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The map label for this gene is pepP

Identifier: 15836346

GI number: 15836346

Start: 920192

End: 921259

Strand: Direct

Name: pepP

Synonym: CPj0813

Alternate gene names: 15836346

Gene position: 920192-921259 (Clockwise)

Preceding gene: 15836345

Following gene: 15836347

Centisome position: 75.02

GC content: 44.19

Gene sequence:

>1068_bases
ATGTCACACGATCGTATTTTACGTGCTCAAAGAGCCCTCTCAGAACATAATCTTGATGCTATTCTTGTGGAAAAAAGCGA
AGATCTTGCTTATTTCCTGCATGATGAAGCGATTGCAGGGATCTTATTGATAGGGCAGCAAGAAGTGATGTTCTTTGTCT
ACAGAATGGATAAGGACCTCTATTCTCATATCCAACGTGTGCCTTTGACTTTTCTCACTCAGGATGTTGTTGCAGACTTA
TCGCTCTACGTACAAAAACAGAGGTATCAGAAAATAGGATTTGATAGTGCCTCAACAGTGTATCACAAGTTTGCACAGAG
GCAAGTACTTCCCTGTCTTTGGGAGCCTTTAGAGTGCTTCACAGAGAAAATTCGTAGTATAAAATCTGAAGAAGAAATTA
GACGCATGCAAGAAGCTGCAGCTTTGGGATCCGCAGGATATGATTACGTATTGACGTTACTTCGAGAGGGAATCACAGAG
AAAGAGGTCGTGAGACAGCTGCGAGCTTTCTGGGCTGAGGCAGGAGCCGAAGGACCTTCTTTTCCTCCCATTATTGCTTT
TGGAGAGCATTCAGCGTTTCCACACTCGATCCCTACAGACCGTCCTTTAAAGAAAGGAGATATTGTTCTTATTGATATTG
GAGTTCTTCTGAACGGGTATTGTTCTGATATGACCCGGATGACGGCATTAGGAACTCCGCATCCTAAGCTTTTGGAAAGC
TATCCTGTGGTTGTGGAAGCTCAAAAGCGCGCCATGGCTCTTTGCAAAGAAGGAGTGCTTTGGGGAGACATTGATGCAGA
AGCTGTGCGTGTACTGCGAGAGCATCACCTGGATACTTATTTTATCCATGGAATAGGACACGGGGTGGGGAGACATATTC
ATGAGTACCCTTGTTCTCCGCGGGGAAGTCAGGTGAAACTGGAATCTGGCATGACCATTACTGTGGAGCCAGGGGTCTAT
TTTCCTGGGATTGGTGGGATTCGCATCGAGGACACCCTATGTATAGATAAAAATAAAAATTTTAGTTTGACTGCACGTCC
TGTAATCTCAGAGTTAGTTTGTTTATAA

Upstream 100 bases:

>100_bases
CTCAAATTGCTTTGGAGTGTAGGGAAACCTGAAAAAGGATTTGACGGTGCACGAATTCGTCGGTTAATTTTAGACTCTGA
TTTTATGGAAGGATAATCAT

Downstream 100 bases:

>100_bases
ATTAAATTGGATTTAGTTTTTAAATTTAAATTGAATTTAATTTGTTTTTATAAATTGATTTTTTTTGTTTTTTAAGTTAT
CTTATAACTTTATTTTTAAC

Product: aminopeptidase P

Products: NA

Alternate protein names: X-Pro dipeptidase; Imidodipeptidase; Proline dipeptidase; Prolidase [H]

Number of amino acids: Translated: 355; Mature: 354

Protein sequence:

>355_residues
MSHDRILRAQRALSEHNLDAILVEKSEDLAYFLHDEAIAGILLIGQQEVMFFVYRMDKDLYSHIQRVPLTFLTQDVVADL
SLYVQKQRYQKIGFDSASTVYHKFAQRQVLPCLWEPLECFTEKIRSIKSEEEIRRMQEAAALGSAGYDYVLTLLREGITE
KEVVRQLRAFWAEAGAEGPSFPPIIAFGEHSAFPHSIPTDRPLKKGDIVLIDIGVLLNGYCSDMTRMTALGTPHPKLLES
YPVVVEAQKRAMALCKEGVLWGDIDAEAVRVLREHHLDTYFIHGIGHGVGRHIHEYPCSPRGSQVKLESGMTITVEPGVY
FPGIGGIRIEDTLCIDKNKNFSLTARPVISELVCL

Sequences:

>Translated_355_residues
MSHDRILRAQRALSEHNLDAILVEKSEDLAYFLHDEAIAGILLIGQQEVMFFVYRMDKDLYSHIQRVPLTFLTQDVVADL
SLYVQKQRYQKIGFDSASTVYHKFAQRQVLPCLWEPLECFTEKIRSIKSEEEIRRMQEAAALGSAGYDYVLTLLREGITE
KEVVRQLRAFWAEAGAEGPSFPPIIAFGEHSAFPHSIPTDRPLKKGDIVLIDIGVLLNGYCSDMTRMTALGTPHPKLLES
YPVVVEAQKRAMALCKEGVLWGDIDAEAVRVLREHHLDTYFIHGIGHGVGRHIHEYPCSPRGSQVKLESGMTITVEPGVY
FPGIGGIRIEDTLCIDKNKNFSLTARPVISELVCL
>Mature_354_residues
SHDRILRAQRALSEHNLDAILVEKSEDLAYFLHDEAIAGILLIGQQEVMFFVYRMDKDLYSHIQRVPLTFLTQDVVADLS
LYVQKQRYQKIGFDSASTVYHKFAQRQVLPCLWEPLECFTEKIRSIKSEEEIRRMQEAAALGSAGYDYVLTLLREGITEK
EVVRQLRAFWAEAGAEGPSFPPIIAFGEHSAFPHSIPTDRPLKKGDIVLIDIGVLLNGYCSDMTRMTALGTPHPKLLESY
PVVVEAQKRAMALCKEGVLWGDIDAEAVRVLREHHLDTYFIHGIGHGVGRHIHEYPCSPRGSQVKLESGMTITVEPGVYF
PGIGGIRIEDTLCIDKNKNFSLTARPVISELVCL

Specific function: Splits dipeptides with a prolyl in the C-terminal position and a nonpolar amino acid at the N-terminal position [H]

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family. Archaeal-type prolidase subfamily [H]

Homologues:

Organism=Homo sapiens, GI11559925, Length=253, Percent_Identity=28.4584980237154, Blast_Score=95, Evalue=8e-20,
Organism=Homo sapiens, GI264681563, Length=249, Percent_Identity=29.718875502008, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI93141226, Length=188, Percent_Identity=30.3191489361702, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI149589008, Length=296, Percent_Identity=24.3243243243243, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI260593665, Length=296, Percent_Identity=24.3243243243243, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI40385867, Length=206, Percent_Identity=26.6990291262136, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI260593663, Length=239, Percent_Identity=25.5230125523013, Blast_Score=66, Evalue=5e-11,
Organism=Escherichia coli, GI1788728, Length=344, Percent_Identity=29.0697674418605, Blast_Score=156, Evalue=2e-39,
Organism=Escherichia coli, GI1789275, Length=264, Percent_Identity=27.2727272727273, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI1786364, Length=242, Percent_Identity=28.9256198347107, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1790282, Length=429, Percent_Identity=22.6107226107226, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17508215, Length=289, Percent_Identity=25.2595155709343, Blast_Score=75, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6320922, Length=258, Percent_Identity=24.8062015503876, Blast_Score=84, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6321118, Length=283, Percent_Identity=23.321554770318, Blast_Score=72, Evalue=9e-14,
Organism=Drosophila melanogaster, GI21357079, Length=292, Percent_Identity=27.0547945205479, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000587
- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR001131 [H]

Pfam domain/function: PF01321 Creatinase_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.13.9 [H]

Molecular weight: Translated: 39993; Mature: 39861

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHDRILRAQRALSEHNLDAILVEKSEDLAYFLHDEAIAGILLIGQQEVMFFVYRMDKDL
CCHHHHHHHHHHHHHCCCCEEEEECCCCCEEEEEHHHHEEEEEECCHHHHHHHHHHHHHH
YSHIQRVPLTFLTQDVVADLSLYVQKQRYQKIGFDSASTVYHKFAQRQVLPCLWEPLECF
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
TEKIRSIKSEEEIRRMQEAAALGSAGYDYVLTLLREGITEKEVVRQLRAFWAEAGAEGPS
HHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCC
FPPIIAFGEHSAFPHSIPTDRPLKKGDIVLIDIGVLLNGYCSDMTRMTALGTPHPKLLES
CCCEEEECCCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCCHHHHHC
YPVVVEAQKRAMALCKEGVLWGDIDAEAVRVLREHHLDTYFIHGIGHGVGRHIHEYPCSP
CCCEEEHHHHHHHHHHCCCEECCCCHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHCCCCC
RGSQVKLESGMTITVEPGVYFPGIGGIRIEDTLCIDKNKNFSLTARPVISELVCL
CCCEEEECCCCEEEECCCEECCCCCCEEEECEEEEECCCCCEEEHHHHHHHHHCC
>Mature Secondary Structure 
SHDRILRAQRALSEHNLDAILVEKSEDLAYFLHDEAIAGILLIGQQEVMFFVYRMDKDL
CHHHHHHHHHHHHHCCCCEEEEECCCCCEEEEEHHHHEEEEEECCHHHHHHHHHHHHHH
YSHIQRVPLTFLTQDVVADLSLYVQKQRYQKIGFDSASTVYHKFAQRQVLPCLWEPLECF
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
TEKIRSIKSEEEIRRMQEAAALGSAGYDYVLTLLREGITEKEVVRQLRAFWAEAGAEGPS
HHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCC
FPPIIAFGEHSAFPHSIPTDRPLKKGDIVLIDIGVLLNGYCSDMTRMTALGTPHPKLLES
CCCEEEECCCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCCHHHHHC
YPVVVEAQKRAMALCKEGVLWGDIDAEAVRVLREHHLDTYFIHGIGHGVGRHIHEYPCSP
CCCEEEHHHHHHHHHHCCCEECCCCHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHCCCCC
RGSQVKLESGMTITVEPGVYFPGIGGIRIEDTLCIDKNKNFSLTARPVISELVCL
CCCEEEECCCCEEEECCCEECCCCCCEEEECEEEEECCCCCEEEHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9733678; 11223522; 11210522 [H]