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Identifier: 15835076

GI number: 15835076

Start: 556466

End: 557236

Strand: Direct

Name: Not Available

Synonym: TC0458

Alternate gene names: 15835076

Gene position: 556466-557236 (Clockwise)

Preceding gene: 15835075

Following gene: 15835085

Centisome position: 51.86

GC content: 40.21

Gene sequence:

>771_bases
ATGGCTACCCTTATTAGCTTAAATGACGCGAATAGAATGCTTATTGCTGAATCTCAGGAAGATTTTTTACAAATCGCATG
TTACGATTGGATTTCTACAGCAAATAAAGCGATTCAGAAACGCGGAGCTTTCTATGTTGCTCTTTCCGGAGGAAAAACTC
CTTTACAAATCTTCCAAGAAATCGTTAAAAAACGTGCTGCTATTTCGGATTGTTCAAAAATTTTTGTTTTTTGGGGAGAT
GAACGTGCAAGTGAAGATACAGAAGCCGGCAGTAATTATTTAAAGGCTATGGACATCTTAAAATGGCTACGTATTCCTGA
TACACAAATCTTTCGTATGGACACAGCGAATCCCAAGGGAGATGAAATTTATGAAAATCTTATCCGAGAGCATGTTCCTG
ATACCATTTTTGATATGGTCATGCTTGGGGTTGGTGAAGATGGGCATACCCTTTCTCTTTTTCCAGGGACTGCCGCGTTA
GAAGAGAAAGATCGTTTGGTGGTTTTCAATGAGGTCCCCCAATTACAAACTCGTCGGATGACCTTAACCTTTCCGATTGT
TCGGCAAGCCCGTCATTTGGTTGCGTACATTCAAGGAACTGCTAAACAAGATCTTTGTCATAAGCTGTTACATCCTTTAG
GAAGAGATACCTTTCCTATAGAGCGAGTAGGGACTCCTCTAAATCCTCTGCAATGGGTATTGTCATCTGATTGTTGTAGA
GCGGCGGATCTTGCAGATATTCCTGCAGAATGTAAATTAGAAATGTTTTAA

Upstream 100 bases:

>100_bases
TATATTGCAGGATCTTTGCGCCCGCAAGGAGCTGATGAGCTATTATCTAGAGATGGAAGAGCATGGCGTTCTTACTAATT
GATTTTGCGAGAGGTGTTAC

Downstream 100 bases:

>100_bases
CATCCTTTTCGATTGCGGATAGCTGTCCTTTGACGATTTCTAAAAGACCATAACTGCAAAGACATCCATTCTAGACAGCT
TGACGCGGAAGAGTATGTAT

Product: 6-phosphogluconolactonase

Products: NA

Alternate protein names: 6PGL

Number of amino acids: Translated: 256; Mature: 255

Protein sequence:

>256_residues
MATLISLNDANRMLIAESQEDFLQIACYDWISTANKAIQKRGAFYVALSGGKTPLQIFQEIVKKRAAISDCSKIFVFWGD
ERASEDTEAGSNYLKAMDILKWLRIPDTQIFRMDTANPKGDEIYENLIREHVPDTIFDMVMLGVGEDGHTLSLFPGTAAL
EEKDRLVVFNEVPQLQTRRMTLTFPIVRQARHLVAYIQGTAKQDLCHKLLHPLGRDTFPIERVGTPLNPLQWVLSSDCCR
AADLADIPAECKLEMF

Sequences:

>Translated_256_residues
MATLISLNDANRMLIAESQEDFLQIACYDWISTANKAIQKRGAFYVALSGGKTPLQIFQEIVKKRAAISDCSKIFVFWGD
ERASEDTEAGSNYLKAMDILKWLRIPDTQIFRMDTANPKGDEIYENLIREHVPDTIFDMVMLGVGEDGHTLSLFPGTAAL
EEKDRLVVFNEVPQLQTRRMTLTFPIVRQARHLVAYIQGTAKQDLCHKLLHPLGRDTFPIERVGTPLNPLQWVLSSDCCR
AADLADIPAECKLEMF
>Mature_255_residues
ATLISLNDANRMLIAESQEDFLQIACYDWISTANKAIQKRGAFYVALSGGKTPLQIFQEIVKKRAAISDCSKIFVFWGDE
RASEDTEAGSNYLKAMDILKWLRIPDTQIFRMDTANPKGDEIYENLIREHVPDTIFDMVMLGVGEDGHTLSLFPGTAALE
EKDRLVVFNEVPQLQTRRMTLTFPIVRQARHLVAYIQGTAKQDLCHKLLHPLGRDTFPIERVGTPLNPLQWVLSSDCCRA
ADLADIPAECKLEMF

Specific function: Hydrolysis of 6-phosphogluconolactone to 6- phosphogluconate

COG id: COG0363

COG function: function code G; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily

Homologues:

Organism=Homo sapiens, GI52145310, Length=237, Percent_Identity=28.6919831223629, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI6912586, Length=211, Percent_Identity=28.436018957346, Blast_Score=76, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6321957, Length=205, Percent_Identity=28.780487804878, Blast_Score=84, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6321687, Length=188, Percent_Identity=29.7872340425532, Blast_Score=70, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24641119, Length=220, Percent_Identity=29.5454545454545, Blast_Score=76, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): 6PGL_CHLMU (Q9PKK7)

Other databases:

- EMBL:   AE002160
- RefSeq:   NP_296835.1
- ProteinModelPortal:   Q9PKK7
- SMR:   Q9PKK7
- GeneID:   1245813
- GenomeReviews:   AE002160_GR
- KEGG:   cmu:TC0458
- TIGR:   TC_0458
- HOGENOM:   HBG725991
- OMA:   DPESTYG
- PhylomeDB:   Q9PKK7
- ProtClustDB:   CLSK871240
- BioCyc:   CMUR243161:TC_0458-MONOMER
- BRENDA:   3.1.1.31
- InterPro:   IPR005900
- PANTHER:   PTHR11054
- TIGRFAMs:   TIGR01198

Pfam domain/function: NA

EC number: =3.1.1.31

Molecular weight: Translated: 28922; Mature: 28790

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATLISLNDANRMLIAESQEDFLQIACYDWISTANKAIQKRGAFYVALSGGKTPLQIFQE
CCEEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHH
IVKKRAAISDCSKIFVFWGDERASEDTEAGSNYLKAMDILKWLRIPDTQIFRMDTANPKG
HHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCH
DEIYENLIREHVPDTIFDMVMLGVGEDGHTLSLFPGTAALEEKDRLVVFNEVPQLQTRRM
HHHHHHHHHHHCCHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCEEEEECCCCCHHCEE
TLTFPIVRQARHLVAYIQGTAKQDLCHKLLHPLGRDTFPIERVGTPLNPLQWVLSSDCCR
EEEHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHCCCCCCHHHHHHHHCCCC
AADLADIPAECKLEMF
CCCCCCCCCCCEEECC
>Mature Secondary Structure 
ATLISLNDANRMLIAESQEDFLQIACYDWISTANKAIQKRGAFYVALSGGKTPLQIFQE
CEEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHH
IVKKRAAISDCSKIFVFWGDERASEDTEAGSNYLKAMDILKWLRIPDTQIFRMDTANPKG
HHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCH
DEIYENLIREHVPDTIFDMVMLGVGEDGHTLSLFPGTAALEEKDRLVVFNEVPQLQTRRM
HHHHHHHHHHHCCHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCEEEEECCCCCHHCEE
TLTFPIVRQARHLVAYIQGTAKQDLCHKLLHPLGRDTFPIERVGTPLNPLQWVLSSDCCR
EEEHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHCCCCCCHHHHHHHHCCCC
AADLADIPAECKLEMF
CCCCCCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10684935