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Identifier: 15834807

GI number: 15834807

Start: 219191

End: 220042

Strand: Direct

Name: Not Available

Synonym: TC0187

Alternate gene names: 15834807

Gene position: 219191-220042 (Clockwise)

Preceding gene: 15834806

Following gene: 15834808

Centisome position: 20.43

GC content: 40.26

Gene sequence:

>852_bases
ATGCATTTTTTTTCTCCTGCCAAGCTTAATATTTTCTTGCAGTTACTTGGCAAACGGGAAGATGGTTTTCATGAAATCGT
TACGCGCTATCAAGCCGTATCTTTTGGGGATCAACTCTCTTTGTCAGTAAGCTCTCGTGATTCTTTTCAAATCATCAATG
ATTGTCAGCTTGAGATTTCTAATAATTCTATTTGGAAAAGCACAGCCCTCTTTCGTCAATATACTGGAATTACTGATCCC
GTAAGTTGGCGCGTAGTGAAGCATATCCCTATCGGGTCAGGGCTTGCTGGAGGTAGCAGCAATGCTGCAACTGCGTTGTT
TGCCTTGAATCAGATGTTTCAAACGGGATTATCGGATGAAGAGCTGCGCTCTTTAGCAGAAAAAGTCGGTATGGATACTC
CTTTCTTCTTTTCTTCAGGATCTGCTTTGGGATTAGGACGAGGAGAGAAAGTTGTAACCTTAAATGAATTAGTTGTAGAT
AGATATATTTTATATTTTTCTAATAAGGGAGTTTTAACTAGCGAGGCTTTTGCTGTAGTGAAACCTTCAGATTGTTCTCT
CAGTAAGGATCTGGAGTATGCTCGCAATGACTTAGAGAACCCAGTTTTTCGGTTGCGCTTAGATTTGAAAGAGAAAAAAC
GCTGGCTGGAAGATCTATGGAAAGGAATTCCAGTTTACGTAGGACTAACTGGATCAGGAGCAACTTTATTTGTGCGTTAT
CCAAAGGCTCTAGAAAAAAATTCTGCCTACGCCACTCAAATACAAAAAATCATTGCTTTAAGTGGGGGAGTATCAACCTC
GCCTATACAAAGAGATACTCCCAATTGGTATCCGACTATTCTAGAAGCATAG

Upstream 100 bases:

>100_bases
AAAGAACTCCAAAGCATGGAAGAACAAGAAGATTAGACTTCTTGTTTGTTAGGGGGGAGAATTTCTTTCTTCCCCATCTC
TTTTTCTTTAATTTTTAGTT

Downstream 100 bases:

>100_bases
TTGCTGCTACATGGGATACTTTGCAGGGGACTTCTGTATTCATCGCTTTGGAAATAGTAAACTGTTTATCGGATTCAGAA
TGTTTGGAAGCGGAAAGAAT

Product: 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase

Products: NA

Alternate protein names: CMK; 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase

Number of amino acids: Translated: 283; Mature: 283

Protein sequence:

>283_residues
MHFFSPAKLNIFLQLLGKREDGFHEIVTRYQAVSFGDQLSLSVSSRDSFQIINDCQLEISNNSIWKSTALFRQYTGITDP
VSWRVVKHIPIGSGLAGGSSNAATALFALNQMFQTGLSDEELRSLAEKVGMDTPFFFSSGSALGLGRGEKVVTLNELVVD
RYILYFSNKGVLTSEAFAVVKPSDCSLSKDLEYARNDLENPVFRLRLDLKEKKRWLEDLWKGIPVYVGLTGSGATLFVRY
PKALEKNSAYATQIQKIIALSGGVSTSPIQRDTPNWYPTILEA

Sequences:

>Translated_283_residues
MHFFSPAKLNIFLQLLGKREDGFHEIVTRYQAVSFGDQLSLSVSSRDSFQIINDCQLEISNNSIWKSTALFRQYTGITDP
VSWRVVKHIPIGSGLAGGSSNAATALFALNQMFQTGLSDEELRSLAEKVGMDTPFFFSSGSALGLGRGEKVVTLNELVVD
RYILYFSNKGVLTSEAFAVVKPSDCSLSKDLEYARNDLENPVFRLRLDLKEKKRWLEDLWKGIPVYVGLTGSGATLFVRY
PKALEKNSAYATQIQKIIALSGGVSTSPIQRDTPNWYPTILEA
>Mature_283_residues
MHFFSPAKLNIFLQLLGKREDGFHEIVTRYQAVSFGDQLSLSVSSRDSFQIINDCQLEISNNSIWKSTALFRQYTGITDP
VSWRVVKHIPIGSGLAGGSSNAATALFALNQMFQTGLSDEELRSLAEKVGMDTPFFFSSGSALGLGRGEKVVTLNELVVD
RYILYFSNKGVLTSEAFAVVKPSDCSLSKDLEYARNDLENPVFRLRLDLKEKKRWLEDLWKGIPVYVGLTGSGATLFVRY
PKALEKNSAYATQIQKIIALSGGVSTSPIQRDTPNWYPTILEA

Specific function: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol

COG id: COG1947

COG function: function code I; 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. IspE subfamily

Homologues:

Organism=Escherichia coli, GI1787459, Length=160, Percent_Identity=35.625, Blast_Score=85, Evalue=5e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ISPE_CHLMU (Q9PLC0)

Other databases:

- EMBL:   AE002160
- PIR:   G81732
- RefSeq:   NP_296566.1
- ProteinModelPortal:   Q9PLC0
- SMR:   Q9PLC0
- GeneID:   1246313
- GenomeReviews:   AE002160_GR
- KEGG:   cmu:TC0187
- TIGR:   TC_0187
- HOGENOM:   HBG413867
- OMA:   GFHEMTT
- PhylomeDB:   Q9PLC0
- ProtClustDB:   PRK00650
- BioCyc:   CMUR243161:TC_0187-MONOMER
- BRENDA:   2.7.1.148
- HAMAP:   MF_00061
- InterPro:   IPR006204
- InterPro:   IPR004424
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.230.10
- PANTHER:   PTHR20861:SF2
- PIRSF:   PIRSF010376
- TIGRFAMs:   TIGR00154

Pfam domain/function: PF00288 GHMP_kinases_N; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =2.7.1.148

Molecular weight: Translated: 31435; Mature: 31435

Theoretical pI: Translated: 8.18; Mature: 8.18

Prosite motif: NA

Important sites: ACT_SITE 8-8 ACT_SITE 132-132

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHFFSPAKLNIFLQLLGKREDGFHEIVTRYQAVSFGDQLSLSVSSRDSFQIINDCQLEIS
CCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEEEEEEEC
NNSIWKSTALFRQYTGITDPVSWRVVKHIPIGSGLAGGSSNAATALFALNQMFQTGLSDE
CCCCHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHH
ELRSLAEKVGMDTPFFFSSGSALGLGRGEKVVTLNELVVDRYILYFSNKGVLTSEAFAVV
HHHHHHHHHCCCCCEEECCCCEEECCCCCEEEEHHHHHHHHEEEEEECCCCEECCCEEEE
KPSDCSLSKDLEYARNDLENPVFRLRLDLKEKKRWLEDLWKGIPVYVGLTGSGATLFVRY
CCCCCCCHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHCCCEEEEEEECCCCEEEEEC
PKALEKNSAYATQIQKIIALSGGVSTSPIQRDTPNWYPTILEA
CHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEECC
>Mature Secondary Structure
MHFFSPAKLNIFLQLLGKREDGFHEIVTRYQAVSFGDQLSLSVSSRDSFQIINDCQLEIS
CCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEEEEEEEC
NNSIWKSTALFRQYTGITDPVSWRVVKHIPIGSGLAGGSSNAATALFALNQMFQTGLSDE
CCCCHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHH
ELRSLAEKVGMDTPFFFSSGSALGLGRGEKVVTLNELVVDRYILYFSNKGVLTSEAFAVV
HHHHHHHHHCCCCCEEECCCCEEECCCCCEEEEHHHHHHHHEEEEEECCCCEECCCEEEE
KPSDCSLSKDLEYARNDLENPVFRLRLDLKEKKRWLEDLWKGIPVYVGLTGSGATLFVRY
CCCCCCCHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHCCCEEEEEEECCCCEEEEEC
PKALEKNSAYATQIQKIIALSGGVSTSPIQRDTPNWYPTILEA
CHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10684935