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The map label for this gene is gyrA-2

Identifier: 15835079

GI number: 15835079

Start: 558734

End: 561235

Strand: Reverse

Name: gyrA-2

Synonym: TC0461

Alternate gene names: 15835079

Gene position: 561235-558734 (Counterclockwise)

Preceding gene: 15835080

Following gene: 15835078

Centisome position: 52.31

GC content: 41.01

Gene sequence:

>2502_bases
ATGCTAAATAAAGAAGAAATCATCGTCCCTAAAAATCTTGAAGAGGAGATGAAGGAGAGCTACCTTCGCTACTCTATGTC
TGTAATTATTTCCCGAGCTTTGCCTGATGTTAGGGATGGATTAAAGCCTTCTCAGCGGCGTATTTTATACGCTATGAAAC
AATTGAATTTGACTCCAGGAGCGAAACACAGAAAGTGCGCAAAAATTTGTGGAGACACTTCTGGGGATTATCACCCTCAT
GGTGAGGCTGTTATTTATCCTACATTGGTGCGAATGGCTCAAGACTGGGCGATGCGATATCCGCTAGTTGACGGTCAAGG
GAATTTTGGATCCATCGATGGAGATCCTGCTGCTGCGATGCGATATACAGAGGCCCGGTTGACTCATAGTTCGATCTTTT
TATTAGAGGACCTAGATAAAGATACTGTAGACATGGTCCCTAACTATGACGAAACAAAGTATGAGCCTGTCGTTTTCCCC
TCAAAGTTTCCTAATCTACTTTGTAATGGTTCTTCAGGAATCGCTGTAGGTATGGCGACTAATATTCCTCCTCATAATTT
AGGAGAATTGATTGAAGCTACGCTGTTAGTTTTAGCTAACCCACAAACTTCTATTGAGGAAATTTTGGAAGTTATGCCTG
GTCCTGATTTCCCTACCGGAGGAATTATTTGTGGAACGGAAGGCATTCGTTCTACTTATTACACAGGAAGAGGGAAATTA
CGTTTGCGTGCTCGTATACACGTAGAGGAAAACTCTGATAAGCAACGGGAGAATATCATTCTCACGGAAATGCCCTATAA
CGTAAATAAATCGCGATTAGTTGAGCAGATAGCAGAACTGATTAATGAAAAAACTTTAACAGGGATATCTGATGTTCGCG
ATGAGTCTGATAAAGACGGTATTCGTGTTGTATTGGAGTTGAAAAAAGGCGAATCTTCTGAAGTCATTATCAATCGTTTA
TATAAGTTCACGGATGTACAAGTGACATTTGGGGCTAATATGTTAGCGTTGGATAAAAATCTTCCGCGAACTATGAGTAT
CCATAGAATGATTTCTGCTTGGATCCGTCATCGTATGGACGTTATTCGACGGAGAACTCGTTACGAGTTAAATAAAGCAG
AAACACGCGCACATATATTGGAAGGCTTTTTAAAAGCTCTTTCTTGTATGGATGAAGTGGTCAAAACTATTCGTGAAAGC
TCGAACAAAGAGCATGCGAAGCAGCAATTGGTTGAATTGTTTGGCTTTTCGGAAGCACAGTCTCTTGCCATTCTCGAATT
GCGATTATACCAACTCACTGGCTTAGAAATAGACAAAGTACAGAAAGAGTATAACGAGCTTTTAGAGAAGATCGCCTACT
ATCGCAGAGTTTTGGCAGAAGAAGAACTTGTCAAAGATATTATTCGTGAAGAGCTTCAAGAATTACATAAAGTTCATAAG
ACTCCTCGACGCACCACAATTGAAATGGATGCGGGAGATGTTCGAGATATAGAAGATATCATTGCGGACGAGTCAGTAAT
CATTACTATTTCAGGTGATGATTATGTGAAGCGTATGCCTGTGAAAGTTTTCCGTGAGCAGAAACGAGGTGGGCAAGGAG
TGACTGGGTTTGACATGAAGAAAGGCTCAGACTTCTTGAAAGCAGTTTATTCTGCATCAACAAAAGATTACTTGCTGATC
TTTACTAATATGGGTCAATGTTACTGGTTAAAAGTTTGGCAACTTCCTGAAGGAGAACGACGTGCTAAAGGCAAGCCTAT
TATCAACTTTTTAGAAGGTATTCGTCCTGGCGAACAGGTTGCTGCGGTCCTTAATGTGAAGCGTTTCGAACAAGGAGAAT
ATCTCCTTTTAGCTACGAAGAAAGGTGTGGTTAAAAAAGTCTCTTTAGATGCCTTCGGTAGCCCACGTAAGAAAGGAATT
CGTGCATTAGAAATAGATGATGGCGATGAACTTATTGCGGCTCGTCACATAGTGAATGACGAGGAAAAGGTTATGTTATT
TACTCGTTTAGGAATGGCTGTTCGCTTCCCTCATGATAAAGTACGTCCAATGGGACGTGCAGCTCGAGGAGTCCGTGGTG
TTTCTTTGAAGAATGAAGAAGACTTTGTGGTCAGTTGTCAAGTTGTTACAGATGATCAAAGTGTTTTAGTTGTTTGTGAT
AATGGATTCGGAAAGCGTTCTTTAGTTTGTGATTTTAGGGAAACTAACCGAGGTAGCGTTGGCGTTCGCTCTATCTTAAT
TAATCAAAGAAATGGAGATGTATTAGGAGCTATTTCGGTAACAGACTTTGATAGTATATTGCTTATGTCTGCTCAAGGGC
AGGCTATCCGAATCAATATGCAGGATGTTCGGGTAATGGGAAGAGCTACTCAGGGAGTTCGTCTTGTAAATCTTCGAGAA
GGGGATACTCTGGTTGCTATGGAAAAATTATCAGTGAATACAGAGTCTGGAGAAACAGAAGAAAGCGTTAGCATCCAAGT
TGGACATGCGGTAGAGGAATAG

Upstream 100 bases:

>100_bases
TGTTAATGGGAGAAGAAGTCCCTCCGCGACGTGAATTTATTGAAAGCCATGCGCTATCCATTCGGATGAGTAATTTAGAT
ATTTAGGAGACAGAATCGCC

Downstream 100 bases:

>100_bases
AGTGTTTATTGTAGTAGAAGGCGGAGAAGGTGCTGGGAAAACCCAATTTACACAGGCACTTTCTAAACGTTTAATGGAAG
AAGGGAAAGAGGTTGTTTTA

Product: DNA gyrase subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 833; Mature: 833

Protein sequence:

>833_residues
MLNKEEIIVPKNLEEEMKESYLRYSMSVIISRALPDVRDGLKPSQRRILYAMKQLNLTPGAKHRKCAKICGDTSGDYHPH
GEAVIYPTLVRMAQDWAMRYPLVDGQGNFGSIDGDPAAAMRYTEARLTHSSIFLLEDLDKDTVDMVPNYDETKYEPVVFP
SKFPNLLCNGSSGIAVGMATNIPPHNLGELIEATLLVLANPQTSIEEILEVMPGPDFPTGGIICGTEGIRSTYYTGRGKL
RLRARIHVEENSDKQRENIILTEMPYNVNKSRLVEQIAELINEKTLTGISDVRDESDKDGIRVVLELKKGESSEVIINRL
YKFTDVQVTFGANMLALDKNLPRTMSIHRMISAWIRHRMDVIRRRTRYELNKAETRAHILEGFLKALSCMDEVVKTIRES
SNKEHAKQQLVELFGFSEAQSLAILELRLYQLTGLEIDKVQKEYNELLEKIAYYRRVLAEEELVKDIIREELQELHKVHK
TPRRTTIEMDAGDVRDIEDIIADESVIITISGDDYVKRMPVKVFREQKRGGQGVTGFDMKKGSDFLKAVYSASTKDYLLI
FTNMGQCYWLKVWQLPEGERRAKGKPIINFLEGIRPGEQVAAVLNVKRFEQGEYLLLATKKGVVKKVSLDAFGSPRKKGI
RALEIDDGDELIAARHIVNDEEKVMLFTRLGMAVRFPHDKVRPMGRAARGVRGVSLKNEEDFVVSCQVVTDDQSVLVVCD
NGFGKRSLVCDFRETNRGSVGVRSILINQRNGDVLGAISVTDFDSILLMSAQGQAIRINMQDVRVMGRATQGVRLVNLRE
GDTLVAMEKLSVNTESGETEESVSIQVGHAVEE

Sequences:

>Translated_833_residues
MLNKEEIIVPKNLEEEMKESYLRYSMSVIISRALPDVRDGLKPSQRRILYAMKQLNLTPGAKHRKCAKICGDTSGDYHPH
GEAVIYPTLVRMAQDWAMRYPLVDGQGNFGSIDGDPAAAMRYTEARLTHSSIFLLEDLDKDTVDMVPNYDETKYEPVVFP
SKFPNLLCNGSSGIAVGMATNIPPHNLGELIEATLLVLANPQTSIEEILEVMPGPDFPTGGIICGTEGIRSTYYTGRGKL
RLRARIHVEENSDKQRENIILTEMPYNVNKSRLVEQIAELINEKTLTGISDVRDESDKDGIRVVLELKKGESSEVIINRL
YKFTDVQVTFGANMLALDKNLPRTMSIHRMISAWIRHRMDVIRRRTRYELNKAETRAHILEGFLKALSCMDEVVKTIRES
SNKEHAKQQLVELFGFSEAQSLAILELRLYQLTGLEIDKVQKEYNELLEKIAYYRRVLAEEELVKDIIREELQELHKVHK
TPRRTTIEMDAGDVRDIEDIIADESVIITISGDDYVKRMPVKVFREQKRGGQGVTGFDMKKGSDFLKAVYSASTKDYLLI
FTNMGQCYWLKVWQLPEGERRAKGKPIINFLEGIRPGEQVAAVLNVKRFEQGEYLLLATKKGVVKKVSLDAFGSPRKKGI
RALEIDDGDELIAARHIVNDEEKVMLFTRLGMAVRFPHDKVRPMGRAARGVRGVSLKNEEDFVVSCQVVTDDQSVLVVCD
NGFGKRSLVCDFRETNRGSVGVRSILINQRNGDVLGAISVTDFDSILLMSAQGQAIRINMQDVRVMGRATQGVRLVNLRE
GDTLVAMEKLSVNTESGETEESVSIQVGHAVEE
>Mature_833_residues
MLNKEEIIVPKNLEEEMKESYLRYSMSVIISRALPDVRDGLKPSQRRILYAMKQLNLTPGAKHRKCAKICGDTSGDYHPH
GEAVIYPTLVRMAQDWAMRYPLVDGQGNFGSIDGDPAAAMRYTEARLTHSSIFLLEDLDKDTVDMVPNYDETKYEPVVFP
SKFPNLLCNGSSGIAVGMATNIPPHNLGELIEATLLVLANPQTSIEEILEVMPGPDFPTGGIICGTEGIRSTYYTGRGKL
RLRARIHVEENSDKQRENIILTEMPYNVNKSRLVEQIAELINEKTLTGISDVRDESDKDGIRVVLELKKGESSEVIINRL
YKFTDVQVTFGANMLALDKNLPRTMSIHRMISAWIRHRMDVIRRRTRYELNKAETRAHILEGFLKALSCMDEVVKTIRES
SNKEHAKQQLVELFGFSEAQSLAILELRLYQLTGLEIDKVQKEYNELLEKIAYYRRVLAEEELVKDIIREELQELHKVHK
TPRRTTIEMDAGDVRDIEDIIADESVIITISGDDYVKRMPVKVFREQKRGGQGVTGFDMKKGSDFLKAVYSASTKDYLLI
FTNMGQCYWLKVWQLPEGERRAKGKPIINFLEGIRPGEQVAAVLNVKRFEQGEYLLLATKKGVVKKVSLDAFGSPRKKGI
RALEIDDGDELIAARHIVNDEEKVMLFTRLGMAVRFPHDKVRPMGRAARGVRGVSLKNEEDFVVSCQVVTDDQSVLVVCD
NGFGKRSLVCDFRETNRGSVGVRSILINQRNGDVLGAISVTDFDSILLMSAQGQAIRINMQDVRVMGRATQGVRLVNLRE
GDTLVAMEKLSVNTESGETEESVSIQVGHAVEE

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=316, Percent_Identity=24.0506329113924, Blast_Score=74, Evalue=4e-13,
Organism=Homo sapiens, GI19913406, Length=315, Percent_Identity=24.1269841269841, Blast_Score=73, Evalue=1e-12,
Organism=Escherichia coli, GI1788562, Length=838, Percent_Identity=45.2267303102625, Blast_Score=718, Evalue=0.0,
Organism=Escherichia coli, GI1789396, Length=673, Percent_Identity=35.2154531946508, Blast_Score=384, Evalue=1e-107,
Organism=Caenorhabditis elegans, GI212645845, Length=488, Percent_Identity=23.5655737704918, Blast_Score=81, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6324241, Length=343, Percent_Identity=26.8221574344023, Blast_Score=85, Evalue=4e-17,
Organism=Drosophila melanogaster, GI17136538, Length=363, Percent_Identity=22.8650137741047, Blast_Score=71, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR005743
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 93885; Mature: 93885

Theoretical pI: Translated: 6.58; Mature: 6.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNKEEIIVPKNLEEEMKESYLRYSMSVIISRALPDVRDGLKPSQRRILYAMKQLNLTPG
CCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHHHCCCCCC
AKHRKCAKICGDTSGDYHPHGEAVIYPTLVRMAQDWAMRYPLVDGQGNFGSIDGDPAAAM
CCHHHHHHHHCCCCCCCCCCCCEEEHHHHHHHHHHHHHHCCEECCCCCCCCCCCCHHHHH
RYTEARLTHSSIFLLEDLDKDTVDMVPNYDETKYEPVVFPSKFPNLLCNGSSGIAVGMAT
HHHHHHHCCCEEEEEECCCCCHHHCCCCCCCCCCCCEECCCCCCCEEECCCCCEEEEEEC
NIPPHNLGELIEATLLVLANPQTSIEEILEVMPGPDFPTGGIICGTEGIRSTYYTGRGKL
CCCCCCHHHHHHHHEEEEECCCHHHHHHHHHCCCCCCCCCCEEECCCCCCCCEECCCCEE
RLRARIHVEENSDKQRENIILTEMPYNVNKSRLVEQIAELINEKTLTGISDVRDESDKDG
EEEEEEEEECCCCCCHHCEEEEECCCCCCHHHHHHHHHHHHCHHHCCCHHHHCCCCCCCC
IRVVLELKKGESSEVIINRLYKFTDVQVTFGANMLALDKNLPRTMSIHRMISAWIRHRMD
EEEEEEECCCCCHHHHHHHHHHHEEEEEEECCCEEEECCCCCHHHHHHHHHHHHHHHHHH
VIRRRTRYELNKAETRAHILEGFLKALSCMDEVVKTIRESSNKEHAKQQLVELFGFSEAQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCC
SLAILELRLYQLTGLEIDKVQKEYNELLEKIAYYRRVLAEEELVKDIIREELQELHKVHK
CEEEEEEEEHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
TPRRTTIEMDAGDVRDIEDIIADESVIITISGDDYVKRMPVKVFREQKRGGQGVTGFDMK
CCCCEEEEECCCCCHHHHHHHCCCEEEEEECCCHHHHHCCHHHHHHHHCCCCCCCCCCCC
KGSDFLKAVYSASTKDYLLIFTNMGQCYWLKVWQLPEGERRAKGKPIINFLEGIRPGEQV
CCHHHHHHHHHCCCCCEEEEEECCCCEEEEEEEECCCCHHHCCCCHHHHHHHCCCCHHHH
AAVLNVKRFEQGEYLLLATKKGVVKKVSLDAFGSPRKKGIRALEIDDGDELIAARHIVND
HHHHHHHHCCCCCEEEEEECCCCEEEEECCCCCCCHHHCCEEEEECCCCHHHHHHHHCCC
EEKVMLFTRLGMAVRFPHDKVRPMGRAARGVRGVSLKNEEDFVVSCQVVTDDQSVLVVCD
CHHEEEEEECCCEEECCCHHCCHHHHHHCCCCCCCCCCCCCEEEEEEEEECCCEEEEEEC
NGFGKRSLVCDFRETNRGSVGVRSILINQRNGDVLGAISVTDFDSILLMSAQGQAIRINM
CCCCCCCEEEEHHHCCCCCCEEEEEEEECCCCCEEEEEEECCCCEEEEEECCCCEEEEEH
QDVRVMGRATQGVRLVNLREGDTLVAMEKLSVNTESGETEESVSIQVGHAVEE
HHHHHHHCCCCCEEEEEECCCCEEEEEEEEECCCCCCCCCCCEEEEECCCCCC
>Mature Secondary Structure
MLNKEEIIVPKNLEEEMKESYLRYSMSVIISRALPDVRDGLKPSQRRILYAMKQLNLTPG
CCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHHHCCCCCC
AKHRKCAKICGDTSGDYHPHGEAVIYPTLVRMAQDWAMRYPLVDGQGNFGSIDGDPAAAM
CCHHHHHHHHCCCCCCCCCCCCEEEHHHHHHHHHHHHHHCCEECCCCCCCCCCCCHHHHH
RYTEARLTHSSIFLLEDLDKDTVDMVPNYDETKYEPVVFPSKFPNLLCNGSSGIAVGMAT
HHHHHHHCCCEEEEEECCCCCHHHCCCCCCCCCCCCEECCCCCCCEEECCCCCEEEEEEC
NIPPHNLGELIEATLLVLANPQTSIEEILEVMPGPDFPTGGIICGTEGIRSTYYTGRGKL
CCCCCCHHHHHHHHEEEEECCCHHHHHHHHHCCCCCCCCCCEEECCCCCCCCEECCCCEE
RLRARIHVEENSDKQRENIILTEMPYNVNKSRLVEQIAELINEKTLTGISDVRDESDKDG
EEEEEEEEECCCCCCHHCEEEEECCCCCCHHHHHHHHHHHHCHHHCCCHHHHCCCCCCCC
IRVVLELKKGESSEVIINRLYKFTDVQVTFGANMLALDKNLPRTMSIHRMISAWIRHRMD
EEEEEEECCCCCHHHHHHHHHHHEEEEEEECCCEEEECCCCCHHHHHHHHHHHHHHHHHH
VIRRRTRYELNKAETRAHILEGFLKALSCMDEVVKTIRESSNKEHAKQQLVELFGFSEAQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCC
SLAILELRLYQLTGLEIDKVQKEYNELLEKIAYYRRVLAEEELVKDIIREELQELHKVHK
CEEEEEEEEHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
TPRRTTIEMDAGDVRDIEDIIADESVIITISGDDYVKRMPVKVFREQKRGGQGVTGFDMK
CCCCEEEEECCCCCHHHHHHHCCCEEEEEECCCHHHHHCCHHHHHHHHCCCCCCCCCCCC
KGSDFLKAVYSASTKDYLLIFTNMGQCYWLKVWQLPEGERRAKGKPIINFLEGIRPGEQV
CCHHHHHHHHHCCCCCEEEEEECCCCEEEEEEEECCCCHHHCCCCHHHHHHHCCCCHHHH
AAVLNVKRFEQGEYLLLATKKGVVKKVSLDAFGSPRKKGIRALEIDDGDELIAARHIVND
HHHHHHHHCCCCCEEEEEECCCCEEEEECCCCCCCHHHCCEEEEECCCCHHHHHHHHCCC
EEKVMLFTRLGMAVRFPHDKVRPMGRAARGVRGVSLKNEEDFVVSCQVVTDDQSVLVVCD
CHHEEEEEECCCEEECCCHHCCHHHHHHCCCCCCCCCCCCCEEEEEEEEECCCEEEEEEC
NGFGKRSLVCDFRETNRGSVGVRSILINQRNGDVLGAISVTDFDSILLMSAQGQAIRINM
CCCCCCCEEEEHHHCCCCCCEEEEEEEECCCCCEEEEEEECCCCEEEEEECCCCEEEEEH
QDVRVMGRATQGVRLVNLREGDTLVAMEKLSVNTESGETEESVSIQVGHAVEE
HHHHHHHCCCCCEEEEEECCCCEEEEEEEEECCCCCCCCCCCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9784136 [H]