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Identifier: 16752697

GI number: 16752697

Start: 452710

End: 453849

Strand: Direct

Name: Not Available

Synonym: CP0415

Alternate gene names: 16752697

Gene position: 452710-453849 (Clockwise)

Preceding gene: 16752696

Following gene: 16752698

Centisome position: 36.81

GC content: 40.3

Gene sequence:

>1140_bases
TTGAAACATTTAGCCGTTCTTGGGTCAACAGGTAGTATTGGCCGTCAAACATTAGAGATTGTGCGGCGCTATCCTTCAGA
ATTTAAAATTATTTCTATGGCTTCTTATGGAAATAATCTAAGGTTATTTTTTCAGCAACTAGAGGAGTTTGCTCCGTTAG
CCGCAGCGGTCTATAACGAAGAGGTTTATAACGAGGCCTGTCAGCGATTCCCCCATATGCAATTTTTCCTAGGCCAGGAG
GGTTTAACCCAACTTTGTATCATGGATACAGTCACTACTGTCGTTGCTGCTTCTTCAGGAATCGAGGCGCTACCCGCGAT
TCTAGAGTCGATGAAAAAAGGAAAAGCACTAGCTTTAGCAAACAAAGAAATTTTAGTTTGTGCTGGCGAATTGGTTTCTA
AGACTGCAAAGGAAAATGGTATAAAAGTTCTTCCTATTGATAGCGAGCATAATGCTTTGTATCAATGTTTAGAAGGCAGG
ACGATTGAGGGAATCAAGAAACTGATTCTTACAGCTTCTGGAGGGCCTCTGCTCAACAAGTCTTTAGAAGAGCTTTCTTG
TGTAACAAAACAAGATGTTTTGAACCATCCTATATGGAATATGGGTTCAAAAGTGACTGTGGACTCATCCACATTGGTCA
ATAAGGGACTCGAAATTATCGAGGCGTATTGGCTGTTTGGTTTAGAAAATRTTGAAATCCTGGCTGTAATTCATCCTCAG
AGCTTAATCCATGGTATGGTAGAGTTTTTAGATGGGAGTGTGATTTCTATCATGAATCCGCCTGATATGCTCTTCCCAAT
ACAATACGCTTTAACAGCTCCAGAGCGTTTTGCATCTCCTAGGGATGGTATGGATTTTTCGAAGAAACAAACTTTAGAAT
TTTTTCCGGTAGATGAGGAGCGATTTCCTAGTATCCGTTTAGCACAACAGGTATTAGAGAAACAGGGGTCTTCTGGAAGC
TTTTTTAATGCAGCCAATGAAGTATTAGTGCGGAGGTTCCTTTGCGAAGAGATTTCTTGGTGTGACATTTTACGCAAATT
AACGACTCTTATGGAATGTCATAAGGTTTATGCCTGCCACTCTTTAGAAGATATTTTAGAAGTAGATGGTGAGGCTAGAG
CTCTTGCTCAAGAAATATAA

Upstream 100 bases:

>100_bases
GTTTAGTCCACTTTAGTTAGAAATAGTATCAATAGAGAATTGACAATTCCTCGACTTGCGGAGTATGATTCTCTTTTTCA
CCTAGTTAAAGGTAGCATGC

Downstream 100 bases:

>100_bases
TCGAGTAGGTATATGACAATAATCTATTTTATTCTAGCAGCCCTAGCTTTAGGGATTTTAGTGTTAATTCATGAACTTGG
TCATCTGGTAGTAGCAAAAG

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase [H]

Number of amino acids: Translated: 379; Mature: 379

Protein sequence:

>379_residues
MKHLAVLGSTGSIGRQTLEIVRRYPSEFKIISMASYGNNLRLFFQQLEEFAPLAAAVYNEEVYNEACQRFPHMQFFLGQE
GLTQLCIMDTVTTVVAASSGIEALPAILESMKKGKALALANKEILVCAGELVSKTAKENGIKVLPIDSEHNALYQCLEGR
TIEGIKKLILTASGGPLLNKSLEELSCVTKQDVLNHPIWNMGSKVTVDSSTLVNKGLEIIEAYWLFGLENXEILAVIHPQ
SLIHGMVEFLDGSVISIMNPPDMLFPIQYALTAPERFASPRDGMDFSKKQTLEFFPVDEERFPSIRLAQQVLEKQGSSGS
FFNAANEVLVRRFLCEEISWCDILRKLTTLMECHKVYACHSLEDILEVDGEARALAQEI

Sequences:

>Translated_379_residues
MKHLAVLGSTGSIGRQTLEIVRRYPSEFKIISMASYGNNLRLFFQQLEEFAPLAAAVYNEEVYNEACQRFPHMQFFLGQE
GLTQLCIMDTVTTVVAASSGIEALPAILESMKKGKALALANKEILVCAGELVSKTAKENGIKVLPIDSEHNALYQCLEGR
TIEGIKKLILTASGGPLLNKSLEELSCVTKQDVLNHPIWNMGSKVTVDSSTLVNKGLEIIEAYWLFGLENXEILAVIHPQ
SLIHGMVEFLDGSVISIMNPPDMLFPIQYALTAPERFASPRDGMDFSKKQTLEFFPVDEERFPSIRLAQQVLEKQGSSGS
FFNAANEVLVRRFLCEEISWCDILRKLTTLMECHKVYACHSLEDILEVDGEARALAQEI
>Mature_379_residues
MKHLAVLGSTGSIGRQTLEIVRRYPSEFKIISMASYGNNLRLFFQQLEEFAPLAAAVYNEEVYNEACQRFPHMQFFLGQE
GLTQLCIMDTVTTVVAASSGIEALPAILESMKKGKALALANKEILVCAGELVSKTAKENGIKVLPIDSEHNALYQCLEGR
TIEGIKKLILTASGGPLLNKSLEELSCVTKQDVLNHPIWNMGSKVTVDSSTLVNKGLEIIEAYWLFGLENXEILAVIHPQ
SLIHGMVEFLDGSVISIMNPPDMLFPIQYALTAPERFASPRDGMDFSKKQTLEFFPVDEERFPSIRLAQQVLEKQGSSGS
FFNAANEVLVRRFLCEEISWCDILRKLTTLMECHKVYACHSLEDILEVDGEARALAQEI

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) [H]

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family [H]

Homologues:

Organism=Escherichia coli, GI1786369, Length=393, Percent_Identity=35.6234096692112, Blast_Score=245, Evalue=3e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom [H]

EC number: =1.1.1.267 [H]

Molecular weight: Translated: 42108; Mature: 42108

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHLAVLGSTGSIGRQTLEIVRRYPSEFKIISMASYGNNLRLFFQQLEEFAPLAAAVYNE
CCCEEEECCCCCHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
EVYNEACQRFPHMQFFLGQEGLTQLCIMDTVTTVVAASSGIEALPAILESMKKGKALALA
HHHHHHHHHCCCCEEHHCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEE
NKEILVCAGELVSKTAKENGIKVLPIDSEHNALYQCLEGRTIEGIKKLILTASGGPLLNK
CCCEEEECHHHHHHHHHHCCCEEEEECCCHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHH
SLEELSCVTKQDVLNHPIWNMGSKVTVDSSTLVNKGLEIIEAYWLFGLENXEILAVIHPQ
HHHHHHHHHHHHHHCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHCCCCCCEEEEECHH
SLIHGMVEFLDGSVISIMNPPDMLFPIQYALTAPERFASPRDGMDFSKKQTLEFFPVDEE
HHHHHHHHHHCCCEEEECCCCCCEEHHHHHHCCHHHHCCCCCCCCCCCCCCEEEECCCHH
RFPSIRLAQQVLEKQGSSGSFFNAANEVLVRRFLCEEISWCDILRKLTTLMECHKVYACH
HCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLEDILEVDGEARALAQEI
HHHHHHHCCCHHHHHHHCC
>Mature Secondary Structure
MKHLAVLGSTGSIGRQTLEIVRRYPSEFKIISMASYGNNLRLFFQQLEEFAPLAAAVYNE
CCCEEEECCCCCHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
EVYNEACQRFPHMQFFLGQEGLTQLCIMDTVTTVVAASSGIEALPAILESMKKGKALALA
HHHHHHHHHCCCCEEHHCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEE
NKEILVCAGELVSKTAKENGIKVLPIDSEHNALYQCLEGRTIEGIKKLILTASGGPLLNK
CCCEEEECHHHHHHHHHHCCCEEEEECCCHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHH
SLEELSCVTKQDVLNHPIWNMGSKVTVDSSTLVNKGLEIIEAYWLFGLENXEILAVIHPQ
HHHHHHHHHHHHHHCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHCCCCCCEEEEECHH
SLIHGMVEFLDGSVISIMNPPDMLFPIQYALTAPERFASPRDGMDFSKKQTLEFFPVDEE
HHHHHHHHHHCCCEEEECCCCCCEEHHHHHHCCHHHHCCCCCCCCCCCCCCEEEECCCHH
RFPSIRLAQQVLEKQGSSGSFFNAANEVLVRRFLCEEISWCDILRKLTTLMECHKVYACH
HCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLEDILEVDGEARALAQEI
HHHHHHHCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362 [H]