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The map label for this gene is mutL

Identifier: 15836345

GI number: 15836345

Start: 918445

End: 920187

Strand: Direct

Name: mutL

Synonym: CPj0812

Alternate gene names: 15836345

Gene position: 918445-920187 (Clockwise)

Preceding gene: 15836340

Following gene: 15836346

Centisome position: 74.88

GC content: 42.91

Gene sequence:

>1743_bases
ATGTCTACAAGAAGGCCTATTCAGTTACTTGACCCCCTGACCATCAATCAAATTGCTGCTGGTGAGGTCATTGAAAACTC
CGTTTCTGTTGTTAAAGAACTGATTGAGAATTCCTTAGATGCTGGCGCCGATGAAATAGAAATCGAAACTTTAGGAGGGG
GACAAGGCGCAATCATTATCAGAGATAATGGTTGTGGCTTCAGAGCCGAAGACATCCCCATTGCCCTCCAACGTCACGCC
ACTTCAAAAATAAGAGAATTCTCTGATATTTTTTCTTTAAATAGCTTTGGCTTTCGAGGCGAGGCTCTACCCTCCATTGC
CTCGATTTCTAAAATGGAAATACAATCTTCCATTGAGGGGGACGAGGGTGTACGTACCGTAATTCATGGGGGAGACATCG
TTTCTTGTGAGCCCTGTGCTCGGCAACTAGGAACCACAGTGATTGTGAACTCCCTGTTTTATAATGTTCCTGTGCGTCGT
GGATTCCAAAAGAGCATGCAATCGGATCGCTTAGGGATTCGCAAGCTGATAGAAAATCGGATTTTATCCACAGCAAACAT
AGGGTGGTCCTGGATTAGCGAGGGACATCATGAAATTCAGATTGCTAAGCAGCAAGGATTTCAAGAAAGAGTCGCCTATG
TGATGGGAGACCACTTCATGCAGGATGCCCTCACCATAGATAAAGAGGCAAATGGTGTCCGTATTGTAGGGGTGTTAGGG
TCTCCCAGCTTCCACCGTCCCACACGTCAAGGACAGAAAATCTTTATTAACGATCGCCCTATAGAGTCTTTATTTATTTC
TAAGAAGGTTGGGGACGCCTATGCCTTGCTTCTGCCTCTACACAGGTATCCTGTTTTTGTGCTGAAGCTCTATCTTCCTT
CGTCATGGTGTGATTTTAATGTCCACCCACAAAAAATAGAGGCTCGAATTCTTAAGGAAGAACTTGTTGGAGATTGTATC
AAAGAAGCTATCGTAGAGACTCTAGCATGTCCTCCTGGCATCTTATGTCGTACGCATCAAGAAATAGAAGAATCTGATTC
GGTGCCCTTACCCATGTTTCGTATGTTGGAAACAAGCGATGTGCAAGAAGAAGAGAGTGTAGAGTTTGATCAAAATCTTT
TTGCATATAGTTCAGAAGATGTTTCCTTAGAGAAACAAGAATATACATCTAGAGGACCTAAGTCCCAAATGGATTGGATA
TATTCTAGCGACGTTCGTTTTTTAACTTCTTTAGGTCGTGTGGTCCTGGCTGAGGATCTTGAGGGTGTGCACATTATTTT
TACAGCTGCAGCGCGAAAGCACCTGTTTTTTCTGTCTTTGATGCAAGAGAATTCTCGCATGTATCAATCACAAGCATTAC
TGATTCCTCTACGCCTTCAGGTGACTCCTGAGGAGGCTTTTTTCTTCTCTCATCACGGAAGAACGTTATGCGACTTAGGA
ATAGAAATATCACAGGTAGGACCTTGTGTTTTCTCTATTGAAAGTACCCCCACTGTCATTGGTGAAGAAGAGCTAAAAGA
ATGGTTATTGCTATTGGCAGCAAGGGGCTCTACTGATATAAACTCAGAGGCTTTAACAGCATTGATGAAAGAAACTTTGA
CGCAGGCAACGTTTTCTAAACATCAGCATGTTTTTGATGTTTCCTGGCTCAAATTGCTTTGGAGTGTAGGGAAACCTGAA
AAAGGATTTGACGGTGCACGAATTCGTCGGTTAATTTTAGACTCTGATTTTATGGAAGGATAA

Upstream 100 bases:

>100_bases
CGTTCATTTTTAAGGAAAAATGGAAATTAGACGGAAGCTTTCTTGACATTAGCTTTAGGGTATTTTAATTTGCTGGCTCG
GAAATTTAACGAAGGCACCT

Downstream 100 bases:

>100_bases
TCATATGTCACACGATCGTATTTTACGTGCTCAAAGAGCCCTCTCAGAACATAATCTTGATGCTATTCTTGTGGAAAAAA
GCGAAGATCTTGCTTATTTC

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 580; Mature: 579

Protein sequence:

>580_residues
MSTRRPIQLLDPLTINQIAAGEVIENSVSVVKELIENSLDAGADEIEIETLGGGQGAIIIRDNGCGFRAEDIPIALQRHA
TSKIREFSDIFSLNSFGFRGEALPSIASISKMEIQSSIEGDEGVRTVIHGGDIVSCEPCARQLGTTVIVNSLFYNVPVRR
GFQKSMQSDRLGIRKLIENRILSTANIGWSWISEGHHEIQIAKQQGFQERVAYVMGDHFMQDALTIDKEANGVRIVGVLG
SPSFHRPTRQGQKIFINDRPIESLFISKKVGDAYALLLPLHRYPVFVLKLYLPSSWCDFNVHPQKIEARILKEELVGDCI
KEAIVETLACPPGILCRTHQEIEESDSVPLPMFRMLETSDVQEEESVEFDQNLFAYSSEDVSLEKQEYTSRGPKSQMDWI
YSSDVRFLTSLGRVVLAEDLEGVHIIFTAAARKHLFFLSLMQENSRMYQSQALLIPLRLQVTPEEAFFFSHHGRTLCDLG
IEISQVGPCVFSIESTPTVIGEEELKEWLLLLAARGSTDINSEALTALMKETLTQATFSKHQHVFDVSWLKLLWSVGKPE
KGFDGARIRRLILDSDFMEG

Sequences:

>Translated_580_residues
MSTRRPIQLLDPLTINQIAAGEVIENSVSVVKELIENSLDAGADEIEIETLGGGQGAIIIRDNGCGFRAEDIPIALQRHA
TSKIREFSDIFSLNSFGFRGEALPSIASISKMEIQSSIEGDEGVRTVIHGGDIVSCEPCARQLGTTVIVNSLFYNVPVRR
GFQKSMQSDRLGIRKLIENRILSTANIGWSWISEGHHEIQIAKQQGFQERVAYVMGDHFMQDALTIDKEANGVRIVGVLG
SPSFHRPTRQGQKIFINDRPIESLFISKKVGDAYALLLPLHRYPVFVLKLYLPSSWCDFNVHPQKIEARILKEELVGDCI
KEAIVETLACPPGILCRTHQEIEESDSVPLPMFRMLETSDVQEEESVEFDQNLFAYSSEDVSLEKQEYTSRGPKSQMDWI
YSSDVRFLTSLGRVVLAEDLEGVHIIFTAAARKHLFFLSLMQENSRMYQSQALLIPLRLQVTPEEAFFFSHHGRTLCDLG
IEISQVGPCVFSIESTPTVIGEEELKEWLLLLAARGSTDINSEALTALMKETLTQATFSKHQHVFDVSWLKLLWSVGKPE
KGFDGARIRRLILDSDFMEG
>Mature_579_residues
STRRPIQLLDPLTINQIAAGEVIENSVSVVKELIENSLDAGADEIEIETLGGGQGAIIIRDNGCGFRAEDIPIALQRHAT
SKIREFSDIFSLNSFGFRGEALPSIASISKMEIQSSIEGDEGVRTVIHGGDIVSCEPCARQLGTTVIVNSLFYNVPVRRG
FQKSMQSDRLGIRKLIENRILSTANIGWSWISEGHHEIQIAKQQGFQERVAYVMGDHFMQDALTIDKEANGVRIVGVLGS
PSFHRPTRQGQKIFINDRPIESLFISKKVGDAYALLLPLHRYPVFVLKLYLPSSWCDFNVHPQKIEARILKEELVGDCIK
EAIVETLACPPGILCRTHQEIEESDSVPLPMFRMLETSDVQEEESVEFDQNLFAYSSEDVSLEKQEYTSRGPKSQMDWIY
SSDVRFLTSLGRVVLAEDLEGVHIIFTAAARKHLFFLSLMQENSRMYQSQALLIPLRLQVTPEEAFFFSHHGRTLCDLGI
EISQVGPCVFSIESTPTVIGEEELKEWLLLLAARGSTDINSEALTALMKETLTQATFSKHQHVFDVSWLKLLWSVGKPEK
GFDGARIRRLILDSDFMEG

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family

Homologues:

Organism=Homo sapiens, GI4557757, Length=328, Percent_Identity=30.4878048780488, Blast_Score=155, Evalue=1e-37,
Organism=Homo sapiens, GI4505913, Length=349, Percent_Identity=28.9398280802292, Blast_Score=137, Evalue=4e-32,
Organism=Homo sapiens, GI310128478, Length=349, Percent_Identity=29.2263610315186, Blast_Score=136, Evalue=4e-32,
Organism=Homo sapiens, GI4505911, Length=335, Percent_Identity=30.7462686567164, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI189458898, Length=335, Percent_Identity=30.7462686567164, Blast_Score=131, Evalue=2e-30,
Organism=Homo sapiens, GI189458896, Length=316, Percent_Identity=31.9620253164557, Blast_Score=127, Evalue=4e-29,
Organism=Homo sapiens, GI310128480, Length=300, Percent_Identity=27.6666666666667, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI91992160, Length=259, Percent_Identity=28.5714285714286, Blast_Score=70, Evalue=8e-12,
Organism=Homo sapiens, GI263191589, Length=234, Percent_Identity=24.3589743589744, Blast_Score=70, Evalue=8e-12,
Organism=Homo sapiens, GI91992162, Length=259, Percent_Identity=28.5714285714286, Blast_Score=69, Evalue=8e-12,
Organism=Escherichia coli, GI1790612, Length=552, Percent_Identity=29.8913043478261, Blast_Score=196, Evalue=3e-51,
Organism=Caenorhabditis elegans, GI17562796, Length=350, Percent_Identity=27.4285714285714, Blast_Score=122, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI71991825, Length=321, Percent_Identity=25.8566978193146, Blast_Score=117, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6323819, Length=322, Percent_Identity=29.1925465838509, Blast_Score=150, Evalue=6e-37,
Organism=Saccharomyces cerevisiae, GI6324247, Length=380, Percent_Identity=26.5789473684211, Blast_Score=125, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6325093, Length=332, Percent_Identity=24.3975903614458, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI17136968, Length=323, Percent_Identity=30.030959752322, Blast_Score=163, Evalue=3e-40,
Organism=Drosophila melanogaster, GI17136970, Length=376, Percent_Identity=28.1914893617021, Blast_Score=120, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MUTL_CHLPN (Q9Z794)

Other databases:

- EMBL:   AE001363
- EMBL:   AE002161
- EMBL:   BA000008
- EMBL:   AE009440
- PIR:   A72032
- PIR:   B86592
- RefSeq:   NP_225007.1
- RefSeq:   NP_300869.1
- RefSeq:   NP_445596.1
- RefSeq:   NP_877113.1
- ProteinModelPortal:   Q9Z794
- GeneID:   1467520
- GeneID:   894840
- GeneID:   919584
- GeneID:   963542
- GenomeReviews:   AE001363_GR
- GenomeReviews:   AE002161_GR
- GenomeReviews:   AE009440_GR
- GenomeReviews:   BA000008_GR
- KEGG:   cpa:CP1059
- KEGG:   cpn:CPn0812
- KEGG:   cpt:CpB0841
- TIGR:   CP_1059
- HOGENOM:   HBG414122
- OMA:   RRGFQKS
- ProtClustDB:   PRK00095
- BioCyc:   CPNE115711:CP_1059-MONOMER
- BioCyc:   CPNE115713:CPN0812-MONOMER
- BioCyc:   CPNE138677:CPJ0812-MONOMER
- BioCyc:   CPNE182082:CPB0841-MONOMER
- HAMAP:   MF_00149
- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.565.10
- Gene3D:   G3DSA:3.30.230.10
- PANTHER:   PTHR10073
- SMART:   SM00387
- SMART:   SM00853
- TIGRFAMs:   TIGR00585

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C; SSF55874 ATP_bd_ATPase; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: NA

Molecular weight: Translated: 65002; Mature: 64871

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTRRPIQLLDPLTINQIAAGEVIENSVSVVKELIENSLDAGADEIEIETLGGGQGAIII
CCCCCCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEE
RDNGCGFRAEDIPIALQRHATSKIREFSDIFSLNSFGFRGEALPSIASISKMEIQSSIEG
EECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCC
DEGVRTVIHGGDIVSCEPCARQLGTTVIVNSLFYNVPVRRGFQKSMQSDRLGIRKLIENR
CCCCEEEEECCCEEECCHHHHHHCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
ILSTANIGWSWISEGHHEIQIAKQQGFQERVAYVMGDHFMQDALTIDKEANGVRIVGVLG
HHHHCCCCHHHHCCCCCEEEEHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEC
SPSFHRPTRQGQKIFINDRPIESLFISKKVGDAYALLLPLHRYPVFVLKLYLPSSWCDFN
CCCCCCCCCCCCEEEEECCCHHHHHHHHHCCCCEEEEHHHHHCCEEEEEEECCCCCCCCC
VHPQKIEARILKEELVGDCIKEAIVETLACPPGILCRTHQEIEESDSVPLPMFRMLETSD
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCHHHHHHCCCCCCHHHHHHHHCC
VQEEESVEFDQNLFAYSSEDVSLEKQEYTSRGPKSQMDWIYSSDVRFLTSLGRVVLAEDL
CCCHHCCCHHCHHEEECCCCCCCCHHHHHCCCCCCHHCEECCCCHHHHHHHCHHEEECCC
EGVHIIFTAAARKHLFFLSLMQENSRMYQSQALLIPLRLQVTPEEAFFFSHHGRTLCDLG
CCEEEEEEHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEEEECCCHHEEEECCCCEEECCC
IEISQVGPCVFSIESTPTVIGEEELKEWLLLLAARGSTDINSEALTALMKETLTQATFSK
CCHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHH
HQHVFDVSWLKLLWSVGKPEKGFDGARIRRLILDSDFMEG
CCEEEHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
STRRPIQLLDPLTINQIAAGEVIENSVSVVKELIENSLDAGADEIEIETLGGGQGAIII
CCCCCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEE
RDNGCGFRAEDIPIALQRHATSKIREFSDIFSLNSFGFRGEALPSIASISKMEIQSSIEG
EECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCC
DEGVRTVIHGGDIVSCEPCARQLGTTVIVNSLFYNVPVRRGFQKSMQSDRLGIRKLIENR
CCCCEEEEECCCEEECCHHHHHHCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
ILSTANIGWSWISEGHHEIQIAKQQGFQERVAYVMGDHFMQDALTIDKEANGVRIVGVLG
HHHHCCCCHHHHCCCCCEEEEHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEC
SPSFHRPTRQGQKIFINDRPIESLFISKKVGDAYALLLPLHRYPVFVLKLYLPSSWCDFN
CCCCCCCCCCCCEEEEECCCHHHHHHHHHCCCCEEEEHHHHHCCEEEEEEECCCCCCCCC
VHPQKIEARILKEELVGDCIKEAIVETLACPPGILCRTHQEIEESDSVPLPMFRMLETSD
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCHHHHHHCCCCCCHHHHHHHHCC
VQEEESVEFDQNLFAYSSEDVSLEKQEYTSRGPKSQMDWIYSSDVRFLTSLGRVVLAEDL
CCCHHCCCHHCHHEEECCCCCCCCHHHHHCCCCCCHHCEECCCCHHHHHHHCHHEEECCC
EGVHIIFTAAARKHLFFLSLMQENSRMYQSQALLIPLRLQVTPEEAFFFSHHGRTLCDLG
CCEEEEEEHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEEEECCCHHEEEECCCCEEECCC
IEISQVGPCVFSIESTPTVIGEEELKEWLLLLAARGSTDINSEALTALMKETLTQATFSK
CCHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHH
HQHVFDVSWLKLLWSVGKPEKGFDGARIRRLILDSDFMEG
CCEEEHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362