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The map label for this gene is ung

Identifier: 15836306

GI number: 15836306

Start: 871809

End: 872519

Strand: Direct

Name: ung

Synonym: CPj0773

Alternate gene names: 15836306

Gene position: 871809-872519 (Clockwise)

Preceding gene: 15836303

Following gene: 15836307

Centisome position: 71.08

GC content: 41.91

Gene sequence:

>711_bases
ATGCAGAATGCTACTATAGATCAGCTCCCTGTGTCTTGGCAAGAACAGCTTCCTTTATGTTGGCGTGAGCAACTTAAGGA
AGAGTGGTCCAAACCCTACATGCAGCAACTTCTTATTTTTTTAAAACAGGAGTATAAAGAGCATACTGTTTACCCTGAGG
AGAATTGCGTATTTTCTGCTTTGAGAAGCACGCCCTTTGATCAGGTGCGTGTTGTTATCTTGGGTCAAGATCCTTATCCA
GGAAAGGGGCAAGCTCATGGATTGAGCTTTAGTGTTCCCGAAGGTCAGCGTTTGCCCCCTTCTTTAATTAATATTTTCCG
AGAGTTAAAAACAGATTTGGGGATTGAAAATCATAAGGGGTGTTTGCAGTCTTGGGCAAACCAAGGGATCTTATTATTGA
ACACAGTATTGACGGTGCGTGCGGGAGAACCCTTCTCTCATGCTGGTAAAGGTTGGGAGCTGTTTACAGATGCCATTGTG
ACGAAACTGATTCAAGAGAGAACCCATATCATCTTTGTTTTATGGGGAGCTGCTGCAAGAAAAAAATGCGAGCTTTTATT
TAATTCAAAACATCAACATGCGGTTCTATCCTCTCCTCACCCCTCTCCGTTAGCTGCTCACCGTGGTTTTTTTGGTTGTT
CACACTTTTCAAAAATTAACTATCTCCTTAATAAGCTGAATAAACCAATGATTAATTGGAAGCTCCCATGA

Upstream 100 bases:

>100_bases
TAAGTCCTAATTTTTAGCTTTACACCTCGAGACTGACAATCTCTGTCGAGCTAAAATAAAAAGCGAGTATACTTTCATCA
CAATTATAGAAAGGTGATTT

Downstream 100 bases:

>100_bases
ATGAAGGTATCCACTCTGTCTGTTTTCAAAAAACACCTCGGCTTACTGCGAAGTCCGTAGTGAGTATGGAGATGCTCTTA
ACTACTCAACAGCTTCCTTC

Product: uracil-DNA glycosylase

Products: NA

Alternate protein names: UDG

Number of amino acids: Translated: 236; Mature: 236

Protein sequence:

>236_residues
MQNATIDQLPVSWQEQLPLCWREQLKEEWSKPYMQQLLIFLKQEYKEHTVYPEENCVFSALRSTPFDQVRVVILGQDPYP
GKGQAHGLSFSVPEGQRLPPSLINIFRELKTDLGIENHKGCLQSWANQGILLLNTVLTVRAGEPFSHAGKGWELFTDAIV
TKLIQERTHIIFVLWGAAARKKCELLFNSKHQHAVLSSPHPSPLAAHRGFFGCSHFSKINYLLNKLNKPMINWKLP

Sequences:

>Translated_236_residues
MQNATIDQLPVSWQEQLPLCWREQLKEEWSKPYMQQLLIFLKQEYKEHTVYPEENCVFSALRSTPFDQVRVVILGQDPYP
GKGQAHGLSFSVPEGQRLPPSLINIFRELKTDLGIENHKGCLQSWANQGILLLNTVLTVRAGEPFSHAGKGWELFTDAIV
TKLIQERTHIIFVLWGAAARKKCELLFNSKHQHAVLSSPHPSPLAAHRGFFGCSHFSKINYLLNKLNKPMINWKLP
>Mature_236_residues
MQNATIDQLPVSWQEQLPLCWREQLKEEWSKPYMQQLLIFLKQEYKEHTVYPEENCVFSALRSTPFDQVRVVILGQDPYP
GKGQAHGLSFSVPEGQRLPPSLINIFRELKTDLGIENHKGCLQSWANQGILLLNTVLTVRAGEPFSHAGKGWELFTDAIV
TKLIQERTHIIFVLWGAAARKKCELLFNSKHQHAVLSSPHPSPLAAHRGFFGCSHFSKINYLLNKLNKPMINWKLP

Specific function: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine

COG id: COG0692

COG function: function code L; Uracil DNA glycosylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uracil-DNA glycosylase family

Homologues:

Organism=Homo sapiens, GI19718751, Length=228, Percent_Identity=47.8070175438597, Blast_Score=201, Evalue=4e-52,
Organism=Homo sapiens, GI6224979, Length=228, Percent_Identity=47.8070175438597, Blast_Score=201, Evalue=6e-52,
Organism=Escherichia coli, GI1788934, Length=219, Percent_Identity=49.7716894977169, Blast_Score=207, Evalue=5e-55,
Organism=Caenorhabditis elegans, GI17556304, Length=221, Percent_Identity=44.3438914027149, Blast_Score=170, Evalue=6e-43,
Organism=Saccharomyces cerevisiae, GI6323620, Length=237, Percent_Identity=44.7257383966245, Blast_Score=187, Evalue=1e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UNG_CHLPN (Q9Z7D3)

Other databases:

- EMBL:   AE001363
- EMBL:   AE002161
- EMBL:   BA000008
- EMBL:   AE009440
- PIR:   C86587
- PIR:   H72035
- RefSeq:   NP_224968.1
- RefSeq:   NP_300830.1
- RefSeq:   NP_445636.1
- RefSeq:   NP_877073.1
- ProteinModelPortal:   Q9Z7D3
- SMR:   Q9Z7D3
- GeneID:   1467480
- GeneID:   895046
- GeneID:   919542
- GeneID:   963587
- GenomeReviews:   AE001363_GR
- GenomeReviews:   AE002161_GR
- GenomeReviews:   AE009440_GR
- GenomeReviews:   BA000008_GR
- KEGG:   cpa:CP1099
- KEGG:   cpn:CPn0773
- KEGG:   cpt:CpB0801
- TIGR:   CP_1099
- HOGENOM:   HBG605450
- OMA:   GAHAQKK
- PhylomeDB:   Q9Z7D3
- ProtClustDB:   PRK05254
- BioCyc:   CPNE115711:CP_1099-MONOMER
- BioCyc:   CPNE115713:CPN0773-MONOMER
- BioCyc:   CPNE138677:CPJ0773-MONOMER
- BioCyc:   CPNE182082:CPB0801-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00148
- InterPro:   IPR002043
- InterPro:   IPR018085
- InterPro:   IPR005122
- Gene3D:   G3DSA:3.40.470.10
- PANTHER:   PTHR11264
- TIGRFAMs:   TIGR00628

Pfam domain/function: PF03167 UDG; SSF52141 UDNA_glycsylseSF

EC number: =3.2.2.27

Molecular weight: Translated: 27007; Mature: 27007

Theoretical pI: Translated: 8.97; Mature: 8.97

Prosite motif: PS00130 U_DNA_GLYCOSYLASE

Important sites: ACT_SITE 77-77

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQNATIDQLPVSWQEQLPLCWREQLKEEWSKPYMQQLLIFLKQEYKEHTVYPEENCVFSA
CCCCCCCCCCCCHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
LRSTPFDQVRVVILGQDPYPGKGQAHGLSFSVPEGQRLPPSLINIFRELKTDLGIENHKG
HHCCCCCCEEEEEECCCCCCCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHCCCCCCHH
CLQSWANQGILLLNTVLTVRAGEPFSHAGKGWELFTDAIVTKLIQERTHIIFVLWGAAAR
HHHHHHCCCEEEEHHHHHHCCCCCHHHCCCCHHHHHHHHHHHHHHCCCCEEEEEECCHHH
KKCELLFNSKHQHAVLSSPHPSPLAAHRGFFGCSHFSKINYLLNKLNKPMINWKLP
HHHHHHHCCCCCCEECCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHCCCCEECCCC
>Mature Secondary Structure
MQNATIDQLPVSWQEQLPLCWREQLKEEWSKPYMQQLLIFLKQEYKEHTVYPEENCVFSA
CCCCCCCCCCCCHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
LRSTPFDQVRVVILGQDPYPGKGQAHGLSFSVPEGQRLPPSLINIFRELKTDLGIENHKG
HHCCCCCCEEEEEECCCCCCCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHCCCCCCHH
CLQSWANQGILLLNTVLTVRAGEPFSHAGKGWELFTDAIVTKLIQERTHIIFVLWGAAAR
HHHHHHCCCEEEEHHHHHHCCCCCHHHCCCCHHHHHHHHHHHHHHCCCCEEEEEECCHHH
KKCELLFNSKHQHAVLSSPHPSPLAAHRGFFGCSHFSKINYLLNKLNKPMINWKLP
HHHHHHHCCCCCCEECCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHCCCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362