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The map label for this gene is tbpC

Identifier: 16120090

GI number: 16120090

Start: 111987

End: 112532

Strand: Direct

Name: tbpC

Synonym: VNG6140G

Alternate gene names: 16120090

Gene position: 111987-112532 (Clockwise)

Preceding gene: 16120089

Following gene: 16120097

Centisome position: 30.65

GC content: 53.48

Gene sequence:

>546_bases
ATGACGGTCGAGATTGCGAACATCGTTGGCTCCGGCGATCTTGGAGTGGAGCTGGATGTTGAGCCCTTGGAAGCTGACTT
GTCCACGCCGTATTCAGAGTACGATCCATCGAACTACCACGGCCTCTACGTTCGTCTCGAAGAAAACGGACCACTCATCA
CGGTATATCGGAGCGGGAAGTACATCATCACCGGGTGCGCCAGTATGGAGTCGCTGCACGAGACGAATGAGGAGTTCTTG
GGGATGCTTGCGGATCTAGGTGTGACCGAGGAAGACACGCAGACCGGGTTCACCGTCGAGAACGTCGTTTGTACGGCGAT
GCTTGACGAGCTAGTTTCTCTGAATGCCCTCGCAATCGGACTAGGATTGGAAGTGACGGAGTACGAGCCTGAGCAGTTCC
CAGGACTTGTCTACCGACCCGAGGAGATCGGTGCCGTGTTGCTAGTATTCGCTAACGGGAAGATGGTTATCACGGGAGCC
AAAGACACCGAAACGGCTGAATCAGCGTATGAGTACTTTCAGTCGAAAGTCCAAGAATTAGTTTAA

Upstream 100 bases:

>100_bases
ACGAGGAATTAGCCCGCTTGGAAGAGGAAAAACACGTCACCCCTGAGGAGCCAGAGTTGATGACCACATCACTGGTTCTC
GACAATCAACCGGGAGAGAG

Downstream 100 bases:

>100_bases
TCGGATTTGTTTAAACCTTATTAGTCAGATACTATTCTCGGTGAATCAGCCGGTAAGTAGGTGTGCGTATTGACCGTCAA
AGAACCTATCATTCTACAAA

Product: transcription factor

Products: NA

Alternate protein names: Box A-binding protein C; BAP C; TATA sequence-binding protein C; TBP C; TATA-box factor C

Number of amino acids: Translated: 181; Mature: 180

Protein sequence:

>181_residues
MTVEIANIVGSGDLGVELDVEPLEADLSTPYSEYDPSNYHGLYVRLEENGPLITVYRSGKYIITGCASMESLHETNEEFL
GMLADLGVTEEDTQTGFTVENVVCTAMLDELVSLNALAIGLGLEVTEYEPEQFPGLVYRPEEIGAVLLVFANGKMVITGA
KDTETAESAYEYFQSKVQELV

Sequences:

>Translated_181_residues
MTVEIANIVGSGDLGVELDVEPLEADLSTPYSEYDPSNYHGLYVRLEENGPLITVYRSGKYIITGCASMESLHETNEEFL
GMLADLGVTEEDTQTGFTVENVVCTAMLDELVSLNALAIGLGLEVTEYEPEQFPGLVYRPEEIGAVLLVFANGKMVITGA
KDTETAESAYEYFQSKVQELV
>Mature_180_residues
TVEIANIVGSGDLGVELDVEPLEADLSTPYSEYDPSNYHGLYVRLEENGPLITVYRSGKYIITGCASMESLHETNEEFLG
MLADLGVTEEDTQTGFTVENVVCTAMLDELVSLNALAIGLGLEVTEYEPEQFPGLVYRPEEIGAVLLVFANGKMVITGAK
DTETAESAYEYFQSKVQELV

Specific function: General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TBP family

Homologues:

Organism=Homo sapiens, GI285026520, Length=168, Percent_Identity=29.7619047619048, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI39930602, Length=168, Percent_Identity=29.1666666666667, Blast_Score=79, Evalue=2e-15,
Organism=Homo sapiens, GI4507379, Length=168, Percent_Identity=29.7619047619048, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17555358, Length=166, Percent_Identity=32.5301204819277, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6320996, Length=167, Percent_Identity=31.1377245508982, Blast_Score=91, Evalue=1e-19,
Organism=Drosophila melanogaster, GI17136834, Length=162, Percent_Identity=32.0987654320988, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI17647997, Length=168, Percent_Identity=27.9761904761905, Blast_Score=76, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TBPC_HALSA (O52004)

Other databases:

- EMBL:   AF016485
- EMBL:   AE004438
- PIR:   T08317
- RefSeq:   NP_046045.1
- RefSeq:   NP_395678.1
- ProteinModelPortal:   O52004
- SMR:   O52004
- GeneID:   1446797
- GeneID:   1449313
- GenomeReviews:   AE004438_GR
- GenomeReviews:   AF016485_GR
- KEGG:   hal:VNG6140G
- HOGENOM:   HBG499930
- OMA:   IVANISF
- ProtClustDB:   PRK00394
- BioCyc:   HSP64091:TBPC-MONOMER
- BioCyc:   HSP64091:VNG6140G-MONOMER
- HAMAP:   MF_00408
- InterPro:   IPR012295
- InterPro:   IPR000814
- InterPro:   IPR012294
- Gene3D:   G3DSA:3.30.310.10
- PANTHER:   PTHR10126
- PRINTS:   PR00686

Pfam domain/function: PF00352 TBP; SSF55945 TFIID_C/glycos_N

EC number: NA

Molecular weight: Translated: 19761; Mature: 19630

Theoretical pI: Translated: 3.65; Mature: 3.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVEIANIVGSGDLGVELDVEPLEADLSTPYSEYDPSNYHGLYVRLEENGPLITVYRSGK
CEEEEEEEECCCCCCEEEECCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCEEEEEECCC
YIITGCASMESLHETNEEFLGMLADLGVTEEDTQTGFTVENVVCTAMLDELVSLNALAIG
EEEEECHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHEEEE
LGLEVTEYEPEQFPGLVYRPEEIGAVLLVFANGKMVITGAKDTETAESAYEYFQSKVQEL
CCCEEECCCCCCCCCEEECHHHCCEEEEEEECCEEEEECCCCCCHHHHHHHHHHHHHHHH
V
C
>Mature Secondary Structure 
TVEIANIVGSGDLGVELDVEPLEADLSTPYSEYDPSNYHGLYVRLEENGPLITVYRSGK
EEEEEEEECCCCCCEEEECCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCEEEEEECCC
YIITGCASMESLHETNEEFLGMLADLGVTEEDTQTGFTVENVVCTAMLDELVSLNALAIG
EEEEECHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHEEEE
LGLEVTEYEPEQFPGLVYRPEEIGAVLLVFANGKMVITGAKDTETAESAYEYFQSKVQEL
CCCEEECCCCCCCCCEEECHHHCCEEEEEEECCEEEEECCCCCCHHHHHHHHHHHHHHHH
V
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9847077; 11016950