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The map label for this gene is zwf

Identifier: 15835075

GI number: 15835075

Start: 554920

End: 556443

Strand: Direct

Name: zwf

Synonym: TC0457

Alternate gene names: 15835075

Gene position: 554920-556443 (Clockwise)

Preceding gene: 15835074

Following gene: 15835076

Centisome position: 51.72

GC content: 38.71

Gene sequence:

>1524_bases
GTGGAAGAAATAAAAGAAATGGGGCCCACATTACCAGCCTGCCCTCCTTGTGTCATGGTTATTTTTGGGGCTACAGGAGA
CTTGACTGCAAGGAAGCTTTTTCCCGCTTTATACAATTTAACAAAAGAGGGACGGTTATCTGAAAACTTTGTTTGCGTGG
GATTTGCCAGAAGACCCAAATCTCATGAGCAATTTCGTGAAGAAATGAGACAAGCTATTCAAAATTTCTCTCATTCATCA
GAAATTGATATTCGTGTTTGGGAGAGCCTTGAACACAGAATTTTCTATCATCAGGCGAATTTTTCCGAAGCAGAAGGGTA
TTCTTCTTTAAGATCTTTCTTAGAGAGCGTGGATCAAAAATATGGGACAAAAGGAAATCGTCTTTTCTACCTCTCCACTC
CTCCAGATTATTTCCAAGAAATAATCCGGAACTTGAACAGACACCAACTATTTTATCATGAGCAAGGAGCCCAACAGCCC
TGGTCTAGGCTAATTATAGAAAAGCCTTTTGGAGTTGATTTACAAACTGCTCAAGAGCTTCAGCAATGCATTGATGCTAA
TATCAATGAAGAATCTGTTTATCGAATAGATCATTATCTTGGGAAAGAAACTGTTCAAAATATTCTGACCATACGTTTTG
CTAATACGCTATTCGAATCTTGTTGGAACTCTCAATATATAGATCATGTACAGATTAGTGTTAGTGAATCGATTGGTATA
GGCTCTCGAGGGAACTTTTTTGAAAAGTCTGGCATGCTAAGGGATATGGTGCAAAATCACCTGATGCAATTACTGTGTCT
ACTTACTATGGAGCCCCCTTCTGAATTTTCTTCTGCAGAGATCAAAAAAGAAAAAATTAAGATTCTAAAAAAAATCCTTC
CTATTCGAGAAGAAGACGTAATTCGTGGTCAATATGGTGAAGGAGTTGTGCAAGGCGTTTCTGTTTCTGGCTACAGAGAA
GAAGAAAATGTTGATCCAAATTCTTTGGTAGAAACTTACGTAGCCTTGAAATTATTCATTGATAATCCTCGCTGGAAAGG
GGTTCCTTTTTATTTACAAGCAGGGAAACGTCTTCCTAAAAGGACAACGGATATTGCCGTTATCTTTAAAAAATCTAGTT
ACGACTTGTTTAATTCAGAAAATTGCCCTCTGTGCCCTTTAGAGAATGATTTGCTCATCATCCGCATTCAACCAGATGAA
GGAGTTGCTCTACAATTTAACTGCAAAGTTCCAGGGACAAATAAACTCGTTCGTCCTGTGAAAATGGATTTCCGTTACGA
TAGTTATTTTAATACAGTTACTCCAGAAGCTTATGAACGATTGTTGTGTGATTGTATCCTTGGCGATAGGACCCTTTTCA
CTAGCAATGAAGAAGTCTTAGCATCTTGGGAACTATTTTCTCCCTTATTGGAGCAATGGTCTAAGATCCGTCCCATTTTC
CCTAATTATATTGCAGGATCTTTGCGCCCGCAAGGAGCTGATGAGCTATTATCTAGAGATGGAAGAGCATGGCGTTCTTA
CTAA

Upstream 100 bases:

>100_bases
AAGCCTGTGTTTAGGAAAGAAATCTTTTTAGGCACATATTCCTATTTTTGGTATCGTGGGCTTTTTCTTTAAAAATTAAC
ACTCTATATTAGGTTGTACC

Downstream 100 bases:

>100_bases
TTGATTTTGCGAGAGGTGTTACATGGCTACCCTTATTAGCTTAAATGACGCGAATAGAATGCTTATTGCTGAATCTCAGG
AAGATTTTTTACAAATCGCA

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD

Number of amino acids: Translated: 507; Mature: 507

Protein sequence:

>507_residues
MEEIKEMGPTLPACPPCVMVIFGATGDLTARKLFPALYNLTKEGRLSENFVCVGFARRPKSHEQFREEMRQAIQNFSHSS
EIDIRVWESLEHRIFYHQANFSEAEGYSSLRSFLESVDQKYGTKGNRLFYLSTPPDYFQEIIRNLNRHQLFYHEQGAQQP
WSRLIIEKPFGVDLQTAQELQQCIDANINEESVYRIDHYLGKETVQNILTIRFANTLFESCWNSQYIDHVQISVSESIGI
GSRGNFFEKSGMLRDMVQNHLMQLLCLLTMEPPSEFSSAEIKKEKIKILKKILPIREEDVIRGQYGEGVVQGVSVSGYRE
EENVDPNSLVETYVALKLFIDNPRWKGVPFYLQAGKRLPKRTTDIAVIFKKSSYDLFNSENCPLCPLENDLLIIRIQPDE
GVALQFNCKVPGTNKLVRPVKMDFRYDSYFNTVTPEAYERLLCDCILGDRTLFTSNEEVLASWELFSPLLEQWSKIRPIF
PNYIAGSLRPQGADELLSRDGRAWRSY

Sequences:

>Translated_507_residues
MEEIKEMGPTLPACPPCVMVIFGATGDLTARKLFPALYNLTKEGRLSENFVCVGFARRPKSHEQFREEMRQAIQNFSHSS
EIDIRVWESLEHRIFYHQANFSEAEGYSSLRSFLESVDQKYGTKGNRLFYLSTPPDYFQEIIRNLNRHQLFYHEQGAQQP
WSRLIIEKPFGVDLQTAQELQQCIDANINEESVYRIDHYLGKETVQNILTIRFANTLFESCWNSQYIDHVQISVSESIGI
GSRGNFFEKSGMLRDMVQNHLMQLLCLLTMEPPSEFSSAEIKKEKIKILKKILPIREEDVIRGQYGEGVVQGVSVSGYRE
EENVDPNSLVETYVALKLFIDNPRWKGVPFYLQAGKRLPKRTTDIAVIFKKSSYDLFNSENCPLCPLENDLLIIRIQPDE
GVALQFNCKVPGTNKLVRPVKMDFRYDSYFNTVTPEAYERLLCDCILGDRTLFTSNEEVLASWELFSPLLEQWSKIRPIF
PNYIAGSLRPQGADELLSRDGRAWRSY
>Mature_507_residues
MEEIKEMGPTLPACPPCVMVIFGATGDLTARKLFPALYNLTKEGRLSENFVCVGFARRPKSHEQFREEMRQAIQNFSHSS
EIDIRVWESLEHRIFYHQANFSEAEGYSSLRSFLESVDQKYGTKGNRLFYLSTPPDYFQEIIRNLNRHQLFYHEQGAQQP
WSRLIIEKPFGVDLQTAQELQQCIDANINEESVYRIDHYLGKETVQNILTIRFANTLFESCWNSQYIDHVQISVSESIGI
GSRGNFFEKSGMLRDMVQNHLMQLLCLLTMEPPSEFSSAEIKKEKIKILKKILPIREEDVIRGQYGEGVVQGVSVSGYRE
EENVDPNSLVETYVALKLFIDNPRWKGVPFYLQAGKRLPKRTTDIAVIFKKSSYDLFNSENCPLCPLENDLLIIRIQPDE
GVALQFNCKVPGTNKLVRPVKMDFRYDSYFNTVTPEAYERLLCDCILGDRTLFTSNEEVLASWELFSPLLEQWSKIRPIF
PNYIAGSLRPQGADELLSRDGRAWRSY

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family

Homologues:

Organism=Homo sapiens, GI109389365, Length=486, Percent_Identity=35.1851851851852, Blast_Score=315, Evalue=8e-86,
Organism=Homo sapiens, GI108773793, Length=486, Percent_Identity=35.1851851851852, Blast_Score=314, Evalue=1e-85,
Organism=Homo sapiens, GI52145310, Length=494, Percent_Identity=29.9595141700405, Blast_Score=192, Evalue=8e-49,
Organism=Escherichia coli, GI1788158, Length=500, Percent_Identity=39.2, Blast_Score=362, Evalue=1e-101,
Organism=Caenorhabditis elegans, GI17538218, Length=492, Percent_Identity=33.3333333333333, Blast_Score=303, Evalue=2e-82,
Organism=Saccharomyces cerevisiae, GI6324088, Length=488, Percent_Identity=36.8852459016393, Blast_Score=316, Evalue=6e-87,
Organism=Drosophila melanogaster, GI24643350, Length=485, Percent_Identity=35.0515463917526, Blast_Score=283, Evalue=1e-76,
Organism=Drosophila melanogaster, GI24643352, Length=485, Percent_Identity=35.0515463917526, Blast_Score=283, Evalue=2e-76,
Organism=Drosophila melanogaster, GI221513548, Length=489, Percent_Identity=27.6073619631902, Blast_Score=220, Evalue=2e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): G6PD_CHLMU (Q9PKK8)

Other databases:

- EMBL:   AE002160
- RefSeq:   NP_296834.1
- ProteinModelPortal:   Q9PKK8
- SMR:   Q9PKK8
- GeneID:   1245812
- GenomeReviews:   AE002160_GR
- KEGG:   cmu:TC0457
- TIGR:   TC_0457
- HOGENOM:   HBG322449
- OMA:   VGVDHNA
- PhylomeDB:   Q9PKK8
- ProtClustDB:   PRK05722
- BioCyc:   CMUR243161:TC_0457-MONOMER
- BRENDA:   1.1.1.49
- GO:   GO:0005488
- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PANTHER:   PTHR23429
- PIRSF:   PIRSF000110
- PRINTS:   PR00079
- TIGRFAMs:   TIGR00871

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N

EC number: =1.1.1.49

Molecular weight: Translated: 58548; Mature: 58548

Theoretical pI: Translated: 5.74; Mature: 5.74

Prosite motif: PS00069 G6P_DEHYDROGENASE

Important sites: ACT_SITE 260-260 BINDING 25-25 BINDING 57-57 BINDING 198-198 BINDING 202-202

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEEIKEMGPTLPACPPCVMVIFGATGDLTARKLFPALYNLTKEGRLSENFVCVGFARRPK
CCCHHHHCCCCCCCCHHEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCC
SHEQFREEMRQAIQNFSHSSEIDIRVWESLEHRIFYHQANFSEAEGYSSLRSFLESVDQK
CHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHEEEEEECCCCHHCCHHHHHHHHHHHHHH
YGTKGNRLFYLSTPPDYFQEIIRNLNRHQLFYHEQGAQQPWSRLIIEKPFGVDLQTAQEL
HCCCCCEEEEECCCHHHHHHHHHHCCHHEEEEECCCCCCHHHHHEECCCCCCCHHHHHHH
QQCIDANINEESVYRIDHYLGKETVQNILTIRFANTLFESCWNSQYIDHVQISVSESIGI
HHHHCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCC
GSRGNFFEKSGMLRDMVQNHLMQLLCLLTMEPPSEFSSAEIKKEKIKILKKILPIREEDV
CCCCCCHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHH
IRGQYGEGVVQGVSVSGYREEENVDPNSLVETYVALKLFIDNPRWKGVPFYLQAGKRLPK
HCCCCCCCCEECCCCCCCCCCCCCCHHHHHHHHHHHHEEECCCCCCCCCHHHHCCCCCCC
RTTDIAVIFKKSSYDLFNSENCPLCPLENDLLIIRIQPDEGVALQFNCKVPGTNKLVRPV
CCCCEEEEEECCCCCCCCCCCCCCCCCCCCEEEEEEECCCCEEEEEEECCCCCCCCCCCE
KMDFRYDSYFNTVTPEAYERLLCDCILGDRTLFTSNEEVLASWELFSPLLEQWSKIRPIF
EECEEECCCCCCCCHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHCCCCC
PNYIAGSLRPQGADELLSRDGRAWRSY
CHHHCCCCCCCCHHHHHHCCCCHHCCC
>Mature Secondary Structure
MEEIKEMGPTLPACPPCVMVIFGATGDLTARKLFPALYNLTKEGRLSENFVCVGFARRPK
CCCHHHHCCCCCCCCHHEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCC
SHEQFREEMRQAIQNFSHSSEIDIRVWESLEHRIFYHQANFSEAEGYSSLRSFLESVDQK
CHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHEEEEEECCCCHHCCHHHHHHHHHHHHHH
YGTKGNRLFYLSTPPDYFQEIIRNLNRHQLFYHEQGAQQPWSRLIIEKPFGVDLQTAQEL
HCCCCCEEEEECCCHHHHHHHHHHCCHHEEEEECCCCCCHHHHHEECCCCCCCHHHHHHH
QQCIDANINEESVYRIDHYLGKETVQNILTIRFANTLFESCWNSQYIDHVQISVSESIGI
HHHHCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCC
GSRGNFFEKSGMLRDMVQNHLMQLLCLLTMEPPSEFSSAEIKKEKIKILKKILPIREEDV
CCCCCCHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHH
IRGQYGEGVVQGVSVSGYREEENVDPNSLVETYVALKLFIDNPRWKGVPFYLQAGKRLPK
HCCCCCCCCEECCCCCCCCCCCCCCHHHHHHHHHHHHEEECCCCCCCCCHHHHCCCCCCC
RTTDIAVIFKKSSYDLFNSENCPLCPLENDLLIIRIQPDEGVALQFNCKVPGTNKLVRPV
CCCCEEEEEECCCCCCCCCCCCCCCCCCCCEEEEEEECCCCEEEEEEECCCCCCCCCCCE
KMDFRYDSYFNTVTPEAYERLLCDCILGDRTLFTSNEEVLASWELFSPLLEQWSKIRPIF
EECEEECCCCCCCCHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHCCCCC
PNYIAGSLRPQGADELLSRDGRAWRSY
CHHHCCCCCCCCHHHHHHCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10684935