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The map label for this gene is glmS

Identifier: 15836501

GI number: 15836501

Start: 1109244

End: 1111073

Strand: Direct

Name: glmS

Synonym: CPj0968

Alternate gene names: 15836501

Gene position: 1109244-1111073 (Clockwise)

Preceding gene: 15836500

Following gene: 15836502

Centisome position: 90.43

GC content: 41.42

Gene sequence:

>1830_bases
ATGTGCGGGATATTTGGATATTTGGGAAACCAAGATGGTGTGTCTATTGTTCTAGAAGGCTTGGCAAAGTTAGAATATCG
TGGTTATGATTCCGCAGGTCTTGCTGCTGTAGTTGAACAAGAGCTTTTTATTAGAAAAACTGTAGGTCGTGTTCAAGAGC
TTTCAAACTTGTTTCAAGAAAGAGAAATCCCTACGGCATCAGTTATTGGCCATACCCGTTGGGCAACTCATGGAGTGCCT
ACCGAGATTAATGCTCATCCACATGTGGATGAGGGAAGGTCGTGTGCTGTAGTCCATAATGGAATTATAGAAAATTTCAA
AGAGTTGCGACGCGAGCTGACTGCGCAAGGCATTTCATTTGCTTCAGATACCGATTCAGAAATTATTGTTCAGCTGTTTT
CTCTATATTATCAAGAGTCCCAAGATCTTGTGTTCAGCTTTTGTCAGACTCTAGCTCAACTCCGAGGTAGCGTAGCCTGC
GCTTTGATTCATAAAGATCATCCTCATACGATTCTTTGCGCTTCTCAAGAGAGCCCTTTAATTCTTGGTTTAGGGAAAGA
AGAGACGTTTATTGCTTCAGATTCGCGAGCTTTCTTCAAATATACTCGACATTCTCAAGCCTTGGCCTCCGGAGAATTTG
CTATAGTTTCTCAAGGGAAAGAACCTGAGGTTTATAATTTGGAGCTTAAGAAAATCCATAAGGATGTACGACAAATCACC
TGTAGTGAAGATGCTTCGGATAAAAGTGGCTACGGCTATTATATGCTGAAGGAAATCTATGATCAGCCAGAAGTTTTAGA
AGGTCTGATTCAAAAACATATGGATGAAGAAGGACATATTTTATCTGAATTTTTATCAGATGTTCCTATCAAGAGTTTTA
AAGAAATCACGATTGTTGCTTGCGGGTCTTCCTATCATGCTGGTTATCTCGCTAAATATATTATAGAGTCCTTAGTTTCA
ATTCCTGTACATATTGAAGTGGCTTCCGAATTTCGCTATCGACGTCCCTACATAGGTAAAGATACTTTGGGGATTTTGAT
CAGTCAATCAGGAGAAACAGCTGATACCCTAGCTGCTTTGAAGGAATTACGTCGCAGAAACATTGCTTATCTCCTAGGCA
TTTGCAATGTCCCGGAATCAGCAATTGCTCTTGGTGTGGATCACTGTCTGTTTTTAGAAGCGGGGGTGGAAATCGGTGTA
GCTACGACAAAGGCTTTTACCTCGCAACTCTTGTTGCTTGTGTTTTTGGGTTTGAAATTAGCAAATGTACATGGTGCCTT
GACTCACGCAGAACAATGTTCCTTTGGCCAGGGATTACAAAGCTTACCAGATCTCTGTCAAAAACTTCTTGCCAACGAGT
CTCTCCATTCTTGGGCGCAGCCTTACTCCTATGAAGATAAGTTTCTTTTTCTAGGCCGTAGGTTGATGTATCCGGTGGTT
ATGGAGGCTGCCCTCAAACTCAAAGAAATTGCTTATATTGAAGCGAATGCGTATCCTGGTGGAGAAATGAAACATGGGCC
CATAGCTTTAATTAGCAAAGGTACCCCTGTTATTGCATTTTGCGGTGATGATATTGTCTATGAAAAGATGATAGGCAACA
TGATGGAGGTTAAAGCTCGTCATGCTCATGTGATTGCTATTGCTCCTGAATCTCGTGAAGATATCGCTGCAGTTTCTGAT
CAACAGATCTTTGTCCCAGATTGTCATTTTCTCGCTGCTCCTGTGTTATATACTATAGTTGGTCAAGTGATGGCATATGC
TATGGCGTTAGCAAAAGGAATGGAGATTGACTGTCCCAGAAATCTTGCCAAGTCTGTTACTGTAGAGTAA

Upstream 100 bases:

>100_bases
GGTTGAAGGTCATAAAAAACATCAAGTAGACTGCCTTGCCAAGGCTCTTGCGGATGTTATTGATGCAGAATTAGGTACAG
GTAGTAGAGAGTAGGATCGT

Downstream 100 bases:

>100_bases
GTACTTCACAGTAGTAGACCTCGCAATCCTATGATGAAACTCTTTAGAACTTGTCTTAAGAGTGCATATGAAATTTAGGT
ATACGTTATGTCAAATAAAG

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase

Number of amino acids: Translated: 609; Mature: 609

Protein sequence:

>609_residues
MCGIFGYLGNQDGVSIVLEGLAKLEYRGYDSAGLAAVVEQELFIRKTVGRVQELSNLFQEREIPTASVIGHTRWATHGVP
TEINAHPHVDEGRSCAVVHNGIIENFKELRRELTAQGISFASDTDSEIIVQLFSLYYQESQDLVFSFCQTLAQLRGSVAC
ALIHKDHPHTILCASQESPLILGLGKEETFIASDSRAFFKYTRHSQALASGEFAIVSQGKEPEVYNLELKKIHKDVRQIT
CSEDASDKSGYGYYMLKEIYDQPEVLEGLIQKHMDEEGHILSEFLSDVPIKSFKEITIVACGSSYHAGYLAKYIIESLVS
IPVHIEVASEFRYRRPYIGKDTLGILISQSGETADTLAALKELRRRNIAYLLGICNVPESAIALGVDHCLFLEAGVEIGV
ATTKAFTSQLLLLVFLGLKLANVHGALTHAEQCSFGQGLQSLPDLCQKLLANESLHSWAQPYSYEDKFLFLGRRLMYPVV
MEAALKLKEIAYIEANAYPGGEMKHGPIALISKGTPVIAFCGDDIVYEKMIGNMMEVKARHAHVIAIAPESREDIAAVSD
QQIFVPDCHFLAAPVLYTIVGQVMAYAMALAKGMEIDCPRNLAKSVTVE

Sequences:

>Translated_609_residues
MCGIFGYLGNQDGVSIVLEGLAKLEYRGYDSAGLAAVVEQELFIRKTVGRVQELSNLFQEREIPTASVIGHTRWATHGVP
TEINAHPHVDEGRSCAVVHNGIIENFKELRRELTAQGISFASDTDSEIIVQLFSLYYQESQDLVFSFCQTLAQLRGSVAC
ALIHKDHPHTILCASQESPLILGLGKEETFIASDSRAFFKYTRHSQALASGEFAIVSQGKEPEVYNLELKKIHKDVRQIT
CSEDASDKSGYGYYMLKEIYDQPEVLEGLIQKHMDEEGHILSEFLSDVPIKSFKEITIVACGSSYHAGYLAKYIIESLVS
IPVHIEVASEFRYRRPYIGKDTLGILISQSGETADTLAALKELRRRNIAYLLGICNVPESAIALGVDHCLFLEAGVEIGV
ATTKAFTSQLLLLVFLGLKLANVHGALTHAEQCSFGQGLQSLPDLCQKLLANESLHSWAQPYSYEDKFLFLGRRLMYPVV
MEAALKLKEIAYIEANAYPGGEMKHGPIALISKGTPVIAFCGDDIVYEKMIGNMMEVKARHAHVIAIAPESREDIAAVSD
QQIFVPDCHFLAAPVLYTIVGQVMAYAMALAKGMEIDCPRNLAKSVTVE
>Mature_609_residues
MCGIFGYLGNQDGVSIVLEGLAKLEYRGYDSAGLAAVVEQELFIRKTVGRVQELSNLFQEREIPTASVIGHTRWATHGVP
TEINAHPHVDEGRSCAVVHNGIIENFKELRRELTAQGISFASDTDSEIIVQLFSLYYQESQDLVFSFCQTLAQLRGSVAC
ALIHKDHPHTILCASQESPLILGLGKEETFIASDSRAFFKYTRHSQALASGEFAIVSQGKEPEVYNLELKKIHKDVRQIT
CSEDASDKSGYGYYMLKEIYDQPEVLEGLIQKHMDEEGHILSEFLSDVPIKSFKEITIVACGSSYHAGYLAKYIIESLVS
IPVHIEVASEFRYRRPYIGKDTLGILISQSGETADTLAALKELRRRNIAYLLGICNVPESAIALGVDHCLFLEAGVEIGV
ATTKAFTSQLLLLVFLGLKLANVHGALTHAEQCSFGQGLQSLPDLCQKLLANESLHSWAQPYSYEDKFLFLGRRLMYPVV
MEAALKLKEIAYIEANAYPGGEMKHGPIALISKGTPVIAFCGDDIVYEKMIGNMMEVKARHAHVIAIAPESREDIAAVSD
QQIFVPDCHFLAAPVLYTIVGQVMAYAMALAKGMEIDCPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains

Homologues:

Organism=Homo sapiens, GI4826742, Length=695, Percent_Identity=31.9424460431655, Blast_Score=323, Evalue=2e-88,
Organism=Homo sapiens, GI205277386, Length=691, Percent_Identity=30.3907380607815, Blast_Score=301, Evalue=1e-81,
Organism=Homo sapiens, GI29570798, Length=198, Percent_Identity=27.7777777777778, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1790167, Length=620, Percent_Identity=41.6129032258065, Blast_Score=455, Evalue=1e-129,
Organism=Escherichia coli, GI1788651, Length=244, Percent_Identity=26.6393442622951, Blast_Score=66, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17532899, Length=449, Percent_Identity=32.5167037861915, Blast_Score=205, Evalue=5e-53,
Organism=Caenorhabditis elegans, GI17532897, Length=449, Percent_Identity=32.5167037861915, Blast_Score=205, Evalue=6e-53,
Organism=Caenorhabditis elegans, GI17539970, Length=444, Percent_Identity=32.2072072072072, Blast_Score=195, Evalue=5e-50,
Organism=Caenorhabditis elegans, GI17554892, Length=256, Percent_Identity=28.90625, Blast_Score=76, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6322745, Length=723, Percent_Identity=32.3651452282158, Blast_Score=301, Evalue=2e-82,
Organism=Saccharomyces cerevisiae, GI6323731, Length=436, Percent_Identity=26.1467889908257, Blast_Score=135, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6323730, Length=205, Percent_Identity=34.1463414634146, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI21357745, Length=686, Percent_Identity=32.6530612244898, Blast_Score=331, Evalue=1e-90,
Organism=Drosophila melanogaster, GI28573187, Length=142, Percent_Identity=31.6901408450704, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24659598, Length=201, Percent_Identity=27.363184079602, Blast_Score=70, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24659604, Length=177, Percent_Identity=28.2485875706215, Blast_Score=67, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLMS_CHLPN (Q9Z6U0)

Other databases:

- EMBL:   AE001363
- EMBL:   AE002161
- EMBL:   BA000008
- EMBL:   AE009440
- PIR:   B81528
- PIR:   E72012
- PIR:   F86611
- RefSeq:   NP_225161.1
- RefSeq:   NP_301025.1
- RefSeq:   NP_445430.1
- RefSeq:   NP_877277.1
- ProteinModelPortal:   Q9Z6U0
- SMR:   Q9Z6U0
- MEROPS:   C44.971
- GeneID:   1467684
- GeneID:   895622
- GeneID:   919731
- GeneID:   963348
- GenomeReviews:   AE001363_GR
- GenomeReviews:   AE002161_GR
- GenomeReviews:   AE009440_GR
- GenomeReviews:   BA000008_GR
- KEGG:   cpa:CP0892
- KEGG:   cpn:CPn0968
- KEGG:   cpt:CpB1005
- TIGR:   CP_0892
- HOGENOM:   HBG645312
- OMA:   ITDRIAY
- ProtClustDB:   PRK00331
- BioCyc:   CPNE115711:CP_0892-MONOMER
- BioCyc:   CPNE115713:CPN0968-MONOMER
- BioCyc:   CPNE138677:CPJ0968-MONOMER
- BioCyc:   CPNE182082:CPB1005-MONOMER
- BRENDA:   2.6.1.16
- GO:   GO:0005737
- HAMAP:   MF_00164
- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347
- TIGRFAMs:   TIGR01135

Pfam domain/function: PF00310 GATase_2; PF01380 SIS

EC number: =2.6.1.16

Molecular weight: Translated: 67203; Mature: 67203

Theoretical pI: Translated: 5.55; Mature: 5.55

Prosite motif: PS51278 GATASE_TYPE_2; PS51464 SIS; PS00443 GATASE_TYPE_II

Important sites: ACT_SITE 2-2 ACT_SITE 604-604

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIFGYLGNQDGVSIVLEGLAKLEYRGYDSAGLAAVVEQELFIRKTVGRVQELSNLFQE
CCCEECCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
REIPTASVIGHTRWATHGVPTEINAHPHVDEGRSCAVVHNGIIENFKELRRELTAQGISF
HCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCC
ASDTDSEIIVQLFSLYYQESQDLVFSFCQTLAQLRGSVACALIHKDHPHTILCASQESPL
CCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCEEEEEEECCCCCEEEEECCCCCE
ILGLGKEETFIASDSRAFFKYTRHSQALASGEFAIVSQGKEPEVYNLELKKIHKDVRQIT
EEECCCCCEEEECCCHHHHHHHHHHHHHHCCCEEEEECCCCCCEEEHHHHHHHHHHHHHH
CSEDASDKSGYGYYMLKEIYDQPEVLEGLIQKHMDEEGHILSEFLSDVPIKSFKEITIVA
CCCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCEEEEE
CGSSYHAGYLAKYIIESLVSIPVHIEVASEFRYRRPYIGKDTLGILISQSGETADTLAAL
ECCCCCHHHHHHHHHHHHHHCCEEEEEHHHHHHCCCCCCCCCEEEEEECCCCHHHHHHHH
KELRRRNIAYLLGICNVPESAIALGVDHCLFLEAGVEIGVATTKAFTSQLLLLVFLGLKL
HHHHHCCCEEEEEECCCCHHHHHHHHHHHEEECCCCEEEEHHHHHHHHHHHHHHHHHHHH
ANVHGALTHAEQCSFGQGLQSLPDLCQKLLANESLHSWAQPYSYEDKFLFLGRRLMYPVV
HHHHHHHHHHHHCCHHCCHHHHHHHHHHHHCCCHHHHHCCCCCCCCHHHHHHHHHHHHHH
MEAALKLKEIAYIEANAYPGGEMKHGPIALISKGTPVIAFCGDDIVYEKMIGNMMEVKAR
HHHHHHHHHHEEEEECCCCCCCCCCCCEEEEECCCCEEEECCCHHHHHHHHHHHHHHHHC
HAHVIAIAPESREDIAAVSDQQIFVPDCHFLAAPVLYTIVGQVMAYAMALAKGMEIDCPR
CEEEEEECCCCCCHHHHCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCH
NLAKSVTVE
HHHHCCCCC
>Mature Secondary Structure
MCGIFGYLGNQDGVSIVLEGLAKLEYRGYDSAGLAAVVEQELFIRKTVGRVQELSNLFQE
CCCEECCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
REIPTASVIGHTRWATHGVPTEINAHPHVDEGRSCAVVHNGIIENFKELRRELTAQGISF
HCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCC
ASDTDSEIIVQLFSLYYQESQDLVFSFCQTLAQLRGSVACALIHKDHPHTILCASQESPL
CCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCEEEEEEECCCCCEEEEECCCCCE
ILGLGKEETFIASDSRAFFKYTRHSQALASGEFAIVSQGKEPEVYNLELKKIHKDVRQIT
EEECCCCCEEEECCCHHHHHHHHHHHHHHCCCEEEEECCCCCCEEEHHHHHHHHHHHHHH
CSEDASDKSGYGYYMLKEIYDQPEVLEGLIQKHMDEEGHILSEFLSDVPIKSFKEITIVA
CCCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCEEEEE
CGSSYHAGYLAKYIIESLVSIPVHIEVASEFRYRRPYIGKDTLGILISQSGETADTLAAL
ECCCCCHHHHHHHHHHHHHHCCEEEEEHHHHHHCCCCCCCCCEEEEEECCCCHHHHHHHH
KELRRRNIAYLLGICNVPESAIALGVDHCLFLEAGVEIGVATTKAFTSQLLLLVFLGLKL
HHHHHCCCEEEEEECCCCHHHHHHHHHHHEEECCCCEEEEHHHHHHHHHHHHHHHHHHHH
ANVHGALTHAEQCSFGQGLQSLPDLCQKLLANESLHSWAQPYSYEDKFLFLGRRLMYPVV
HHHHHHHHHHHHCCHHCCHHHHHHHHHHHHCCCHHHHHCCCCCCCCHHHHHHHHHHHHHH
MEAALKLKEIAYIEANAYPGGEMKHGPIALISKGTPVIAFCGDDIVYEKMIGNMMEVKAR
HHHHHHHHHHEEEEECCCCCCCCCCCCEEEEECCCCEEEECCCHHHHHHHHHHHHHHHHC
HAHVIAIAPESREDIAAVSDQQIFVPDCHFLAAPVLYTIVGQVMAYAMALAKGMEIDCPR
CEEEEEECCCCCCHHHHCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCH
NLAKSVTVE
HHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362