Click here to switch to the map view.

The map label for this gene is guaB

Identifier: 15835707

GI number: 15835707

Start: 212060

End: 212800

Strand: Reverse

Name: guaB

Synonym: CPj0172

Alternate gene names: 15835707

Gene position: 212800-212060 (Counterclockwise)

Preceding gene: 15835708

Following gene: 15835706

Centisome position: 17.35

GC content: 42.11

Gene sequence:

>741_bases
GTGGAAGCTGGAGCAAATGTTCTAGTCATTGACACAGCTCATGCACACTCTAAAGGAGTATTCCAAACAGTTTTAGAAAT
AAAATCCCAGTTCCCACAAATTTCTTTAGTTGTAGGGAATCTTGTTACAGCTGAAGCCGCAGTTTCCTTAGCTGAGATTG
GAGTTGACGCTGTAAAGGTAGGTATTGGCCCAGGATCTATCTGTACAACTAGAATCGTTTCAGGGGTCGGTTATCCACAA
ATTACTGCCATTACAAACGTAGCAAAAGCTCTTAAAAACTCTGCCGTGACTGTAATTGCTGATGGGAGAATCCGCTATTC
TGGAGATGTGGTAAAAGCATTAGCAGCAGGAGCAGACTGTGTCATGCTAGGAAGTTTGCTTGCAGGGACTGATGAAGCTC
CTGGGGATATCGTTTCTATCGATGAGAAGCTTTTTAAAAGGTACCGCGGCATGGGATCTTTAGGCGCTATGAAACAAGGA
AGTGCTGACCGGTATTTTCAAACACAGGGACAGAAAAAGCTGGTTCCTGGGGGAGTTGAAGGACTAGTCGCTTATAAAGG
CTCTGTCCACGATGTCCTCTATCAAATTTTAGGAGGAATACGCTCAGGTATGGGGTATGTTGGAGCTGAAACTCTCAAAG
ATTTAAAAACTAAGGCTTCCTTTGTTCGAATTACTGAATCTGGAAGAGCTGAAAGTCATATTCATAATATTTACAAAGTT
CAACCAACCTTAAATTATTAA

Upstream 100 bases:

>100_bases
AAGCTCATCTGTGAGAAAAATTAAAGAAGCCTATCCTTAAGCTCCCATAGGAGCCGCTATAGGCATTGGTCCTTTAGGAA
TTTCAAGAGCGCATCATCTT

Downstream 100 bases:

>100_bases
GTTGCAGAGTGCAAGGAGACATTTGAACACCATATTTATTCTAGATTTTGGATCTCAATATACTTATGTATTAGCAAAGC
AAGTGCGGAAGTTATTTGTA

Product: inosine 5'-monophosphase dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 246; Mature: 246

Protein sequence:

>246_residues
MEAGANVLVIDTAHAHSKGVFQTVLEIKSQFPQISLVVGNLVTAEAAVSLAEIGVDAVKVGIGPGSICTTRIVSGVGYPQ
ITAITNVAKALKNSAVTVIADGRIRYSGDVVKALAAGADCVMLGSLLAGTDEAPGDIVSIDEKLFKRYRGMGSLGAMKQG
SADRYFQTQGQKKLVPGGVEGLVAYKGSVHDVLYQILGGIRSGMGYVGAETLKDLKTKASFVRITESGRAESHIHNIYKV
QPTLNY

Sequences:

>Translated_246_residues
MEAGANVLVIDTAHAHSKGVFQTVLEIKSQFPQISLVVGNLVTAEAAVSLAEIGVDAVKVGIGPGSICTTRIVSGVGYPQ
ITAITNVAKALKNSAVTVIADGRIRYSGDVVKALAAGADCVMLGSLLAGTDEAPGDIVSIDEKLFKRYRGMGSLGAMKQG
SADRYFQTQGQKKLVPGGVEGLVAYKGSVHDVLYQILGGIRSGMGYVGAETLKDLKTKASFVRITESGRAESHIHNIYKV
QPTLNY
>Mature_246_residues
MEAGANVLVIDTAHAHSKGVFQTVLEIKSQFPQISLVVGNLVTAEAAVSLAEIGVDAVKVGIGPGSICTTRIVSGVGYPQ
ITAITNVAKALKNSAVTVIADGRIRYSGDVVKALAAGADCVMLGSLLAGTDEAPGDIVSIDEKLFKRYRGMGSLGAMKQG
SADRYFQTQGQKKLVPGGVEGLVAYKGSVHDVLYQILGGIRSGMGYVGAETLKDLKTKASFVRITESGRAESHIHNIYKV
QPTLNY

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI50541954, Length=221, Percent_Identity=41.1764705882353, Blast_Score=166, Evalue=2e-41,
Organism=Homo sapiens, GI50541952, Length=221, Percent_Identity=41.1764705882353, Blast_Score=166, Evalue=2e-41,
Organism=Homo sapiens, GI50541948, Length=221, Percent_Identity=41.1764705882353, Blast_Score=166, Evalue=2e-41,
Organism=Homo sapiens, GI50541956, Length=221, Percent_Identity=41.1764705882353, Blast_Score=165, Evalue=3e-41,
Organism=Homo sapiens, GI66933016, Length=250, Percent_Identity=38.8, Blast_Score=161, Evalue=4e-40,
Organism=Homo sapiens, GI217035148, Length=250, Percent_Identity=39.6, Blast_Score=161, Evalue=5e-40,
Organism=Homo sapiens, GI217035146, Length=250, Percent_Identity=39.6, Blast_Score=161, Evalue=5e-40,
Organism=Homo sapiens, GI34328928, Length=250, Percent_Identity=39.6, Blast_Score=161, Evalue=5e-40,
Organism=Homo sapiens, GI156616279, Length=250, Percent_Identity=39.6, Blast_Score=161, Evalue=6e-40,
Organism=Homo sapiens, GI217035150, Length=250, Percent_Identity=39.6, Blast_Score=161, Evalue=6e-40,
Organism=Homo sapiens, GI34328930, Length=250, Percent_Identity=39.6, Blast_Score=161, Evalue=6e-40,
Organism=Homo sapiens, GI217035152, Length=250, Percent_Identity=39.6, Blast_Score=160, Evalue=7e-40,
Organism=Homo sapiens, GI156104880, Length=221, Percent_Identity=38.0090497737557, Blast_Score=156, Evalue=2e-38,
Organism=Escherichia coli, GI1788855, Length=245, Percent_Identity=53.8775510204082, Blast_Score=250, Evalue=6e-68,
Organism=Escherichia coli, GI1786293, Length=233, Percent_Identity=39.0557939914163, Blast_Score=157, Evalue=8e-40,
Organism=Caenorhabditis elegans, GI17560440, Length=221, Percent_Identity=40.2714932126697, Blast_Score=165, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI71994385, Length=252, Percent_Identity=34.9206349206349, Blast_Score=149, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI71994389, Length=169, Percent_Identity=41.4201183431953, Blast_Score=120, Evalue=9e-28,
Organism=Saccharomyces cerevisiae, GI6323585, Length=255, Percent_Identity=35.2941176470588, Blast_Score=153, Evalue=3e-38,
Organism=Saccharomyces cerevisiae, GI6323464, Length=256, Percent_Identity=34.765625, Blast_Score=150, Evalue=3e-37,
Organism=Saccharomyces cerevisiae, GI6322012, Length=256, Percent_Identity=34.765625, Blast_Score=148, Evalue=7e-37,
Organism=Saccharomyces cerevisiae, GI6319353, Length=147, Percent_Identity=34.6938775510204, Blast_Score=77, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6319352, Length=105, Percent_Identity=35.2380952380952, Blast_Score=77, Evalue=4e-15,
Organism=Drosophila melanogaster, GI28571163, Length=251, Percent_Identity=37.0517928286853, Blast_Score=158, Evalue=4e-39,
Organism=Drosophila melanogaster, GI24641071, Length=251, Percent_Identity=37.0517928286853, Blast_Score=157, Evalue=4e-39,
Organism=Drosophila melanogaster, GI24641073, Length=251, Percent_Identity=37.0517928286853, Blast_Score=157, Evalue=4e-39,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 25751; Mature: 25751

Theoretical pI: Translated: 9.23; Mature: 9.23

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEAGANVLVIDTAHAHSKGVFQTVLEIKSQFPQISLVVGNLVTAEAAVSLAEIGVDAVKV
CCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCEEEEEHHHHHHHHHHHHHHHHCHHHEEE
GIGPGSICTTRIVSGVGYPQITAITNVAKALKNSAVTVIADGRIRYSGDVVKALAAGADC
CCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEEEECCEEEECHHHHHHHHCCCHH
VMLGSLLAGTDEAPGDIVSIDEKLFKRYRGMGSLGAMKQGSADRYFQTQGQKKLVPGGVE
HHHHHHHHCCCCCCCCEEHHHHHHHHHHCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCC
GLVAYKGSVHDVLYQILGGIRSGMGYVGAETLKDLKTKASFVRITESGRAESHIHNIYKV
EEEEECCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHEEEEECCCCHHHHHHHHEEE
QPTLNY
CCCCCC
>Mature Secondary Structure
MEAGANVLVIDTAHAHSKGVFQTVLEIKSQFPQISLVVGNLVTAEAAVSLAEIGVDAVKV
CCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCEEEEEHHHHHHHHHHHHHHHHCHHHEEE
GIGPGSICTTRIVSGVGYPQITAITNVAKALKNSAVTVIADGRIRYSGDVVKALAAGADC
CCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEEEECCEEEECHHHHHHHHCCCHH
VMLGSLLAGTDEAPGDIVSIDEKLFKRYRGMGSLGAMKQGSADRYFQTQGQKKLVPGGVE
HHHHHHHHCCCCCCCCEEHHHHHHHHHHCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCC
GLVAYKGSVHDVLYQILGGIRSGMGYVGAETLKDLKTKASFVRITESGRAESHIHNIYKV
EEEEECCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHEEEEECCCCHHHHHHHHEEE
QPTLNY
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]