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The map label for this gene is gnd

Identifier: 15835893

GI number: 15835893

Start: 403628

End: 405067

Strand: Reverse

Name: gnd

Synonym: CPj0360

Alternate gene names: 15835893

Gene position: 405067-403628 (Counterclockwise)

Preceding gene: 15835894

Following gene: 15835891

Centisome position: 33.02

GC content: 44.03

Gene sequence:

>1440_bases
TTGCAAACGAATATTGGTCTTATTGGCTTAGCTGTCATGGGGAAAAATCTTGTCTTAAACATGATAGATCATGGTTTTTC
TGTCTCTGTCTATAATCGGACCCCAGAGAAAACGCGGGACTTCTTGAAAGAATACCCTAACCACCGAGAGCTTGTAGGGT
TTGAATCTTTAGAAGATTTTGTGAATTCATTGGAGAGACCACGAAAGATCATGTTGATGATTCAAGCAGGGAAACCTGTG
GATCAGAGCATTCATGCGTTACTGCCTTTTCTAGAACCCGGCGATGTGATTATCGATGGGGGGAATAGCTATTTTAAAGA
TTCCGAACGACGATGTAAAGAGTTGCAAGAAAAGGGGATTCTCTTCTTAGGCGTGGGGATTTCTGGAGGAGAAGAAGGTG
CACGTCACGGCCCATCAATTATGCCTGGAGGAAATCCTGAGGCGTGGCCATTAGTGGCTCCTATTTTTCAATCAATAGCA
GCAAAAGTACAGGGCCGTCCCTGCTGTTCTTGGGTAGGAACTGGCGGTGCAGGCCACTATGTAAAGGCTGTTCACAATGG
TATAGAATACGGCGATATCCAGTTGATATGCGAAGCTTACGGTATCTTAAGAGATTTCCTAAAGCTCTCCGCAACTGCCG
TTGCTACAATTTTGAAAGAGTGGAATACTCTAGAGTTGGAAAGCTATCTAATTCGTATTGCTTCTGAAGTCCTAGCATTG
AAAGATCCGGAAGGAATCCCTGTTATTGATACGATTTTAGATGTCGTGGGCCAAAAAGGTACAGGAAAGTGGACCGCAAT
CGATGCTTTAAATTCTGGAGTTCCCCTTTCCTTAATCATAGGAGCTGTTCTTGCTCGTTTCCTTTCTTCTTGGAAAGAGA
TACGCGAGCAAGCTGCCCGTAATTATCCAGGAACCCCCTTAATATTTGAAATGCCCCATGATCCCTCGGTATTCATACAA
GATGTCTTTCATGCTTTATACGCTTCCAAGATCATCAGCTATGCTCAGGGATTCATGCTTTTAGGAGAAGCTTCAAAAGA
ATATAATTGGGGATTAGACCTAGGAGAAATTGCTTTGATGTGGCGCGGGGGATGCATTATTCAAAGTGCATTTTTAGATG
TTATACATAAAGGATTTGCTGCCAACCCAGAGAATACCTCGCTCATCTTCCAAGAATATTTCCGTGGAGCATTACGCCAT
GCGGAGATGGGATGGCGTAGAACAGTAGTGACTGCAATTGGTGCAGGGCTACCTATTCCCTGTTTAGCAGCAGCAATCAC
GTTTTATGATGGCTATCGTACAGCAAGCTCTTCAATGTCGTTAGCTCAAGGACTGCGAGATTATTTTGGAGCTCATACCT
ACGAGCGTAACGATCGCCCTCGAGGAGAGTTCTATCATACCGATTGGGTGCACACGAAAACTACAGAAAGAGTGAAGTAA

Upstream 100 bases:

>100_bases
AAGAACAAGACATCTGTTATGGTCACTATGTGTTGTTGGCTCAAGGTAAAAAACGAAAGCTTGTTCTATATTTAAATTAG
TTTAAGGAGGCTAGGTAGCT

Downstream 100 bases:

>100_bases
AAATAAAAAATCTCGAGAAGACCCTAGGTAGCTCGAGATTTAGTTCACCACTACCGAATTTTCAATTGTAAGCAGTGTGC
TGATTTTAAGCGTCAATGTT

Product: 6-phosphogluconate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 479; Mature: 479

Protein sequence:

>479_residues
MQTNIGLIGLAVMGKNLVLNMIDHGFSVSVYNRTPEKTRDFLKEYPNHRELVGFESLEDFVNSLERPRKIMLMIQAGKPV
DQSIHALLPFLEPGDVIIDGGNSYFKDSERRCKELQEKGILFLGVGISGGEEGARHGPSIMPGGNPEAWPLVAPIFQSIA
AKVQGRPCCSWVGTGGAGHYVKAVHNGIEYGDIQLICEAYGILRDFLKLSATAVATILKEWNTLELESYLIRIASEVLAL
KDPEGIPVIDTILDVVGQKGTGKWTAIDALNSGVPLSLIIGAVLARFLSSWKEIREQAARNYPGTPLIFEMPHDPSVFIQ
DVFHALYASKIISYAQGFMLLGEASKEYNWGLDLGEIALMWRGGCIIQSAFLDVIHKGFAANPENTSLIFQEYFRGALRH
AEMGWRRTVVTAIGAGLPIPCLAAAITFYDGYRTASSSMSLAQGLRDYFGAHTYERNDRPRGEFYHTDWVHTKTTERVK

Sequences:

>Translated_479_residues
MQTNIGLIGLAVMGKNLVLNMIDHGFSVSVYNRTPEKTRDFLKEYPNHRELVGFESLEDFVNSLERPRKIMLMIQAGKPV
DQSIHALLPFLEPGDVIIDGGNSYFKDSERRCKELQEKGILFLGVGISGGEEGARHGPSIMPGGNPEAWPLVAPIFQSIA
AKVQGRPCCSWVGTGGAGHYVKAVHNGIEYGDIQLICEAYGILRDFLKLSATAVATILKEWNTLELESYLIRIASEVLAL
KDPEGIPVIDTILDVVGQKGTGKWTAIDALNSGVPLSLIIGAVLARFLSSWKEIREQAARNYPGTPLIFEMPHDPSVFIQ
DVFHALYASKIISYAQGFMLLGEASKEYNWGLDLGEIALMWRGGCIIQSAFLDVIHKGFAANPENTSLIFQEYFRGALRH
AEMGWRRTVVTAIGAGLPIPCLAAAITFYDGYRTASSSMSLAQGLRDYFGAHTYERNDRPRGEFYHTDWVHTKTTERVK
>Mature_479_residues
MQTNIGLIGLAVMGKNLVLNMIDHGFSVSVYNRTPEKTRDFLKEYPNHRELVGFESLEDFVNSLERPRKIMLMIQAGKPV
DQSIHALLPFLEPGDVIIDGGNSYFKDSERRCKELQEKGILFLGVGISGGEEGARHGPSIMPGGNPEAWPLVAPIFQSIA
AKVQGRPCCSWVGTGGAGHYVKAVHNGIEYGDIQLICEAYGILRDFLKLSATAVATILKEWNTLELESYLIRIASEVLAL
KDPEGIPVIDTILDVVGQKGTGKWTAIDALNSGVPLSLIIGAVLARFLSSWKEIREQAARNYPGTPLIFEMPHDPSVFIQ
DVFHALYASKIISYAQGFMLLGEASKEYNWGLDLGEIALMWRGGCIIQSAFLDVIHKGFAANPENTSLIFQEYFRGALRH
AEMGWRRTVVTAIGAGLPIPCLAAAITFYDGYRTASSSMSLAQGLRDYFGAHTYERNDRPRGEFYHTDWVHTKTTERVK

Specific function: Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH

COG id: COG0362

COG function: function code G; 6-phosphogluconate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family

Homologues:

Organism=Homo sapiens, GI40068518, Length=470, Percent_Identity=54.0425531914894, Blast_Score=511, Evalue=1e-145,
Organism=Escherichia coli, GI1788341, Length=470, Percent_Identity=47.6595744680851, Blast_Score=453, Evalue=1e-128,
Organism=Caenorhabditis elegans, GI17542558, Length=472, Percent_Identity=51.0593220338983, Blast_Score=507, Evalue=1e-144,
Organism=Saccharomyces cerevisiae, GI6321695, Length=451, Percent_Identity=52.7716186252772, Blast_Score=506, Evalue=1e-144,
Organism=Saccharomyces cerevisiae, GI6321977, Length=476, Percent_Identity=50.4201680672269, Blast_Score=487, Evalue=1e-138,
Organism=Drosophila melanogaster, GI24639279, Length=471, Percent_Identity=52.8662420382166, Blast_Score=491, Evalue=1e-139,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): 6PGD_CHLPN (Q9Z8I3)

Other databases:

- EMBL:   AE001363
- EMBL:   AE002161
- EMBL:   BA000008
- EMBL:   AE009440
- PIR:   C72088
- PIR:   F86535
- RefSeq:   NP_224560.1
- RefSeq:   NP_300417.1
- RefSeq:   NP_444947.1
- RefSeq:   NP_876643.1
- ProteinModelPortal:   Q9Z8I3
- SMR:   Q9Z8I3
- GeneID:   1467050
- GeneID:   895135
- GeneID:   919866
- GeneID:   963777
- GenomeReviews:   AE001363_GR
- GenomeReviews:   AE002161_GR
- GenomeReviews:   AE009440_GR
- GenomeReviews:   BA000008_GR
- KEGG:   cpa:CP0398
- KEGG:   cpn:CPn0360
- KEGG:   cpt:CpB0369
- TIGR:   CP_0398
- HOGENOM:   HBG286913
- OMA:   CIIRAGF
- PhylomeDB:   Q9Z8I3
- ProtClustDB:   PRK09287
- BioCyc:   CPNE115711:CP_0398-MONOMER
- BioCyc:   CPNE115713:CPN0360-MONOMER
- BioCyc:   CPNE138677:CPJ0360-MONOMER
- BioCyc:   CPNE182082:CPB0369-MONOMER
- BRENDA:   1.1.1.44
- InterPro:   IPR008927
- InterPro:   IPR006114
- InterPro:   IPR006113
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR012284
- InterPro:   IPR016040
- InterPro:   IPR006183
- Gene3D:   G3DSA:1.20.5.320
- Gene3D:   G3DSA:3.40.50.720
- Gene3D:   G3DSA:1.10.1040.10
- PIRSF:   PIRSF000109
- PRINTS:   PR00076
- TIGRFAMs:   TIGR00873

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2; SSF48179 6DGDH_C_like

EC number: =1.1.1.44

Molecular weight: Translated: 52939; Mature: 52939

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: PS00461 6PGD

Important sites: ACT_SITE 182-182 ACT_SITE 189-189 BINDING 102-102 BINDING 102-102 BINDING 190-190 BINDING 259-259 BINDING 286-286 BINDING 446-446 BINDING 452-452

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTNIGLIGLAVMGKNLVLNMIDHGFSVSVYNRTPEKTRDFLKEYPNHRELVGFESLEDF
CCCCCCEEEHHHHCCHHHHHHHCCCCEEEEECCCCHHHHHHHHHCCCCCHHCCHHHHHHH
VNSLERPRKIMLMIQAGKPVDQSIHALLPFLEPGDVIIDGGNSYFKDSERRCKELQEKGI
HHHHCCCCEEEEEEECCCCHHHHHHHHHCCCCCCCEEEECCCCCCCCHHHHHHHHHHCCE
LFLGVGISGGEEGARHGPSIMPGGNPEAWPLVAPIFQSIAAKVQGRPCCSWVGTGGAGHY
EEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHH
VKAVHNGIEYGDIQLICEAYGILRDFLKLSATAVATILKEWNTLELESYLIRIASEVLAL
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHC
KDPEGIPVIDTILDVVGQKGTGKWTAIDALNSGVPLSLIIGAVLARFLSSWKEIREQAAR
CCCCCCCHHHHHHHHHCCCCCCCEEEEHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
NYPGTPLIFEMPHDPSVFIQDVFHALYASKIISYAQGFMLLGEASKEYNWGLDLGEIALM
CCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCHHHHHHH
WRGGCIIQSAFLDVIHKGFAANPENTSLIFQEYFRGALRHAEMGWRRTVVTAIGAGLPIP
HCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHH
CLAAAITFYDGYRTASSSMSLAQGLRDYFGAHTYERNDRPRGEFYHTDWVHTKTTERVK
HHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEECCCCCCCCCCCCC
>Mature Secondary Structure
MQTNIGLIGLAVMGKNLVLNMIDHGFSVSVYNRTPEKTRDFLKEYPNHRELVGFESLEDF
CCCCCCEEEHHHHCCHHHHHHHCCCCEEEEECCCCHHHHHHHHHCCCCCHHCCHHHHHHH
VNSLERPRKIMLMIQAGKPVDQSIHALLPFLEPGDVIIDGGNSYFKDSERRCKELQEKGI
HHHHCCCCEEEEEEECCCCHHHHHHHHHCCCCCCCEEEECCCCCCCCHHHHHHHHHHCCE
LFLGVGISGGEEGARHGPSIMPGGNPEAWPLVAPIFQSIAAKVQGRPCCSWVGTGGAGHY
EEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHH
VKAVHNGIEYGDIQLICEAYGILRDFLKLSATAVATILKEWNTLELESYLIRIASEVLAL
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHC
KDPEGIPVIDTILDVVGQKGTGKWTAIDALNSGVPLSLIIGAVLARFLSSWKEIREQAAR
CCCCCCCHHHHHHHHHCCCCCCCEEEEHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
NYPGTPLIFEMPHDPSVFIQDVFHALYASKIISYAQGFMLLGEASKEYNWGLDLGEIALM
CCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCHHHHHHH
WRGGCIIQSAFLDVIHKGFAANPENTSLIFQEYFRGALRHAEMGWRRTVVTAIGAGLPIP
HCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHH
CLAAAITFYDGYRTASSSMSLAQGLRDYFGAHTYERNDRPRGEFYHTDWVHTKTTERVK
HHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362