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The map label for this gene is mraY

Identifier: 15836433

GI number: 15836433

Start: 1031556

End: 1032605

Strand: Direct

Name: mraY

Synonym: CPj0900

Alternate gene names: 15836433

Gene position: 1031556-1032605 (Clockwise)

Preceding gene: 15836432

Following gene: 15836434

Centisome position: 84.1

GC content: 42.38

Gene sequence:

>1050_bases
ATGATCCCCTTAATTCCAATGTTTCTAAAACAGTCTCTATTTTTTTCTTTGGCTTTGACAGGGATGACCACCCTTGTGCT
TACAGTATCTCTGGGTGTTCCTGTAATGAAATGGCTGAAAAGAAAAAATTATCGTGATTACATCCACAAAGAATACTGTG
AGAAACTTGAAATGCTTCACAAAGATAAAGCCGAGGTTCCTACGGGAGGAGGAGTCTTACTTTTTATCTCGTTAATTGCT
TCTTTACTTGTTTGGTTGCCTTGGGGAAAATTTTCAACATGGTTCTTTATTATACTCCTGACATGTTATGCAGGTCTGGG
TTGGTATGATGATAGAATAAAAATTAAACGGAAACAGGGACATGGACTGAAGGCAAAGCATAAGTTCATGGTCCAAATTG
CCATTGCAGCTTTTACACTCATTGCTCTTCCTTACATTTACGGAAGTACCGAACCCTTATGGACTCTCAAGATCCCTTTT
ATGGAAGGGATGCTTTCTCTTCCCTTTTGGCTAGGAAAAGTCTTTTGCTTAGGACTCGCTCTTGTCGCTATTATAGGGAC
AAGCAATGCAGTAAATCTTACCGATGGTTTGGATGGACTTGCTGCAGGAACCATGTCCTTTGCTGCTCTGGGCTTTATTT
TCGTAGCTCTAAGAAGTTCTACAATTCCTATAGCTCAAGATGTGGCTTATGTTTTAGCTGCTCTTGTAGGGGCTTGTATC
GGATTCTTATGGTATAATGGTTTCCCGGCCCAGCTCTTCATGGGAGATACCGGGTCACTACTTCTAGGGGGCCTGCTAGG
GAGCTGCGCTGTTATGCTGCGCGCAGAATGCATCCTAGTCGTGATCGGAGGAGTTTTTGTTGCTGAAGCGGGATCTGTCA
TTCTACAAGTACTTAGTTGTAGATTAAGGAAAAAACGCCTTTTCTTATGCTCTCCATTGCATCACCATTATGAATATCAG
GGCCTCCCAGAGACTAAAATCGTCATGCGCTTTTGGATCTTTAGTTTTGTATGCGCAGGTCTAGGTATAGCGGCTGTCTT
ATGGAGATAG

Upstream 100 bases:

>100_bases
AAGCAAGTGGCACGCTATGGGGACGTGATTCTACTGAAAGGTTCTCGTGCCCTCGCTCTCGAATCCTTATTAGCTTGTTT
TTAATTTCTTAGGAGCAAGT

Downstream 100 bases:

>100_bases
ATATGTGTCAGCGCATTCTTATTTTAGGGACTGGAATCACAGGAAAGTCGGTAGCAAGGTTTTTATATCAGCAAGGACAC
TATCTCATAGGAGCAGACAA

Product: phospho-N-acetylmuramoyl-pentapeptide- transferase

Products: NA

Alternate protein names: UDP-MurNAc-pentapeptide phosphotransferase

Number of amino acids: Translated: 349; Mature: 349

Protein sequence:

>349_residues
MIPLIPMFLKQSLFFSLALTGMTTLVLTVSLGVPVMKWLKRKNYRDYIHKEYCEKLEMLHKDKAEVPTGGGVLLFISLIA
SLLVWLPWGKFSTWFFIILLTCYAGLGWYDDRIKIKRKQGHGLKAKHKFMVQIAIAAFTLIALPYIYGSTEPLWTLKIPF
MEGMLSLPFWLGKVFCLGLALVAIIGTSNAVNLTDGLDGLAAGTMSFAALGFIFVALRSSTIPIAQDVAYVLAALVGACI
GFLWYNGFPAQLFMGDTGSLLLGGLLGSCAVMLRAECILVVIGGVFVAEAGSVILQVLSCRLRKKRLFLCSPLHHHYEYQ
GLPETKIVMRFWIFSFVCAGLGIAAVLWR

Sequences:

>Translated_349_residues
MIPLIPMFLKQSLFFSLALTGMTTLVLTVSLGVPVMKWLKRKNYRDYIHKEYCEKLEMLHKDKAEVPTGGGVLLFISLIA
SLLVWLPWGKFSTWFFIILLTCYAGLGWYDDRIKIKRKQGHGLKAKHKFMVQIAIAAFTLIALPYIYGSTEPLWTLKIPF
MEGMLSLPFWLGKVFCLGLALVAIIGTSNAVNLTDGLDGLAAGTMSFAALGFIFVALRSSTIPIAQDVAYVLAALVGACI
GFLWYNGFPAQLFMGDTGSLLLGGLLGSCAVMLRAECILVVIGGVFVAEAGSVILQVLSCRLRKKRLFLCSPLHHHYEYQ
GLPETKIVMRFWIFSFVCAGLGIAAVLWR
>Mature_349_residues
MIPLIPMFLKQSLFFSLALTGMTTLVLTVSLGVPVMKWLKRKNYRDYIHKEYCEKLEMLHKDKAEVPTGGGVLLFISLIA
SLLVWLPWGKFSTWFFIILLTCYAGLGWYDDRIKIKRKQGHGLKAKHKFMVQIAIAAFTLIALPYIYGSTEPLWTLKIPF
MEGMLSLPFWLGKVFCLGLALVAIIGTSNAVNLTDGLDGLAAGTMSFAALGFIFVALRSSTIPIAQDVAYVLAALVGACI
GFLWYNGFPAQLFMGDTGSLLLGGLLGSCAVMLRAECILVVIGGVFVAEAGSVILQVLSCRLRKKRLFLCSPLHHHYEYQ
GLPETKIVMRFWIFSFVCAGLGIAAVLWR

Specific function: First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan

COG id: COG0472

COG function: function code M; UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyltransferase 4 family. MraY subfamily

Homologues:

Organism=Escherichia coli, GI1786275, Length=345, Percent_Identity=38.2608695652174, Blast_Score=206, Evalue=1e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MRAY_CHLPN (Q9Z706)

Other databases:

- EMBL:   AE001363
- EMBL:   AE002161
- EMBL:   BA000008
- EMBL:   AE009440
- PIR:   A81519
- PIR:   B86603
- PIR:   G72021
- RefSeq:   NP_225095.1
- RefSeq:   NP_300957.1
- RefSeq:   NP_445503.1
- RefSeq:   NP_877204.1
- GeneID:   1467611
- GeneID:   895314
- GeneID:   919665
- GeneID:   963432
- GenomeReviews:   AE001363_GR
- GenomeReviews:   AE002161_GR
- GenomeReviews:   AE009440_GR
- GenomeReviews:   BA000008_GR
- KEGG:   cpa:CP0966
- KEGG:   cpn:CPn0900
- KEGG:   cpt:CpB0932
- TIGR:   CP_0966
- HOGENOM:   HBG708263
- OMA:   CEKLEML
- PhylomeDB:   Q9Z706
- ProtClustDB:   PRK00108
- BioCyc:   CPNE115711:CP_0966-MONOMER
- BioCyc:   CPNE115713:CPN0900-MONOMER
- BioCyc:   CPNE138677:CPJ0900-MONOMER
- BioCyc:   CPNE182082:CPB0932-MONOMER
- BRENDA:   2.7.8.13
- HAMAP:   MF_00038
- InterPro:   IPR000715
- InterPro:   IPR003524
- InterPro:   IPR018480
- PANTHER:   PTHR22926
- PANTHER:   PTHR22926:SF3
- TIGRFAMs:   TIGR00445

Pfam domain/function: PF00953 Glycos_transf_4

EC number: =2.7.8.13

Molecular weight: Translated: 38590; Mature: 38590

Theoretical pI: Translated: 9.59; Mature: 9.59

Prosite motif: PS01347 MRAY_1; PS01348 MRAY_2

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xc919d14)-; HASH(0xdd797d0)-; HASH(0xdcd81ec)-; HASH(0xd532f78)-; HASH(0xd9b4408)-; HASH(0xdcd7e50)-; HASH(0xdd640b0)-; HASH(0xdd4fec4)-; HASH(0xdd63e94)-; HASH(0xdd7ba0c)-;

Cys/Met content:

2.6 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIPLIPMFLKQSLFFSLALTGMTTLVLTVSLGVPVMKWLKRKNYRDYIHKEYCEKLEMLH
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHH
KDKAEVPTGGGVLLFISLIASLLVWLPWGKFSTWFFIILLTCYAGLGWYDDRIKIKRKQG
CCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCEECCCEEEEECCC
HGLKAKHKFMVQIAIAAFTLIALPYIYGSTEPLWTLKIPFMEGMLSLPFWLGKVFCLGLA
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHH
LVAIIGTSNAVNLTDGLDGLAAGTMSFAALGFIFVALRSSTIPIAQDVAYVLAALVGACI
HHHHHCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
GFLWYNGFPAQLFMGDTGSLLLGGLLGSCAVMLRAECILVVIGGVFVAEAGSVILQVLSC
HHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLRKKRLFLCSPLHHHYEYQGLPETKIVMRFWIFSFVCAGLGIAAVLWR
HHHHHHHHHCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCH
>Mature Secondary Structure
MIPLIPMFLKQSLFFSLALTGMTTLVLTVSLGVPVMKWLKRKNYRDYIHKEYCEKLEMLH
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHH
KDKAEVPTGGGVLLFISLIASLLVWLPWGKFSTWFFIILLTCYAGLGWYDDRIKIKRKQG
CCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCEECCCEEEEECCC
HGLKAKHKFMVQIAIAAFTLIALPYIYGSTEPLWTLKIPFMEGMLSLPFWLGKVFCLGLA
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHH
LVAIIGTSNAVNLTDGLDGLAAGTMSFAALGFIFVALRSSTIPIAQDVAYVLAALVGACI
HHHHHCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
GFLWYNGFPAQLFMGDTGSLLLGGLLGSCAVMLRAECILVVIGGVFVAEAGSVILQVLSC
HHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLRKKRLFLCSPLHHHYEYQGLPETKIVMRFWIFSFVCAGLGIAAVLWR
HHHHHHHHHCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362