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The map label for this gene is accC

Identifier: 15835717

GI number: 15835717

Start: 218954

End: 220318

Strand: Reverse

Name: accC

Synonym: CPj0182

Alternate gene names: 15835717

Gene position: 220318-218954 (Counterclockwise)

Preceding gene: 15835718

Following gene: 15835716

Centisome position: 17.96

GC content: 39.49

Gene sequence:

>1365_bases
ATGAAAAAAGTCTTAATCGCTAATAGAGGGGAAATTGCTGTTAGAATTATACGTGCCTGTCATGATTTAGGATTGTCGAC
AGTGGCTGTATATTCTTTAGCAGATCAAGAGGCTCTCCACGTACTTCTTGCTGACGAGGCTATTTGTATTGGAGAGCCTC
AAGCAGCAAAGTCTTATTTAAAGATATCCAATATCTTGGCTGCCTGTGAGATCACAGGAGCTGATGCTGTGCATCCTGGA
TATGGGTTTTTAAGTGAAAACGCAAACTTTGCTTCAATATGCGAGAGCTGTGGCTTAACCTTTATAGGGCCGAGTTCAGA
GTCTATTGCTATGATGGGGGATAAGATTGCTGCGAAGTCCCTGGCAAAGAAAATCAAATGTCCTGTTATTCCAGGTTCTG
AAGGCATTATTGAAGACGAGAGCGAAGGTTTAAAAATAGCTGAAAAAATAGGTTTCCCTATTGTTATTAAAGCCGTTGCT
GGAGGTGGGGGAAGAGGAATTCGTATTGTTAAAGAAAAGGACGAATTCTATAGAGCGTTTTCTGCCGCACGTGCAGAAGC
CGAAGCCGGTTTTAATAACCCCAATGTTTATATTGAAAAGTTTATAGAAAATCCAAGGCATTTAGAAATCCAAGTCATTG
GGGATACCCATGGAAATTATGTGCATTTAGGAGAAAGAGACTGCACCATTCAACGGCGACGTCAAAAGTTGATTGAAGAG
ACTCCTAGTCCCATTCTCAATGCGGAAATCCGAGTCAAAGTAGGAAAAATTGCTGTAGATCTAGCAAGAAGCGCCGGATA
TTTTTCTGTTGGAACAGTCGAATTCTTATTAGATAAAGACAAAAAATTCTACTTTATGGAAATGAATACCCGAATTCAGG
TAGAGCATACCATTACTGAAGAAGTCACAGGTATAGATCTTGTAAAAGAACAGATTCATGTAGCCATGGGAAATAAGCTG
CCTTGGAAACAAAAGAACATTGAGTTCTCGGGTCATATCATCCAATGTCGCATTAACGCTGAGGATCCTACCAATAATTT
CTCACCATCTCCAGGTCGTTTAGATTATTATCTTCCTCCTGCAGGTCCTTCAATTCGTGTAGATGGAGCTTGTTATAGCG
GCTATGCAATCCCTCCTTATTATGATTCTATGATAGCAAAGGTAATTGCTAAGGGCAAAAACCGAGAAGAAGCTATAGCT
ATCATGAAACGAGCTTTGAAAGAGTTTCATATCGGTGGTGTGCAGTCTACAATACCTTTCCACCAGTTTATGTTGGATAA
TCCGAAGTTTCTAGAATCTAATTACGATATTAACTATATCGATAACCTACTTGCTCAAGGAAATTCTTTTTTTAAAGAAT
TCTAA

Upstream 100 bases:

>100_bases
TGAAAGCAGGAATGAGTGGGCGTGTTCTTGAAGTATTGATTACCAATGGGGATCCTGTCCAATTTGGGTCTAAGTTGTTT
CGTATAGCTAAAGATGCATC

Downstream 100 bases:

>100_bases
ATAATTTAAGAATCTTCCTTAGGGCTCTTGAAGCTCGGAGGCTTTTCTAATTAAATTTACAATGGTCTAAGAATTATTTT
TATATAAATATTTCTTTATA

Product: acetyl-CoA carboxylase biotin carboxylase subunit

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 454; Mature: 454

Protein sequence:

>454_residues
MKKVLIANRGEIAVRIIRACHDLGLSTVAVYSLADQEALHVLLADEAICIGEPQAAKSYLKISNILAACEITGADAVHPG
YGFLSENANFASICESCGLTFIGPSSESIAMMGDKIAAKSLAKKIKCPVIPGSEGIIEDESEGLKIAEKIGFPIVIKAVA
GGGGRGIRIVKEKDEFYRAFSAARAEAEAGFNNPNVYIEKFIENPRHLEIQVIGDTHGNYVHLGERDCTIQRRRQKLIEE
TPSPILNAEIRVKVGKIAVDLARSAGYFSVGTVEFLLDKDKKFYFMEMNTRIQVEHTITEEVTGIDLVKEQIHVAMGNKL
PWKQKNIEFSGHIIQCRINAEDPTNNFSPSPGRLDYYLPPAGPSIRVDGACYSGYAIPPYYDSMIAKVIAKGKNREEAIA
IMKRALKEFHIGGVQSTIPFHQFMLDNPKFLESNYDINYIDNLLAQGNSFFKEF

Sequences:

>Translated_454_residues
MKKVLIANRGEIAVRIIRACHDLGLSTVAVYSLADQEALHVLLADEAICIGEPQAAKSYLKISNILAACEITGADAVHPG
YGFLSENANFASICESCGLTFIGPSSESIAMMGDKIAAKSLAKKIKCPVIPGSEGIIEDESEGLKIAEKIGFPIVIKAVA
GGGGRGIRIVKEKDEFYRAFSAARAEAEAGFNNPNVYIEKFIENPRHLEIQVIGDTHGNYVHLGERDCTIQRRRQKLIEE
TPSPILNAEIRVKVGKIAVDLARSAGYFSVGTVEFLLDKDKKFYFMEMNTRIQVEHTITEEVTGIDLVKEQIHVAMGNKL
PWKQKNIEFSGHIIQCRINAEDPTNNFSPSPGRLDYYLPPAGPSIRVDGACYSGYAIPPYYDSMIAKVIAKGKNREEAIA
IMKRALKEFHIGGVQSTIPFHQFMLDNPKFLESNYDINYIDNLLAQGNSFFKEF
>Mature_454_residues
MKKVLIANRGEIAVRIIRACHDLGLSTVAVYSLADQEALHVLLADEAICIGEPQAAKSYLKISNILAACEITGADAVHPG
YGFLSENANFASICESCGLTFIGPSSESIAMMGDKIAAKSLAKKIKCPVIPGSEGIIEDESEGLKIAEKIGFPIVIKAVA
GGGGRGIRIVKEKDEFYRAFSAARAEAEAGFNNPNVYIEKFIENPRHLEIQVIGDTHGNYVHLGERDCTIQRRRQKLIEE
TPSPILNAEIRVKVGKIAVDLARSAGYFSVGTVEFLLDKDKKFYFMEMNTRIQVEHTITEEVTGIDLVKEQIHVAMGNKL
PWKQKNIEFSGHIIQCRINAEDPTNNFSPSPGRLDYYLPPAGPSIRVDGACYSGYAIPPYYDSMIAKVIAKGKNREEAIA
IMKRALKEFHIGGVQSTIPFHQFMLDNPKFLESNYDINYIDNLLAQGNSFFKEF

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI189095269, Length=447, Percent_Identity=47.6510067114094, Blast_Score=414, Evalue=1e-115,
Organism=Homo sapiens, GI65506442, Length=447, Percent_Identity=47.6510067114094, Blast_Score=413, Evalue=1e-115,
Organism=Homo sapiens, GI295821183, Length=447, Percent_Identity=47.6510067114094, Blast_Score=413, Evalue=1e-115,
Organism=Homo sapiens, GI106049528, Length=446, Percent_Identity=46.8609865470852, Blast_Score=411, Evalue=1e-115,
Organism=Homo sapiens, GI106049295, Length=446, Percent_Identity=46.8609865470852, Blast_Score=411, Evalue=1e-115,
Organism=Homo sapiens, GI106049292, Length=446, Percent_Identity=46.8609865470852, Blast_Score=411, Evalue=1e-115,
Organism=Homo sapiens, GI116805327, Length=443, Percent_Identity=44.920993227991, Blast_Score=404, Evalue=1e-113,
Organism=Homo sapiens, GI38679974, Length=506, Percent_Identity=30.6324110671937, Blast_Score=246, Evalue=2e-65,
Organism=Homo sapiens, GI38679977, Length=506, Percent_Identity=30.6324110671937, Blast_Score=246, Evalue=2e-65,
Organism=Homo sapiens, GI38679967, Length=506, Percent_Identity=30.6324110671937, Blast_Score=246, Evalue=2e-65,
Organism=Homo sapiens, GI38679971, Length=506, Percent_Identity=30.6324110671937, Blast_Score=246, Evalue=2e-65,
Organism=Homo sapiens, GI38679960, Length=506, Percent_Identity=30.6324110671937, Blast_Score=246, Evalue=3e-65,
Organism=Homo sapiens, GI134142062, Length=507, Percent_Identity=30.5719921104536, Blast_Score=243, Evalue=4e-64,
Organism=Escherichia coli, GI1789654, Length=445, Percent_Identity=49.8876404494382, Blast_Score=440, Evalue=1e-124,
Organism=Caenorhabditis elegans, GI17567343, Length=447, Percent_Identity=46.0850111856823, Blast_Score=402, Evalue=1e-112,
Organism=Caenorhabditis elegans, GI71987519, Length=441, Percent_Identity=46.2585034013605, Blast_Score=397, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI17562816, Length=446, Percent_Identity=46.1883408071749, Blast_Score=396, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI133931226, Length=490, Percent_Identity=32.4489795918367, Blast_Score=232, Evalue=4e-61,
Organism=Caenorhabditis elegans, GI71997168, Length=427, Percent_Identity=29.2740046838407, Blast_Score=187, Evalue=8e-48,
Organism=Caenorhabditis elegans, GI71997163, Length=427, Percent_Identity=29.2740046838407, Blast_Score=187, Evalue=9e-48,
Organism=Saccharomyces cerevisiae, GI6319695, Length=447, Percent_Identity=45.413870246085, Blast_Score=386, Evalue=1e-108,
Organism=Saccharomyces cerevisiae, GI6321376, Length=447, Percent_Identity=45.8612975391499, Blast_Score=375, Evalue=1e-105,
Organism=Saccharomyces cerevisiae, GI6319685, Length=441, Percent_Identity=41.4965986394558, Blast_Score=347, Evalue=3e-96,
Organism=Saccharomyces cerevisiae, GI6323863, Length=459, Percent_Identity=32.244008714597, Blast_Score=225, Evalue=1e-59,
Organism=Saccharomyces cerevisiae, GI6324343, Length=514, Percent_Identity=30.9338521400778, Blast_Score=224, Evalue=2e-59,
Organism=Drosophila melanogaster, GI281363050, Length=446, Percent_Identity=47.7578475336323, Blast_Score=407, Evalue=1e-113,
Organism=Drosophila melanogaster, GI24652224, Length=446, Percent_Identity=47.7578475336323, Blast_Score=407, Evalue=1e-113,
Organism=Drosophila melanogaster, GI24652222, Length=446, Percent_Identity=47.7578475336323, Blast_Score=407, Evalue=1e-113,
Organism=Drosophila melanogaster, GI24652220, Length=446, Percent_Identity=47.7578475336323, Blast_Score=407, Evalue=1e-113,
Organism=Drosophila melanogaster, GI24652218, Length=446, Percent_Identity=47.7578475336323, Blast_Score=407, Evalue=1e-113,
Organism=Drosophila melanogaster, GI24652212, Length=446, Percent_Identity=47.7578475336323, Blast_Score=406, Evalue=1e-113,
Organism=Drosophila melanogaster, GI24652210, Length=446, Percent_Identity=47.7578475336323, Blast_Score=406, Evalue=1e-113,
Organism=Drosophila melanogaster, GI24652214, Length=446, Percent_Identity=47.7578475336323, Blast_Score=406, Evalue=1e-113,
Organism=Drosophila melanogaster, GI19921944, Length=446, Percent_Identity=47.7578475336323, Blast_Score=406, Evalue=1e-113,
Organism=Drosophila melanogaster, GI24652216, Length=446, Percent_Identity=47.7578475336323, Blast_Score=406, Evalue=1e-113,
Organism=Drosophila melanogaster, GI24651757, Length=444, Percent_Identity=44.5945945945946, Blast_Score=395, Evalue=1e-110,
Organism=Drosophila melanogaster, GI24651759, Length=406, Percent_Identity=43.8423645320197, Blast_Score=355, Evalue=4e-98,
Organism=Drosophila melanogaster, GI161076407, Length=501, Percent_Identity=30.3393213572854, Blast_Score=239, Evalue=2e-63,
Organism=Drosophila melanogaster, GI24586460, Length=501, Percent_Identity=30.3393213572854, Blast_Score=239, Evalue=2e-63,
Organism=Drosophila melanogaster, GI24586458, Length=501, Percent_Identity=30.3393213572854, Blast_Score=239, Evalue=2e-63,
Organism=Drosophila melanogaster, GI161076409, Length=501, Percent_Identity=30.3393213572854, Blast_Score=239, Evalue=2e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 50093; Mature: 50093

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: PS50975 ATP_GRASP ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKVLIANRGEIAVRIIRACHDLGLSTVAVYSLADQEALHVLLADEAICIGEPQAAKSYL
CCEEEEECCCHHHHHHHHHHHHCCCHHEEEEECCCHHHEEEEEECCEEECCCCHHHHHHH
KISNILAACEITGADAVHPGYGFLSENANFASICESCGLTFIGPSSESIAMMGDKIAAKS
HHHHHHHEEEECCCCCCCCCCCEECCCCCHHHHHHHCCCEEECCCCCCEEEHHHHHHHHH
LAKKIKCPVIPGSEGIIEDESEGLKIAEKIGFPIVIKAVAGGGGRGIRIVKEKDEFYRAF
HHHHCCCCCCCCCCCCCCCCCCCCHHHHHCCCCEEEEEEECCCCCEEEEEECHHHHHHHH
SAARAEAEAGFNNPNVYIEKFIENPRHLEIQVIGDTHGNYVHLGERDCTIQRRRQKLIEE
HHHHHHHHCCCCCCCEEHHHHHCCCCEEEEEEEECCCCCEEEECCCCCHHHHHHHHHHHH
TPSPILNAEIRVKVGKIAVDLARSAGYFSVGTVEFLLDKDKKFYFMEMNTRIQVEHTITE
CCCCCCCCEEEEEEEHEEEEHHHCCCCEEECEEEEEECCCCEEEEEEECCEEEEEEEHHH
EVTGIDLVKEQIHVAMGNKLPWKQKNIEFSGHIIQCRINAEDPTNNFSPSPGRLDYYLPP
HHHHHHHHHHHHHHHCCCCCCCCCCCEEECCEEEEEEECCCCCCCCCCCCCCCEEEEECC
AGPSIRVDGACYSGYAIPPYYDSMIAKVIAKGKNREEAIAIMKRALKEFHIGGVQSTIPF
CCCCEEECCEEECCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCH
HQFMLDNPKFLESNYDINYIDNLLAQGNSFFKEF
HHHHCCCCHHCCCCCCHHHHHHHHHCCCHHHHCC
>Mature Secondary Structure
MKKVLIANRGEIAVRIIRACHDLGLSTVAVYSLADQEALHVLLADEAICIGEPQAAKSYL
CCEEEEECCCHHHHHHHHHHHHCCCHHEEEEECCCHHHEEEEEECCEEECCCCHHHHHHH
KISNILAACEITGADAVHPGYGFLSENANFASICESCGLTFIGPSSESIAMMGDKIAAKS
HHHHHHHEEEECCCCCCCCCCCEECCCCCHHHHHHHCCCEEECCCCCCEEEHHHHHHHHH
LAKKIKCPVIPGSEGIIEDESEGLKIAEKIGFPIVIKAVAGGGGRGIRIVKEKDEFYRAF
HHHHCCCCCCCCCCCCCCCCCCCCHHHHHCCCCEEEEEEECCCCCEEEEEECHHHHHHHH
SAARAEAEAGFNNPNVYIEKFIENPRHLEIQVIGDTHGNYVHLGERDCTIQRRRQKLIEE
HHHHHHHHCCCCCCCEEHHHHHCCCCEEEEEEEECCCCCEEEECCCCCHHHHHHHHHHHH
TPSPILNAEIRVKVGKIAVDLARSAGYFSVGTVEFLLDKDKKFYFMEMNTRIQVEHTITE
CCCCCCCCEEEEEEEHEEEEHHHCCCCEEECEEEEEECCCCEEEEEEECCEEEEEEEHHH
EVTGIDLVKEQIHVAMGNKLPWKQKNIEFSGHIIQCRINAEDPTNNFSPSPGRLDYYLPP
HHHHHHHHHHHHHHHCCCCCCCCCCCEEECCEEEEEEECCCCCCCCCCCCCCCEEEEECC
AGPSIRVDGACYSGYAIPPYYDSMIAKVIAKGKNREEAIAIMKRALKEFHIGGVQSTIPF
CCCCEEECCEEECCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCH
HQFMLDNPKFLESNYDINYIDNLLAQGNSFFKEF
HHHHCCCCHHCCCCCCHHHHHHHHHCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8102363; 11759840 [H]