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The map label for this gene is tyrP_1

Identifier: 15836502

GI number: 15836502

Start: 1111161

End: 1112351

Strand: Direct

Name: tyrP_1

Synonym: CPj0969

Alternate gene names: 15836502

Gene position: 1111161-1112351 (Clockwise)

Preceding gene: 15836501

Following gene: 15836503

Centisome position: 90.59

GC content: 40.3

Gene sequence:

>1191_bases
ATGTCAAATAAAGTTCTAGGTGGGTCCTTGCTTATTGCAGGTTCTGCCATCGGTGCTGGTGTTTTAGCAGTTCCTGTATT
GACCGCAAAAGGCGGTTTTTTCCCTGCAACTTTTCTCTATATTGTCTCCTGGCTTTTTTCTATGGCCTCAGGCCTTTGCC
TTCTTGAAGTCATGACTTGGATGAAAGAATCAAAGAACCCAGTGAACATGCTTTCTATGGCGGAATCTATTTTAGGTCAT
GTAGGCAAGATTTCTATATGCCTTGTCTACTTGTTTCTCTTTTACTCCCTACTGATTGCCTATTTCTGCGAAGGGGGAAA
CATCTTATGCCGCGTGTTTAATTGTCAAAATTTAGGAATCTCGTGGATTCGTCACCTTGGCCCTCTAGGTTTTGCTATAT
TGATGGGGCCTATCATTATGGCGGGAACAAAAGTGATTGATTACTGTAATCGTTTCTTTATGTTCGGCTTAACTGTAGCT
TTTGGAATTTTCTGTGCCCTTGGATTTTTAAAAATCCAACCTAGCTTTCTGGTGCGTTCCTCATGGTTAACTACAATAAA
CGCATTTCCTGTGTTTTTCCTTGCTTTTGGATTCCAAAGTATCATTCCTACGTTGTACTACTACATGGACAAAAAAGTTG
GAGATGTTAAAAAGGCAATTCTCATAGGAACGTTGATTCCTCTTGTTCTCTATGTCTTATGGGAAGTTGTGGTTTTAGGT
GCTGTCTCTCTTCCGATTCTTTCCCAGGCTAAGATAGGTGGATATACTGCTGTAGAAGCTCTCAAGCAGGCCCATCGTTC
TTGGGCATTTTATATTGCTGGAGAACTTTTTGGCTTCTTTGCTTTGGTCTCCTCTTTTGTAGGAGTTGCTCTCGGTGTTA
TGGACTTCCTGGCAGACGGTTTAAAATGGAATAAAAAATCACATCCATTTTCAATTTTCTTTTTAACATTTATTATTCCC
CTTGCTTGGGCTGTTTGTTATCCTGAAATTGTTTTGACCTGTCTTAAGTATGCTGGGGGATTCGGGGCCGCCGTGATTAT
CGGGGTATTCCCAACATTGATTGTGTGGAAAGGGCGTTATGGCAAACAACATCACAGAGAGAAACAGTTAGTTCCAGGAG
GAAAGTTTGCTTTATTTTTGATGTTCTTGTTGATAGTAATAAATGTAGTTAGCATTTATCATGAGCTTTAA

Upstream 100 bases:

>100_bases
TACTGTAGAGTAAGTACTTCACAGTAGTAGACCTCGCAATCCTATGATGAAACTCTTTAGAACTTGTCTTAAGAGTGCAT
ATGAAATTTAGGTATACGTT

Downstream 100 bases:

>100_bases
ATTTGTTTTGCTCTATTTTTCAATTTCAAGTGAGCAAATAGGAGGGTTCTATGGGACTATATGATCGTGACTATATACAA
GATTCTCGAGTGCAGGGAAC

Product: tyrosine transport

Products: Proton [Cytoplasm]; L-tyrosine [Cytoplasm] [C]

Alternate protein names: Tyrosine permease [H]

Number of amino acids: Translated: 396; Mature: 395

Protein sequence:

>396_residues
MSNKVLGGSLLIAGSAIGAGVLAVPVLTAKGGFFPATFLYIVSWLFSMASGLCLLEVMTWMKESKNPVNMLSMAESILGH
VGKISICLVYLFLFYSLLIAYFCEGGNILCRVFNCQNLGISWIRHLGPLGFAILMGPIIMAGTKVIDYCNRFFMFGLTVA
FGIFCALGFLKIQPSFLVRSSWLTTINAFPVFFLAFGFQSIIPTLYYYMDKKVGDVKKAILIGTLIPLVLYVLWEVVVLG
AVSLPILSQAKIGGYTAVEALKQAHRSWAFYIAGELFGFFALVSSFVGVALGVMDFLADGLKWNKKSHPFSIFFLTFIIP
LAWAVCYPEIVLTCLKYAGGFGAAVIIGVFPTLIVWKGRYGKQHHREKQLVPGGKFALFLMFLLIVINVVSIYHEL

Sequences:

>Translated_396_residues
MSNKVLGGSLLIAGSAIGAGVLAVPVLTAKGGFFPATFLYIVSWLFSMASGLCLLEVMTWMKESKNPVNMLSMAESILGH
VGKISICLVYLFLFYSLLIAYFCEGGNILCRVFNCQNLGISWIRHLGPLGFAILMGPIIMAGTKVIDYCNRFFMFGLTVA
FGIFCALGFLKIQPSFLVRSSWLTTINAFPVFFLAFGFQSIIPTLYYYMDKKVGDVKKAILIGTLIPLVLYVLWEVVVLG
AVSLPILSQAKIGGYTAVEALKQAHRSWAFYIAGELFGFFALVSSFVGVALGVMDFLADGLKWNKKSHPFSIFFLTFIIP
LAWAVCYPEIVLTCLKYAGGFGAAVIIGVFPTLIVWKGRYGKQHHREKQLVPGGKFALFLMFLLIVINVVSIYHEL
>Mature_395_residues
SNKVLGGSLLIAGSAIGAGVLAVPVLTAKGGFFPATFLYIVSWLFSMASGLCLLEVMTWMKESKNPVNMLSMAESILGHV
GKISICLVYLFLFYSLLIAYFCEGGNILCRVFNCQNLGISWIRHLGPLGFAILMGPIIMAGTKVIDYCNRFFMFGLTVAF
GIFCALGFLKIQPSFLVRSSWLTTINAFPVFFLAFGFQSIIPTLYYYMDKKVGDVKKAILIGTLIPLVLYVLWEVVVLGA
VSLPILSQAKIGGYTAVEALKQAHRSWAFYIAGELFGFFALVSSFVGVALGVMDFLADGLKWNKKSHPFSIFFLTFIIPL
AWAVCYPEIVLTCLKYAGGFGAAVIIGVFPTLIVWKGRYGKQHHREKQLVPGGKFALFLMFLLIVINVVSIYHEL

Specific function: Involved in transporting tyrosine across the cytoplasmic membrane [H]

COG id: COG0814

COG function: function code E; Amino acid permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid/polyamine transporter 2 family. Mtr/TnaB/TyrP permease subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788218, Length=396, Percent_Identity=31.5656565656566, Blast_Score=154, Evalue=1e-38,
Organism=Escherichia coli, GI1789552, Length=374, Percent_Identity=26.7379679144385, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1790145, Length=398, Percent_Identity=26.6331658291457, Blast_Score=85, Evalue=6e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002091
- InterPro:   IPR013061
- InterPro:   IPR013059
- InterPro:   IPR018227 [H]

Pfam domain/function: PF03222 Trp_Tyr_perm [H]

EC number: NA

Molecular weight: Translated: 43593; Mature: 43462

Theoretical pI: Translated: 9.49; Mature: 9.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SNKVLGGSLLIAGSAIGAGVLAVPVLTAKGGFFPATFLYIVSWLFSMASGLCLLEVMTW
CCCCCCCHHEEECHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHH
MKESKNPVNMLSMAESILGHVGKISICLVYLFLFYSLLIAYFCEGGNILCRVFNCQNLGI
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCH
SWIRHLGPLGFAILMGPIIMAGTKVIDYCNRFFMFGLTVAFGIFCALGFLKIQPSFLVRS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
SWLTTINAFPVFFLAFGFQSIIPTLYYYMDKKVGDVKKAILIGTLIPLVLYVLWEVVVLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVSLPILSQAKIGGYTAVEALKQAHRSWAFYIAGELFGFFALVSSFVGVALGVMDFLADG
HHHCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
LKWNKKSHPFSIFFLTFIIPLAWAVCYPEIVLTCLKYAGGFGAAVIIGVFPTLIVWKGRY
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCC
GKQHHREKQLVPGGKFALFLMFLLIVINVVSIYHEL
CCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-tyrosine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-tyrosine [Periplasm] = Proton [Cytoplasm] + L-tyrosine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3049553; 9097040; 9278503 [H]