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The map label for this gene is trxA

Identifier: 15836191

GI number: 15836191

Start: 738854

End: 739162

Strand: Direct

Name: trxA

Synonym: CPj0659

Alternate gene names: 15836191

Gene position: 738854-739162 (Clockwise)

Preceding gene: 15836188

Following gene: 15836197

Centisome position: 60.24

GC content: 41.42

Gene sequence:

>309_bases
ATGGTAAAGATCATATCAAGTGAAAATTTTGACTCTTTTATTGCATCGGGGCTCGTTCTCGTTGATTTCTTTGCAGAATG
GTGTGGCCCCTGTCGGATGCTCACTCCTATCTTAGAAAATCTTGCTGCGGAACTTCCTCATGTCACTATTGGAAAAATCA
ATATAGATGAGAACAGCAAGCCTGCAGAAACGTACGAAGTCAGCTCTATTCCTACGCTTATTCTTTTTAAGGATGGGAAC
GAGGTGGCTCGGGTCGTAGGTCTTAAGGATAAAGAATTCCTAACCAATCTTATCAATAAGCACGCTTAA

Upstream 100 bases:

>100_bases
GATTCAGGTTCTAGTGAGCTTATGCTCATGGAAGTTCAAGTCTTCTTAGCTGCAAGAAAATAACAGGGACAGTAATTCGA
TTTTTCGAGAAGGGAAACTT

Downstream 100 bases:

>100_bases
AAAGACGCTGCAATATTAAACCGTAGGATTCTTTTGCAATGCTACGGTTTTCTGCCTTACCACTTCATATAAAACGATCC
CTACACTGGTAGCTAAATTT

Product: thioredoxin

Products: NA

Alternate protein names: Trx

Number of amino acids: Translated: 102; Mature: 102

Protein sequence:

>102_residues
MVKIISSENFDSFIASGLVLVDFFAEWCGPCRMLTPILENLAAELPHVTIGKINIDENSKPAETYEVSSIPTLILFKDGN
EVARVVGLKDKEFLTNLINKHA

Sequences:

>Translated_102_residues
MVKIISSENFDSFIASGLVLVDFFAEWCGPCRMLTPILENLAAELPHVTIGKINIDENSKPAETYEVSSIPTLILFKDGN
EVARVVGLKDKEFLTNLINKHA
>Mature_102_residues
MVKIISSENFDSFIASGLVLVDFFAEWCGPCRMLTPILENLAAELPHVTIGKINIDENSKPAETYEVSSIPTLILFKDGN
EVARVVGLKDKEFLTNLINKHA

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain

Homologues:

Organism=Homo sapiens, GI21361403, Length=83, Percent_Identity=42.1686746987952, Blast_Score=77, Evalue=4e-15,
Organism=Homo sapiens, GI224493972, Length=97, Percent_Identity=36.0824742268041, Blast_Score=69, Evalue=9e-13,
Organism=Homo sapiens, GI42794771, Length=97, Percent_Identity=36.0824742268041, Blast_Score=69, Evalue=9e-13,
Organism=Homo sapiens, GI21361657, Length=103, Percent_Identity=34.9514563106796, Blast_Score=67, Evalue=2e-12,
Organism=Homo sapiens, GI50592994, Length=104, Percent_Identity=36.5384615384615, Blast_Score=65, Evalue=9e-12,
Organism=Escherichia coli, GI87082331, Length=100, Percent_Identity=42, Blast_Score=87, Evalue=2e-19,
Organism=Escherichia coli, GI1788936, Length=97, Percent_Identity=32.9896907216495, Blast_Score=61, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17507705, Length=87, Percent_Identity=37.9310344827586, Blast_Score=76, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI71998175, Length=98, Percent_Identity=35.7142857142857, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI212646193, Length=81, Percent_Identity=40.7407407407407, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17509965, Length=76, Percent_Identity=40.7894736842105, Blast_Score=63, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6321648, Length=89, Percent_Identity=48.314606741573, Blast_Score=95, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6323072, Length=83, Percent_Identity=48.1927710843374, Blast_Score=92, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6319925, Length=69, Percent_Identity=39.1304347826087, Blast_Score=70, Evalue=7e-14,
Organism=Drosophila melanogaster, GI21358065, Length=93, Percent_Identity=40.8602150537634, Blast_Score=74, Evalue=1e-14,
Organism=Drosophila melanogaster, GI28573567, Length=83, Percent_Identity=40.9638554216867, Blast_Score=74, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24639826, Length=86, Percent_Identity=40.6976744186046, Blast_Score=74, Evalue=2e-14,
Organism=Drosophila melanogaster, GI18859803, Length=101, Percent_Identity=38.6138613861386, Blast_Score=72, Evalue=9e-14,
Organism=Drosophila melanogaster, GI24664269, Length=99, Percent_Identity=40.4040404040404, Blast_Score=69, Evalue=5e-13,
Organism=Drosophila melanogaster, GI17648013, Length=81, Percent_Identity=40.7407407407407, Blast_Score=68, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24583090, Length=81, Percent_Identity=40.7407407407407, Blast_Score=68, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24658597, Length=90, Percent_Identity=34.4444444444444, Blast_Score=66, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24639068, Length=97, Percent_Identity=32.9896907216495, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): THIO_CHLPN (Q9Z7P5)

Other databases:

- EMBL:   AE001363
- EMBL:   AE002161
- EMBL:   BA000008
- EMBL:   AE009440
- PIR:   D72052
- PIR:   H86572
- RefSeq:   NP_224855.1
- RefSeq:   NP_300715.1
- RefSeq:   NP_444640.1
- RefSeq:   NP_876957.1
- ProteinModelPortal:   Q9Z7P5
- SMR:   Q9Z7P5
- PHCI-2DPAGE:   Q9Z7P5
- GeneID:   1467364
- GeneID:   895251
- GeneID:   919421
- GeneID:   963778
- GenomeReviews:   AE001363_GR
- GenomeReviews:   AE002161_GR
- GenomeReviews:   AE009440_GR
- GenomeReviews:   BA000008_GR
- KEGG:   cpa:CP0088
- KEGG:   cpn:CPn0659
- KEGG:   cpt:CpB0685
- TIGR:   CP_0088
- HOGENOM:   HBG493509
- OMA:   YEVSSIP
- PhylomeDB:   Q9Z7P5
- ProtClustDB:   CLSK871432
- BioCyc:   CPNE115711:CP_0088-MONOMER
- BioCyc:   CPNE115713:CPN0659-MONOMER
- BioCyc:   CPNE138677:CPJ0659-MONOMER
- BioCyc:   CPNE182082:CPB0685-MONOMER
- GO:   GO:0006810
- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335
- Gene3D:   G3DSA:3.40.30.10
- PANTHER:   PTHR10438
- PIRSF:   PIRSF000077
- PRINTS:   PR00421
- TIGRFAMs:   TIGR01068

Pfam domain/function: PF00085 Thioredoxin; SSF52833 Thiordxn-like_fd

EC number: NA

Molecular weight: Translated: 11292; Mature: 11292

Theoretical pI: Translated: 4.61; Mature: 4.61

Prosite motif: PS00194 THIOREDOXIN_1; PS51352 THIOREDOXIN_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKIISSENFDSFIASGLVLVDFFAEWCGPCRMLTPILENLAAELPHVTIGKINIDENSK
CEEECCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCEEEEEEEECCCCC
PAETYEVSSIPTLILFKDGNEVARVVGLKDKEFLTNLINKHA
CCCEEECCCCCEEEEEECCCCEEHHHCCCCHHHHHHHHHCCC
>Mature Secondary Structure
MVKIISSENFDSFIASGLVLVDFFAEWCGPCRMLTPILENLAAELPHVTIGKINIDENSK
CEEECCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCEEEEEEEECCCCC
PAETYEVSSIPTLILFKDGNEVARVVGLKDKEFLTNLINKHA
CCCEEECCCCCEEEEEECCCCEEHHHCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362