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The map label for this gene is tlyC_1

Identifier: 15835927

GI number: 15835927

Start: 440445

End: 441680

Strand: Direct

Name: tlyC_1

Synonym: CPj0394

Alternate gene names: 15835927

Gene position: 440445-441680 (Clockwise)

Preceding gene: 15835926

Following gene: 15835928

Centisome position: 35.91

GC content: 39.97

Gene sequence:

>1236_bases
ATGATTCCTACCATGTTAATGTTCTTCATTATCTGTTTTACTTTATGCTCGGGATTCATTTCGTTATCTCAAATTGCTTT
GTTTTCTTTGCCTACGAGTTTGATCTCGCACTATAAGCGCTCTAAATCTAAGAAACAGCAGCGAGTAGCTACCCTTCTTC
TACATCCCCACCACCTGCTCATCACCTTAATTTTTTGTGATATCGGACTGAATATTGCTATTCAAAACTGCCTTGCCATT
CTATTTGGAGATGCAGCTTCGTGGTGGTTTACTGTAGGTCTTCCTTTAGCAATTACTTTGATCTTAGGTGAGATTCTCCC
TAAAGCAGTAGCTCTTCCTTTTAATACACAGATTGCTAGTTCCGTAGCCCCTCTTATTCTTTGTGTTACTAAAATCTTCA
AACCCCTACTCCACTGGGGTATCGTAGGAATTAATTATGTGGTCCAATGGATTTTATCGAAGCAACAGATTGATATCATC
CAACCCCAAGAGCTGAAGGAAGTATTGCAAAGTTGTAAGGATTTCGGCGTAGTCAATCAAGAAGAAAGCCGTTTACTCTA
TGGTTATCTTTCTCTTAGTGATTGTAGTGTTAAAGAGCGTATGCAGCCACGCCAGGATATTTTATTTTATGATATCCAAA
CCCCTTTAGAGAACCTCTATCTTTTATTTTCTAAACAGCATTGCTCACGAGTTCCTATATGTAACGATAACCTCCAAAAC
CTTCTGGGCATTTGCACAGCGCGCTCTCTTCTTTTACATGACAAGCCACTGCAATCTTCGGATGATCTCCTCCCCTTGCT
GAAAAAACCGTATTATATGCCAGAAACCATCTCTGCAAAAATGGCTTTATGTCAGATGGCAGCTGAAGACGAAACCCTAG
GGATGATCATTGATGAATACGGATCTATTGAAGGATTGATCACTCAAGAAGACCTCTTTGAAATTGTTGCTGGAGAAATT
GTAGACCAGAGAGATAATAAAATACTCTATACCACCTCAGGAGCTGATGTTATTATTGCCTCAGGAACTTTAGAACTCCG
TGAGTTTAGTGAGATCTTCGATATCAACCTACCGACGAACAATAATATTGCGACTATAGGAGGCTGGTTAATAGAGCAAA
TCGGAACGATTCCGACAACAGGAATGAAACTCTCTTGGAATAACTTGCTTTTCCAGGTATTAGACGCTGCTCCGAATCGC
ATTCGCCGTGTGTATATAAGGAAATTGTATGACTAA

Upstream 100 bases:

>100_bases
AGCTGCTTTAATCCAGCGTCTGGGTCTCATTCCTAAAGGCTATAAGAAACTCTGTGTCTCCCCAAAGCAACAATCAGAAA
ATAAGGACTGAAAAGAGACC

Downstream 100 bases:

>100_bases
TTCTGCTCTCTTTTGGATAGGAGTCAACATTATCTGTATTGTCTTACAAGGATTCTATTCGATGATGGAAATGGCCTGCG
TGTCATTTAACCGTGTACGA

Product: CBS domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 411; Mature: 411

Protein sequence:

>411_residues
MIPTMLMFFIICFTLCSGFISLSQIALFSLPTSLISHYKRSKSKKQQRVATLLLHPHHLLITLIFCDIGLNIAIQNCLAI
LFGDAASWWFTVGLPLAITLILGEILPKAVALPFNTQIASSVAPLILCVTKIFKPLLHWGIVGINYVVQWILSKQQIDII
QPQELKEVLQSCKDFGVVNQEESRLLYGYLSLSDCSVKERMQPRQDILFYDIQTPLENLYLLFSKQHCSRVPICNDNLQN
LLGICTARSLLLHDKPLQSSDDLLPLLKKPYYMPETISAKMALCQMAAEDETLGMIIDEYGSIEGLITQEDLFEIVAGEI
VDQRDNKILYTTSGADVIIASGTLELREFSEIFDINLPTNNNIATIGGWLIEQIGTIPTTGMKLSWNNLLFQVLDAAPNR
IRRVYIRKLYD

Sequences:

>Translated_411_residues
MIPTMLMFFIICFTLCSGFISLSQIALFSLPTSLISHYKRSKSKKQQRVATLLLHPHHLLITLIFCDIGLNIAIQNCLAI
LFGDAASWWFTVGLPLAITLILGEILPKAVALPFNTQIASSVAPLILCVTKIFKPLLHWGIVGINYVVQWILSKQQIDII
QPQELKEVLQSCKDFGVVNQEESRLLYGYLSLSDCSVKERMQPRQDILFYDIQTPLENLYLLFSKQHCSRVPICNDNLQN
LLGICTARSLLLHDKPLQSSDDLLPLLKKPYYMPETISAKMALCQMAAEDETLGMIIDEYGSIEGLITQEDLFEIVAGEI
VDQRDNKILYTTSGADVIIASGTLELREFSEIFDINLPTNNNIATIGGWLIEQIGTIPTTGMKLSWNNLLFQVLDAAPNR
IRRVYIRKLYD
>Mature_411_residues
MIPTMLMFFIICFTLCSGFISLSQIALFSLPTSLISHYKRSKSKKQQRVATLLLHPHHLLITLIFCDIGLNIAIQNCLAI
LFGDAASWWFTVGLPLAITLILGEILPKAVALPFNTQIASSVAPLILCVTKIFKPLLHWGIVGINYVVQWILSKQQIDII
QPQELKEVLQSCKDFGVVNQEESRLLYGYLSLSDCSVKERMQPRQDILFYDIQTPLENLYLLFSKQHCSRVPICNDNLQN
LLGICTARSLLLHDKPLQSSDDLLPLLKKPYYMPETISAKMALCQMAAEDETLGMIIDEYGSIEGLITQEDLFEIVAGEI
VDQRDNKILYTTSGADVIIASGTLELREFSEIFDINLPTNNNIATIGGWLIEQIGTIPTTGMKLSWNNLLFQVLDAAPNR
IRRVYIRKLYD

Specific function: Unknown

COG id: COG1253

COG function: function code R; Hemolysins and related proteins containing CBS domains

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI310128564, Length=282, Percent_Identity=26.9503546099291, Blast_Score=100, Evalue=3e-21,
Organism=Escherichia coli, GI145693175, Length=408, Percent_Identity=22.7941176470588, Blast_Score=115, Evalue=6e-27,
Organism=Escherichia coli, GI87082033, Length=266, Percent_Identity=27.0676691729323, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1790664, Length=436, Percent_Identity=22.2477064220184, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1786879, Length=257, Percent_Identity=24.5136186770428, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1788119, Length=237, Percent_Identity=27.0042194092827, Blast_Score=79, Evalue=7e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016169
- InterPro:   IPR000644
- InterPro:   IPR002550
- InterPro:   IPR005170 [H]

Pfam domain/function: PF00571 CBS; PF03471 CorC_HlyC; PF01595 DUF21 [H]

EC number: NA

Molecular weight: Translated: 46310; Mature: 46310

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIPTMLMFFIICFTLCSGFISLSQIALFSLPTSLISHYKRSKSKKQQRVATLLLHPHHLL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHH
ITLIFCDIGLNIAIQNCLAILFGDAASWWFTVGLPLAITLILGEILPKAVALPFNTQIAS
HHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
SVAPLILCVTKIFKPLLHWGIVGINYVVQWILSKQQIDIIQPQELKEVLQSCKDFGVVNQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCC
EESRLLYGYLSLSDCSVKERMQPRQDILFYDIQTPLENLYLLFSKQHCSRVPICNDNLQN
CCCEEEEEEEECCCCCHHHHCCCCCCEEEEEHHCCHHHHHHHHHHHCCCCCCCCCCCHHH
LLGICTARSLLLHDKPLQSSDDLLPLLKKPYYMPETISAKMALCQMAAEDETLGMIIDEY
HHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHC
GSIEGLITQEDLFEIVAGEIVDQRDNKILYTTSGADVIIASGTLELREFSEIFDINLPTN
CCCCCEECHHHHHHHHHHHHHCCCCCEEEEEECCCCEEEECCCHHHHHHHHHHEEECCCC
NNIATIGGWLIEQIGTIPTTGMKLSWNNLLFQVLDAAPNRIRRVYIRKLYD
CCEEHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIPTMLMFFIICFTLCSGFISLSQIALFSLPTSLISHYKRSKSKKQQRVATLLLHPHHLL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHH
ITLIFCDIGLNIAIQNCLAILFGDAASWWFTVGLPLAITLILGEILPKAVALPFNTQIAS
HHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
SVAPLILCVTKIFKPLLHWGIVGINYVVQWILSKQQIDIIQPQELKEVLQSCKDFGVVNQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCC
EESRLLYGYLSLSDCSVKERMQPRQDILFYDIQTPLENLYLLFSKQHCSRVPICNDNLQN
CCCEEEEEEEECCCCCHHHHCCCCCCEEEEEHHCCHHHHHHHHHHHCCCCCCCCCCCHHH
LLGICTARSLLLHDKPLQSSDDLLPLLKKPYYMPETISAKMALCQMAAEDETLGMIIDEY
HHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHC
GSIEGLITQEDLFEIVAGEIVDQRDNKILYTTSGADVIIASGTLELREFSEIFDINLPTN
CCCCCEECHHHHHHHHHHHHHCCCCCEEEEEECCCCEEEECCCHHHHHHHHHHEEECCCC
NNIATIGGWLIEQIGTIPTTGMKLSWNNLLFQVLDAAPNRIRRVYIRKLYD
CCEEHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]