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The map label for this gene is accB

Identifier: 15835718

GI number: 15835718

Start: 220315

End: 220818

Strand: Reverse

Name: accB

Synonym: CPj0183

Alternate gene names: 15835718

Gene position: 220818-220315 (Counterclockwise)

Preceding gene: 15835719

Following gene: 15835717

Centisome position: 18.0

GC content: 39.09

Gene sequence:

>504_bases
ATGGACTTAAAACAAATAGAAAAGCTCATGATTGCTATGGGACGCAATGGTATGAAGCGTTTTGCTATAAAACGTGAAGG
GCTTGAATTGGAGTTGGAAAGAGATACTAGGGAGGGGAATAGACAAGAGCCTGTGTTTTATGACAGCAGGTTATTTAGTG
GATTTTCTCAAGAACGACCTATCCCAACGGACCCTAAAAAAGATACAATTAAAGAGACTACTACAGAAAATTCAGAAACT
TCTACTACAACAAGTTCCGGAGACTTTATAAGTTCTCCTTTAGTGGGAACTTTCTATGGTTCTCCAGCCCCAGATTCTCC
TTCTTTTGTAAAACCTGGCGATATTGTTTCGGAAGATACTATTGTTTGTATCGTTGAGGCTATGAAAGTAATGAATGAAG
TGAAAGCAGGAATGAGTGGGCGTGTTCTTGAAGTATTGATTACCAATGGGGATCCTGTCCAATTTGGGTCTAAGTTGTTT
CGTATAGCTAAAGATGCATCATGA

Upstream 100 bases:

>100_bases
ATGGTCCCACCTTTTGTAGAAATTGGTGATGTTATAAAAATAGATACGCGGACTTGTGAGTATATTCAACGCGTCTAATT
TCAATTAAAGAAGACTTGGT

Downstream 100 bases:

>100_bases
AAAAAGTCTTAATCGCTAATAGAGGGGAAATTGCTGTTAGAATTATACGTGCCTGTCATGATTTAGGATTGTCGACAGTG
GCTGTATATTCTTTAGCAGA

Product: acetyl-CoA carboxylase biotin carboxyl carrier protein subunit

Products: Malonyl-CoA; malonyl-CoA; phosphate; ADP [C]

Alternate protein names: BCCP

Number of amino acids: Translated: 167; Mature: 167

Protein sequence:

>167_residues
MDLKQIEKLMIAMGRNGMKRFAIKREGLELELERDTREGNRQEPVFYDSRLFSGFSQERPIPTDPKKDTIKETTTENSET
STTTSSGDFISSPLVGTFYGSPAPDSPSFVKPGDIVSEDTIVCIVEAMKVMNEVKAGMSGRVLEVLITNGDPVQFGSKLF
RIAKDAS

Sequences:

>Translated_167_residues
MDLKQIEKLMIAMGRNGMKRFAIKREGLELELERDTREGNRQEPVFYDSRLFSGFSQERPIPTDPKKDTIKETTTENSET
STTTSSGDFISSPLVGTFYGSPAPDSPSFVKPGDIVSEDTIVCIVEAMKVMNEVKAGMSGRVLEVLITNGDPVQFGSKLF
RIAKDAS
>Mature_167_residues
MDLKQIEKLMIAMGRNGMKRFAIKREGLELELERDTREGNRQEPVFYDSRLFSGFSQERPIPTDPKKDTIKETTTENSET
STTTSSGDFISSPLVGTFYGSPAPDSPSFVKPGDIVSEDTIVCIVEAMKVMNEVKAGMSGRVLEVLITNGDPVQFGSKLF
RIAKDAS

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA

COG id: COG0511

COG function: function code I; Biotin carboxyl carrier protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotinyl-binding domain

Homologues:

Organism=Escherichia coli, GI1789653, Length=164, Percent_Identity=29.8780487804878, Blast_Score=78, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): BCCP_CHLPN (Q9Z901)

Other databases:

- EMBL:   AE001363
- EMBL:   AE002161
- EMBL:   BA000008
- EMBL:   AE009440
- PIR:   F72110
- PIR:   G86513
- RefSeq:   NP_224392.1
- RefSeq:   NP_300242.1
- RefSeq:   NP_445128.1
- RefSeq:   NP_876462.1
- ProteinModelPortal:   Q9Z901
- SMR:   Q9Z901
- PHCI-2DPAGE:   Q9Z901
- GeneID:   1466869
- GeneID:   894979
- GeneID:   918978
- GeneID:   962699
- GenomeReviews:   AE001363_GR
- GenomeReviews:   AE002161_GR
- GenomeReviews:   AE009440_GR
- GenomeReviews:   BA000008_GR
- KEGG:   cpa:CP0585
- KEGG:   cpn:CPn0183
- KEGG:   cpt:CpB0186
- TIGR:   CP_0585
- HOGENOM:   HBG745267
- OMA:   RIAKDAS
- ProtClustDB:   PRK06302
- BioCyc:   CPNE115711:CP_0585-MONOMER
- BioCyc:   CPNE115713:CPN0183-MONOMER
- BioCyc:   CPNE138677:CPJ0183-MONOMER
- BioCyc:   CPNE182082:CPB0186-MONOMER
- InterPro:   IPR001249
- InterPro:   IPR001882
- InterPro:   IPR000089
- InterPro:   IPR011053
- PRINTS:   PR01071
- TIGRFAMs:   TIGR00531

Pfam domain/function: PF00364 Biotin_lipoyl; SSF51230 Hybrid_motif

EC number: NA

Molecular weight: Translated: 18461; Mature: 18461

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: PS00188 BIOTIN; PS50968 BIOTINYL_LIPOYL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLKQIEKLMIAMGRNGMKRFAIKREGLELELERDTREGNRQEPVFYDSRLFSGFSQERP
CCHHHHHHHHHHHCCCCHHHHHHHCCCCEEEEECCCCCCCCCCCEEEHHHHHCCCCCCCC
IPTDPKKDTIKETTTENSETSTTTSSGDFISSPLVGTFYGSPAPDSPSFVKPGDIVSEDT
CCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCH
IVCIVEAMKVMNEVKAGMSGRVLEVLITNGDPVQFGSKLFRIAKDAS
HHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDLKQIEKLMIAMGRNGMKRFAIKREGLELELERDTREGNRQEPVFYDSRLFSGFSQERP
CCHHHHHHHHHHHCCCCHHHHHHHCCCCEEEEECCCCCCCCCCCEEEHHHHHCCCCCCCC
IPTDPKKDTIKETTTENSETSTTTSSGDFISSPLVGTFYGSPAPDSPSFVKPGDIVSEDT
CCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCH
IVCIVEAMKVMNEVKAGMSGRVLEVLITNGDPVQFGSKLFRIAKDAS
HHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Acetyl-CoA; HCO3-; Proton; acetyl-CoA; ATP [C]

Specific reaction: acetyl-CoA = malonyl-CoA HCO3- + Proton + acetyl-CoA + ATP = malonyl-CoA + phosphate + ADP [C]

General reaction: Ligases; Forming Carbon-Carbon Bonds; acetyl-CoA carboxylase Reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362