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The map label for this gene is gmk

Identifier: 15835656

GI number: 15835656

Start: 150875

End: 151492

Strand: Direct

Name: gmk

Synonym: CPj0120

Alternate gene names: 15835656

Gene position: 150875-151492 (Clockwise)

Preceding gene: 15835655

Following gene: 15835657

Centisome position: 12.3

GC content: 40.78

Gene sequence:

>618_bases
ATGAATAAGATCCTAGTTGACTCTCCTTTTTCTCCAGATCACCAGAAGTGCTGTCCTAAGCTTTTTACAATTAGTGCTCC
TGCTGGAGTTGGAAAGACAACACTTGTCCGTATGTTAGAGCAAGAGTTTTCTTCTGCTTTTGCTGAGACTATATCGGTAA
CAACAAGGAAACCTCGAGAGGGTGAAGTCCCAGGTAAAGATTATCATTTTGTTTCCCACGAAGAATTTCAAAGACTTTTG
GATCGTCAGGCTCTCTTAGAATGGGTGTTCTTATTCGGAGAGTGTTACGGAACAAGTATGTTAGAGATTGAAAGAATTTG
GAGCCTAGGGAAGCACGCTGTTGCTGTTATTGATATCCAAGGAGCCTTGTTTATTCGCTCTCGGATGCCTAGTGTATCTA
TTTTTATTGCTCCACCTTCACAGGAGGAGTTAGAAAGAAGGTTAGCTTCACGGGGATCTGAAGAGGGCTCTCAAAGAAAA
GAACGGCTGGAGCACAGTCTTATTGAGCTAGCAGCTGCAAATCAGTTTGATTATGTCATTATTAACGACGACTTAAATCA
AGCGTACAGGGTTTTAAAAAGCATTTTTATAGCTGAAGAACATAGGAACATATTATGA

Upstream 100 bases:

>100_bases
GATACGGAACTTCCTTGCATGTAGAAGCAATACGACGTTATGGTCCCAGTCCCTGCCATAGGAAGAGCTTTTCTCCAATA
AAGCAAATGTGTGCTATTGT

Downstream 100 bases:

>100_bases
TTAAAAAAGATCGTTTCACTAATGAAAAGTTAAATAAGCTTTTCGATAGTCCTTTTAGCCTAGTGAACTACGCGATTAAA
CAAGCAAAGATCAAAATTGC

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase

Number of amino acids: Translated: 205; Mature: 205

Protein sequence:

>205_residues
MNKILVDSPFSPDHQKCCPKLFTISAPAGVGKTTLVRMLEQEFSSAFAETISVTTRKPREGEVPGKDYHFVSHEEFQRLL
DRQALLEWVFLFGECYGTSMLEIERIWSLGKHAVAVIDIQGALFIRSRMPSVSIFIAPPSQEELERRLASRGSEEGSQRK
ERLEHSLIELAAANQFDYVIINDDLNQAYRVLKSIFIAEEHRNIL

Sequences:

>Translated_205_residues
MNKILVDSPFSPDHQKCCPKLFTISAPAGVGKTTLVRMLEQEFSSAFAETISVTTRKPREGEVPGKDYHFVSHEEFQRLL
DRQALLEWVFLFGECYGTSMLEIERIWSLGKHAVAVIDIQGALFIRSRMPSVSIFIAPPSQEELERRLASRGSEEGSQRK
ERLEHSLIELAAANQFDYVIINDDLNQAYRVLKSIFIAEEHRNIL
>Mature_205_residues
MNKILVDSPFSPDHQKCCPKLFTISAPAGVGKTTLVRMLEQEFSSAFAETISVTTRKPREGEVPGKDYHFVSHEEFQRLL
DRQALLEWVFLFGECYGTSMLEIERIWSLGKHAVAVIDIQGALFIRSRMPSVSIFIAPPSQEELERRLASRGSEEGSQRK
ERLEHSLIELAAANQFDYVIINDDLNQAYRVLKSIFIAEEHRNIL

Specific function: Essential for recycling GMP and indirectly, cGMP

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain

Homologues:

Organism=Homo sapiens, GI226874833, Length=179, Percent_Identity=36.8715083798883, Blast_Score=115, Evalue=2e-26,
Organism=Homo sapiens, GI4504221, Length=179, Percent_Identity=36.8715083798883, Blast_Score=115, Evalue=2e-26,
Organism=Homo sapiens, GI226874831, Length=179, Percent_Identity=36.8715083798883, Blast_Score=115, Evalue=3e-26,
Organism=Homo sapiens, GI38570142, Length=170, Percent_Identity=32.3529411764706, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI14780902, Length=194, Percent_Identity=28.3505154639175, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI148539578, Length=162, Percent_Identity=29.6296296296296, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI148539628, Length=162, Percent_Identity=29.6296296296296, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI21361598, Length=185, Percent_Identity=28.1081081081081, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI4505237, Length=178, Percent_Identity=25.2808988764045, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI262118263, Length=178, Percent_Identity=25.2808988764045, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI262118255, Length=178, Percent_Identity=25.2808988764045, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI262118259, Length=178, Percent_Identity=25.2808988764045, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI186700629, Length=175, Percent_Identity=26.2857142857143, Blast_Score=65, Evalue=3e-11,
Organism=Homo sapiens, GI186972120, Length=175, Percent_Identity=26.2857142857143, Blast_Score=65, Evalue=3e-11,
Organism=Homo sapiens, GI186700627, Length=175, Percent_Identity=26.2857142857143, Blast_Score=65, Evalue=3e-11,
Organism=Escherichia coli, GI1790080, Length=184, Percent_Identity=41.304347826087, Blast_Score=139, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI193203132, Length=179, Percent_Identity=37.4301675977654, Blast_Score=113, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI17508835, Length=179, Percent_Identity=37.4301675977654, Blast_Score=112, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI71988041, Length=170, Percent_Identity=28.2352941176471, Blast_Score=67, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI71988048, Length=168, Percent_Identity=27.9761904761905, Blast_Score=66, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6320662, Length=182, Percent_Identity=40.1098901098901, Blast_Score=142, Evalue=4e-35,
Organism=Drosophila melanogaster, GI21356141, Length=185, Percent_Identity=35.6756756756757, Blast_Score=105, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24641280, Length=165, Percent_Identity=27.8787878787879, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI161077752, Length=168, Percent_Identity=27.9761904761905, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI45554813, Length=162, Percent_Identity=28.3950617283951, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI45554804, Length=170, Percent_Identity=27.6470588235294, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI161077754, Length=162, Percent_Identity=28.3950617283951, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI281360700, Length=165, Percent_Identity=27.8787878787879, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24641282, Length=165, Percent_Identity=27.8787878787879, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI45554818, Length=165, Percent_Identity=27.8787878787879, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI45554791, Length=162, Percent_Identity=28.3950617283951, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI45554489, Length=170, Percent_Identity=28.2352941176471, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24640542, Length=170, Percent_Identity=28.2352941176471, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI161077626, Length=170, Percent_Identity=28.2352941176471, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI116007136, Length=170, Percent_Identity=28.2352941176471, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI85724806, Length=170, Percent_Identity=28.2352941176471, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI45554481, Length=170, Percent_Identity=28.2352941176471, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI161078487, Length=177, Percent_Identity=27.1186440677966, Blast_Score=64, Evalue=7e-11,
Organism=Drosophila melanogaster, GI24648808, Length=186, Percent_Identity=26.3440860215054, Blast_Score=64, Evalue=7e-11,
Organism=Drosophila melanogaster, GI161078485, Length=177, Percent_Identity=26.5536723163842, Blast_Score=64, Evalue=7e-11,
Organism=Drosophila melanogaster, GI24648810, Length=177, Percent_Identity=26.5536723163842, Blast_Score=64, Evalue=7e-11,
Organism=Drosophila melanogaster, GI281362232, Length=177, Percent_Identity=26.5536723163842, Blast_Score=64, Evalue=8e-11,
Organism=Drosophila melanogaster, GI281362230, Length=186, Percent_Identity=26.3440860215054, Blast_Score=64, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KGUA_CHLPN (Q9Z961)

Other databases:

- EMBL:   AE001363
- EMBL:   AE002161
- EMBL:   BA000008
- EMBL:   AE009440
- PIR:   A86506
- PIR:   F72117
- RefSeq:   NP_224328.1
- RefSeq:   NP_300180.1
- RefSeq:   NP_445195.1
- RefSeq:   NP_876397.2
- ProteinModelPortal:   Q9Z961
- SMR:   Q9Z961
- PHCI-2DPAGE:   Q9Z961
- GeneID:   1466804
- GeneID:   895034
- GeneID:   918908
- GeneID:   963237
- GenomeReviews:   AE001363_GR
- GenomeReviews:   AE002161_GR
- GenomeReviews:   AE009440_GR
- GenomeReviews:   BA000008_GR
- KEGG:   cpa:CP0653
- KEGG:   cpn:CPn0120
- KEGG:   cpt:CpB0121
- TIGR:   CP_0653
- HOGENOM:   HBG671982
- OMA:   EWAEFAG
- PhylomeDB:   Q9Z961
- ProtClustDB:   PRK00300
- BioCyc:   CPNE115711:CP_0653-MONOMER
- BioCyc:   CPNE115713:CPN0120-MONOMER
- BioCyc:   CPNE138677:CPJ0120-MONOMER
- BioCyc:   CPNE182082:CPB0121-MONOMER
- BRENDA:   2.7.4.8
- GO:   GO:0005737
- HAMAP:   MF_00328
- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665
- SMART:   SM00072
- TIGRFAMs:   TIGR03263

Pfam domain/function: PF00625 Guanylate_kin

EC number: =2.7.4.8

Molecular weight: Translated: 23368; Mature: 23368

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: PS00856 GUANYLATE_KINASE_1; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKILVDSPFSPDHQKCCPKLFTISAPAGVGKTTLVRMLEQEFSSAFAETISVTTRKPRE
CCCEEECCCCCCCHHHHCCHHEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
GEVPGKDYHFVSHEEFQRLLDRQALLEWVFLFGECYGTSMLEIERIWSLGKHAVAVIDIQ
CCCCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCEEEEEEEC
GALFIRSRMPSVSIFIAPPSQEELERRLASRGSEEGSQRKERLEHSLIELAAANQFDYVI
CCEEEECCCCCEEEEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCEEE
INDDLNQAYRVLKSIFIAEEHRNIL
EECCHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNKILVDSPFSPDHQKCCPKLFTISAPAGVGKTTLVRMLEQEFSSAFAETISVTTRKPRE
CCCEEECCCCCCCHHHHCCHHEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
GEVPGKDYHFVSHEEFQRLLDRQALLEWVFLFGECYGTSMLEIERIWSLGKHAVAVIDIQ
CCCCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCEEEEEEEC
GALFIRSRMPSVSIFIAPPSQEELERRLASRGSEEGSQRKERLEHSLIELAAANQFDYVI
CCEEEECCCCCEEEEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCEEE
INDDLNQAYRVLKSIFIAEEHRNIL
EECCHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362