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The map label for this gene is gcp_2

Identifier: 15835729

GI number: 15835729

Start: 232825

End: 233859

Strand: Direct

Name: gcp_2

Synonym: CPj0194

Alternate gene names: 15835729

Gene position: 232825-233859 (Clockwise)

Preceding gene: 15835725

Following gene: 15835730

Centisome position: 18.98

GC content: 41.55

Gene sequence:

>1035_bases
ATGCTCACCCTAGGCTTGGAAAGTTCTTGCGATGAGACTGCCTGCGCTATAGTTAATGAGGATAAGCAGATATTAGCAAA
TATTATTGCCTCTCAAGATATCCATGCATCCTATGGCGGAGTCGTTCCTGAACTTGCTTCAAGAGCACATCTCCATATCT
TCCCACAAGTGATAAATAAAGCTCTACAACAGGCCAACTTATTGATCGAAGATATGGATCTGATTGCAGTAACGCAAACT
CCAGGGTTGATAGGTTCTCTATCAGTAGGAGTGCATTTTGGTAAAGGCATTGCCATAGGAGCAAAAAAATCCTTGATTGG
AGTCAATCACGTCGAAGCTCATCTCTATGCTGCCTATATGGCAGCGCAAAACGTGCAATTCCCTGCTTTAGGTCTTGTGG
TCTCTGGAGCTCATACCGCAGCGTTTTTTATAGAAAATCCTACATCCTATAAACTCATAGGAAAAACTCGAGATGATGCT
ATAGGAGAAACTTTTGATAAAGTAGGACGCTTTCTAGGATTACCATACCCTGCAGGCCCATTAATTGAAAAACTCGCTTT
AGAAGGCTCTGAGGACAGTTATCCTTTTAGTCCAGCTAAAGTCCCAAACTATGACTTTTCATTCAGCGGTCTTAAAACAG
CTGTTCTCTACGCAATCAAAGGAAATAATAGTAGCCCCCGCTCTCCTGCTCCAGAGATATCTTTAGAAAAACAAAGAGAT
ATCGCTGCTTCATTTCAAAAAGCGGCCTGCACTACTATTGCACAAAAACTTCCCACTATTATAAAAGAATTTTCGTGCCG
ATCTATACTTATTGGAGGTGGCGTAGCCATTAATGAATACTTTAGATCCGCAATACAAACTGCGTGTAATCTACCTGTAT
ACTTCCCCCCTGCTAAACTATGCTCAGATAATGCTGCTATGATTGCAGGTCTAGGGGGAGAAAATTTTCAAAAAAACTCT
AGTATTCCGGAAATTCGTATATGCGCAAGATATCAGTGGGAATCTGTATCACCATTCTCCTTAGCCTCTCCGTAG

Upstream 100 bases:

>100_bases
GTTACTTTTTTTTTCATAAAAACCCCATGTAACTTTTACTTGCTCATATTGAGAAGTCCCCCATACTATAAAAGGCAACG
TTTTCTTTTCTTGGTTTTTT

Downstream 100 bases:

>100_bases
TCCTCCAAGGCTGCAAGGAGTCCAGTCACTCCTCTACATCTCGGGGAGAACTCGCTATTAATATAAGAGATGAACCCCGT
TCTTTAGATCCAAGACAAGT

Product: putative DNA-binding/iron metalloprotein/AP endonuclease

Products: NA

Alternate protein names: Glycoprotease

Number of amino acids: Translated: 344; Mature: 344

Protein sequence:

>344_residues
MLTLGLESSCDETACAIVNEDKQILANIIASQDIHASYGGVVPELASRAHLHIFPQVINKALQQANLLIEDMDLIAVTQT
PGLIGSLSVGVHFGKGIAIGAKKSLIGVNHVEAHLYAAYMAAQNVQFPALGLVVSGAHTAAFFIENPTSYKLIGKTRDDA
IGETFDKVGRFLGLPYPAGPLIEKLALEGSEDSYPFSPAKVPNYDFSFSGLKTAVLYAIKGNNSSPRSPAPEISLEKQRD
IAASFQKAACTTIAQKLPTIIKEFSCRSILIGGGVAINEYFRSAIQTACNLPVYFPPAKLCSDNAAMIAGLGGENFQKNS
SIPEIRICARYQWESVSPFSLASP

Sequences:

>Translated_344_residues
MLTLGLESSCDETACAIVNEDKQILANIIASQDIHASYGGVVPELASRAHLHIFPQVINKALQQANLLIEDMDLIAVTQT
PGLIGSLSVGVHFGKGIAIGAKKSLIGVNHVEAHLYAAYMAAQNVQFPALGLVVSGAHTAAFFIENPTSYKLIGKTRDDA
IGETFDKVGRFLGLPYPAGPLIEKLALEGSEDSYPFSPAKVPNYDFSFSGLKTAVLYAIKGNNSSPRSPAPEISLEKQRD
IAASFQKAACTTIAQKLPTIIKEFSCRSILIGGGVAINEYFRSAIQTACNLPVYFPPAKLCSDNAAMIAGLGGENFQKNS
SIPEIRICARYQWESVSPFSLASP
>Mature_344_residues
MLTLGLESSCDETACAIVNEDKQILANIIASQDIHASYGGVVPELASRAHLHIFPQVINKALQQANLLIEDMDLIAVTQT
PGLIGSLSVGVHFGKGIAIGAKKSLIGVNHVEAHLYAAYMAAQNVQFPALGLVVSGAHTAAFFIENPTSYKLIGKTRDDA
IGETFDKVGRFLGLPYPAGPLIEKLALEGSEDSYPFSPAKVPNYDFSFSGLKTAVLYAIKGNNSSPRSPAPEISLEKQRD
IAASFQKAACTTIAQKLPTIIKEFSCRSILIGGGVAINEYFRSAIQTACNLPVYFPPAKLCSDNAAMIAGLGGENFQKNS
SIPEIRICARYQWESVSPFSLASP

Specific function: Could Be A Metalloprotease. [C]

COG id: COG0533

COG function: function code O; Metal-dependent proteases with possible chaperone activity

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M22 family

Homologues:

Organism=Homo sapiens, GI116812636, Length=339, Percent_Identity=32.7433628318584, Blast_Score=151, Evalue=9e-37,
Organism=Homo sapiens, GI8923380, Length=342, Percent_Identity=26.0233918128655, Blast_Score=87, Evalue=2e-17,
Organism=Escherichia coli, GI1789445, Length=339, Percent_Identity=36.5781710914454, Blast_Score=218, Evalue=4e-58,
Organism=Caenorhabditis elegans, GI17557464, Length=329, Percent_Identity=32.5227963525836, Blast_Score=140, Evalue=7e-34,
Organism=Caenorhabditis elegans, GI71995670, Length=321, Percent_Identity=27.1028037383178, Blast_Score=80, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6320099, Length=367, Percent_Identity=30.2452316076294, Blast_Score=142, Evalue=6e-35,
Organism=Saccharomyces cerevisiae, GI6322891, Length=346, Percent_Identity=25.1445086705202, Blast_Score=75, Evalue=1e-14,
Organism=Drosophila melanogaster, GI20129063, Length=362, Percent_Identity=30.3867403314917, Blast_Score=155, Evalue=4e-38,
Organism=Drosophila melanogaster, GI21357207, Length=346, Percent_Identity=27.1676300578035, Blast_Score=107, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCP_CHLPN (Q9Z8Z0)

Other databases:

- EMBL:   AE001363
- EMBL:   AE002161
- EMBL:   AE009440
- EMBL:   BA000008
- PIR:   B86515
- PIR:   H72106
- RefSeq:   NP_224403.1
- RefSeq:   NP_300253.1
- RefSeq:   NP_445116.1
- RefSeq:   NP_876473.1
- ProteinModelPortal:   Q9Z8Z0
- MEROPS:   M22.001
- GeneID:   1466880
- GeneID:   895167
- GeneID:   918990
- GeneID:   963718
- GenomeReviews:   AE001363_GR
- GenomeReviews:   AE002161_GR
- GenomeReviews:   AE009440_GR
- GenomeReviews:   BA000008_GR
- KEGG:   cpa:CP0573
- KEGG:   cpn:CPn0194
- KEGG:   cpt:CpB0197
- TIGR:   CP_0573
- HOGENOM:   HBG304663
- OMA:   PAVGVHH
- PhylomeDB:   Q9Z8Z0
- ProtClustDB:   PRK09604
- BioCyc:   CPNE115711:CP_0573-MONOMER
- BioCyc:   CPNE115713:CPN0194-MONOMER
- BioCyc:   CPNE138677:CPJ0194-MONOMER
- BioCyc:   CPNE182082:CPB0197-MONOMER
- BRENDA:   3.4.24.57
- GO:   GO:0006508
- HAMAP:   MF_01445
- InterPro:   IPR022450
- InterPro:   IPR000905
- InterPro:   IPR017861
- PANTHER:   PTHR11735
- PRINTS:   PR00789
- TIGRFAMs:   TIGR03723
- TIGRFAMs:   TIGR00329

Pfam domain/function: PF00814 Peptidase_M22

EC number: =3.4.24.57

Molecular weight: Translated: 36719; Mature: 36719

Theoretical pI: Translated: 6.62; Mature: 6.62

Prosite motif: PS01016 GLYCOPROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTLGLESSCDETACAIVNEDKQILANIIASQDIHASYGGVVPELASRAHLHIFPQVINK
CEEECCCCCCCCCEEEEECCCHHHHHHHHHCCCCCCCCCCHHHHHHCCCEEEEHHHHHHH
ALQQANLLIEDMDLIAVTQTPGLIGSLSVGVHFGKGIAIGAKKSLIGVNHVEAHLYAAYM
HHHHHHHEEECCCEEEEECCCCCEEEEEECEEECCCEEECCCCCEECCHHHHHHHHHHHH
AAQNVQFPALGLVVSGAHTAAFFIENPTSYKLIGKTRDDAIGETFDKVGRFLGLPYPAGP
HHCCCCCCEEEEEEECCCEEEEEEECCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCH
LIEKLALEGSEDSYPFSPAKVPNYDFSFSGLKTAVLYAIKGNNSSPRSPAPEISLEKQRD
HHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCCCCCCCCCCHHHHH
IAASFQKAACTTIAQKLPTIIKEFSCRSILIGGGVAINEYFRSAIQTACNLPVYFPPAKL
HHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHCCCEECCCHHH
CSDNAAMIAGLGGENFQKNSSIPEIRICARYQWESVSPFSLASP
CCCCCEEEEECCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCC
>Mature Secondary Structure
MLTLGLESSCDETACAIVNEDKQILANIIASQDIHASYGGVVPELASRAHLHIFPQVINK
CEEECCCCCCCCCEEEEECCCHHHHHHHHHCCCCCCCCCCHHHHHHCCCEEEEHHHHHHH
ALQQANLLIEDMDLIAVTQTPGLIGSLSVGVHFGKGIAIGAKKSLIGVNHVEAHLYAAYM
HHHHHHHEEECCCEEEEECCCCCEEEEEECEEECCCEEECCCCCEECCHHHHHHHHHHHH
AAQNVQFPALGLVVSGAHTAAFFIENPTSYKLIGKTRDDAIGETFDKVGRFLGLPYPAGP
HHCCCCCCEEEEEEECCCEEEEEEECCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCH
LIEKLALEGSEDSYPFSPAKVPNYDFSFSGLKTAVLYAIKGNNSSPRSPAPEISLEKQRD
HHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCCCCCCCCCCHHHHH
IAASFQKAACTTIAQKLPTIIKEFSCRSILIGGGVAINEYFRSAIQTACNLPVYFPPAKL
HHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHCCCEECCCHHH
CSDNAAMIAGLGGENFQKNSSIPEIRICARYQWESVSPFSLASP
CCCCCEEEEECCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10192388; 10871362; 10684935