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The map label for this gene is clpP_1

Identifier: 15836051

GI number: 15836051

Start: 600963

End: 601538

Strand: Reverse

Name: clpP_1

Synonym: CPj0520

Alternate gene names: 15836051

Gene position: 601538-600963 (Counterclockwise)

Preceding gene: 15836052

Following gene: 15836050

Centisome position: 49.04

GC content: 40.45

Gene sequence:

>576_bases
ATGGCAGACGGGGAAGTTCATAAATTACGTGATATTATAGAAAAAGAGTTATTGGAAGCGCGCAGAGTATTTTTCTCAGA
GCCTGTAACAGAGAAAAGTGCTTCCGATGCAATTAAAAAGCTTTGGTATTTGGAATTAAAAGATCCTGGAAAGCCTATAG
TTTTTGTGATCAATAGTCCTGGGGGATCTGTGGACGCAGGTTTTGCTGTTTGGGATCAAATTAAAATGTTAACCTCACCC
GTCACTACTGTTGTGACAGGGTTGGCAGCTTCTATGGGCTCGGTATTGAGTTTATGTGCAGCTCCTGGAAGGAGATTTGC
AACTCCTCATTCTAGAATTATGATTCATCAACCTTCAATAGGTGGACCGATTACCGGTCAGGCAACCGATTTAGACATTC
ATGCGAGAGAGATTTTAAAAACAAAAGCTCGCATTATAGATGTCTATGTAGAGGCGACAAATCAACCTCGAGATATCATA
GAAAAGGCTATCGATAGAGATATGTGGATGACAGCCAACGAAGCTAAGGATTTTGGTTTATTGGATGGCATTTTATTCTC
CTTCAACGATCTCTAA

Upstream 100 bases:

>100_bases
CAGGAAGCTAGAGATCGTGTTCGCAACTTGTTGCTGCGTTTCCCGCTCTACCCTGAAATTGATTTAGAAGCTTTAGTTTA
GTTAGGAGAGACATTATTTT

Downstream 100 bases:

>100_bases
ATATTTTATCTATTCTGGAGCAGGAAATCGTTTCCTTCTTGGTGAAACACTTCCTGAGGTTGAAGATGTTCGGTTCTTAT
GCCAAGAGACGAGGGTTGAT

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp 1

Number of amino acids: Translated: 191; Mature: 190

Protein sequence:

>191_residues
MADGEVHKLRDIIEKELLEARRVFFSEPVTEKSASDAIKKLWYLELKDPGKPIVFVINSPGGSVDAGFAVWDQIKMLTSP
VTTVVTGLAASMGSVLSLCAAPGRRFATPHSRIMIHQPSIGGPITGQATDLDIHAREILKTKARIIDVYVEATNQPRDII
EKAIDRDMWMTANEAKDFGLLDGILFSFNDL

Sequences:

>Translated_191_residues
MADGEVHKLRDIIEKELLEARRVFFSEPVTEKSASDAIKKLWYLELKDPGKPIVFVINSPGGSVDAGFAVWDQIKMLTSP
VTTVVTGLAASMGSVLSLCAAPGRRFATPHSRIMIHQPSIGGPITGQATDLDIHAREILKTKARIIDVYVEATNQPRDII
EKAIDRDMWMTANEAKDFGLLDGILFSFNDL
>Mature_190_residues
ADGEVHKLRDIIEKELLEARRVFFSEPVTEKSASDAIKKLWYLELKDPGKPIVFVINSPGGSVDAGFAVWDQIKMLTSPV
TTVVTGLAASMGSVLSLCAAPGRRFATPHSRIMIHQPSIGGPITGQATDLDIHAREILKTKARIIDVYVEATNQPRDIIE
KAIDRDMWMTANEAKDFGLLDGILFSFNDL

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family

Homologues:

Organism=Homo sapiens, GI5174419, Length=173, Percent_Identity=43.9306358381503, Blast_Score=147, Evalue=6e-36,
Organism=Escherichia coli, GI1786641, Length=177, Percent_Identity=41.8079096045198, Blast_Score=145, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI17538017, Length=182, Percent_Identity=45.0549450549451, Blast_Score=146, Evalue=8e-36,
Organism=Drosophila melanogaster, GI20129427, Length=182, Percent_Identity=39.010989010989, Blast_Score=136, Evalue=8e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPP1_CHLPN (Q9Z832)

Other databases:

- EMBL:   AE001363
- EMBL:   AE002161
- EMBL:   BA000008
- EMBL:   AE009440
- PIR:   D86555
- PIR:   G72067
- RefSeq:   NP_224716.1
- RefSeq:   NP_300575.1
- RefSeq:   NP_444784.1
- RefSeq:   NP_876813.1
- ProteinModelPortal:   Q9Z832
- SMR:   Q9Z832
- MEROPS:   S14.005
- PHCI-2DPAGE:   Q9Z832
- GeneID:   1467220
- GeneID:   895481
- GeneID:   919275
- GeneID:   962928
- GenomeReviews:   AE001363_GR
- GenomeReviews:   AE002161_GR
- GenomeReviews:   AE009440_GR
- GenomeReviews:   BA000008_GR
- KEGG:   cpa:CP0233
- KEGG:   cpn:CPn0520
- KEGG:   cpt:CpB0541
- TIGR:   CP_0233
- HOGENOM:   HBG558421
- OMA:   FSEPVTD
- ProtClustDB:   PRK12553
- BioCyc:   CPNE115711:CP_0233-MONOMER
- BioCyc:   CPNE115713:CPN0520-MONOMER
- BioCyc:   CPNE138677:CPJ0520-MONOMER
- BioCyc:   CPNE182082:CPB0541-MONOMER
- BRENDA:   3.4.21.92
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00444
- InterPro:   IPR001907
- InterPro:   IPR018215
- PANTHER:   PTHR10381
- PRINTS:   PR00127

Pfam domain/function: PF00574 CLP_protease

EC number: =3.4.21.92

Molecular weight: Translated: 21021; Mature: 20889

Theoretical pI: Translated: 5.68; Mature: 5.68

Prosite motif: PS00382 CLP_PROTEASE_HIS; PS00381 CLP_PROTEASE_SER

Important sites: ACT_SITE 91-91 ACT_SITE 116-116

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADGEVHKLRDIIEKELLEARRVFFSEPVTEKSASDAIKKLWYLELKDPGKPIVFVINSP
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHEEEECCCCCCEEEEEECC
GGSVDAGFAVWDQIKMLTSPVTTVVTGLAASMGSVLSLCAAPGRRFATPHSRIMIHQPSI
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCC
GGPITGQATDLDIHAREILKTKARIIDVYVEATNQPRDIIEKAIDRDMWMTANEAKDFGL
CCCCCCCCCCCHHHHHHHHHHHHHHEEEEEECCCCCHHHHHHHHCHHHCCCCCCCCCHHH
LDGILFSFNDL
HHHHHHHHCCC
>Mature Secondary Structure 
ADGEVHKLRDIIEKELLEARRVFFSEPVTEKSASDAIKKLWYLELKDPGKPIVFVINSP
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHEEEECCCCCCEEEEEECC
GGSVDAGFAVWDQIKMLTSPVTTVVTGLAASMGSVLSLCAAPGRRFATPHSRIMIHQPSI
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCC
GGPITGQATDLDIHAREILKTKARIIDVYVEATNQPRDIIEKAIDRDMWMTANEAKDFGL
CCCCCCCCCCCHHHHHHHHHHHHHHEEEEEECCCCCHHHHHHHHCHHHCCCCCCCCCHHH
LDGILFSFNDL
HHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362