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The map label for this gene is htrA

Identifier: 15836510

GI number: 15836510

Start: 1120385

End: 1121851

Strand: Direct

Name: htrA

Synonym: CPj0978

Alternate gene names: 15836510

Gene position: 1120385-1121851 (Clockwise)

Preceding gene: 15836509

Following gene: 15836512

Centisome position: 91.34

GC content: 42.13

Gene sequence:

>1467_bases
ATGATAACTAAGCAATTGCGTTCGTGGCTAGCTGTACTTGTTGGTTCAAGTCTGCTAGCTCTTCCTTTATCAGGGCAAGC
TGTCGGGAAAAAAGAATCTCGAGTTTCCGAGCTGCCTCAAGACGTTCTTCTTAAAGAGATCTCGGGAGGGTTTTCTAAGG
TCGCTACCAAGGCGACTCCCGCTGTTGTGTACATAGAAAGTTTCCCAAAGAGCCAGGCTGTAACACATCCTTCTCCTGGA
CGCCGTGGGCCTTATGAAAATCCTTTTGATTATTTTAATGATGAGTTTTTCAATCGTTTTTTTGGTCTACCTTCACAGAG
GGAAAAACCTCAAAGTAAAGAGGCGGTTCGAGGAACAGGTTTCCTAGTATCTCCAGATGGCTATATTGTGACTAATAACC
ATGTTGTCGAAGATACAGGTAAGATTCACGTAACTCTTCATGATGGGCAAAAGTACCCAGCAACTGTAATCGGACTCGAT
CCTAAAACAGACCTTGCAGTCATTAAAATTAAATCCCAAAACCTCCCGTATCTTTCTTTTGGAAACTCCGACCACTTAAA
AGTCGGAGATTGGGCAATTGCAATTGGAAATCCCTTCGGTCTTCAAGCTACGGTCACCGTAGGTGTCATCAGTGCTAAAG
GAAGAAATCAACTCCACATTGCAGATTTTGAAGATTTTATTCAGACAGATGCTGCGATTAATCCAGGCAACTCTGGAGGC
CCTCTTCTAAATATTGATGGACAGGTCATCGGTGTTAATACTGCCATTGTCAGTGGTAGTGGTGGCTATATTGGAATCGG
GTTTGCGATTCCTAGCCTTATGGCAAATAGAATCATAGATCAGCTGATTCGTGATGGTCAAGTTACCCGAGGATTCTTAG
GAGTGACTTTACAACCTATAGATGCGGAACTCGCTGCTTGCTACAAACTCGAAAAGGTTTATGGCGCTTTAGTCACAGAT
GTTGTTAAAGGATCTCCAGCAGATAAAGCAGGGCTAAAACAAGAAGATGTGATCATTGCTTATAATGGGAAAGAAGTCGA
TTCACTGAGTATGTTCCGTAATGCTGTTTCTTTAATGAATCCAGATACACGTATTGTTCTAAAGGTAGTTCGTGAAGGAA
AGGTTATCGAAATACCCGTGACAGTTTCTCAAGCTCCAAAAGAAGATGGAATGTCGGCTTTACAGCGTGTGGGAATCCGT
GTGCAAAACCTAACTCCTGAAACTGCTAAGAAGCTGGGAATTGCTCCAGAGACTAAAGGCATTTTGATTATAAGTGTTGA
ACCAGGGTCTGTAGCAGCTTCTTCAGGAATTGCTCCTGGTCAGCTGATCCTTGCTGTGAATAGACAAAAAGTATCTTCGA
TTGAAGATCTGAATAGAACGTTAAAAGATTCTAACAATGAGAATATTCTTCTTATGGTTTCTCAAGGAGATGTTATTCGC
TTCATTGCCCTGAAACCTGAAGAATAA

Upstream 100 bases:

>100_bases
TATGATTTGTTTTTCGTAATTACTAGGTAGCAGAACCTGTGTTAGCTAGTATACGATGGTATTCTGCTTCATCGAAAGAC
AACCTTCTTGAGGGATAGAT

Downstream 100 bases:

>100_bases
AAAGCTTGGAGTCATACATTTGATTCATAAAGAGGAATGAAGAGAGTTCTCTCTTCACTCTTTTATTTTAGGAAGCTTAT
CAAGAAGCTGACAAATAGAA

Product: DO serine protease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 488; Mature: 488

Protein sequence:

>488_residues
MITKQLRSWLAVLVGSSLLALPLSGQAVGKKESRVSELPQDVLLKEISGGFSKVATKATPAVVYIESFPKSQAVTHPSPG
RRGPYENPFDYFNDEFFNRFFGLPSQREKPQSKEAVRGTGFLVSPDGYIVTNNHVVEDTGKIHVTLHDGQKYPATVIGLD
PKTDLAVIKIKSQNLPYLSFGNSDHLKVGDWAIAIGNPFGLQATVTVGVISAKGRNQLHIADFEDFIQTDAAINPGNSGG
PLLNIDGQVIGVNTAIVSGSGGYIGIGFAIPSLMANRIIDQLIRDGQVTRGFLGVTLQPIDAELAACYKLEKVYGALVTD
VVKGSPADKAGLKQEDVIIAYNGKEVDSLSMFRNAVSLMNPDTRIVLKVVREGKVIEIPVTVSQAPKEDGMSALQRVGIR
VQNLTPETAKKLGIAPETKGILIISVEPGSVAASSGIAPGQLILAVNRQKVSSIEDLNRTLKDSNNENILLMVSQGDVIR
FIALKPEE

Sequences:

>Translated_488_residues
MITKQLRSWLAVLVGSSLLALPLSGQAVGKKESRVSELPQDVLLKEISGGFSKVATKATPAVVYIESFPKSQAVTHPSPG
RRGPYENPFDYFNDEFFNRFFGLPSQREKPQSKEAVRGTGFLVSPDGYIVTNNHVVEDTGKIHVTLHDGQKYPATVIGLD
PKTDLAVIKIKSQNLPYLSFGNSDHLKVGDWAIAIGNPFGLQATVTVGVISAKGRNQLHIADFEDFIQTDAAINPGNSGG
PLLNIDGQVIGVNTAIVSGSGGYIGIGFAIPSLMANRIIDQLIRDGQVTRGFLGVTLQPIDAELAACYKLEKVYGALVTD
VVKGSPADKAGLKQEDVIIAYNGKEVDSLSMFRNAVSLMNPDTRIVLKVVREGKVIEIPVTVSQAPKEDGMSALQRVGIR
VQNLTPETAKKLGIAPETKGILIISVEPGSVAASSGIAPGQLILAVNRQKVSSIEDLNRTLKDSNNENILLMVSQGDVIR
FIALKPEE
>Mature_488_residues
MITKQLRSWLAVLVGSSLLALPLSGQAVGKKESRVSELPQDVLLKEISGGFSKVATKATPAVVYIESFPKSQAVTHPSPG
RRGPYENPFDYFNDEFFNRFFGLPSQREKPQSKEAVRGTGFLVSPDGYIVTNNHVVEDTGKIHVTLHDGQKYPATVIGLD
PKTDLAVIKIKSQNLPYLSFGNSDHLKVGDWAIAIGNPFGLQATVTVGVISAKGRNQLHIADFEDFIQTDAAINPGNSGG
PLLNIDGQVIGVNTAIVSGSGGYIGIGFAIPSLMANRIIDQLIRDGQVTRGFLGVTLQPIDAELAACYKLEKVYGALVTD
VVKGSPADKAGLKQEDVIIAYNGKEVDSLSMFRNAVSLMNPDTRIVLKVVREGKVIEIPVTVSQAPKEDGMSALQRVGIR
VQNLTPETAKKLGIAPETKGILIISVEPGSVAASSGIAPGQLILAVNRQKVSSIEDLNRTLKDSNNENILLMVSQGDVIR
FIALKPEE

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains

Homologues:

Organism=Homo sapiens, GI4506141, Length=265, Percent_Identity=40.377358490566, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI24308541, Length=261, Percent_Identity=40.9961685823755, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI22129776, Length=341, Percent_Identity=34.6041055718475, Blast_Score=158, Evalue=1e-38,
Organism=Homo sapiens, GI7019477, Length=309, Percent_Identity=35.5987055016181, Blast_Score=149, Evalue=6e-36,
Organism=Escherichia coli, GI1786356, Length=370, Percent_Identity=39.4594594594595, Blast_Score=266, Evalue=3e-72,
Organism=Escherichia coli, GI1789629, Length=464, Percent_Identity=36.8534482758621, Blast_Score=265, Evalue=4e-72,
Organism=Escherichia coli, GI1789630, Length=276, Percent_Identity=38.4057971014493, Blast_Score=174, Evalue=1e-44,
Organism=Drosophila melanogaster, GI24646839, Length=290, Percent_Identity=33.448275862069, Blast_Score=145, Evalue=5e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DEGP_CHLPN (Q9Z6T0)

Other databases:

- EMBL:   AE001363
- EMBL:   AE002161
- EMBL:   BA000008
- EMBL:   AE009440
- PIR:   G72011
- PIR:   G81528
- PIR:   H86612
- RefSeq:   NP_225173.1
- RefSeq:   NP_301034.1
- RefSeq:   NP_445415.1
- RefSeq:   NP_877288.1
- ProteinModelPortal:   Q9Z6T0
- SMR:   Q9Z6T0
- MEROPS:   S01.480
- PHCI-2DPAGE:   Q9Z6T0
- GeneID:   1467695
- GeneID:   895609
- GeneID:   919746
- GeneID:   963330
- GenomeReviews:   AE001363_GR
- GenomeReviews:   AE002161_GR
- GenomeReviews:   AE009440_GR
- GenomeReviews:   BA000008_GR
- KEGG:   cpa:CP0877
- KEGG:   cpn:CPn0979
- KEGG:   cpt:CpB1016
- TIGR:   CP_0877
- HOGENOM:   HBG585708
- OMA:   ASAMREA
- PhylomeDB:   Q9Z6T0
- ProtClustDB:   CLSK871616
- BioCyc:   CPNE115711:CP_0877-MONOMER
- BioCyc:   CPNE115713:CPN0979-MONOMER
- BioCyc:   CPNE138677:CPJ0979-MONOMER
- BioCyc:   CPNE182082:CPB1016-MONOMER
- GO:   GO:0006508
- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940
- PRINTS:   PR00834
- SMART:   SM00228
- SMART:   SM00020
- TIGRFAMs:   TIGR02037

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin; SSF50156 PDZ; SSF50494 Pept_Ser_Cys

EC number: 3.4.21.-

Molecular weight: Translated: 52312; Mature: 52312

Theoretical pI: Translated: 7.74; Mature: 7.74

Prosite motif: PS50106 PDZ

Important sites: ACT_SITE 134-134 ACT_SITE 164-164 ACT_SITE 238-238

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITKQLRSWLAVLVGSSLLALPLSGQAVGKKESRVSELPQDVLLKEISGGFSKVATKATP
CCHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHCCHHHHHHHHCCCHHHHHHCCCC
AVVYIESFPKSQAVTHPSPGRRGPYENPFDYFNDEFFNRFFGLPSQREKPQSKEAVRGTG
EEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHCCCC
FLVSPDGYIVTNNHVVEDTGKIHVTLHDGQKYPATVIGLDPKTDLAVIKIKSQNLPYLSF
EEECCCCEEEECCEEEECCCEEEEEEECCCCCCEEEEECCCCCCEEEEEEECCCCCEEEE
GNSDHLKVGDWAIAIGNPFGLQATVTVGVISAKGRNQLHIADFEDFIQTDAAINPGNSGG
CCCCCEEECCEEEEECCCCCCEEEEEEEEEECCCCCEEEECCHHHHHHHCCCCCCCCCCC
PLLNIDGQVIGVNTAIVSGSGGYIGIGFAIPSLMANRIIDQLIRDGQVTRGFLGVTLQPI
CEEEECCEEEEEEEEEEECCCCEEEEHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECC
DAELAACYKLEKVYGALVTDVVKGSPADKAGLKQEDVIIAYNGKEVDSLSMFRNAVSLMN
CHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHCC
PDTRIVLKVVREGKVIEIPVTVSQAPKEDGMSALQRVGIRVQNLTPETAKKLGIAPETKG
CCHHHHHEEHHCCCEEEEEEECCCCCCHHHHHHHHHHCCEEECCCHHHHHHCCCCCCCCC
ILIISVEPGSVAASSGIAPGQLILAVNRQKVSSIEDLNRTLKDSNNENILLMVSQGDVIR
EEEEEECCCCEECCCCCCCCEEEEEECHHHHHHHHHHHHHHHCCCCCEEEEEEECCCEEE
FIALKPEE
EEEECCCC
>Mature Secondary Structure
MITKQLRSWLAVLVGSSLLALPLSGQAVGKKESRVSELPQDVLLKEISGGFSKVATKATP
CCHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHCCHHHHHHHHCCCHHHHHHCCCC
AVVYIESFPKSQAVTHPSPGRRGPYENPFDYFNDEFFNRFFGLPSQREKPQSKEAVRGTG
EEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHCCCC
FLVSPDGYIVTNNHVVEDTGKIHVTLHDGQKYPATVIGLDPKTDLAVIKIKSQNLPYLSF
EEECCCCEEEECCEEEECCCEEEEEEECCCCCCEEEEECCCCCCEEEEEEECCCCCEEEE
GNSDHLKVGDWAIAIGNPFGLQATVTVGVISAKGRNQLHIADFEDFIQTDAAINPGNSGG
CCCCCEEECCEEEEECCCCCCEEEEEEEEEECCCCCEEEECCHHHHHHHCCCCCCCCCCC
PLLNIDGQVIGVNTAIVSGSGGYIGIGFAIPSLMANRIIDQLIRDGQVTRGFLGVTLQPI
CEEEECCEEEEEEEEEEECCCCEEEEHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECC
DAELAACYKLEKVYGALVTDVVKGSPADKAGLKQEDVIIAYNGKEVDSLSMFRNAVSLMN
CHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHCC
PDTRIVLKVVREGKVIEIPVTVSQAPKEDGMSALQRVGIRVQNLTPETAKKLGIAPETKG
CCHHHHHEEHHCCCEEEEEEECCCCCCHHHHHHHHHHCCEEECCCHHHHHHCCCCCCCCC
ILIISVEPGSVAASSGIAPGQLILAVNRQKVSSIEDLNRTLKDSNNENILLMVSQGDVIR
EEEEEECCCCEECCCCCCCCEEEEEECHHHHHHHHHHHHHHHCCCCCEEEEEEECCCEEE
FIALKPEE
EEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362