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Identifier: 15835145

GI number: 15835145

Start: 637425

End: 638663

Strand: Direct

Name: Not Available

Synonym: TC0527

Alternate gene names: 15835145

Gene position: 637425-638663 (Clockwise)

Preceding gene: 15835143

Following gene: 15835146

Centisome position: 59.41

GC content: 37.13

Gene sequence:

>1239_bases
ATGTTCTCTCCAGTAATTATTGTTTTAACTGCAGTTTTCGTCCTGTGCTCGGGGTTTATTTCTTTATCGCACATTGCTCT
ATTTTCTCTCCCCTCGTCTCTTATTGCACACTATAATCACTCCAAGAACAAACAGCTTCGACAAATCGCCAATCTCATGG
CTTACCCCAATCATTTACTCATTACCCTGGTCTTTTTCGACATAGGGATTAATATTGGGGTACAAAATTGTATAGCAACG
TTAGTCGGAGACTCTGCATCATTTCTAATGACCGTAGGAGTTCCCCTCGCTTTAACGCTTGTTTTAGGAGAAATTATTCC
TAAAGTCATTGCTATTCCTTACAATGTTCGAATCGCACGTCTTGTAACTCCCATTATCTTTGTCTCAACTAAAAGCTTCC
GTCCTATTTTTGATTGGGCTATTTCAGGCATTAATTTTATCATTCAAAAAATGTTAGTTCATCAAGAGGGTGATTTTATT
CAACCTCAAGAACTAAAAGAAGTCTTGCGCAGTTGTAAAGACTTTGGAGTCGTAAATCATGAAGAAAGTAGGTTACTGTT
TGGATACCTCTCTATGGAAGAGGGAAGTATTAAAGAAAGAATGAAACCCAAACAGGAAATTGTTTTTTATGATGTCCTTA
CTCCTATTGAAAATTTATATCGGCTATTTTCTGGACAACGCTACTCAAGAATTCTTGTCTGCAAAGATGGACTACAAAAT
CTTTTAGGAGTTTGCTCTGCTAAATCTCTTGTCCTCCATAAGGAACAGTTACAATCTTCAGAAGATCTTCTTCCTCTTCT
TAGAAAACCTCATTATATTCCTGAAACTGTATCTGCTAAAACAGCTTTATATCACCTAGCTAAAGAAGATAGTGGATTAG
GTATCATTATTGATGAATATGGATCTATAGAGGGGTTAATCACCCAAAATGATCTATTTGAAATTGTTTCTAATGAAGTT
TCCCATATCCGTCCTGCTTCCAAACAGTTCGCTCACTCAGATAAAAATGTTATCATCGCTGCAGGGACCTATGAGCTTTC
TGATTTCTATGATCTTTTTGGAGTAGATCTTCCTACCACTTCTAATTGTGTTACAATCGGTGGGTGGCTTACAGAACAAT
TAGGAGAAATCCCTGAAACAGGAACAAAATTTGCCTGGGGACAATTTGTATTTCAGGTACTAGATGCAGCTCCTAATTGT
GTAAAGCGAGTGTATATAAGGAAAACACATGGAAACTGA

Upstream 100 bases:

>100_bases
TACTAAAGCTTCCAGAACTCTAGAGAAAAAGTAGAATTCTACTAGCATTTTTTATAGATAATAAGAATAATCCGAATCCG
CTCACAATAACCCAGATCGA

Downstream 100 bases:

>100_bases
CTCTCCATTCTTCTGGTTAGGAGTTAATCTCGTCTGCATTTTCGTCCAAGGTTTTTTCTCTATGATGGAAATGGCTTGCG
TATCATTTAATCGTGTGCGT

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 412; Mature: 412

Protein sequence:

>412_residues
MFSPVIIVLTAVFVLCSGFISLSHIALFSLPSSLIAHYNHSKNKQLRQIANLMAYPNHLLITLVFFDIGINIGVQNCIAT
LVGDSASFLMTVGVPLALTLVLGEIIPKVIAIPYNVRIARLVTPIIFVSTKSFRPIFDWAISGINFIIQKMLVHQEGDFI
QPQELKEVLRSCKDFGVVNHEESRLLFGYLSMEEGSIKERMKPKQEIVFYDVLTPIENLYRLFSGQRYSRILVCKDGLQN
LLGVCSAKSLVLHKEQLQSSEDLLPLLRKPHYIPETVSAKTALYHLAKEDSGLGIIIDEYGSIEGLITQNDLFEIVSNEV
SHIRPASKQFAHSDKNVIIAAGTYELSDFYDLFGVDLPTTSNCVTIGGWLTEQLGEIPETGTKFAWGQFVFQVLDAAPNC
VKRVYIRKTHGN

Sequences:

>Translated_412_residues
MFSPVIIVLTAVFVLCSGFISLSHIALFSLPSSLIAHYNHSKNKQLRQIANLMAYPNHLLITLVFFDIGINIGVQNCIAT
LVGDSASFLMTVGVPLALTLVLGEIIPKVIAIPYNVRIARLVTPIIFVSTKSFRPIFDWAISGINFIIQKMLVHQEGDFI
QPQELKEVLRSCKDFGVVNHEESRLLFGYLSMEEGSIKERMKPKQEIVFYDVLTPIENLYRLFSGQRYSRILVCKDGLQN
LLGVCSAKSLVLHKEQLQSSEDLLPLLRKPHYIPETVSAKTALYHLAKEDSGLGIIIDEYGSIEGLITQNDLFEIVSNEV
SHIRPASKQFAHSDKNVIIAAGTYELSDFYDLFGVDLPTTSNCVTIGGWLTEQLGEIPETGTKFAWGQFVFQVLDAAPNC
VKRVYIRKTHGN
>Mature_412_residues
MFSPVIIVLTAVFVLCSGFISLSHIALFSLPSSLIAHYNHSKNKQLRQIANLMAYPNHLLITLVFFDIGINIGVQNCIAT
LVGDSASFLMTVGVPLALTLVLGEIIPKVIAIPYNVRIARLVTPIIFVSTKSFRPIFDWAISGINFIIQKMLVHQEGDFI
QPQELKEVLRSCKDFGVVNHEESRLLFGYLSMEEGSIKERMKPKQEIVFYDVLTPIENLYRLFSGQRYSRILVCKDGLQN
LLGVCSAKSLVLHKEQLQSSEDLLPLLRKPHYIPETVSAKTALYHLAKEDSGLGIIIDEYGSIEGLITQNDLFEIVSNEV
SHIRPASKQFAHSDKNVIIAAGTYELSDFYDLFGVDLPTTSNCVTIGGWLTEQLGEIPETGTKFAWGQFVFQVLDAAPNC
VKRVYIRKTHGN

Specific function: Unknown

COG id: COG1253

COG function: function code R; Hemolysins and related proteins containing CBS domains

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI310128564, Length=300, Percent_Identity=24.3333333333333, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI145693175, Length=405, Percent_Identity=24.1975308641975, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1790664, Length=429, Percent_Identity=21.4452214452214, Blast_Score=92, Evalue=9e-20,
Organism=Escherichia coli, GI87082033, Length=367, Percent_Identity=24.7956403269755, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1786879, Length=252, Percent_Identity=19.047619047619, Blast_Score=62, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016169
- InterPro:   IPR000644
- InterPro:   IPR002550
- InterPro:   IPR005170 [H]

Pfam domain/function: PF00571 CBS; PF03471 CorC_HlyC; PF01595 DUF21 [H]

EC number: NA

Molecular weight: Translated: 46004; Mature: 46004

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFSPVIIVLTAVFVLCSGFISLSHIALFSLPSSLIAHYNHSKNKQLRQIANLMAYPNHLL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHH
ITLVFFDIGINIGVQNCIATLVGDSASFLMTVGVPLALTLVLGEIIPKVIAIPYNVRIAR
HHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
LVTPIIFVSTKSFRPIFDWAISGINFIIQKMLVHQEGDFIQPQELKEVLRSCKDFGVVNH
HHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCC
EESRLLFGYLSMEEGSIKERMKPKQEIVFYDVLTPIENLYRLFSGQRYSRILVCKDGLQN
CCCEEEEEEEECCCCCHHHHCCCHHHEEHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHH
LLGVCSAKSLVLHKEQLQSSEDLLPLLRKPHYIPETVSAKTALYHLAKEDSGLGIIIDEY
HHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCEEEEECC
GSIEGLITQNDLFEIVSNEVSHIRPASKQFAHSDKNVIIAAGTYELSDFYDLFGVDLPTT
CCCCEEEEHHHHHHHHHHHHHHCCCHHHHHHCCCCCEEEEECCEEHHHHHHHHCCCCCCC
SNCVTIGGWLTEQLGEIPETGTKFAWGQFVFQVLDAAPNCVKRVYIRKTHGN
CCCEEECCHHHHHHCCCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHEECCCC
>Mature Secondary Structure
MFSPVIIVLTAVFVLCSGFISLSHIALFSLPSSLIAHYNHSKNKQLRQIANLMAYPNHLL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHH
ITLVFFDIGINIGVQNCIATLVGDSASFLMTVGVPLALTLVLGEIIPKVIAIPYNVRIAR
HHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
LVTPIIFVSTKSFRPIFDWAISGINFIIQKMLVHQEGDFIQPQELKEVLRSCKDFGVVNH
HHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCC
EESRLLFGYLSMEEGSIKERMKPKQEIVFYDVLTPIENLYRLFSGQRYSRILVCKDGLQN
CCCEEEEEEEECCCCCHHHHCCCHHHEEHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHH
LLGVCSAKSLVLHKEQLQSSEDLLPLLRKPHYIPETVSAKTALYHLAKEDSGLGIIIDEY
HHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCEEEEECC
GSIEGLITQNDLFEIVSNEVSHIRPASKQFAHSDKNVIIAAGTYELSDFYDLFGVDLPTT
CCCCEEEEHHHHHHHHHHHHHHCCCHHHHHHCCCCCEEEEECCEEHHHHHHHHCCCCCCC
SNCVTIGGWLTEQLGEIPETGTKFAWGQFVFQVLDAAPNCVKRVYIRKTHGN
CCCEEECCHHHHHHCCCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503; 3045760 [H]