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The map label for this gene is pyrG

Identifier: 15835073

GI number: 15835073

Start: 552755

End: 554365

Strand: Direct

Name: pyrG

Synonym: TC0455

Alternate gene names: 15835073

Gene position: 552755-554365 (Clockwise)

Preceding gene: 15835072

Following gene: 15835074

Centisome position: 51.52

GC content: 41.09

Gene sequence:

>1611_bases
ATGTCCTTCAAAAGTATCTTTTTGACCGGAGGCGTGGTTTCTTCTTTAGGGAAAGGGCTAACCGCGGCTTCTTTAGCTCT
CCTATTAGAGAGACAAGGCCTAAAAGTCGCCATGCTTAAGTTAGATCCTTACTTGAATGTGGATCCTGGAACCATGAACC
CTTATGAGCATGGAGAGGTGTATGTTACTGATGATGGCGTAGAAACAGATCTTGACCTTGGGCATTATCACCGTTTTTCT
TCCGTTCAGCTGTCCAAACATTCTACTGCTACCTCTGGGCAAATCTATACCCGAGTGATTACTAAAGAACGAAATGGGGA
ATTCTTAGGAAGTACAGTTCAAGTCATCCCTCATGTCACCAATGAAATTATCAATGTCATTCAAGCATGTGCAGAACATC
ATAAACCAGATGTTCTTATTATAGAAATCGGAGGGACTATTGGTGATATTGAATCTCTTCCTTTTCTAGAGGCAGTAAGG
CAATTTCGCTGTGAACATCCTCAGGATTGTCTCAGCATTCATATGACTTATGTCCCTTATCTAAAATCAGCAAAGGAAAT
TAAAACCAAACCAACACAACATTCTGTTCAAAATTTACGGAGTATCGGCATCTCTCCTGATGTAATCCTCTGCCGTTCTG
AGGTGTCCCTTAGTTCAGAAGTGAAAAGAAAAATTAGCCTATTTTGCAACGTTCCAGAGAACGCTGTTTTCAATGCGATA
GACTTAGAGAACTCCATTTATGAAATGCCTCTGCTCTTGGCTCGAGAAAATATTGTAGACTTCTTATTGTCCAAATTTGG
TTTTTCGCCTAAATCCTTAGATCTTACTGATTGGCAAAATCTTGTAACGACTTTGTGTGATGGGAATCGGCATCTTGTTC
GTATAGGACTCGTTGGTAAGTATTTAGAACACAAAGATGCTTACAAATCAGTGTTTGAATCGCTCTCTCATGCTTCCATC
CCTGCAAACTGTTCCCTCGAGATAGTTCCTATTTCTCCTGAATCTGAAGCTCTTACTAATCAACTCTCTCAATGCGACGG
CTGTTTAATTCCCGGAGGGTTTGGAACCAGAAGCTGGGAAGGGAAAATTGCTGCTGCGCGCTATTGCAGAGATAACAACA
TCCCTTGCTTCGGGATTTGTTTAGGAATGCAGGCATTAGTAGTTGAGTATGCAAGATATGCTTTAAGCCTTCCTCTTGCT
AATTCCTTAGAAATGGATCCTAACACACCAGATCCTGTTGTCTGTATGATGCAGGGGCAAGATACCATGATTAAAGGAGG
GACCATGAGACTAGGCGCCTATCCTTGCCAAATTACGCCTAAATCTTTAGCCTTCGAAGCTTATAAGACAGATCTTGTCC
AAGAACGTCACAGACATCGTTATGAAGTGAACCCTGCTTATGTAGATCTTCTACAAAAAAATGGATTAAGAATAGTGGGA
GTTTGTCCTCAGGGAGATCTTTGTGAGATTATTGAAATCCCTAATCACAGATGGATGCTTGGTGTACAATTCCATCCTGA
ATTTTTATCAAAACTAGCTGCTCCCCATCCTCTTTTTGTAAAATTTCTTAGCGCTGCTCTAGACTATTCTTTGGAGAAAG
GTCGTGAATAG

Upstream 100 bases:

>100_bases
TGGAATCTGGTCGTTCTATCTATGTTCACGTCGTTCAAAATGCAACAGGACCTTCAGTAGATTATCCCGAAGATATATCC
AAAGTGGAGCAGTACTTATT

Downstream 100 bases:

>100_bases
CATGAAACAAAAAGAGGCTTTTTTAGGAGTGGATTATGGGAAAAAACGTATTGGTCTAGCCTTTGCTAGCGCTCCTCTTT
TGATCACGCTACCTATAGGA

Product: CTP synthetase

Products: NA

Alternate protein names: CTP synthetase; UTP--ammonia ligase

Number of amino acids: Translated: 536; Mature: 535

Protein sequence:

>536_residues
MSFKSIFLTGGVVSSLGKGLTAASLALLLERQGLKVAMLKLDPYLNVDPGTMNPYEHGEVYVTDDGVETDLDLGHYHRFS
SVQLSKHSTATSGQIYTRVITKERNGEFLGSTVQVIPHVTNEIINVIQACAEHHKPDVLIIEIGGTIGDIESLPFLEAVR
QFRCEHPQDCLSIHMTYVPYLKSAKEIKTKPTQHSVQNLRSIGISPDVILCRSEVSLSSEVKRKISLFCNVPENAVFNAI
DLENSIYEMPLLLARENIVDFLLSKFGFSPKSLDLTDWQNLVTTLCDGNRHLVRIGLVGKYLEHKDAYKSVFESLSHASI
PANCSLEIVPISPESEALTNQLSQCDGCLIPGGFGTRSWEGKIAAARYCRDNNIPCFGICLGMQALVVEYARYALSLPLA
NSLEMDPNTPDPVVCMMQGQDTMIKGGTMRLGAYPCQITPKSLAFEAYKTDLVQERHRHRYEVNPAYVDLLQKNGLRIVG
VCPQGDLCEIIEIPNHRWMLGVQFHPEFLSKLAAPHPLFVKFLSAALDYSLEKGRE

Sequences:

>Translated_536_residues
MSFKSIFLTGGVVSSLGKGLTAASLALLLERQGLKVAMLKLDPYLNVDPGTMNPYEHGEVYVTDDGVETDLDLGHYHRFS
SVQLSKHSTATSGQIYTRVITKERNGEFLGSTVQVIPHVTNEIINVIQACAEHHKPDVLIIEIGGTIGDIESLPFLEAVR
QFRCEHPQDCLSIHMTYVPYLKSAKEIKTKPTQHSVQNLRSIGISPDVILCRSEVSLSSEVKRKISLFCNVPENAVFNAI
DLENSIYEMPLLLARENIVDFLLSKFGFSPKSLDLTDWQNLVTTLCDGNRHLVRIGLVGKYLEHKDAYKSVFESLSHASI
PANCSLEIVPISPESEALTNQLSQCDGCLIPGGFGTRSWEGKIAAARYCRDNNIPCFGICLGMQALVVEYARYALSLPLA
NSLEMDPNTPDPVVCMMQGQDTMIKGGTMRLGAYPCQITPKSLAFEAYKTDLVQERHRHRYEVNPAYVDLLQKNGLRIVG
VCPQGDLCEIIEIPNHRWMLGVQFHPEFLSKLAAPHPLFVKFLSAALDYSLEKGRE
>Mature_535_residues
SFKSIFLTGGVVSSLGKGLTAASLALLLERQGLKVAMLKLDPYLNVDPGTMNPYEHGEVYVTDDGVETDLDLGHYHRFSS
VQLSKHSTATSGQIYTRVITKERNGEFLGSTVQVIPHVTNEIINVIQACAEHHKPDVLIIEIGGTIGDIESLPFLEAVRQ
FRCEHPQDCLSIHMTYVPYLKSAKEIKTKPTQHSVQNLRSIGISPDVILCRSEVSLSSEVKRKISLFCNVPENAVFNAID
LENSIYEMPLLLARENIVDFLLSKFGFSPKSLDLTDWQNLVTTLCDGNRHLVRIGLVGKYLEHKDAYKSVFESLSHASIP
ANCSLEIVPISPESEALTNQLSQCDGCLIPGGFGTRSWEGKIAAARYCRDNNIPCFGICLGMQALVVEYARYALSLPLAN
SLEMDPNTPDPVVCMMQGQDTMIKGGTMRLGAYPCQITPKSLAFEAYKTDLVQERHRHRYEVNPAYVDLLQKNGLRIVGV
CPQGDLCEIIEIPNHRWMLGVQFHPEFLSKLAAPHPLFVKFLSAALDYSLEKGRE

Specific function: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen

COG id: COG0504

COG function: function code F; CTP synthase (UTP-ammonia lyase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain

Homologues:

Organism=Homo sapiens, GI148491070, Length=561, Percent_Identity=42.7807486631016, Blast_Score=432, Evalue=1e-121,
Organism=Homo sapiens, GI28559085, Length=561, Percent_Identity=41.8894830659537, Blast_Score=422, Evalue=1e-118,
Organism=Homo sapiens, GI28559083, Length=561, Percent_Identity=41.8894830659537, Blast_Score=422, Evalue=1e-118,
Organism=Homo sapiens, GI221316689, Length=561, Percent_Identity=41.8894830659537, Blast_Score=422, Evalue=1e-118,
Organism=Escherichia coli, GI1789142, Length=549, Percent_Identity=46.6302367941712, Blast_Score=490, Evalue=1e-140,
Organism=Caenorhabditis elegans, GI25148299, Length=602, Percent_Identity=37.375415282392, Blast_Score=387, Evalue=1e-108,
Organism=Saccharomyces cerevisiae, GI6322563, Length=562, Percent_Identity=42.5266903914591, Blast_Score=434, Evalue=1e-122,
Organism=Saccharomyces cerevisiae, GI6319432, Length=560, Percent_Identity=41.0714285714286, Blast_Score=419, Evalue=1e-118,
Organism=Drosophila melanogaster, GI24664469, Length=552, Percent_Identity=45.4710144927536, Blast_Score=447, Evalue=1e-126,
Organism=Drosophila melanogaster, GI21357815, Length=496, Percent_Identity=44.5564516129032, Blast_Score=382, Evalue=1e-106,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PYRG_CHLMU (Q9PKL0)

Other databases:

- EMBL:   AE002160
- PIR:   D81700
- RefSeq:   NP_296832.1
- ProteinModelPortal:   Q9PKL0
- SMR:   Q9PKL0
- GeneID:   1245810
- GenomeReviews:   AE002160_GR
- KEGG:   cmu:TC0455
- TIGR:   TC_0455
- HOGENOM:   HBG597806
- OMA:   TEWLRGN
- ProtClustDB:   PRK05380
- BioCyc:   CMUR243161:TC_0455-MONOMER
- BRENDA:   6.3.4.2
- HAMAP:   MF_01227
- InterPro:   IPR004468
- InterPro:   IPR017456
- InterPro:   IPR017926
- InterPro:   IPR000991
- TIGRFAMs:   TIGR00337

Pfam domain/function: PF06418 CTP_synth_N; PF00117 GATase

EC number: =6.3.4.2

Molecular weight: Translated: 59509; Mature: 59378

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: PS51273 GATASE_TYPE_1

Important sites: ACT_SITE 380-380 ACT_SITE 505-505 ACT_SITE 507-507

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFKSIFLTGGVVSSLGKGLTAASLALLLERQGLKVAMLKLDPYLNVDPGTMNPYEHGEV
CCCCEEEEECHHHHHHCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCCEE
YVTDDGVETDLDLGHYHRFSSVQLSKHSTATSGQIYTRVITKERNGEFLGSTVQVIPHVT
EEECCCCCCCCCCCHHHCCCCEEECCCCCCCCCEEEEEEEEECCCCCHHCCHHHHHHHHH
NEIINVIQACAEHHKPDVLIIEIGGTIGDIESLPFLEAVRQFRCEHPQDCLSIHMTYVPY
HHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHH
LKSAKEIKTKPTQHSVQNLRSIGISPDVILCRSEVSLSSEVKRKISLFCNVPENAVFNAI
HHHHHHHCCCCHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHEEECCCCCHHEEEE
DLENSIYEMPLLLARENIVDFLLSKFGFSPKSLDLTDWQNLVTTLCDGNRHLVRIGLVGK
ECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEHHHH
YLEHKDAYKSVFESLSHASIPANCSLEIVPISPESEALTNQLSQCDGCLIPGGFGTRSWE
HHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCEEECCCCCCCCCC
GKIAAARYCRDNNIPCFGICLGMQALVVEYARYALSLPLANSLEMDPNTPDPVVCMMQGQ
CCHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCC
DTMIKGGTMRLGAYPCQITPKSLAFEAYKTDLVQERHRHRYEVNPAYVDLLQKNGLRIVG
CEEEECCEEEECCEECEECHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCEEEE
VCPQGDLCEIIEIPNHRWMLGVQFHPEFLSKLAAPHPLFVKFLSAALDYSLEKGRE
ECCCCCCCCEEECCCCCEEEEEEECHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SFKSIFLTGGVVSSLGKGLTAASLALLLERQGLKVAMLKLDPYLNVDPGTMNPYEHGEV
CCCEEEEECHHHHHHCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCCEE
YVTDDGVETDLDLGHYHRFSSVQLSKHSTATSGQIYTRVITKERNGEFLGSTVQVIPHVT
EEECCCCCCCCCCCHHHCCCCEEECCCCCCCCCEEEEEEEEECCCCCHHCCHHHHHHHHH
NEIINVIQACAEHHKPDVLIIEIGGTIGDIESLPFLEAVRQFRCEHPQDCLSIHMTYVPY
HHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHH
LKSAKEIKTKPTQHSVQNLRSIGISPDVILCRSEVSLSSEVKRKISLFCNVPENAVFNAI
HHHHHHHCCCCHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHEEECCCCCHHEEEE
DLENSIYEMPLLLARENIVDFLLSKFGFSPKSLDLTDWQNLVTTLCDGNRHLVRIGLVGK
ECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEHHHH
YLEHKDAYKSVFESLSHASIPANCSLEIVPISPESEALTNQLSQCDGCLIPGGFGTRSWE
HHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCEEECCCCCCCCCC
GKIAAARYCRDNNIPCFGICLGMQALVVEYARYALSLPLANSLEMDPNTPDPVVCMMQGQ
CCHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCC
DTMIKGGTMRLGAYPCQITPKSLAFEAYKTDLVQERHRHRYEVNPAYVDLLQKNGLRIVG
CEEEECCEEEECCEECEECHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCEEEE
VCPQGDLCEIIEIPNHRWMLGVQFHPEFLSKLAAPHPLFVKFLSAALDYSLEKGRE
ECCCCCCCCEEECCCCCEEEEEEECHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10684935