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The map label for this gene is kdsB

Identifier: 15835072

GI number: 15835072

Start: 551952

End: 552779

Strand: Direct

Name: kdsB

Synonym: TC0454

Alternate gene names: 15835072

Gene position: 551952-552779 (Clockwise)

Preceding gene: 15835068

Following gene: 15835073

Centisome position: 51.44

GC content: 40.82

Gene sequence:

>828_bases
GTGTGTTACGACTCTGATTTAAGAAATTTTTTCTTAGGAAGAGTGTATTTAAGGGGGTGCGATGTGTTTGCGTTCTTAAC
AAGCAAAAGAGTCGGTATTCTCCCCGCTAGATGGGGAAGCTCTCGCTTCCCTGGAAAACCTTTAGCAAAGATTTTAGGGA
AAACCCTTATTCAAAGGTCCTATGAAAACGCCCTAACCAGTCGATCTCTCGATTGTGTTGTAGTGGCAACAGATGATCAA
AGAATCTTTGATCACGTCGTGGAATTCGGAGGACTGTGCGTGATGACTTGTGAATCGTGTGCTAATGGAACAGAACGAGT
GGAGGAAGCTGTTTCTCAACATTTTCCTCAAGCTGAAATCGTTGTGAATATCCAGGGTGATGAACCCTGCTTATCTCCAA
GCATCATAGATGGCCTTGTAGAAATGCTCGAAGGCAATCCCGCTATAGATATAGCTACACCCGTTACAGAAACAGTTGAT
CCTGATGCAATTTTAACCAATCACAAAGTAAAGTGCGTTTTCGATAAAACTGGCCGAGCTCTTTATTTTAGCAGAAGCGT
TATTCCTAATAACTTCAAACGCTCAACTCCTATTTATTTACACATAGGCGTTTACGCTTTTAGAAGAGCTTTTCTTAGTG
AATATGTGAAAATTCCTCCTTCTTCATTAAGTTTAGCTGAGGATCTCGAACAGTTGCGAGTGTTGGAATCTGGTCGTTCT
ATCTATGTTCACGTCGTTCAAAATGCAACAGGACCTTCAGTAGATTATCCCGAAGATATATCCAAAGTGGAGCAGTACTT
ATTATGTCCTTCAAAAGTATCTTTTTGA

Upstream 100 bases:

>100_bases
GGAAAGATCCATTATTTAAAACTTGGAAAAGCAGATACAGATTATGACCTGTGAATAATCTTGATAGTTAACAATCTCCT
TGTTAGGATGATCTGTTTCT

Downstream 100 bases:

>100_bases
CCGGAGGCGTGGTTTCTTCTTTAGGGAAAGGGCTAACCGCGGCTTCTTTAGCTCTCCTATTAGAGAGACAAGGCCTAAAA
GTCGCCATGCTTAAGTTAGA

Product: 3-deoxy-manno-octulosonate cytidylyltransferase

Products: NA

Alternate protein names: CMP-2-keto-3-deoxyoctulosonic acid synthase; CKS; CMP-KDO synthase [H]

Number of amino acids: Translated: 275; Mature: 275

Protein sequence:

>275_residues
MCYDSDLRNFFLGRVYLRGCDVFAFLTSKRVGILPARWGSSRFPGKPLAKILGKTLIQRSYENALTSRSLDCVVVATDDQ
RIFDHVVEFGGLCVMTCESCANGTERVEEAVSQHFPQAEIVVNIQGDEPCLSPSIIDGLVEMLEGNPAIDIATPVTETVD
PDAILTNHKVKCVFDKTGRALYFSRSVIPNNFKRSTPIYLHIGVYAFRRAFLSEYVKIPPSSLSLAEDLEQLRVLESGRS
IYVHVVQNATGPSVDYPEDISKVEQYLLCPSKVSF

Sequences:

>Translated_275_residues
MCYDSDLRNFFLGRVYLRGCDVFAFLTSKRVGILPARWGSSRFPGKPLAKILGKTLIQRSYENALTSRSLDCVVVATDDQ
RIFDHVVEFGGLCVMTCESCANGTERVEEAVSQHFPQAEIVVNIQGDEPCLSPSIIDGLVEMLEGNPAIDIATPVTETVD
PDAILTNHKVKCVFDKTGRALYFSRSVIPNNFKRSTPIYLHIGVYAFRRAFLSEYVKIPPSSLSLAEDLEQLRVLESGRS
IYVHVVQNATGPSVDYPEDISKVEQYLLCPSKVSF
>Mature_275_residues
MCYDSDLRNFFLGRVYLRGCDVFAFLTSKRVGILPARWGSSRFPGKPLAKILGKTLIQRSYENALTSRSLDCVVVATDDQ
RIFDHVVEFGGLCVMTCESCANGTERVEEAVSQHFPQAEIVVNIQGDEPCLSPSIIDGLVEMLEGNPAIDIATPVTETVD
PDAILTNHKVKCVFDKTGRALYFSRSVIPNNFKRSTPIYLHIGVYAFRRAFLSEYVKIPPSSLSLAEDLEQLRVLESGRS
IYVHVVQNATGPSVDYPEDISKVEQYLLCPSKVSF

Specific function: Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria [H]

COG id: COG1212

COG function: function code M; CMP-2-keto-3-deoxyoctulosonic acid synthetase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the kdsB family [H]

Homologues:

Organism=Escherichia coli, GI1787147, Length=242, Percent_Identity=37.603305785124, Blast_Score=144, Evalue=7e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003329
- InterPro:   IPR004528 [H]

Pfam domain/function: PF02348 CTP_transf_3 [H]

EC number: =2.7.7.38 [H]

Molecular weight: Translated: 30594; Mature: 30594

Theoretical pI: Translated: 5.69; Mature: 5.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.3 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
3.3 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCYDSDLRNFFLGRVYLRGCDVFAFLTSKRVGILPARWGSSRFPGKPLAKILGKTLIQRS
CCCCHHHHHHHHHHHHHHHCHHEEEHHCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHH
YENALTSRSLDCVVVATDDQRIFDHVVEFGGLCVMTCESCANGTERVEEAVSQHFPQAEI
HHHHHHCCCCCEEEEECCCHHHHHHHHHHCCEEEEEHHHHCCHHHHHHHHHHHHCCCEEE
VVNIQGDEPCLSPSIIDGLVEMLEGNPAIDIATPVTETVDPDAILTNHKVKCVFDKTGRA
EEEECCCCCCCCHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCEECCCEEEEEEECCCCE
LYFSRSVIPNNFKRSTPIYLHIGVYAFRRAFLSEYVKIPPSSLSLAEDLEQLRVLESGRS
EEEECCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCE
IYVHVVQNATGPSVDYPEDISKVEQYLLCPSKVSF
EEEEEEECCCCCCCCCHHHHHHHHHHHCCCHHCCC
>Mature Secondary Structure
MCYDSDLRNFFLGRVYLRGCDVFAFLTSKRVGILPARWGSSRFPGKPLAKILGKTLIQRS
CCCCHHHHHHHHHHHHHHHCHHEEEHHCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHH
YENALTSRSLDCVVVATDDQRIFDHVVEFGGLCVMTCESCANGTERVEEAVSQHFPQAEI
HHHHHHCCCCCEEEEECCCHHHHHHHHHHCCEEEEEHHHHCCHHHHHHHHHHHHCCCEEE
VVNIQGDEPCLSPSIIDGLVEMLEGNPAIDIATPVTETVDPDAILTNHKVKCVFDKTGRA
EEEECCCCCCCCHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCEECCCEEEEEEECCCCE
LYFSRSVIPNNFKRSTPIYLHIGVYAFRRAFLSEYVKIPPSSLSLAEDLEQLRVLESGRS
EEEECCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCE
IYVHVVQNATGPSVDYPEDISKVEQYLLCPSKVSF
EEEEEEECCCCCCCCCHHHHHHHHHHHCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10684935 [H]