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The map label for this gene is yaeS

Identifier: 15836097

GI number: 15836097

Start: 655462

End: 656214

Strand: Direct

Name: yaeS

Synonym: CPj0566

Alternate gene names: 15836097

Gene position: 655462-656214 (Clockwise)

Preceding gene: 15836090

Following gene: 15836098

Centisome position: 53.44

GC content: 39.71

Gene sequence:

>753_bases
TTGTCTTTAGCTACCAACAATGCTGAATCCAAGTTCCCCTCTCTACAGCGCCTTCCCAACCATGTTGCTATCATTATGGA
CGGCAATCGCCGATGGTACAAAAAGCATAGGGAGGAGTGCGGCCACACACACACGTCAGGTCATTATTATGGCGCTAAAG
TCCTTCCAAATATTTTAAATGCGGTTCTTGATTTAGGAATTAAAGTTCTTACTCTCTATACGTTTTCAACAGAAAATTTT
GGGAGACCAAAAGAGGAAATTCAAGAAATATTTAATATTTTCTATACTCAGTTAGACAAGCAACTTCCTTATCTAATGGA
AAATGAAATCTGCTTACGTTGTATAGGAGACCTTTCCAAGCTCCCTAAAGGCATCCAAACGAAAATCAACCATGTGAGTC
GCATGACGGCATCGTTCTCGCGTTTAGAGCTCGTATTAGCTGTCAACTACGGTGGCAAAGATGAGTTAGTCCGTGCATTT
AAAAAATTACATGTTGATATTCTAAATAAAAAAATATCTTCTGACGACCTTTCAGAATCTTTGATTAGCTCATACTTAGA
TACTTCAGGACTTACGGACCCCGACTTACTTATCCGTACAGGGGGTGAAATGCGTGTCAGTAATTTCTTATTGTGGCAAA
TAGCATATACAGAACTATATATCACGGATACCTTGTGGCCAGATTTTACGCCTCAAGATTTGTTTGAAGCGATTAACGTA
TACCAGCAAAGATCAAGACGAGGGGGGAAATAG

Upstream 100 bases:

>100_bases
CTTAGGTAAGTGAACGAATTCTCCTTTCTTAAAAATAGGTTCGAAACGTTGTTCCTGAGAACGAATTGTGACTTACGCCC
TAATAAATGATCCTGTAGAC

Downstream 100 bases:

>100_bases
GTGCTTAATTCAAATAAGTTTAAATCGAAGACCGGTGCATACGGTGATTTATTTCAGCGTGTTGTTGTTCATTCGTTAGT
ACTTACATTTTTGGTTCTTC

Product: undecaprenyl pyrophosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS

Number of amino acids: Translated: 250; Mature: 249

Protein sequence:

>250_residues
MSLATNNAESKFPSLQRLPNHVAIIMDGNRRWYKKHREECGHTHTSGHYYGAKVLPNILNAVLDLGIKVLTLYTFSTENF
GRPKEEIQEIFNIFYTQLDKQLPYLMENEICLRCIGDLSKLPKGIQTKINHVSRMTASFSRLELVLAVNYGGKDELVRAF
KKLHVDILNKKISSDDLSESLISSYLDTSGLTDPDLLIRTGGEMRVSNFLLWQIAYTELYITDTLWPDFTPQDLFEAINV
YQQRSRRGGK

Sequences:

>Translated_250_residues
MSLATNNAESKFPSLQRLPNHVAIIMDGNRRWYKKHREECGHTHTSGHYYGAKVLPNILNAVLDLGIKVLTLYTFSTENF
GRPKEEIQEIFNIFYTQLDKQLPYLMENEICLRCIGDLSKLPKGIQTKINHVSRMTASFSRLELVLAVNYGGKDELVRAF
KKLHVDILNKKISSDDLSESLISSYLDTSGLTDPDLLIRTGGEMRVSNFLLWQIAYTELYITDTLWPDFTPQDLFEAINV
YQQRSRRGGK
>Mature_249_residues
SLATNNAESKFPSLQRLPNHVAIIMDGNRRWYKKHREECGHTHTSGHYYGAKVLPNILNAVLDLGIKVLTLYTFSTENFG
RPKEEIQEIFNIFYTQLDKQLPYLMENEICLRCIGDLSKLPKGIQTKINHVSRMTASFSRLELVLAVNYGGKDELVRAFK
KLHVDILNKKISSDDLSESLISSYLDTSGLTDPDLLIRTGGEMRVSNFLLWQIAYTELYITDTLWPDFTPQDLFEAINVY
QQRSRRGGK

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family

Homologues:

Organism=Homo sapiens, GI45580742, Length=239, Percent_Identity=35.1464435146443, Blast_Score=150, Evalue=9e-37,
Organism=Homo sapiens, GI45580738, Length=228, Percent_Identity=35.5263157894737, Blast_Score=149, Evalue=2e-36,
Organism=Escherichia coli, GI1786371, Length=241, Percent_Identity=40.6639004149378, Blast_Score=191, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI71993029, Length=237, Percent_Identity=36.7088607594937, Blast_Score=147, Evalue=5e-36,
Organism=Saccharomyces cerevisiae, GI6319474, Length=219, Percent_Identity=32.4200913242009, Blast_Score=99, Evalue=5e-22,
Organism=Saccharomyces cerevisiae, GI6323748, Length=219, Percent_Identity=31.0502283105023, Blast_Score=98, Evalue=9e-22,
Organism=Drosophila melanogaster, GI18857969, Length=229, Percent_Identity=32.3144104803493, Blast_Score=134, Evalue=7e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UPPS_CHLPN (Q9Z7Y7)

Other databases:

- EMBL:   AE001363
- EMBL:   AE002161
- EMBL:   BA000008
- EMBL:   AE009440
- PIR:   B86561
- PIR:   G72062
- PIR:   H81604
- RefSeq:   NP_224762.1
- RefSeq:   NP_300621.1
- RefSeq:   NP_444734.1
- RefSeq:   NP_876860.1
- ProteinModelPortal:   Q9Z7Y7
- SMR:   Q9Z7Y7
- GeneID:   1467267
- GeneID:   895338
- GeneID:   919326
- GeneID:   962965
- GenomeReviews:   AE001363_GR
- GenomeReviews:   AE002161_GR
- GenomeReviews:   AE009440_GR
- GenomeReviews:   BA000008_GR
- KEGG:   cpa:CP0183
- KEGG:   cpn:CPn0566
- KEGG:   cpt:CpB0588
- TIGR:   CP_0183
- HOGENOM:   HBG627837
- OMA:   RVRWAGR
- ProtClustDB:   PRK14840
- BioCyc:   CPNE115711:CP_0183-MONOMER
- BioCyc:   CPNE115713:CPN0566-MONOMER
- BioCyc:   CPNE138677:CPJ0566-MONOMER
- BioCyc:   CPNE182082:CPB0588-MONOMER
- BRENDA:   2.5.1.31
- HAMAP:   MF_01139
- InterPro:   IPR001441
- InterPro:   IPR018520
- Gene3D:   G3DSA:3.40.1180.10
- PANTHER:   PTHR10291
- TIGRFAMs:   TIGR00055

Pfam domain/function: PF01255 Prenyltransf; SSF64005 UPP_synth

EC number: =2.5.1.31

Molecular weight: Translated: 28679; Mature: 28548

Theoretical pI: Translated: 8.07; Mature: 8.07

Prosite motif: PS01066 UPP_SYNTHASE

Important sites: ACT_SITE 27-27

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLATNNAESKFPSLQRLPNHVAIIMDGNRRWYKKHREECGHTHTSGHYYGAKVLPNILN
CCCCCCCCHHCCCHHHHCCCEEEEEEECCHHHHHHHHHHHCCCCCCCCEEHHHHHHHHHH
AVLDLGIKVLTLYTFSTENFGRPKEEIQEIFNIFYTQLDKQLPYLMENEICLRCIGDLSK
HHHHCCHHHHHEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHCCHHHHHHHHHHHH
LPKGIQTKINHVSRMTASFSRLELVLAVNYGGKDELVRAFKKLHVDILNKKISSDDLSES
CCHHHHHHHHHHHHHHHHHHHEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHH
LISSYLDTSGLTDPDLLIRTGGEMRVSNFLLWQIAYTELYITDTLWPDFTPQDLFEAINV
HHHHHHHCCCCCCCCCEEECCCCEEHHHHHHHEEHHHHEEEECCCCCCCCHHHHHHHHHH
YQQRSRRGGK
HHHHHHCCCC
>Mature Secondary Structure 
SLATNNAESKFPSLQRLPNHVAIIMDGNRRWYKKHREECGHTHTSGHYYGAKVLPNILN
CCCCCCCHHCCCHHHHCCCEEEEEEECCHHHHHHHHHHHCCCCCCCCEEHHHHHHHHHH
AVLDLGIKVLTLYTFSTENFGRPKEEIQEIFNIFYTQLDKQLPYLMENEICLRCIGDLSK
HHHHCCHHHHHEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHCCHHHHHHHHHHHH
LPKGIQTKINHVSRMTASFSRLELVLAVNYGGKDELVRAFKKLHVDILNKKISSDDLSES
CCHHHHHHHHHHHHHHHHHHHEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHH
LISSYLDTSGLTDPDLLIRTGGEMRVSNFLLWQIAYTELYITDTLWPDFTPQDLFEAINV
HHHHHHHCCCCCCCCCEEECCCCEEHHHHHHHEEHHHHEEEECCCCCCCCHHHHHHHHHH
YQQRSRRGGK
HHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362