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The map label for this gene is atpA

Identifier: 15835623

GI number: 15835623

Start: 106044

End: 107819

Strand: Direct

Name: atpA

Synonym: CPj0088

Alternate gene names: 15835623

Gene position: 106044-107819 (Clockwise)

Preceding gene: 15835622

Following gene: 15835624

Centisome position: 8.65

GC content: 42.0

Gene sequence:

>1776_bases
ATGGTAACAGTTTCAGAACAAACTGCTCAGGGACATGTTATAGAAGCTTATGGAAACTTGTTACGTGTACGCTTTGACGG
ATATGTTAGACAAGGTGAAGTTGCATATGTCAACGTAGATAATACCTGGTTAAAAGCAGAAGTGATTGAAGTTGCTGATC
AAGAAGTCAAGGTTCAGGTATTTGAAGATACACAAGGCGCGTGTCGAGGAGCTCTTGTTACGTTTTCAGGACATCTTTTA
GAAGCCGAGTTAGGGCCTGGCTTGCTTCAGGGCATTTTCGATGGACTTCAAAATCGTCTTGAGGTGCTAGCTGAAGATAG
TTCTTTCTTGCAGAGAGGCAAGCATGTTAATGCTATTTCTGATCATAATTTATGGAATTATACTCCCGTAGCTTCTGTTG
GGGATACTTTAAGACGAGGAGATCTTCTAGGAACAGTACCTGAAGGACGATTTACTCATAAGATTATGGTTCCTTTTTCT
TGCTTTCAAGAGGTTACCCTGACTTGGGTAATTTCTGAAGGAACCTATAATGCTCATACTGTGGTCGCAAAAGCTCGAGA
TGCTCAGGGTAAAGAATGTGCCTTTACTATGGTGCAAAGATGGCCGATCAAACAAGCTTTTATTGAAGGAGAGAAGATCC
CTGCGCATAAGATTATGGATGTGGGTTTGCGAATCTTAGATACGCAAATTCCAGTATTGAAGGGGGGAACTTTCTGTACC
CCAGGACCTTTTGGTGCAGGGAAAACAGTCTTACAACACCATCTTTCTAAGTACGCTGCTGTAGATATTGTGATTTTGTG
TGCGTGCGGAGAGCGTGCTGGTGAAGTTGTTGAGGTATTACAAGAGTTCCCTCATCTTATCGACCCCCATACCGGAAAGT
CTTTAATGCACAGAACATGTATTATTTGTAACACATCATCCATGCCTGTGGCTGCCCGAGAGTCTTCGATCTATTTAGGA
GTGACGATTGCAGAATACTATCGCCAGATGGGACTAGATATTCTGCTTTTAGCTGATTCTACATCCCGATGGGCACAAGC
CCTTAGAGAGATTTCGGGACGTCTTGAAGAAATCCCTGGAGAGGAAGCATTTCCTGCATACCTGTCTTCTAGAATAGCTG
CTTTTTATGAGCGAGGAGGAGCTATCACCACGAAAGATGGTTCTGAAGGATCTTTAACTATATGTGGTGCGGTGTCTCCT
GCAGGAGGAAACTTTGAAGAACCAGTCACTCAATCTACATTAGCTGTAGTCGGAGCGTTCTGTGGTCTTTCAAAAGCACG
AGCTGACGCACGTAGGTATCCTTCAATAGACCCTTTGATTTCTTGGTCAAAATATTTGAACCAGGTAGGACAAATTTTAG
AAGAGAAGGTTTCAGGCTGGGGTGGTGCTGTGAAAAAAGCAGCACAGTTTCTAGAGAAAGGTTCAGAAATCGGCAAGCGT
ATGGAAGTTGTCGGTGAAGAAGGGGTTTCTATGGAAGACATGGAAATCTACTTAAAGGCAGAACTTTATGATTTTTGTTA
TCTCCAGCAGAACGCATTCGATCCTGTGGACTGTTATTGTCCTTTTGAGAGACAGATAGAGTTATTTTCATTAATCAGTC
GTATTTTTGATGCTAAATTTGTTTTTGATAGTCCTGATGATGCAAGAAGCTTTTTCCTTGAGCTGCAGAGCAAGATTAAG
ACATTAAATGGCCTGAAATTTCTTTCAGAGGAATATCATGAGAGTAAAGAGGTCATAGTTAGACTGTTGGAAAAAACAAT
GGTACAAATGGCGTAA

Upstream 100 bases:

>100_bases
TTTTAGCAAGATGTGCTACATATATGTTTGCTATTCGTAACAGCTTAGCAAGTGTTGAAAAAGGAAGAGAAATTATTAAT
CATATAGAAAAGGCAATCAA

Downstream 100 bases:

>100_bases
GGATATGCAAACAATCTACACAAAAATAACTGATATTAAAGGCAATTTAATCACTGTAGAAGCAGAGGGAGCTCGTTTAG
GGGAGCTTGCTACAATCACA

Product: V-type ATP synthase subunit A

Products: NA

Alternate protein names: V-ATPase subunit A

Number of amino acids: Translated: 591; Mature: 591

Protein sequence:

>591_residues
MVTVSEQTAQGHVIEAYGNLLRVRFDGYVRQGEVAYVNVDNTWLKAEVIEVADQEVKVQVFEDTQGACRGALVTFSGHLL
EAELGPGLLQGIFDGLQNRLEVLAEDSSFLQRGKHVNAISDHNLWNYTPVASVGDTLRRGDLLGTVPEGRFTHKIMVPFS
CFQEVTLTWVISEGTYNAHTVVAKARDAQGKECAFTMVQRWPIKQAFIEGEKIPAHKIMDVGLRILDTQIPVLKGGTFCT
PGPFGAGKTVLQHHLSKYAAVDIVILCACGERAGEVVEVLQEFPHLIDPHTGKSLMHRTCIICNTSSMPVAARESSIYLG
VTIAEYYRQMGLDILLLADSTSRWAQALREISGRLEEIPGEEAFPAYLSSRIAAFYERGGAITTKDGSEGSLTICGAVSP
AGGNFEEPVTQSTLAVVGAFCGLSKARADARRYPSIDPLISWSKYLNQVGQILEEKVSGWGGAVKKAAQFLEKGSEIGKR
MEVVGEEGVSMEDMEIYLKAELYDFCYLQQNAFDPVDCYCPFERQIELFSLISRIFDAKFVFDSPDDARSFFLELQSKIK
TLNGLKFLSEEYHESKEVIVRLLEKTMVQMA

Sequences:

>Translated_591_residues
MVTVSEQTAQGHVIEAYGNLLRVRFDGYVRQGEVAYVNVDNTWLKAEVIEVADQEVKVQVFEDTQGACRGALVTFSGHLL
EAELGPGLLQGIFDGLQNRLEVLAEDSSFLQRGKHVNAISDHNLWNYTPVASVGDTLRRGDLLGTVPEGRFTHKIMVPFS
CFQEVTLTWVISEGTYNAHTVVAKARDAQGKECAFTMVQRWPIKQAFIEGEKIPAHKIMDVGLRILDTQIPVLKGGTFCT
PGPFGAGKTVLQHHLSKYAAVDIVILCACGERAGEVVEVLQEFPHLIDPHTGKSLMHRTCIICNTSSMPVAARESSIYLG
VTIAEYYRQMGLDILLLADSTSRWAQALREISGRLEEIPGEEAFPAYLSSRIAAFYERGGAITTKDGSEGSLTICGAVSP
AGGNFEEPVTQSTLAVVGAFCGLSKARADARRYPSIDPLISWSKYLNQVGQILEEKVSGWGGAVKKAAQFLEKGSEIGKR
MEVVGEEGVSMEDMEIYLKAELYDFCYLQQNAFDPVDCYCPFERQIELFSLISRIFDAKFVFDSPDDARSFFLELQSKIK
TLNGLKFLSEEYHESKEVIVRLLEKTMVQMA
>Mature_591_residues
MVTVSEQTAQGHVIEAYGNLLRVRFDGYVRQGEVAYVNVDNTWLKAEVIEVADQEVKVQVFEDTQGACRGALVTFSGHLL
EAELGPGLLQGIFDGLQNRLEVLAEDSSFLQRGKHVNAISDHNLWNYTPVASVGDTLRRGDLLGTVPEGRFTHKIMVPFS
CFQEVTLTWVISEGTYNAHTVVAKARDAQGKECAFTMVQRWPIKQAFIEGEKIPAHKIMDVGLRILDTQIPVLKGGTFCT
PGPFGAGKTVLQHHLSKYAAVDIVILCACGERAGEVVEVLQEFPHLIDPHTGKSLMHRTCIICNTSSMPVAARESSIYLG
VTIAEYYRQMGLDILLLADSTSRWAQALREISGRLEEIPGEEAFPAYLSSRIAAFYERGGAITTKDGSEGSLTICGAVSP
AGGNFEEPVTQSTLAVVGAFCGLSKARADARRYPSIDPLISWSKYLNQVGQILEEKVSGWGGAVKKAAQFLEKGSEIGKR
MEVVGEEGVSMEDMEIYLKAELYDFCYLQQNAFDPVDCYCPFERQIELFSLISRIFDAKFVFDSPDDARSFFLELQSKIK
TLNGLKFLSEEYHESKEVIVRLLEKTMVQMA

Specific function: Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit

COG id: COG1155

COG function: function code C; Archaeal/vacuolar-type H+-ATPase subunit A

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase alpha/beta chains family

Homologues:

Organism=Homo sapiens, GI19913424, Length=510, Percent_Identity=40, Blast_Score=382, Evalue=1e-106,
Organism=Homo sapiens, GI32189394, Length=240, Percent_Identity=30, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI19913426, Length=206, Percent_Identity=26.6990291262136, Blast_Score=76, Evalue=9e-14,
Organism=Homo sapiens, GI19913428, Length=206, Percent_Identity=25.7281553398058, Blast_Score=74, Evalue=5e-13,
Organism=Escherichia coli, GI1790170, Length=308, Percent_Identity=25.3246753246753, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1788251, Length=245, Percent_Identity=26.1224489795918, Blast_Score=85, Evalue=2e-17,
Organism=Escherichia coli, GI1790172, Length=285, Percent_Identity=25.2631578947368, Blast_Score=70, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17565854, Length=510, Percent_Identity=38.8235294117647, Blast_Score=361, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI25144756, Length=244, Percent_Identity=31.1475409836066, Blast_Score=90, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17510931, Length=207, Percent_Identity=28.0193236714976, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17570191, Length=207, Percent_Identity=26.0869565217391, Blast_Score=72, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6320016, Length=271, Percent_Identity=41.3284132841328, Blast_Score=224, Evalue=2e-59,
Organism=Saccharomyces cerevisiae, GI6322581, Length=269, Percent_Identity=28.6245353159851, Blast_Score=86, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6319603, Length=224, Percent_Identity=25.8928571428571, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24583992, Length=502, Percent_Identity=38.4462151394422, Blast_Score=365, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24583988, Length=503, Percent_Identity=38.9662027833002, Blast_Score=362, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24583986, Length=503, Percent_Identity=38.9662027833002, Blast_Score=362, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24583984, Length=503, Percent_Identity=38.9662027833002, Blast_Score=362, Evalue=1e-100,
Organism=Drosophila melanogaster, GI20129479, Length=512, Percent_Identity=37.109375, Blast_Score=353, Evalue=3e-97,
Organism=Drosophila melanogaster, GI24638766, Length=244, Percent_Identity=30.327868852459, Blast_Score=90, Evalue=4e-18,
Organism=Drosophila melanogaster, GI28574560, Length=283, Percent_Identity=28.2685512367491, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI281361666, Length=255, Percent_Identity=24.3137254901961, Blast_Score=77, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24646341, Length=255, Percent_Identity=24.3137254901961, Blast_Score=77, Evalue=4e-14,
Organism=Drosophila melanogaster, GI17136796, Length=255, Percent_Identity=24.3137254901961, Blast_Score=77, Evalue=4e-14,

Paralogues:

None

Copy number: 10836 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 8,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): VATA_CHLPN (Q9Z993)

Other databases:

- EMBL:   AE001363
- EMBL:   AE002161
- EMBL:   BA000008
- EMBL:   AE009440
- PIR:   B72121
- PIR:   H86501
- RefSeq:   NP_224296.1
- RefSeq:   NP_300147.1
- RefSeq:   NP_445228.1
- RefSeq:   NP_876364.1
- ProteinModelPortal:   Q9Z993
- SMR:   Q9Z993
- GeneID:   1466771
- GeneID:   895697
- GeneID:   918880
- GeneID:   963222
- GenomeReviews:   AE001363_GR
- GenomeReviews:   AE002161_GR
- GenomeReviews:   AE009440_GR
- GenomeReviews:   BA000008_GR
- KEGG:   cpa:CP0686
- KEGG:   cpn:CPn0088
- KEGG:   cpt:CpB0088
- TIGR:   CP_0686
- HOGENOM:   HBG288114
- OMA:   QMGLDIL
- ProtClustDB:   PRK04192
- BioCyc:   CPNE115711:CP_0686-MONOMER
- BioCyc:   CPNE115713:CPN0088-MONOMER
- BioCyc:   CPNE138677:CPJ0088-MONOMER
- BioCyc:   CPNE182082:CPB0088-MONOMER
- BRENDA:   3.6.3.14
- HAMAP:   MF_00309
- InterPro:   IPR020003
- InterPro:   IPR000194
- InterPro:   IPR000793
- InterPro:   IPR004100
- InterPro:   IPR022878

Pfam domain/function: PF00006 ATP-synt_ab; PF00306 ATP-synt_ab_C; PF02874 ATP-synt_ab_N

EC number: =3.6.3.14

Molecular weight: Translated: 65360; Mature: 65360

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: PS00152 ATPASE_ALPHA_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTVSEQTAQGHVIEAYGNLLRVRFDGYVRQGEVAYVNVDNTWLKAEVIEVADQEVKVQV
CCCCCCCCCCCCEEECCCCEEEEEECCEEECCCEEEEECCCCCHHHHHHHHCCCCEEEEE
FEDTQGACRGALVTFSGHLLEAELGPGLLQGIFDGLQNRLEVLAEDSSFLQRGKHVNAIS
EECCCCHHCCEEEEECCCEEEECCCCHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCC
DHNLWNYTPVASVGDTLRRGDLLGTVPEGRFTHKIMVPFSCFQEVTLTWVISEGTYNAHT
CCCCCCCCCHHHHHHHHHCCCCEECCCCCCCEEEEECCHHHHCCEEEEEEEECCCCCCEE
VVAKARDAQGKECAFTMVQRWPIKQAFIEGEKIPAHKIMDVGLRILDTQIPVLKGGTFCT
EEEECCCCCCCHHHHHHHHHCCHHHHHHCCCCCCHHHHHHHHHHHHCCCCCEEECCCCCC
PGPFGAGKTVLQHHLSKYAAVDIVILCACGERAGEVVEVLQEFPHLIDPHTGKSLMHRTC
CCCCCCCHHHHHHHHHHHHHHEEEEEEECCCCHHHHHHHHHHHHHHCCCCCCHHHHHCEE
IICNTSSMPVAARESSIYLGVTIAEYYRQMGLDILLLADSTSRWAQALREISGRLEEIPG
EEECCCCCCCEECCCCEEEEEEHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHCCC
EEAFPAYLSSRIAAFYERGGAITTKDGSEGSLTICGAVSPAGGNFEEPVTQSTLAVVGAF
CCCHHHHHHHHHHHHHHCCCEEEECCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHH
CGLSKARADARRYPSIDPLISWSKYLNQVGQILEEKVSGWGGAVKKAAQFLEKGSEIGKR
HCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
MEVVGEEGVSMEDMEIYLKAELYDFCYLQQNAFDPVDCYCPFERQIELFSLISRIFDAKF
HHHHCCCCCCCCHHHEEEEHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCEE
VFDSPDDARSFFLELQSKIKTLNGLKFLSEEYHESKEVIVRLLEKTMVQMA
EECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MVTVSEQTAQGHVIEAYGNLLRVRFDGYVRQGEVAYVNVDNTWLKAEVIEVADQEVKVQV
CCCCCCCCCCCCEEECCCCEEEEEECCEEECCCEEEEECCCCCHHHHHHHHCCCCEEEEE
FEDTQGACRGALVTFSGHLLEAELGPGLLQGIFDGLQNRLEVLAEDSSFLQRGKHVNAIS
EECCCCHHCCEEEEECCCEEEECCCCHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCC
DHNLWNYTPVASVGDTLRRGDLLGTVPEGRFTHKIMVPFSCFQEVTLTWVISEGTYNAHT
CCCCCCCCCHHHHHHHHHCCCCEECCCCCCCEEEEECCHHHHCCEEEEEEEECCCCCCEE
VVAKARDAQGKECAFTMVQRWPIKQAFIEGEKIPAHKIMDVGLRILDTQIPVLKGGTFCT
EEEECCCCCCCHHHHHHHHHCCHHHHHHCCCCCCHHHHHHHHHHHHCCCCCEEECCCCCC
PGPFGAGKTVLQHHLSKYAAVDIVILCACGERAGEVVEVLQEFPHLIDPHTGKSLMHRTC
CCCCCCCHHHHHHHHHHHHHHEEEEEEECCCCHHHHHHHHHHHHHHCCCCCCHHHHHCEE
IICNTSSMPVAARESSIYLGVTIAEYYRQMGLDILLLADSTSRWAQALREISGRLEEIPG
EEECCCCCCCEECCCCEEEEEEHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHCCC
EEAFPAYLSSRIAAFYERGGAITTKDGSEGSLTICGAVSPAGGNFEEPVTQSTLAVVGAF
CCCHHHHHHHHHHHHHHCCCEEEECCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHH
CGLSKARADARRYPSIDPLISWSKYLNQVGQILEEKVSGWGGAVKKAAQFLEKGSEIGKR
HCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
MEVVGEEGVSMEDMEIYLKAELYDFCYLQQNAFDPVDCYCPFERQIELFSLISRIFDAKF
HHHHCCCCCCCCHHHEEEEHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCEE
VFDSPDDARSFFLELQSKIKTLNGLKFLSEEYHESKEVIVRLLEKTMVQMA
EECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362