEEPVTQATLSVVGAF
CCCHHHHHHHHHHHHHHCCCEEEECCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHH
CGLSKARADARRYPSIDPMISWSKYLDSVAEILEKKVPGWGDSVKKASRFLEEGAEIGKR
HCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCE
IEVVGEEGISMEDIEIFLKSELYDFCYLQQNAFDAEDCYCPFDRQIELFSLMSHIFSSRF
EEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCC
CFDCPDNARSFFLELQSKIKTLNGQKFLSEDYQKGLEVIYKLLESKMVQTA
EECCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MVATSKQTTQGYVVEAYGNLLRVHFDGHVRQGEVAYVSVDDTWLKAEIIEVVGDEVKVQV
CCCCCCCCCCCEEEEECCCEEEEEECCCCCCCCEEEEEECCCHHHHHHHHHCCCCEEEEE
FEETQGISRGALVTFSGHLLEAELGPGLLQGIFDGLQNRLEVLADTSLFLKRGEYVNAIC
EHHCCCCCCCEEEEEECCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
RETVWAYTQKASVGDVLSRGDVLGTVKEGRFDHKIMVPFSCFEEVTITWVISSGDYTVDT
HHHHHHHHHCCCHHHHHHCCCEEEECCCCCCCCEEECCHHHCCCEEEEEEEECCCEEEEE
VIAKGRTASGAELEFTMVQKWPIKQAFLEGEKVPSHEIMDVGLRVLDTQIPVLKGGTFCT
EEECCCCCCCCEEEEEEEECCCHHHHHHCCCCCCCHHHHHHHHHHHHCCCCEEECCCCCC
PGPFGAGKTVLQHHLSKYAAVDIVVLCACGERAGEVVEILQEFPHLTDPHTGQSLMHRTC
CCCCCCCHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHCCCCCCCCCCHHHHHCEE
IICNTSSMPVAARESSIYLGITIAEYYRQMGLHVLLLADSTSRWAQALREISGRLEEIPG
EEECCCCCCCEECCCCEEEEEEHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHCCC
EEAFPAYLASRIAAFYERGGAVKMKDGSEGSLTICGAVSPAGGNFEEPVTQATLSVVGAF
CCCHHHHHHHHHHHHHHCCCEEEECCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHH
CGLSKARADARRYPSIDPMISWSKYLDSVAEILEKKVPGWGDSVKKASRFLEEGAEIGKR
HCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCE
IEVVGEEGISMEDIEIFLKSELYDFCYLQQNAFDAEDCYCPFDRQIELFSLMSHIFSSRF
EEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCC
CFDCPDNARSFFLELQSKIKTLNGQKFLSEDYQKGLEVIYKLLESKMVQTA
EECCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10684935