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The map label for this gene is lon

Identifier: 15835564

GI number: 15835564

Start: 39446

End: 41905

Strand: Reverse

Name: lon

Synonym: CPj0027

Alternate gene names: 15835564

Gene position: 41905-39446 (Counterclockwise)

Preceding gene: 15835565

Following gene: 15835563

Centisome position: 3.42

GC content: 40.81

Gene sequence:

>2460_bases
GTGGACTCTACAACCAATAGCGACTCCCCCATCTTAGATCCAAATCCAGAAGATGTTGAAAAGCTTTTAGATGAATCTGA
AGAGGAATCCGAAGATCAGTCTACGGAGCGTTTGCTGCCTTCTGAGTTATTTATCCTGCCATTAAATAAACGACCTTTTT
TCCCCGGAATGGCGGCTCCCATTCTTATTGAGTCGGGTCCTTATTATGAAGTATTAAAGGTTTTAGCGAAGTCGTCTCAA
AAATATATTGGTCTTGTCTTAACCAAAAAAGAGAACGCCGATATTTTAAAAGTGAGCTTCAACCAGCTGCATAAAACTGG
AGTTGCCGCAAGAATCCTCCGTATCATGCCAATCGAGGGTGGCAGTGCTCAAGTTCTTTTAAGCATTGAAGAGCGTATTC
GGATTATAGAACCCATTAAAGACAAATATCTTAAAGCTCGAGTTTCCTATCATGCGGACAATAAAGAGCTTACAGAAGAG
CTAAAAGCGTACTCTATTAGTATTGTCTCTGTCATCAAAGACCTTTTAAAACTAAATCCTCTCTTTAAAGAAGAACTACA
AATTTTTCTTGGTCATTCGGATTTTACTGAACCAGGCAAGCTTGCGGATTTCTCTGTTGCTTTAACAACAGCAACTCGGG
AAGAGCTCCAAGAGGTCTTAGAGACCACCAACATGCATGATCGCATTGATAAGGCACTGATCTTACTAAAAAAGGAATTA
GACTTAAGCCGCCTCCAGAGCAGCATTAATCAAAAAATTGAAGCTACGATTACAAAAAGCCAAAAGGAATTCTTCTTAAA
AGAGCAGTTAAAAACGATTAAAAAAGAACTGGGGTTAGAGAAAGAAGACCGCGCTATTGATATAGAGAAGTTTTCGGAAA
GGCTAAGAAAACGCCATGTTCCTGATTATGCTATGGAAGTGATTCAAGATGAAATTGAAAAACTTCAGACTTTAGAAACT
TCTTCGGCGGAATATACCGTATGCCGCAATTACCTGGATTGGCTGACAATCATTCCTTGGGGCATACAAAGTAAAGAATA
CCATGACTTAAAGAAAGCAGAAATCGTCCTGAACAAGGATCACTATGGCCTTGATGAGATTAAACAACGCATTCTCGAGT
TAATCAGTGTAGGTAAGCTTTCCAAAGGATTAAAAGGAAGTATCATCTGTCTTGTAGGCCCTCCAGGAGTTGGGAAAACA
AGCATAGGGCGCAGCATTGCTAAAGTCCTGCATAGAAAGTTCTTCCGTTTCTCAGTAGGAGGCATGCGTGATGAGGCCGA
GATCAAGGGGCATCGCCGCACCTATATTGGGGCAATGCCAGGAAAAATGGTCCAGGCGCTCAAGCAAAGCCAAGCTATGA
ATCCTGTGATTATGATTGATGAGGTAGATAAAATTGGTGCGAGTTATCATGGAGATCCTGCCTCTGCCTTATTAGAGGTT
TTAGATCCTGAGCAAAACAAAGATTTTCTTGATCATTATTTAGACGTACGTGTTGATCTATCCAATGTACTATTCATTTT
AACTGCCAATGTTCTAGATACCATTCCGGATCCTCTTTTAGATCGCATGGAGATTCTCCGACTTTCTGGCTACATTTTAG
AAGAGAAACTTCAAATTGCTAAAAAGTATCTAGTTCCCAAAGCTCGCAAAGAAATCGGTTTAACAGCAAGCGAAGTGAAT
TTCCAACCTGAAGCTTTAAAGTACATGATCAATAACTATGCACGAGAAGCTGGGGTACGTACTCTTAATGGGAATATCAA
AAAAGTATTGAGGAAAGTTGCTTTAAAGATTGTTCAAAATCAAGAAAAACCCAAATCTAAGAAGATTACTTTTAAAATCT
CTTCGAAAAATCTGCAGACCTACTTAGGGAAACCGATATTTTCTAGCGATCGCTTCTATGAATCCACTCCTGTAGGAGTG
GCCACAGGACTTGCCTGGACCTCTTTAGGTGGAGCAACGTTATATATAGAAAGTGTACAGGTGTCCTCACTCAAAACAGA
CATGCACCTTACAGGTCAGGCTGGGGAAGTAATGAAGGAGTCTTCTCAGATTGCTTGGACCTACCTTCACAGTGCTCTCC
ATCGGTATGCCCCAGGCTATACGTTCTTTCCAAAGTCTCAAGTACATATCCACATTCCTGAGGGAGCCACCCCTAAAGAC
GGTCCTTCTGCAGGAATTACTATGGTGACCTCTCTCCTTTCGTTGCTGTTGGAAACTCCGGTAGTGAATAATTTGGGAAT
GACTGGAGAAATTACTCTTACAGGTCGTGTTTTAGGTGTAGGAGGCATTCGAGAGAAACTGATTGCAGCTCGAAGATCAC
GATTGAACATCTTGATTTTCCCTGAAGACAACCGTAGAGACTATGAAGAGCTTCCTGCATATCTGAAAACAGGGTTGAAA
ATACATTTTGTTTCACACTATGATGATGTTCTCAAAGTTGCTTTTCCCAAGCTAAAATAG

Upstream 100 bases:

>100_bases
AATATGCAATCTTTTAAAATCGCTCCCTCTTTTTACCCTAGAGAAAAAGAGCCGTATTTACTGGAGCGACAGACAAATAT
AGCCGAGCATAAGGACAATT

Downstream 100 bases:

>100_bases
AAAGCCAAGTTGAACCCTTGTTCTCTTGAGAATCACTATTTTTATACGCATTAAGGTAGATTTAATGCGTATAAAAAAGT
CTGTATATTTACAAACAGAC

Product: Lon ATP-dependent protease

Products: NA

Alternate protein names: ATP-dependent protease La

Number of amino acids: Translated: 819; Mature: 819

Protein sequence:

>819_residues
MDSTTNSDSPILDPNPEDVEKLLDESEEESEDQSTERLLPSELFILPLNKRPFFPGMAAPILIESGPYYEVLKVLAKSSQ
KYIGLVLTKKENADILKVSFNQLHKTGVAARILRIMPIEGGSAQVLLSIEERIRIIEPIKDKYLKARVSYHADNKELTEE
LKAYSISIVSVIKDLLKLNPLFKEELQIFLGHSDFTEPGKLADFSVALTTATREELQEVLETTNMHDRIDKALILLKKEL
DLSRLQSSINQKIEATITKSQKEFFLKEQLKTIKKELGLEKEDRAIDIEKFSERLRKRHVPDYAMEVIQDEIEKLQTLET
SSAEYTVCRNYLDWLTIIPWGIQSKEYHDLKKAEIVLNKDHYGLDEIKQRILELISVGKLSKGLKGSIICLVGPPGVGKT
SIGRSIAKVLHRKFFRFSVGGMRDEAEIKGHRRTYIGAMPGKMVQALKQSQAMNPVIMIDEVDKIGASYHGDPASALLEV
LDPEQNKDFLDHYLDVRVDLSNVLFILTANVLDTIPDPLLDRMEILRLSGYILEEKLQIAKKYLVPKARKEIGLTASEVN
FQPEALKYMINNYAREAGVRTLNGNIKKVLRKVALKIVQNQEKPKSKKITFKISSKNLQTYLGKPIFSSDRFYESTPVGV
ATGLAWTSLGGATLYIESVQVSSLKTDMHLTGQAGEVMKESSQIAWTYLHSALHRYAPGYTFFPKSQVHIHIPEGATPKD
GPSAGITMVTSLLSLLLETPVVNNLGMTGEITLTGRVLGVGGIREKLIAARRSRLNILIFPEDNRRDYEELPAYLKTGLK
IHFVSHYDDVLKVAFPKLK

Sequences:

>Translated_819_residues
MDSTTNSDSPILDPNPEDVEKLLDESEEESEDQSTERLLPSELFILPLNKRPFFPGMAAPILIESGPYYEVLKVLAKSSQ
KYIGLVLTKKENADILKVSFNQLHKTGVAARILRIMPIEGGSAQVLLSIEERIRIIEPIKDKYLKARVSYHADNKELTEE
LKAYSISIVSVIKDLLKLNPLFKEELQIFLGHSDFTEPGKLADFSVALTTATREELQEVLETTNMHDRIDKALILLKKEL
DLSRLQSSINQKIEATITKSQKEFFLKEQLKTIKKELGLEKEDRAIDIEKFSERLRKRHVPDYAMEVIQDEIEKLQTLET
SSAEYTVCRNYLDWLTIIPWGIQSKEYHDLKKAEIVLNKDHYGLDEIKQRILELISVGKLSKGLKGSIICLVGPPGVGKT
SIGRSIAKVLHRKFFRFSVGGMRDEAEIKGHRRTYIGAMPGKMVQALKQSQAMNPVIMIDEVDKIGASYHGDPASALLEV
LDPEQNKDFLDHYLDVRVDLSNVLFILTANVLDTIPDPLLDRMEILRLSGYILEEKLQIAKKYLVPKARKEIGLTASEVN
FQPEALKYMINNYAREAGVRTLNGNIKKVLRKVALKIVQNQEKPKSKKITFKISSKNLQTYLGKPIFSSDRFYESTPVGV
ATGLAWTSLGGATLYIESVQVSSLKTDMHLTGQAGEVMKESSQIAWTYLHSALHRYAPGYTFFPKSQVHIHIPEGATPKD
GPSAGITMVTSLLSLLLETPVVNNLGMTGEITLTGRVLGVGGIREKLIAARRSRLNILIFPEDNRRDYEELPAYLKTGLK
IHFVSHYDDVLKVAFPKLK
>Mature_819_residues
MDSTTNSDSPILDPNPEDVEKLLDESEEESEDQSTERLLPSELFILPLNKRPFFPGMAAPILIESGPYYEVLKVLAKSSQ
KYIGLVLTKKENADILKVSFNQLHKTGVAARILRIMPIEGGSAQVLLSIEERIRIIEPIKDKYLKARVSYHADNKELTEE
LKAYSISIVSVIKDLLKLNPLFKEELQIFLGHSDFTEPGKLADFSVALTTATREELQEVLETTNMHDRIDKALILLKKEL
DLSRLQSSINQKIEATITKSQKEFFLKEQLKTIKKELGLEKEDRAIDIEKFSERLRKRHVPDYAMEVIQDEIEKLQTLET
SSAEYTVCRNYLDWLTIIPWGIQSKEYHDLKKAEIVLNKDHYGLDEIKQRILELISVGKLSKGLKGSIICLVGPPGVGKT
SIGRSIAKVLHRKFFRFSVGGMRDEAEIKGHRRTYIGAMPGKMVQALKQSQAMNPVIMIDEVDKIGASYHGDPASALLEV
LDPEQNKDFLDHYLDVRVDLSNVLFILTANVLDTIPDPLLDRMEILRLSGYILEEKLQIAKKYLVPKARKEIGLTASEVN
FQPEALKYMINNYAREAGVRTLNGNIKKVLRKVALKIVQNQEKPKSKKITFKISSKNLQTYLGKPIFSSDRFYESTPVGV
ATGLAWTSLGGATLYIESVQVSSLKTDMHLTGQAGEVMKESSQIAWTYLHSALHRYAPGYTFFPKSQVHIHIPEGATPKD
GPSAGITMVTSLLSLLLETPVVNNLGMTGEITLTGRVLGVGGIREKLIAARRSRLNILIFPEDNRRDYEELPAYLKTGLK
IHFVSHYDDVLKVAFPKLK

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain

Homologues:

Organism=Homo sapiens, GI21396489, Length=671, Percent_Identity=52.1609538002981, Blast_Score=724, Evalue=0.0,
Organism=Homo sapiens, GI31377667, Length=567, Percent_Identity=41.2698412698413, Blast_Score=456, Evalue=1e-128,
Organism=Escherichia coli, GI1786643, Length=785, Percent_Identity=40.2547770700637, Blast_Score=553, Evalue=1e-158,
Organism=Caenorhabditis elegans, GI17505831, Length=695, Percent_Identity=47.6258992805755, Blast_Score=647, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17556486, Length=634, Percent_Identity=33.2807570977918, Blast_Score=387, Evalue=1e-107,
Organism=Saccharomyces cerevisiae, GI6319449, Length=715, Percent_Identity=48.1118881118881, Blast_Score=687, Evalue=0.0,
Organism=Drosophila melanogaster, GI24666867, Length=670, Percent_Identity=52.5373134328358, Blast_Score=716, Evalue=0.0,
Organism=Drosophila melanogaster, GI221513036, Length=670, Percent_Identity=52.5373134328358, Blast_Score=716, Evalue=0.0,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): LON_CHLPN (Q9Z9F4)

Other databases:

- EMBL:   AE001363
- EMBL:   AE002161
- EMBL:   BA000008
- EMBL:   AE009440
- PIR:   B72128
- PIR:   E86494
- RefSeq:   NP_224235.1
- RefSeq:   NP_300088.1
- RefSeq:   NP_445291.1
- RefSeq:   NP_876307.1
- ProteinModelPortal:   Q9Z9F4
- MEROPS:   S16.002
- GeneID:   1466714
- GeneID:   894928
- GeneID:   918819
- GeneID:   963156
- GenomeReviews:   AE001363_GR
- GenomeReviews:   AE002161_GR
- GenomeReviews:   AE009440_GR
- GenomeReviews:   BA000008_GR
- KEGG:   cpa:CP0749
- KEGG:   cpn:CPn0027
- KEGG:   cpt:CpB0031
- TIGR:   CP_0749
- HOGENOM:   HBG566281
- OMA:   NIKNGIN
- PhylomeDB:   Q9Z9F4
- ProtClustDB:   CLSK2459232
- BioCyc:   CPNE115711:CP_0749-MONOMER
- BioCyc:   CPNE115713:CPN0027-MONOMER
- BioCyc:   CPNE138677:CPJ0027-MONOMER
- BioCyc:   CPNE182082:CPB0031-MONOMER
- BRENDA:   3.4.21.53
- GO:   GO:0005737
- GO:   GO:0006508
- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568
- PRINTS:   PR00830
- SMART:   SM00382
- SMART:   SM00464
- TIGRFAMs:   TIGR00763

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C; SSF88697 PUA-like; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =3.4.21.53

Molecular weight: Translated: 92277; Mature: 92277

Theoretical pI: Translated: 8.64; Mature: 8.64

Prosite motif: PS01046 LON_SER

Important sites: ACT_SITE 723-723 ACT_SITE 766-766

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDSTTNSDSPILDPNPEDVEKLLDESEEESEDQSTERLLPSELFILPLNKRPFFPGMAAP
CCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCC
ILIESGPYYEVLKVLAKSSQKYIGLVLTKKENADILKVSFNQLHKTGVAARILRIMPIEG
EEECCCCHHHHHHHHHHCCCCEEEEEEEECCCCCEEEEEHHHHHHHHHHHHHHHHEECCC
GSAQVLLSIEERIRIIEPIKDKYLKARVSYHADNKELTEELKAYSISIVSVIKDLLKLNP
CCCEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
LFKEELQIFLGHSDFTEPGKLADFSVALTTATREELQEVLETTNMHDRIDKALILLKKEL
HHHHHHHEEECCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHC
DLSRLQSSINQKIEATITKSQKEFFLKEQLKTIKKELGLEKEDRAIDIEKFSERLRKRHV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECHHHHHHHHHHCCC
PDYAMEVIQDEIEKLQTLETSSAEYTVCRNYLDWLTIIPWGIQSKEYHDLKKAEIVLNKD
CHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHCCCCEEEEECCC
HYGLDEIKQRILELISVGKLSKGLKGSIICLVGPPGVGKTSIGRSIAKVLHRKFFRFSVG
CCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCC
GMRDEAEIKGHRRTYIGAMPGKMVQALKQSQAMNPVIMIDEVDKIGASYHGDPASALLEV
CCCCHHHHCCCCEEEEECCCHHHHHHHHHHHCCCCEEEEECHHHHCCCCCCCHHHHHHHH
LDPEQNKDFLDHYLDVRVDLSNVLFILTANVLDTIPDPLLDRMEILRLSGYILEEKLQIA
HCCCCCHHHHHHHHHHEECHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
KKYLVPKARKEIGLTASEVNFQPEALKYMINNYAREAGVRTLNGNIKKVLRKVALKIVQN
HHHHCCHHHHHHCCCHHHCCCCHHHHHHHHHHHHHHHCCEEECCHHHHHHHHHHHHHHHC
QEKPKSKKITFKISSKNLQTYLGKPIFSSDRFYESTPVGVATGLAWTSLGGATLYIESVQ
CCCCCCCEEEEEEECCCHHHHHCCCCCCCCCCCCCCCCCHHHCCHHHCCCCEEEEEEEEE
VSSLKTDMHLTGQAGEVMKESSQIAWTYLHSALHRYAPGYTFFPKSQVHIHIPEGATPKD
HHHHCCCEEECCCHHHHHHHCCHHHHHHHHHHHHHHCCCCEECCCCEEEEECCCCCCCCC
GPSAGITMVTSLLSLLLETPVVNNLGMTGEITLTGRVLGVGGIREKLIAARRSRLNILIF
CCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEEEECCHHHHHHHHHHHCCCEEEEE
PEDNRRDYEELPAYLKTGLKIHFVSHYDDVLKVAFPKLK
CCCCCCCHHHHHHHHHCCCEEEEEHHHHHHHHHHCCCCC
>Mature Secondary Structure
MDSTTNSDSPILDPNPEDVEKLLDESEEESEDQSTERLLPSELFILPLNKRPFFPGMAAP
CCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCC
ILIESGPYYEVLKVLAKSSQKYIGLVLTKKENADILKVSFNQLHKTGVAARILRIMPIEG
EEECCCCHHHHHHHHHHCCCCEEEEEEEECCCCCEEEEEHHHHHHHHHHHHHHHHEECCC
GSAQVLLSIEERIRIIEPIKDKYLKARVSYHADNKELTEELKAYSISIVSVIKDLLKLNP
CCCEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
LFKEELQIFLGHSDFTEPGKLADFSVALTTATREELQEVLETTNMHDRIDKALILLKKEL
HHHHHHHEEECCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHC
DLSRLQSSINQKIEATITKSQKEFFLKEQLKTIKKELGLEKEDRAIDIEKFSERLRKRHV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECHHHHHHHHHHCCC
PDYAMEVIQDEIEKLQTLETSSAEYTVCRNYLDWLTIIPWGIQSKEYHDLKKAEIVLNKD
CHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHCCCCEEEEECCC
HYGLDEIKQRILELISVGKLSKGLKGSIICLVGPPGVGKTSIGRSIAKVLHRKFFRFSVG
CCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCC
GMRDEAEIKGHRRTYIGAMPGKMVQALKQSQAMNPVIMIDEVDKIGASYHGDPASALLEV
CCCCHHHHCCCCEEEEECCCHHHHHHHHHHHCCCCEEEEECHHHHCCCCCCCHHHHHHHH
LDPEQNKDFLDHYLDVRVDLSNVLFILTANVLDTIPDPLLDRMEILRLSGYILEEKLQIA
HCCCCCHHHHHHHHHHEECHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
KKYLVPKARKEIGLTASEVNFQPEALKYMINNYAREAGVRTLNGNIKKVLRKVALKIVQN
HHHHCCHHHHHHCCCHHHCCCCHHHHHHHHHHHHHHHCCEEECCHHHHHHHHHHHHHHHC
QEKPKSKKITFKISSKNLQTYLGKPIFSSDRFYESTPVGVATGLAWTSLGGATLYIESVQ
CCCCCCCEEEEEEECCCHHHHHCCCCCCCCCCCCCCCCCHHHCCHHHCCCCEEEEEEEEE
VSSLKTDMHLTGQAGEVMKESSQIAWTYLHSALHRYAPGYTFFPKSQVHIHIPEGATPKD
HHHHCCCEEECCCHHHHHHHCCHHHHHHHHHHHHHHCCCCEECCCCEEEEECCCCCCCCC
GPSAGITMVTSLLSLLLETPVVNNLGMTGEITLTGRVLGVGGIREKLIAARRSRLNILIF
CCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEEEECCHHHHHHHHHHHCCCEEEEE
PEDNRRDYEELPAYLKTGLKIHFVSHYDDVLKVAFPKLK
CCCCCCCHHHHHHHHHCCCEEEEEHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362