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Identifier: 15834684

GI number: 15834684

Start: 68470

End: 69672

Strand: Direct

Name: Not Available

Synonym: TC0059

Alternate gene names: 15834684

Gene position: 68470-69672 (Clockwise)

Preceding gene: 15834683

Following gene: 15834685

Centisome position: 6.38

GC content: 42.64

Gene sequence:

>1203_bases
ATGTACAATGTGAAAGAAGACTTCCCCATTTTTAGGAATCAGAAAGATCCGTATATTTATTTAGATTCTGCAGCCACTAC
ACATAAGCCTCAGTGTGTGATTGATGCTGTGACAGATTATTATAGCTTTTCATATGCGACTGTAAATCGTGCGATTTACA
GTGCATCGCACGATATATCTTCTGCATATTGGCGAGTACGTTCAAAAGTAGCTGCTTGGATTGGAGCACGATATGACCAG
GAAATTGTTTTTACGAGAGGGACGACCTCTTCACTCAATTTACTAGCTATTGCAGCTAATGATAGTTGGTTGGCCGGAGG
GACTGTTGTGGTTTCGGAAGCCGAGCATCATGCTAATATTTTGTCCTGGGAAATCGCTTGCCGACGTTCTGGAGCTACAG
TAAAAAAGGTCCGAGTGAATGATGAGGGAATCATAGATCTAAGCCATTTGGAAAAATTATTAAAACAAGGTGTGCAACTT
GTTAGTTTAGCTCATGTGAGTAATGTATCGGGAGCAGTTCTACCTGTGCAAGAGGTAGCTTTTTTAGTTCACCGTTACGG
AGCTTTACTTGCCATAGATGGGGCCCAAGGAGTTGGAAGTGGACCTTTAAATCTTTCGGGATGGGATGTAGATTTTTATG
CTTTTTCTGGACATAAACTTTATGCTCCCACTGGTATTGGAGTATTATACGGGAAGAGGGAACTTTTAGAATCTTTGCCA
CCAGTGGAAGGCGGAGGAGATATGGTGGTTGTATATGATTCAGAATCTTCTCGCTATCAAGAGCCGCCTTTACGCTTCGA
AGCCGGGACCCCTCATATCGCAGGAGTGTTAGGATTAGGTGCGGCTATTGATTATTTACAAGCGTTACCTTTTTCTGTGT
CAGACCATTTAACAGCGCTTACCCGCTTTTTATATAACCGGTTGCTTACTATACCTGATATTCAAATTGTGGGACCTCAA
CAAGGAACTCCCCGCGGCTGCTTATGTAGTATCATTATTCCTGGAGTGCAAGCTTCCGATTTAGGTTTTTTGCTAGATGG
GAAAGGTATCGCTGTGCGCTCTGGGCATCAATGCTCGCAACCTGCAATGGCACGTTGGGATTTAGGCCATGTTTTACGTG
CATCATTGGGGGTATATAATGACCAGCAAGATGTTATTTCATTTGTGGAAGCTTTAGAAGATATTTTACGTTCGTATCGT
TAA

Upstream 100 bases:

>100_bases
TTAGCTTGATGGATGCTAAGCAAACTTTGCAGAAAAGTTTTTTAGCATTGGATATAGAGAAAACGTATTTCCCAAAACTG
AAAGACTTGGATCTTTAACG

Downstream 100 bases:

>100_bases
TGATTCCCATTTTAATCCGAATACACGGCATATGTCTCTAGCTTGATTTGGATTGTAAGATTTTGTATCTTGAGTTTTTG
TATTCTTGACGTGTCTGTAG

Product: aminotransferase, class V

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 400; Mature: 400

Protein sequence:

>400_residues
MYNVKEDFPIFRNQKDPYIYLDSAATTHKPQCVIDAVTDYYSFSYATVNRAIYSASHDISSAYWRVRSKVAAWIGARYDQ
EIVFTRGTTSSLNLLAIAANDSWLAGGTVVVSEAEHHANILSWEIACRRSGATVKKVRVNDEGIIDLSHLEKLLKQGVQL
VSLAHVSNVSGAVLPVQEVAFLVHRYGALLAIDGAQGVGSGPLNLSGWDVDFYAFSGHKLYAPTGIGVLYGKRELLESLP
PVEGGGDMVVVYDSESSRYQEPPLRFEAGTPHIAGVLGLGAAIDYLQALPFSVSDHLTALTRFLYNRLLTIPDIQIVGPQ
QGTPRGCLCSIIIPGVQASDLGFLLDGKGIAVRSGHQCSQPAMARWDLGHVLRASLGVYNDQQDVISFVEALEDILRSYR

Sequences:

>Translated_400_residues
MYNVKEDFPIFRNQKDPYIYLDSAATTHKPQCVIDAVTDYYSFSYATVNRAIYSASHDISSAYWRVRSKVAAWIGARYDQ
EIVFTRGTTSSLNLLAIAANDSWLAGGTVVVSEAEHHANILSWEIACRRSGATVKKVRVNDEGIIDLSHLEKLLKQGVQL
VSLAHVSNVSGAVLPVQEVAFLVHRYGALLAIDGAQGVGSGPLNLSGWDVDFYAFSGHKLYAPTGIGVLYGKRELLESLP
PVEGGGDMVVVYDSESSRYQEPPLRFEAGTPHIAGVLGLGAAIDYLQALPFSVSDHLTALTRFLYNRLLTIPDIQIVGPQ
QGTPRGCLCSIIIPGVQASDLGFLLDGKGIAVRSGHQCSQPAMARWDLGHVLRASLGVYNDQQDVISFVEALEDILRSYR
>Mature_400_residues
MYNVKEDFPIFRNQKDPYIYLDSAATTHKPQCVIDAVTDYYSFSYATVNRAIYSASHDISSAYWRVRSKVAAWIGARYDQ
EIVFTRGTTSSLNLLAIAANDSWLAGGTVVVSEAEHHANILSWEIACRRSGATVKKVRVNDEGIIDLSHLEKLLKQGVQL
VSLAHVSNVSGAVLPVQEVAFLVHRYGALLAIDGAQGVGSGPLNLSGWDVDFYAFSGHKLYAPTGIGVLYGKRELLESLP
PVEGGGDMVVVYDSESSRYQEPPLRFEAGTPHIAGVLGLGAAIDYLQALPFSVSDHLTALTRFLYNRLLTIPDIQIVGPQ
QGTPRGCLCSIIIPGVQASDLGFLLDGKGIAVRSGHQCSQPAMARWDLGHVLRASLGVYNDQQDVISFVEALEDILRSYR

Specific function: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine

COG id: COG0520

COG function: function code E; Selenocysteine lyase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily

Homologues:

Organism=Homo sapiens, GI32307132, Length=358, Percent_Identity=28.2122905027933, Blast_Score=119, Evalue=7e-27,
Organism=Escherichia coli, GI1787970, Length=399, Percent_Identity=40.3508771929825, Blast_Score=312, Evalue=2e-86,
Organism=Escherichia coli, GI1789175, Length=393, Percent_Identity=37.4045801526718, Blast_Score=253, Evalue=2e-68,
Organism=Escherichia coli, GI48994898, Length=371, Percent_Identity=30.4582210242588, Blast_Score=116, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI25143064, Length=383, Percent_Identity=25.5874673629243, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI193211090, Length=340, Percent_Identity=25, Blast_Score=90, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6319831, Length=393, Percent_Identity=25.9541984732824, Blast_Score=119, Evalue=9e-28,
Organism=Drosophila melanogaster, GI20129463, Length=361, Percent_Identity=30.4709141274238, Blast_Score=133, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CSD_CHLMU (Q9PLP0)

Other databases:

- EMBL:   AE002160
- RefSeq:   NP_296443.1
- ProteinModelPortal:   Q9PLP0
- SMR:   Q9PLP0
- GeneID:   1245588
- GenomeReviews:   AE002160_GR
- KEGG:   cmu:TC0059
- TIGR:   TC_0059
- HOGENOM:   HBG635316
- OMA:   ANIIPWH
- PhylomeDB:   Q9PLP0
- ProtClustDB:   CLSK871537
- BioCyc:   CMUR243161:TC_0059-MONOMER
- BRENDA:   2.8.1.7
- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010970
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR01979

Pfam domain/function: PF00266 Aminotran_5; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.8.1.7

Molecular weight: Translated: 43584; Mature: 43584

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: ACT_SITE 358-358

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYNVKEDFPIFRNQKDPYIYLDSAATTHKPQCVIDAVTDYYSFSYATVNRAIYSASHDIS
CCCCCCCCCCCCCCCCCEEEEECCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHCCCCHH
SAYWRVRSKVAAWIGARYDQEIVFTRGTTSSLNLLAIAANDSWLAGGTVVVSEAEHHANI
HHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCEEEEEEECCCEEECCEEEEECCCCCCCE
LSWEIACRRSGATVKKVRVNDEGIIDLSHLEKLLKQGVQLVSLAHVSNVSGAVLPVQEVA
EEEEEEECCCCCEEEEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHCCCCCCEECHHHHH
FLVHRYGALLAIDGAQGVGSGPLNLSGWDVDFYAFSGHKLYAPTGIGVLYGKRELLESLP
HHHHHCCCEEEEECCCCCCCCCCCCCCCEEEEEEECCCEEECCCCCEEEECCHHHHHHCC
PVEGGGDMVVVYDSESSRYQEPPLRFEAGTPHIAGVLGLGAAIDYLQALPFSVSDHLTAL
CCCCCCCEEEEECCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
TRFLYNRLLTIPDIQIVGPQQGTPRGCLCSIIIPGVQASDLGFLLDGKGIAVRSGHQCSQ
HHHHHHHCCCCCCEEEECCCCCCCCCEEEEEEECCCCCCCCEEEECCCCEEEECCCCCCC
PAMARWDLGHVLRASLGVYNDQQDVISFVEALEDILRSYR
CCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MYNVKEDFPIFRNQKDPYIYLDSAATTHKPQCVIDAVTDYYSFSYATVNRAIYSASHDIS
CCCCCCCCCCCCCCCCCEEEEECCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHCCCCHH
SAYWRVRSKVAAWIGARYDQEIVFTRGTTSSLNLLAIAANDSWLAGGTVVVSEAEHHANI
HHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCEEEEEEECCCEEECCEEEEECCCCCCCE
LSWEIACRRSGATVKKVRVNDEGIIDLSHLEKLLKQGVQLVSLAHVSNVSGAVLPVQEVA
EEEEEEECCCCCEEEEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHCCCCCCEECHHHHH
FLVHRYGALLAIDGAQGVGSGPLNLSGWDVDFYAFSGHKLYAPTGIGVLYGKRELLESLP
HHHHHCCCEEEEECCCCCCCCCCCCCCCEEEEEEECCCEEECCCCCEEEECCHHHHHHCC
PVEGGGDMVVVYDSESSRYQEPPLRFEAGTPHIAGVLGLGAAIDYLQALPFSVSDHLTAL
CCCCCCCEEEEECCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
TRFLYNRLLTIPDIQIVGPQQGTPRGCLCSIIIPGVQASDLGFLLDGKGIAVRSGHQCSQ
HHHHHHHCCCCCCEEEECCCCCCCCCEEEEEEECCCCCCCCEEEECCCCEEEECCCCCCC
PAMARWDLGHVLRASLGVYNDQQDVISFVEALEDILRSYR
CCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10684935