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The map label for this gene is fabF

Identifier: 15836449

GI number: 15836449

Start: 1046185

End: 1047435

Strand: Direct

Name: fabF

Synonym: CPj0916

Alternate gene names: 15836449

Gene position: 1046185-1047435 (Clockwise)

Preceding gene: 15836448

Following gene: 15836450

Centisome position: 85.29

GC content: 44.36

Gene sequence:

>1251_bases
ATGAGTAAAAAACGCGTAGTTGTTACAGGATTCGGTGTTGTATCTTGCCTCGGTAATGAAGTAGATACCTTTTACGATAA
TCTTCTTGCCGGTGTCAGCGGCGTACGGCCAATTACATCCTTTCCTTGTGAGGATTATGCCACTCGTTTTGCCGGCTGGA
TCCCAGAATTCAATCCCGAGCCTTATGTAGATAAAAAGCAAGCACGTCGTGTCGACCCCTTTATTACCTATGCCATGGTA
GCTGCTAAGAAAGCGATCGCTATGTCACGTTGGGATAAAGACCATCTGCCTTCCGATCCCGTGCGTTGTGGAGTGATTGT
CGGCTCTGGAATGGGTGGGCTCTCTACCCTAGACCAAGGGATGGAAAGACTCTTAGTTATTCATAAAAAATTATCTCCCT
TCTTTATTCCTTATATCATTACAAATATGGCCCCAGCACTTATTGCTATGGACTTTGGTTTGATGGGCCCCAATTATTCT
ATATCAACTGCATGTGCTACAGGAAATTATTGTATTGATGCCGCCTACCAACATTTAGTATCTGGGCGCGCTGATATGAT
CATCTGTGGTGGTACGGAAGCTGCAGTGAACCGTATTGGTTTAGAGGGTTTTATTGCTAATCGTGCTCTCTCTGAGAGAA
ACGATGCTCCAGATCAAGCTTCACGTCCTTGGGATAGAGATCGTGATGGCTTTGTCTTAGGAGAAGGAGCAGGAATTCTT
GTTTTAGAAACCCTAGAGAGTGCTCTACGTCGCGATGCTCCTATTTTTGCTGAGATGTTAGGAAGCTATGTTACATGCGA
TGCCTTCCATATTACCGCTCCTAGAGATGACGGTGAGGGGATTACTGCATGCGTGCTTGGTGCTTTAAATTCCGCAGGAA
TTCCTAAAGAACGTGTCAACTATGTGAATGCTCACGGAACGTCGACTCCATTAGGGGATCTTTCTGAAGTTCTAGCTGTT
AAAAAGGCTTTTGGCTCCCATGTACGAAATCTCCGCATGAACTCCACTAAATCATTGATAGGGCATTGTCTTGGAGCTGC
TGGAGGTGTTGAAGCCGTCGTTGCAATTCAAGCTATCCTTACGGGAAAGCTTCATCCTACGATTAATTTGGATAACCCTA
TCGCAGAAATTGAAGACTTTGATGTAGTTGCAAATAAAGCTCAAGACTGGGATATTGATGTAGCGATGTCCAACTCATTT
GGTTTTGGTGGACATAATTCAACGATATTATTCTCGAGGTATGTACCCTAG

Upstream 100 bases:

>100_bases
GTCTCTGAAATTCGTGGAAAATATCGTTTAGAAGAGCTATGGAAGGACGGATTTATTGTCACATCCAAGCTTTTAGCTTC
TTAATGGAGTAAGGGTCTAC

Downstream 100 bases:

>100_bases
TTATGATGAAGACAAAATATGAGTATTCTTTTGGTGTTATTCCTATAAAATTTTTTGGCACCCCCGATAAGAACACATTA
AAAGCTTGTTTTATTTGCCA

Product: 3-oxoacyl-(acyl carrier protein) synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 416; Mature: 415

Protein sequence:

>416_residues
MSKKRVVVTGFGVVSCLGNEVDTFYDNLLAGVSGVRPITSFPCEDYATRFAGWIPEFNPEPYVDKKQARRVDPFITYAMV
AAKKAIAMSRWDKDHLPSDPVRCGVIVGSGMGGLSTLDQGMERLLVIHKKLSPFFIPYIITNMAPALIAMDFGLMGPNYS
ISTACATGNYCIDAAYQHLVSGRADMIICGGTEAAVNRIGLEGFIANRALSERNDAPDQASRPWDRDRDGFVLGEGAGIL
VLETLESALRRDAPIFAEMLGSYVTCDAFHITAPRDDGEGITACVLGALNSAGIPKERVNYVNAHGTSTPLGDLSEVLAV
KKAFGSHVRNLRMNSTKSLIGHCLGAAGGVEAVVAIQAILTGKLHPTINLDNPIAEIEDFDVVANKAQDWDIDVAMSNSF
GFGGHNSTILFSRYVP

Sequences:

>Translated_416_residues
MSKKRVVVTGFGVVSCLGNEVDTFYDNLLAGVSGVRPITSFPCEDYATRFAGWIPEFNPEPYVDKKQARRVDPFITYAMV
AAKKAIAMSRWDKDHLPSDPVRCGVIVGSGMGGLSTLDQGMERLLVIHKKLSPFFIPYIITNMAPALIAMDFGLMGPNYS
ISTACATGNYCIDAAYQHLVSGRADMIICGGTEAAVNRIGLEGFIANRALSERNDAPDQASRPWDRDRDGFVLGEGAGIL
VLETLESALRRDAPIFAEMLGSYVTCDAFHITAPRDDGEGITACVLGALNSAGIPKERVNYVNAHGTSTPLGDLSEVLAV
KKAFGSHVRNLRMNSTKSLIGHCLGAAGGVEAVVAIQAILTGKLHPTINLDNPIAEIEDFDVVANKAQDWDIDVAMSNSF
GFGGHNSTILFSRYVP
>Mature_415_residues
SKKRVVVTGFGVVSCLGNEVDTFYDNLLAGVSGVRPITSFPCEDYATRFAGWIPEFNPEPYVDKKQARRVDPFITYAMVA
AKKAIAMSRWDKDHLPSDPVRCGVIVGSGMGGLSTLDQGMERLLVIHKKLSPFFIPYIITNMAPALIAMDFGLMGPNYSI
STACATGNYCIDAAYQHLVSGRADMIICGGTEAAVNRIGLEGFIANRALSERNDAPDQASRPWDRDRDGFVLGEGAGILV
LETLESALRRDAPIFAEMLGSYVTCDAFHITAPRDDGEGITACVLGALNSAGIPKERVNYVNAHGTSTPLGDLSEVLAVK
KAFGSHVRNLRMNSTKSLIGHCLGAAGGVEAVVAIQAILTGKLHPTINLDNPIAEIEDFDVVANKAQDWDIDVAMSNSFG
FGGHNSTILFSRYVP

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=416, Percent_Identity=39.4230769230769, Blast_Score=288, Evalue=6e-78,
Organism=Homo sapiens, GI223972627, Length=146, Percent_Identity=47.945205479452, Blast_Score=129, Evalue=4e-30,
Organism=Homo sapiens, GI41872631, Length=436, Percent_Identity=25.4587155963303, Blast_Score=84, Evalue=3e-16,
Organism=Escherichia coli, GI1787337, Length=415, Percent_Identity=44.8192771084337, Blast_Score=317, Evalue=1e-87,
Organism=Escherichia coli, GI1788663, Length=414, Percent_Identity=34.2995169082126, Blast_Score=219, Evalue=2e-58,
Organism=Caenorhabditis elegans, GI71983541, Length=422, Percent_Identity=32.7014218009479, Blast_Score=201, Evalue=7e-52,
Organism=Caenorhabditis elegans, GI71983535, Length=264, Percent_Identity=37.8787878787879, Blast_Score=157, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI17550940, Length=416, Percent_Identity=25.2403846153846, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI212642053, Length=363, Percent_Identity=24.5179063360882, Blast_Score=79, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6320904, Length=449, Percent_Identity=35.6347438752784, Blast_Score=247, Evalue=2e-66,
Organism=Drosophila melanogaster, GI24644341, Length=426, Percent_Identity=40.8450704225352, Blast_Score=296, Evalue=1e-80,
Organism=Drosophila melanogaster, GI221330659, Length=438, Percent_Identity=24.6575342465753, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI19920632, Length=438, Percent_Identity=24.6575342465753, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24581345, Length=432, Percent_Identity=23.8425925925926, Blast_Score=79, Evalue=7e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 44696; Mature: 44564

Theoretical pI: Translated: 5.62; Mature: 5.62

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKKRVVVTGFGVVSCLGNEVDTFYDNLLAGVSGVRPITSFPCEDYATRFAGWIPEFNPE
CCCCCEEEECCHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCCC
PYVDKKQARRVDPFITYAMVAAKKAIAMSRWDKDHLPSDPVRCGVIVGSGMGGLSTLDQG
CCCCHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCHHHHHHH
MERLLVIHKKLSPFFIPYIITNMAPALIAMDFGLMGPNYSISTACATGNYCIDAAYQHLV
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHH
SGRADMIICGGTEAAVNRIGLEGFIANRALSERNDAPDQASRPWDRDRDGFVLGEGAGIL
CCCCCEEEECCCHHHHHHHCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCCCEE
VLETLESALRRDAPIFAEMLGSYVTCDAFHITAPRDDGEGITACVLGALNSAGIPKERVN
EHHHHHHHHHCCCCHHHHHHCCCEEECEEEEECCCCCCCCHHHHHHHHHCCCCCCHHHHC
YVNAHGTSTPLGDLSEVLAVKKAFGSHVRNLRMNSTKSLIGHCLGAAGGVEAVVAIQAIL
EEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHH
TGKLHPTINLDNPIAEIEDFDVVANKAQDWDIDVAMSNSFGFGGHNSTILFSRYVP
HCCCCCEEECCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCEEEEEECCC
>Mature Secondary Structure 
SKKRVVVTGFGVVSCLGNEVDTFYDNLLAGVSGVRPITSFPCEDYATRFAGWIPEFNPE
CCCCEEEECCHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCCC
PYVDKKQARRVDPFITYAMVAAKKAIAMSRWDKDHLPSDPVRCGVIVGSGMGGLSTLDQG
CCCCHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCHHHHHHH
MERLLVIHKKLSPFFIPYIITNMAPALIAMDFGLMGPNYSISTACATGNYCIDAAYQHLV
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHH
SGRADMIICGGTEAAVNRIGLEGFIANRALSERNDAPDQASRPWDRDRDGFVLGEGAGIL
CCCCCEEEECCCHHHHHHHCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCCCEE
VLETLESALRRDAPIFAEMLGSYVTCDAFHITAPRDDGEGITACVLGALNSAGIPKERVN
EHHHHHHHHHCCCCHHHHHHCCCEEECEEEEECCCCCCCCHHHHHHHHHCCCCCCHHHHC
YVNAHGTSTPLGDLSEVLAVKKAFGSHVRNLRMNSTKSLIGHCLGAAGGVEAVVAIQAIL
EEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHH
TGKLHPTINLDNPIAEIEDFDVVANKAQDWDIDVAMSNSFGFGGHNSTILFSRYVP
HCCCCCEEECCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231; 11152607 [H]