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The map label for this gene is hemH

Identifier: 15836135

GI number: 15836135

Start: 693526

End: 694509

Strand: Direct

Name: hemH

Synonym: CPj0603

Alternate gene names: 15836135

Gene position: 693526-694509 (Clockwise)

Preceding gene: 15836128

Following gene: 15836141

Centisome position: 56.54

GC content: 41.57

Gene sequence:

>984_bases
GTGACAACTCCAGCCTATCTACTAGCTAATTTTGGAGGACCTCGTCATGCTAAAGACCTTCAAGAATTTCTGATTTCTCT
ACTTACTGATAGAGATGTTACGGGCACTTTCCTTCCCAGAGTACTGCATAGGCATCTCTTTACTTTCATCGCTAAAAAAC
GTGTTCCGAAAGTTCTCCCTCAATATCAATCTTTGCAAAATTGGTCTCCTATTTATTTTGACACCGAAACTCTTGCAAAA
ACACTCTCTGAAATCTTACGAGCGCCTGTAATTCCATTTCACCGCTATCTACCCAGCACACATGAAAAGACGTTGCTTGC
TTTGCGTACTCTACATACGCGTCACGTGATAGGTATCCCTTTATTCCCTCACTTCACCTATTCTGTTACGGGAAGCATTG
TACGTTTCTTTATGAAGCACGTGCCAGAAATCCCCATTTCTTGGATTCCCCAATTTGGGAGTGATTCTAAATTTGTCTCT
CTCATTACCTGCCACATTCGGGATTTCCTTCAGAAGTTAGGAATCTTAGAAAAAGAGTGCTGCTTCTTATTTTCTGTACA
TGGACTTCCTGTACGCTATATCTCTCAAGGAGATCCCTATAGCAAGCAATGTTATGAATCATTTTCAGCAATTACGACAA
ACTTCAAGCAATCTGAGAATTTTCTTTGCTTCCAATCGAAGTTTGGTCCTGGAAAATGGCTCTCCCCGTCCACTGCGCAA
CTATGTCAAAACATAGATACGGATAAGCCTAATGTCATTGCTGTGCCTTTTGGCTTCATTTCTGATCACTTGGAAACTTT
ATATGAAATAGAAAGGGACTACCTGCCTCTGCTACGTTCTCGAGGATATCGGGCATTACGAATCCCAGCGATTTATAGCT
CCCCTCTTTGGGTATCGACTTTGGTAGATATCGTGAAAGAAAACTCTACAGTAGTTGCCGAGGAGTTAATAAAGAGCGGG
AAAAAACACACAGGGATTCGATAA

Upstream 100 bases:

>100_bases
TAAATCCTGAGTCCTACTTTGTTAATTCTAATGGAAAATTATGAGATTAATTGTTTTAATGCAATGTTTGGTCTCCCTAT
TTTTAGCAAAGAAAGTCACC

Downstream 100 bases:

>100_bases
GATTTTAGGGAAGACGATACCGCTGTTTTATAGCATCGTATTTTCCTGAGCGTCGTGTTTTCACAAGTCCTGCGTTAAAC
CCTTCAAGCAAATCTCCGTT

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase [H]

Number of amino acids: Translated: 327; Mature: 326

Protein sequence:

>327_residues
MTTPAYLLANFGGPRHAKDLQEFLISLLTDRDVTGTFLPRVLHRHLFTFIAKKRVPKVLPQYQSLQNWSPIYFDTETLAK
TLSEILRAPVIPFHRYLPSTHEKTLLALRTLHTRHVIGIPLFPHFTYSVTGSIVRFFMKHVPEIPISWIPQFGSDSKFVS
LITCHIRDFLQKLGILEKECCFLFSVHGLPVRYISQGDPYSKQCYESFSAITTNFKQSENFLCFQSKFGPGKWLSPSTAQ
LCQNIDTDKPNVIAVPFGFISDHLETLYEIERDYLPLLRSRGYRALRIPAIYSSPLWVSTLVDIVKENSTVVAEELIKSG
KKHTGIR

Sequences:

>Translated_327_residues
MTTPAYLLANFGGPRHAKDLQEFLISLLTDRDVTGTFLPRVLHRHLFTFIAKKRVPKVLPQYQSLQNWSPIYFDTETLAK
TLSEILRAPVIPFHRYLPSTHEKTLLALRTLHTRHVIGIPLFPHFTYSVTGSIVRFFMKHVPEIPISWIPQFGSDSKFVS
LITCHIRDFLQKLGILEKECCFLFSVHGLPVRYISQGDPYSKQCYESFSAITTNFKQSENFLCFQSKFGPGKWLSPSTAQ
LCQNIDTDKPNVIAVPFGFISDHLETLYEIERDYLPLLRSRGYRALRIPAIYSSPLWVSTLVDIVKENSTVVAEELIKSG
KKHTGIR
>Mature_326_residues
TTPAYLLANFGGPRHAKDLQEFLISLLTDRDVTGTFLPRVLHRHLFTFIAKKRVPKVLPQYQSLQNWSPIYFDTETLAKT
LSEILRAPVIPFHRYLPSTHEKTLLALRTLHTRHVIGIPLFPHFTYSVTGSIVRFFMKHVPEIPISWIPQFGSDSKFVSL
ITCHIRDFLQKLGILEKECCFLFSVHGLPVRYISQGDPYSKQCYESFSAITTNFKQSENFLCFQSKFGPGKWLSPSTAQL
CQNIDTDKPNVIAVPFGFISDHLETLYEIERDYLPLLRSRGYRALRIPAIYSSPLWVSTLVDIVKENSTVVAEELIKSGK
KHTGIR

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX [H]

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family [H]

Homologues:

Organism=Homo sapiens, GI60499025, Length=331, Percent_Identity=28.3987915407855, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI60499021, Length=331, Percent_Identity=28.3987915407855, Blast_Score=105, Evalue=4e-23,
Organism=Escherichia coli, GI1786681, Length=318, Percent_Identity=26.1006289308176, Blast_Score=92, Evalue=5e-20,
Organism=Saccharomyces cerevisiae, GI6324750, Length=318, Percent_Identity=26.1006289308176, Blast_Score=111, Evalue=2e-25,
Organism=Drosophila melanogaster, GI17864156, Length=323, Percent_Identity=27.2445820433437, Blast_Score=121, Evalue=8e-28,
Organism=Drosophila melanogaster, GI24651774, Length=250, Percent_Identity=27.6, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI45552018, Length=170, Percent_Identity=28.2352941176471, Blast_Score=75, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001015
- InterPro:   IPR019772 [H]

Pfam domain/function: PF00762 Ferrochelatase [H]

EC number: =4.99.1.1 [H]

Molecular weight: Translated: 37475; Mature: 37344

Theoretical pI: Translated: 9.54; Mature: 9.54

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTPAYLLANFGGPRHAKDLQEFLISLLTDRDVTGTFLPRVLHRHLFTFIAKKRVPKVLP
CCCHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
QYQSLQNWSPIYFDTETLAKTLSEILRAPVIPFHRYLPSTHEKTLLALRTLHTRHVIGIP
HHHHHCCCCCCEECHHHHHHHHHHHHHCCCCHHHHHCCCCHHHHHHHHHHHHHHHEEECC
LFPHFTYSVTGSIVRFFMKHVPEIPISWIPQFGSDSKFVSLITCHIRDFLQKLGILEKEC
CCCCHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHH
CFLFSVHGLPVRYISQGDPYSKQCYESFSAITTNFKQSENFLCFQSKFGPGKWLSPSTAQ
HHHHEECCCCEEEECCCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCHHH
LCQNIDTDKPNVIAVPFGFISDHLETLYEIERDYLPLLRSRGYRALRIPAIYSSPLWVST
HHHCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCHHCCCCHHHHH
LVDIVKENSTVVAEELIKSGKKHTGIR
HHHHHHCCCHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
TTPAYLLANFGGPRHAKDLQEFLISLLTDRDVTGTFLPRVLHRHLFTFIAKKRVPKVLP
CCHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
QYQSLQNWSPIYFDTETLAKTLSEILRAPVIPFHRYLPSTHEKTLLALRTLHTRHVIGIP
HHHHHCCCCCCEECHHHHHHHHHHHHHCCCCHHHHHCCCCHHHHHHHHHHHHHHHEEECC
LFPHFTYSVTGSIVRFFMKHVPEIPISWIPQFGSDSKFVSLITCHIRDFLQKLGILEKEC
CCCCHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHH
CFLFSVHGLPVRYISQGDPYSKQCYESFSAITTNFKQSENFLCFQSKFGPGKWLSPSTAQ
HHHHEECCCCEEEECCCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCHHH
LCQNIDTDKPNVIAVPFGFISDHLETLYEIERDYLPLLRSRGYRALRIPAIYSSPLWVST
HHHCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCHHCCCCHHHHH
LVDIVKENSTVVAEELIKSGKKHTGIR
HHHHHHCCCHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362 [H]