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Identifier: 16752379

GI number: 16752379

Start: 100485

End: 101261

Strand: Direct

Name: Not Available

Synonym: CP0086

Alternate gene names: 16752379

Gene position: 100485-101261 (Clockwise)

Preceding gene: 16752378

Following gene: 16752380

Centisome position: 8.17

GC content: 38.66

Gene sequence:

>777_bases
ATGAACAGACGGTGGAATTTAGTTTTAGCAACAGTAGCTCTGGCACTCTCCGTCGCTTCTTGTGACGTACGGTCTAAGGA
TAAAGACAAGGATCAGGGGTCGTTAGTGGAATATAAAGATAACAAAGATACCAATGACATAGAATTATCYGATAATCAAA
AGTTATCCAGAACATTTGGTCATTTATTAGCACGCCAATTACGCAAGTCAGAAGATATGTTTTTTGATATTGCAGAAGTG
GCTAAGGGGTTGCAGGCGGAATTGGTTTGTAAAAGTGCTCCTTTAACAGAAACAGAGTATGAAGAAAAAATGGCTGAAGT
ACAGAAGTTGGTTTTTGAAAAAAAATCAAAAGAAAATCTTTCATTGGCAGAAAAATTCTTAAAAGAAAATAGCAAGAACG
CTGGTGTTGTTGAAGTGCAACCAAGTAAATTGCAATACAAAATTATTAAAGAAGGTGCAGGGAAAGCAATTTCAGGTAAA
CCTTCAGCTCTATTGCACTACAAGGGTTCCTTCATCAATGGCCAAGTATTTAGCAGTTCAGAAGGCAACAATGAGCCTAT
CTTGCTTCCTCTAGGCCAAACAATTCCTGGTTTTGCTTTAGGTATGCAGGGCATGAAAGAAGGAGAAACTCGAGTTCTCT
ACATCCATCCTGATCTTGCTTACGGAACCGCAGGACAACTTCCTCCAAACTCTTTATTAATTTTTGAAATTAACTTGATT
CAGGCTTCAGCAGATGAAGTTGCTGCTGTACCCCAAGAAGGAAATCAAGGTGAATGA

Upstream 100 bases:

>100_bases
TAAAAGAGCTAAGTATTAAGGTAGCTTTTTGATATAAGTTGTAATTGCTTCGGGCATGTAGCATAGTCGTTGCCTTAAGA
TCAAAGATAGGAGAAGGAAA

Downstream 100 bases:

>100_bases
GAGTAGTTCTTCATTGTCCTGATATTCCACAGAATACTGGAAATATAGGTAGAACTTGTGTAGCCCTAGGCGCCGAACTC
ATTTTGGTTCGGCCCTTGGG

Product: peptidyl-prolyl cis-trans isomerase Mip

Products: NA

Alternate protein names: PPIase; Rotamase

Number of amino acids: Translated: 258; Mature: 258

Protein sequence:

>258_residues
MNRRWNLVLATVALALSVASCDVRSKDKDKDQGSLVEYKDNKDTNDIELSDNQKLSRTFGHLLARQLRKSEDMFFDIAEV
AKGLQAELVCKSAPLTETEYEEKMAEVQKLVFEKKSKENLSLAEKFLKENSKNAGVVEVQPSKLQYKIIKEGAGKAISGK
PSALLHYKGSFINGQVFSSSEGNNEPILLPLGQTIPGFALGMQGMKEGETRVLYIHPDLAYGTAGQLPPNSLLIFEINLI
QASADEVAAVPQEGNQGE

Sequences:

>Translated_258_residues
MNRRWNLVLATVALALSVASCDVRSKDKDKDQGSLVEYKDNKDTNDIELSDNQKLSRTFGHLLARQLRKSEDMFFDIAEV
AKGLQAELVCKSAPLTETEYEEKMAEVQKLVFEKKSKENLSLAEKFLKENSKNAGVVEVQPSKLQYKIIKEGAGKAISGK
PSALLHYKGSFINGQVFSSSEGNNEPILLPLGQTIPGFALGMQGMKEGETRVLYIHPDLAYGTAGQLPPNSLLIFEINLI
QASADEVAAVPQEGNQGE
>Mature_258_residues
MNRRWNLVLATVALALSVASCDVRSKDKDKDQGSLVEYKDNKDTNDIELSDNQKLSRTFGHLLARQLRKSEDMFFDIAEV
AKGLQAELVCKSAPLTETEYEEKMAEVQKLVFEKKSKENLSLAEKFLKENSKNAGVVEVQPSKLQYKIIKEGAGKAISGK
PSALLHYKGSFINGQVFSSSEGNNEPILLPLGQTIPGFALGMQGMKEGETRVLYIHPDLAYGTAGQLPPNSLLIFEINLI
QASADEVAAVPQEGNQGE

Specific function: PPIases accelerate the folding of proteins

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Cell outer membrane; Peripheral membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain

Homologues:

Organism=Homo sapiens, GI224809329, Length=88, Percent_Identity=40.9090909090909, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI224809327, Length=88, Percent_Identity=40.9090909090909, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI4758384, Length=88, Percent_Identity=40.9090909090909, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI224809331, Length=88, Percent_Identity=40.9090909090909, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1789745, Length=206, Percent_Identity=28.6407766990291, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI87082390, Length=146, Percent_Identity=33.5616438356164, Blast_Score=79, Evalue=3e-16,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): MIP_CHLPN (Q9Z7P3)

Other databases:

- EMBL:   AE001363
- EMBL:   AE002161
- EMBL:   BA000008
- EMBL:   AE009440
- PIR:   B86573
- PIR:   F72052
- RefSeq:   NP_224857.1
- RefSeq:   NP_300717.1
- RefSeq:   NP_444638.1
- RefSeq:   NP_876959.1
- ProteinModelPortal:   Q9Z7P3
- SMR:   Q9Z7P3
- GeneID:   1467366
- GeneID:   895248
- GeneID:   919423
- GeneID:   963775
- GenomeReviews:   AE001363_GR
- GenomeReviews:   AE002161_GR
- GenomeReviews:   AE009440_GR
- GenomeReviews:   BA000008_GR
- KEGG:   cpa:CP0086
- KEGG:   cpn:CPn0661
- KEGG:   cpt:CpB0687
- TIGR:   CP_0086
- HOGENOM:   HBG731200
- OMA:   KLQYRIV
- PhylomeDB:   Q9Z7P3
- ProtClustDB:   CLSK871434
- BioCyc:   CPNE115711:CP_0086-MONOMER
- BioCyc:   CPNE115713:CPN0661-MONOMER
- BioCyc:   CPNE138677:CPJ0661-MONOMER
- BioCyc:   CPNE182082:CPB0687-MONOMER
- BRENDA:   5.2.1.8
- InterPro:   IPR001179
- InterPro:   IPR000774
- Gene3D:   G3DSA:1.10.287.460
- PANTHER:   PTHR10516

Pfam domain/function: PF00254 FKBP_C; PF01346 FKBP_N

EC number: =5.2.1.8

Molecular weight: Translated: 28331; Mature: 28331

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: PS50059 FKBP_PPIASE; PS51257 PROKAR_LIPOPROTEIN; PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRRWNLVLATVALALSVASCDVRSKDKDKDQGSLVEYKDNKDTNDIELSDNQKLSRTFG
CCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCCCCEEECCCCHHHHHHH
HLLARQLRKSEDMFFDIAEVAKGLQAELVCKSAPLTETEYEEKMAEVQKLVFEKKSKENL
HHHHHHHHHHCCCEEEHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCH
SLAEKFLKENSKNAGVVEVQPSKLQYKIIKEGAGKAISGKPSALLHYKGSFINGQVFSSS
HHHHHHHHCCCCCCCEEEECCCCEEEEEEECCCCCCCCCCCCEEEEECCCEECCEEEECC
EGNNEPILLPLGQTIPGFALGMQGMKEGETRVLYIHPDLAYGTAGQLPPNSLLIFEINLI
CCCCCCEEEECCCCCCCHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCCCCEEEEEEEEE
QASADEVAAVPQEGNQGE
ECCCHHHEECCCCCCCCC
>Mature Secondary Structure
MNRRWNLVLATVALALSVASCDVRSKDKDKDQGSLVEYKDNKDTNDIELSDNQKLSRTFG
CCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCCCCEEECCCCHHHHHHH
HLLARQLRKSEDMFFDIAEVAKGLQAELVCKSAPLTETEYEEKMAEVQKLVFEKKSKENL
HHHHHHHHHHCCCEEEHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCH
SLAEKFLKENSKNAGVVEVQPSKLQYKIIKEGAGKAISGKPSALLHYKGSFINGQVFSSS
HHHHHHHHCCCCCCCEEEECCCCEEEEEEECCCCCCCCCCCCEEEEECCCEECCEEEECC
EGNNEPILLPLGQTIPGFALGMQGMKEGETRVLYIHPDLAYGTAGQLPPNSLLIFEINLI
CCCCCCEEEECCCCCCCHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCCCCEEEEEEEEE
QASADEVAAVPQEGNQGE
ECCCHHHEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362