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The map label for this gene is pdhA_pdhB

Identifier: 15835570

GI number: 15835570

Start: 45809

End: 47845

Strand: Direct

Name: pdhA_pdhB

Synonym: CPj0033

Alternate gene names: 15835570

Gene position: 45809-47845 (Clockwise)

Preceding gene: 15835569

Following gene: 15835573

Centisome position: 3.73

GC content: 45.16

Gene sequence:

>2037_bases
ATGGGAGTAGTACAAAATCAAGTTATTTCTTCTATAAGAGATGTTTTAAAGCTAGTCTGGGAATTGCGGTTCGCAGAGCA
TAAGATGCTTCTCCTCTCTAGGCAGAGCGGCTCGGGCGGCACATTTCAGTTGTCTTGTGCAGGTCATGAGCTTGCCGGCG
TTCTTGCTGGTAAAAGTCTCATTCCTGGTAAAGACTGGTCCTTCCCTTATTATAGAGATCAAGGGTTCCCTATAGGCTTG
GGTTGTGATCTCTCTGAGATCTTTGCTTCGTTTCTAGCTCGTACAACTCCAAATCATTCCTCTGCGAGGATGATGCCTTA
TCACTATTCTCATAAAAAATTGCGTATTTGCTGTCAGTCCAGTGTTGTAGGAACACAGTTTTTACAAGCCGCAGGTCGTG
CTTGGGCTGTCAAGCACTCGTCAGCTGATGAAGTTGTCTATGTTTCTGGAGGCGATGGAGCTACATCTCAGGGTGAATTC
CATGAAATGTTGAACTTTGTAGCACTACACCAACTGCCTTTAATCACTGTAATCCAAAATAATCATTGGGCAATTTCTGT
TCCTTTTGAAGACCAATGTGGAGCCGACCTTGCCAGCTTGGGTCGTTGCCATCAAGGATTAGCTGTCTATGAGGTAGATG
GAGGCAACTATACTTCTCTTACAGAAACTTTTTCTCATGCCGTAGATCAAGCGCGTCAACATTCGGTGCCTGCATTGATT
TTAATCGATGTGGTTCGCTTGAGCTCTCATAGCAATTCCGATAATCAGGAAAAATACCGCTCCGCTTTAGACCTGAAACT
ATCCATGGATAAGGATCCCTTAATCCTTCTAGAGAAAGAGGCTATCAATGTTTTTGGTCTGTCTCCCTTTGAAATCGAGG
AGATCAAGGCTGAAGCTCAAGAAGAAGTTCGAAAATCTTGTGAGATTGCTGAAGCTCTTCCTTTTCCCTCTAAGGGATCT
ACAAGCCATGAAGTCTTCTCTCCTTATACCGAGACTCTCATTGATTATGAGAATTCTGAAAGCGCTCAGAATTTGCGTAA
CTCTGAACCTAAAGTGATGCGTGATGCTATCTCCGAAGCCCTTGTAGAAGAGATGACTCGAGATTCTGGAGTCATTGTCT
TTGGTGAGGATGTCGCTGGAGATAAAGGAGGAGTCTTCGGTGTCACCAGGAATTTGACAGAAAAATTCGGACCACAACGG
TGTTTCAATTCTCCCTTAGCTGAAGCAACCATTATAGGAACCGCCATAGGCATGGCCTTAGACGGGATTCATAAGCCTGT
CGTTGAGATTCAGTTCGCAGATTATATTTGGCCGGGGATCAATCAGCTATTTTCTGAGGCCTCTAGCATCTACTATCGTT
CAGCTGGCGAATGGGAAGTTCCTCTGGTAATACGAGCCCCTTCAGGAGGCTATATCCAGGGAGGACCGTACCATTCGCAA
AGTATAGAAGGGTTCCTAGCACACTGTCCTGGAATTAAAGTTGCCTATCCTTCTAATGCTGCTGATGCTAAAGCTTTGCT
AAAGGCAGCGATTCGAGACCCGAATCCAGTAGTGTTTTTGGAGCATAAGGCCCTCTATCAAAGGCGTATTTTTAGTGCCT
GCCCAGTTTTTTCTCATGACTATGTTCTGCCTTTCGGCAAGGCCGCTATTGTTCATCCCGGGAAAGATCTCACGATAGTT
TCTTGGGGAATGCCTCTGGTATTGAGTTTAGAGGTTGCTCAGGAATTAGCCTCTCGGGGGATTTCCATAGAAGTTATAGA
TTTGCGTACTATGGTGCCTTGTGACTTCGCTACGGTTCTAAAATCCTTAGAGAAAACCGGAAGGTTGTTGGTGATTCACG
AGGCTTCAGAGTTTTGTGGCTTTGGCAGTGAGCTTGTCGCTACTATGTCGGAACAAGGATACGCTTATTTAGATGCTCCT
ATCCGTCGTCTTGGTGGGCTTCATGCTCCCGTTCCCTACTCTAAGGTTCTTGAAAACGAAGTGCTTCCTCATAAGGAGTC
TATTTTACAAGCCGCGAAAAGTCTCGCAGAATTCTAG

Upstream 100 bases:

>100_bases
CTTTCCTAAGAAGCGTAGCTTTTTAGATAAAATCAAAGGTTTTTTTTCTGACTTCACAGTATAAGAAGGAGAAAAGACCG
ACTTTAGCTGAGAGAGATCC

Downstream 100 bases:

>100_bases
GCGATTCTCCAGCTTCTTTCTAGGCCGGGATTTTAATTCAAAAAGAGAGCCCGACACGCTGTTTGTAGAGGTACTTGGGA
GATGCTATTTACTGAAACAT

Product: (pyruvate) oxoisovalerate dehydrogenase alpha and beta fusion

Products: NA

Alternate protein names: Branched-chain alpha-keto acid dehydrogenase E1 component beta chain; BCKDH E1-beta [H]

Number of amino acids: Translated: 678; Mature: 677

Protein sequence:

>678_residues
MGVVQNQVISSIRDVLKLVWELRFAEHKMLLLSRQSGSGGTFQLSCAGHELAGVLAGKSLIPGKDWSFPYYRDQGFPIGL
GCDLSEIFASFLARTTPNHSSARMMPYHYSHKKLRICCQSSVVGTQFLQAAGRAWAVKHSSADEVVYVSGGDGATSQGEF
HEMLNFVALHQLPLITVIQNNHWAISVPFEDQCGADLASLGRCHQGLAVYEVDGGNYTSLTETFSHAVDQARQHSVPALI
LIDVVRLSSHSNSDNQEKYRSALDLKLSMDKDPLILLEKEAINVFGLSPFEIEEIKAEAQEEVRKSCEIAEALPFPSKGS
TSHEVFSPYTETLIDYENSESAQNLRNSEPKVMRDAISEALVEEMTRDSGVIVFGEDVAGDKGGVFGVTRNLTEKFGPQR
CFNSPLAEATIIGTAIGMALDGIHKPVVEIQFADYIWPGINQLFSEASSIYYRSAGEWEVPLVIRAPSGGYIQGGPYHSQ
SIEGFLAHCPGIKVAYPSNAADAKALLKAAIRDPNPVVFLEHKALYQRRIFSACPVFSHDYVLPFGKAAIVHPGKDLTIV
SWGMPLVLSLEVAQELASRGISIEVIDLRTMVPCDFATVLKSLEKTGRLLVIHEASEFCGFGSELVATMSEQGYAYLDAP
IRRLGGLHAPVPYSKVLENEVLPHKESILQAAKSLAEF

Sequences:

>Translated_678_residues
MGVVQNQVISSIRDVLKLVWELRFAEHKMLLLSRQSGSGGTFQLSCAGHELAGVLAGKSLIPGKDWSFPYYRDQGFPIGL
GCDLSEIFASFLARTTPNHSSARMMPYHYSHKKLRICCQSSVVGTQFLQAAGRAWAVKHSSADEVVYVSGGDGATSQGEF
HEMLNFVALHQLPLITVIQNNHWAISVPFEDQCGADLASLGRCHQGLAVYEVDGGNYTSLTETFSHAVDQARQHSVPALI
LIDVVRLSSHSNSDNQEKYRSALDLKLSMDKDPLILLEKEAINVFGLSPFEIEEIKAEAQEEVRKSCEIAEALPFPSKGS
TSHEVFSPYTETLIDYENSESAQNLRNSEPKVMRDAISEALVEEMTRDSGVIVFGEDVAGDKGGVFGVTRNLTEKFGPQR
CFNSPLAEATIIGTAIGMALDGIHKPVVEIQFADYIWPGINQLFSEASSIYYRSAGEWEVPLVIRAPSGGYIQGGPYHSQ
SIEGFLAHCPGIKVAYPSNAADAKALLKAAIRDPNPVVFLEHKALYQRRIFSACPVFSHDYVLPFGKAAIVHPGKDLTIV
SWGMPLVLSLEVAQELASRGISIEVIDLRTMVPCDFATVLKSLEKTGRLLVIHEASEFCGFGSELVATMSEQGYAYLDAP
IRRLGGLHAPVPYSKVLENEVLPHKESILQAAKSLAEF
>Mature_677_residues
GVVQNQVISSIRDVLKLVWELRFAEHKMLLLSRQSGSGGTFQLSCAGHELAGVLAGKSLIPGKDWSFPYYRDQGFPIGLG
CDLSEIFASFLARTTPNHSSARMMPYHYSHKKLRICCQSSVVGTQFLQAAGRAWAVKHSSADEVVYVSGGDGATSQGEFH
EMLNFVALHQLPLITVIQNNHWAISVPFEDQCGADLASLGRCHQGLAVYEVDGGNYTSLTETFSHAVDQARQHSVPALIL
IDVVRLSSHSNSDNQEKYRSALDLKLSMDKDPLILLEKEAINVFGLSPFEIEEIKAEAQEEVRKSCEIAEALPFPSKGST
SHEVFSPYTETLIDYENSESAQNLRNSEPKVMRDAISEALVEEMTRDSGVIVFGEDVAGDKGGVFGVTRNLTEKFGPQRC
FNSPLAEATIIGTAIGMALDGIHKPVVEIQFADYIWPGINQLFSEASSIYYRSAGEWEVPLVIRAPSGGYIQGGPYHSQS
IEGFLAHCPGIKVAYPSNAADAKALLKAAIRDPNPVVFLEHKALYQRRIFSACPVFSHDYVLPFGKAAIVHPGKDLTIVS
WGMPLVLSLEVAQELASRGISIEVIDLRTMVPCDFATVLKSLEKTGRLLVIHEASEFCGFGSELVATMSEQGYAYLDAPI
RRLGGLHAPVPYSKVLENEVLPHKESILQAAKSLAEF

Specific function: The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components:branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltran

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4557353, Length=363, Percent_Identity=38.8429752066116, Blast_Score=236, Evalue=8e-62,
Organism=Homo sapiens, GI34101272, Length=363, Percent_Identity=38.8429752066116, Blast_Score=236, Evalue=8e-62,
Organism=Homo sapiens, GI156564403, Length=323, Percent_Identity=36.8421052631579, Blast_Score=217, Evalue=3e-56,
Organism=Homo sapiens, GI291084858, Length=323, Percent_Identity=34.6749226006192, Blast_Score=195, Evalue=1e-49,
Organism=Homo sapiens, GI4505685, Length=313, Percent_Identity=27.4760383386581, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI291084742, Length=315, Percent_Identity=27.9365079365079, Blast_Score=95, Evalue=3e-19,
Organism=Homo sapiens, GI291084744, Length=289, Percent_Identity=28.0276816608997, Blast_Score=94, Evalue=5e-19,
Organism=Homo sapiens, GI4885543, Length=344, Percent_Identity=25.2906976744186, Blast_Score=92, Evalue=2e-18,
Organism=Homo sapiens, GI258645172, Length=332, Percent_Identity=27.1084337349398, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI11386135, Length=333, Percent_Identity=27.3273273273273, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI291084757, Length=181, Percent_Identity=28.1767955801105, Blast_Score=68, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17538422, Length=329, Percent_Identity=39.5136778115502, Blast_Score=243, Evalue=2e-64,
Organism=Caenorhabditis elegans, GI17506935, Length=361, Percent_Identity=39.612188365651, Blast_Score=218, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI86563357, Length=302, Percent_Identity=30.4635761589404, Blast_Score=105, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI86563355, Length=302, Percent_Identity=30.4635761589404, Blast_Score=105, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI32564172, Length=270, Percent_Identity=24.4444444444444, Blast_Score=68, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17536047, Length=270, Percent_Identity=24.4444444444444, Blast_Score=68, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6319698, Length=341, Percent_Identity=37.5366568914956, Blast_Score=228, Evalue=3e-60,
Organism=Saccharomyces cerevisiae, GI6321026, Length=252, Percent_Identity=22.2222222222222, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI21358145, Length=332, Percent_Identity=38.2530120481928, Blast_Score=240, Evalue=2e-63,
Organism=Drosophila melanogaster, GI24650940, Length=332, Percent_Identity=38.2530120481928, Blast_Score=240, Evalue=2e-63,
Organism=Drosophila melanogaster, GI160714832, Length=328, Percent_Identity=40.5487804878049, Blast_Score=231, Evalue=1e-60,
Organism=Drosophila melanogaster, GI160714828, Length=328, Percent_Identity=40.5487804878049, Blast_Score=231, Evalue=2e-60,
Organism=Drosophila melanogaster, GI21355903, Length=242, Percent_Identity=27.6859504132231, Blast_Score=88, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24639746, Length=195, Percent_Identity=25.1282051282051, Blast_Score=69, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24639740, Length=195, Percent_Identity=25.1282051282051, Blast_Score=69, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24639744, Length=195, Percent_Identity=25.1282051282051, Blast_Score=69, Evalue=1e-11,
Organism=Drosophila melanogaster, GI28571106, Length=195, Percent_Identity=25.1282051282051, Blast_Score=69, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24639748, Length=243, Percent_Identity=27.1604938271605, Blast_Score=66, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =1.2.4.4 [H]

Molecular weight: Translated: 74176; Mature: 74045

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGVVQNQVISSIRDVLKLVWELRFAEHKMLLLSRQSGSGGTFQLSCAGHELAGVLAGKSL
CCCHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEECCCCCCEEEEEECCCHHHHHHHCCCC
IPGKDWSFPYYRDQGFPIGLGCDLSEIFASFLARTTPNHSSARMMPYHYSHKKLRICCQS
CCCCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHCCCCCCCCEECCEECCCCCEEEEHHC
SVVGTQFLQAAGRAWAVKHSSADEVVYVSGGDGATSQGEFHEMLNFVALHQLPLITVIQN
CHHHHHHHHHCCCEEEEECCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHCCCEEEEEEC
NHWAISVPFEDQCGADLASLGRCHQGLAVYEVDGGNYTSLTETFSHAVDQARQHSVPALI
CCEEEECCCCCCCCCCHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCEEH
LIDVVRLSSHSNSDNQEKYRSALDLKLSMDKDPLILLEKEAINVFGLSPFEIEEIKAEAQ
HHHHHHHHCCCCCCHHHHHHHHHCEEEECCCCCEEEEEECCCEEECCCCCHHHHHHHHHH
EEVRKSCEIAEALPFPSKGSTSHEVFSPYTETLIDYENSESAQNLRNSEPKVMRDAISEA
HHHHHHHHHHHHCCCCCCCCCCCHHHCCHHHHHHCCCCCHHHHHHCCCCHHHHHHHHHHH
LVEEMTRDSGVIVFGEDVAGDKGGVFGVTRNLTEKFGPQRCFNSPLAEATIIGTAIGMAL
HHHHHHCCCCEEEECCCCCCCCCCEEEEHHHHHHHCCHHHHHCCCCHHHHHHHHHHHHHH
DGIHKPVVEIQFADYIWPGINQLFSEASSIYYRSAGEWEVPLVIRAPSGGYIQGGPYHSQ
HHCCCCEEEEEEHHHHCCCHHHHHHHHHHEEEECCCCEECEEEEECCCCCCCCCCCCCCH
SIEGFLAHCPGIKVAYPSNAADAKALLKAAIRDPNPVVFLEHKALYQRRIFSACPVFSHD
HHHHHHHHCCCCEEECCCCCHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHCCCCCCC
YVLPFGKAAIVHPGKDLTIVSWGMPLVLSLEVAQELASRGISIEVIDLRTMVPCDFATVL
CCCCCCCEEEEECCCCEEEEECCCCCEEEHHHHHHHHHCCCEEEEEEECCCCCCCHHHHH
KSLEKTGRLLVIHEASEFCGFGSELVATMSEQGYAYLDAPIRRLGGLHAPVPYSKVLENE
HHHHHCCCEEEEEECHHHHCCCHHHHHHHHHCCCEEECHHHHHHCCCCCCCCHHHHHHHC
VLPHKESILQAAKSLAEF
CCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
GVVQNQVISSIRDVLKLVWELRFAEHKMLLLSRQSGSGGTFQLSCAGHELAGVLAGKSL
CCHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEECCCCCCEEEEEECCCHHHHHHHCCCC
IPGKDWSFPYYRDQGFPIGLGCDLSEIFASFLARTTPNHSSARMMPYHYSHKKLRICCQS
CCCCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHCCCCCCCCEECCEECCCCCEEEEHHC
SVVGTQFLQAAGRAWAVKHSSADEVVYVSGGDGATSQGEFHEMLNFVALHQLPLITVIQN
CHHHHHHHHHCCCEEEEECCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHCCCEEEEEEC
NHWAISVPFEDQCGADLASLGRCHQGLAVYEVDGGNYTSLTETFSHAVDQARQHSVPALI
CCEEEECCCCCCCCCCHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCEEH
LIDVVRLSSHSNSDNQEKYRSALDLKLSMDKDPLILLEKEAINVFGLSPFEIEEIKAEAQ
HHHHHHHHCCCCCCHHHHHHHHHCEEEECCCCCEEEEEECCCEEECCCCCHHHHHHHHHH
EEVRKSCEIAEALPFPSKGSTSHEVFSPYTETLIDYENSESAQNLRNSEPKVMRDAISEA
HHHHHHHHHHHHCCCCCCCCCCCHHHCCHHHHHHCCCCCHHHHHHCCCCHHHHHHHHHHH
LVEEMTRDSGVIVFGEDVAGDKGGVFGVTRNLTEKFGPQRCFNSPLAEATIIGTAIGMAL
HHHHHHCCCCEEEECCCCCCCCCCEEEEHHHHHHHCCHHHHHCCCCHHHHHHHHHHHHHH
DGIHKPVVEIQFADYIWPGINQLFSEASSIYYRSAGEWEVPLVIRAPSGGYIQGGPYHSQ
HHCCCCEEEEEEHHHHCCCHHHHHHHHHHEEEECCCCEECEEEEECCCCCCCCCCCCCCH
SIEGFLAHCPGIKVAYPSNAADAKALLKAAIRDPNPVVFLEHKALYQRRIFSACPVFSHD
HHHHHHHHCCCCEEECCCCCHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHCCCCCCC
YVLPFGKAAIVHPGKDLTIVSWGMPLVLSLEVAQELASRGISIEVIDLRTMVPCDFATVL
CCCCCCCEEEEECCCCEEEEECCCCCEEEHHHHHHHHHCCCEEEEEEECCCCCCCHHHHH
KSLEKTGRLLVIHEASEFCGFGSELVATMSEQGYAYLDAPIRRLGGLHAPVPYSKVLENE
HHHHHCCCEEEEEECHHHHCCCHHHHHHHHHCCCEEECHHHHHHCCCCCCCCHHHHHHHC
VLPHKESILQAAKSLAEF
CCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8504804; 8969508; 9384377 [H]