Click here to switch to the map view.

The map label for this gene is dnaX [H]

Identifier: 15594806

GI number: 15594806

Start: 482600

End: 484282

Strand: Direct

Name: dnaX [H]

Synonym: BB0461

Alternate gene names: 15594806

Gene position: 482600-484282 (Clockwise)

Preceding gene: 15594804

Following gene: 15594807

Centisome position: 52.99

GC content: 29.71

Gene sequence:

>1683_bases
ATGGCGTCTTCAAGAGGCACTGCTCTTAAGAAACGCCCCAGAGATTTCAACTCTCTTGAAGGGCAAGACTTTGTTGTTGA
AACTCTAAAGCATTCTATAGAGAAAAATAAAATAGCTAATGCTTATATCTTTTCAGGGCCAAGAGGCGTTGGTAAAACTT
CATCAGCCAGGGCTTTTGCCAGATGCTTAAATTGCAGGAATGGTCCAACAGTTATGCCATGTGGGGAGTGCAGCAATTGT
AAATCTATTGAGAATGATAGCAGCCTTGATGTTGTTGAAATTGATGGTGCCTCAAACACTTCGGTTCAAGATATTAGGCA
AATTAAAGAAGAGATAATGTTTCCTCCTGCAATTTCTAAATATAGAATATATATTATTGACGAAGTTCATATGCTTTCCA
ATTCTGCTTTTAATGCTCTTTTAAAGACAATTGAAGAGCCTCCAAATTATATTGTTTTTATTTTTGCCACTACAGAGTCA
CACAAGCTTCCAGAGACAATAAAAAGCAGATGTCAACATTTTAGTTTTAAACTTTTATCTTTAGATAAGATTTACAATAT
GCTTAAGAAAGTTTGTTTAGAGGATGATATTAAATATGAAGATGAAGCTTTAAAATGGATTGCATATAAAAGTAGTGGTA
GCGTAAGAGATGCTTATACTCTTTTTGATCAGATAGTTTCTTTTACTGATTCTAACATTAAATTAGATCAAATAAGATCC
AAGATGGGCTTAACCAATGATGAATTTTTAGAAAAGTTGTCAGTTAGCATTCTTGGTGAAGATGTGAAAGAGTTAATTTG
TGTTCTTGATTCTATTTTTTTATCTGGAGTGTCTTATGAGCAATTTCTTTTAGATTCAATCGAATTTTTTAGAGAGGCAT
TATTTTTAAAGATAGGTATTAAAAATTTTGAGTTTATTGGAATTAAATCTGAGGATTTGAGAAAGAAATTAATTGAGTTT
GATTTGAACTATCTTGAAAGAATTATTGTTGTTTTGCTTGAAACTTACAGGGATTTGCAATTTTCGGTTAATCCAAGATA
TGAGCTTGAGATTAATTTTATTAAAATTTTAAGACTTAAAAGTTATGTTCCAAATCATGTTTTAATAAAGCAAATTCAAA
ATCTTGAAGACAATCTGTTAGAAAATATTGCTACAGATTCAAACAATTTTGATGTTTTATCAAATAATAAGAGCGAAGAT
GATTTGGCTTTTATTCCATCAAAATCTAGTTTAAAATGTGAATTTCCCGAAATCAAATCTTTAGAAAAAGAGGAGGCTGA
TCGTGATGAAAATTTATCAACAAAAATTGATAAAAATATTTTAGAGACCAATAGTATTGACGAGATTGATGAGATTTTTA
TTGAAGATGATAATGCGAGTAATTCAAATGATTTTATTGATATAAGAGATAAATTTATTTATATTGTTTCAAGATATGTT
CAAACTTTAGTTCATTCGGGAGAGGTTGCTATTGATGACAATGTTCTTTATTATAAGGTGTTTAGTGAGTTTGAATATAA
TGAGCTTCAAAATTATAAAGGTGAGATAAGATCTGAATTTTACAAAGAATTCCCCAATTTAAGCATTGTGTTTCAGAAAA
ATTTTAAAAACCTTGAAAAGGATTTTGAAAAACTAGAAACTGTAAAAAATATTTTTGGAGCAAGTGAAGTTCTGGAGGGA
TAA

Upstream 100 bases:

>100_bases
ATAAAATTCTTTTAAAGTAATAGCTCTGAGATATAAATATGTTGTATAGTATATATTTACTAATATTTTACTTATTAAAG
CATAGGGAGGTAAAAAGTTA

Downstream 100 bases:

>100_bases
AAATATGGCAGTAAATCCGTTAGATTTTTTGAAAAATATGTCTAGCGTTAAGAATAATATTGACAATATTAAAAAGGAAA
TTTCTAAAATTACGGTTTGT

Product: DNA polymerase III subunits gamma/tau

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 560; Mature: 559

Protein sequence:

>560_residues
MASSRGTALKKRPRDFNSLEGQDFVVETLKHSIEKNKIANAYIFSGPRGVGKTSSARAFARCLNCRNGPTVMPCGECSNC
KSIENDSSLDVVEIDGASNTSVQDIRQIKEEIMFPPAISKYRIYIIDEVHMLSNSAFNALLKTIEEPPNYIVFIFATTES
HKLPETIKSRCQHFSFKLLSLDKIYNMLKKVCLEDDIKYEDEALKWIAYKSSGSVRDAYTLFDQIVSFTDSNIKLDQIRS
KMGLTNDEFLEKLSVSILGEDVKELICVLDSIFLSGVSYEQFLLDSIEFFREALFLKIGIKNFEFIGIKSEDLRKKLIEF
DLNYLERIIVVLLETYRDLQFSVNPRYELEINFIKILRLKSYVPNHVLIKQIQNLEDNLLENIATDSNNFDVLSNNKSED
DLAFIPSKSSLKCEFPEIKSLEKEEADRDENLSTKIDKNILETNSIDEIDEIFIEDDNASNSNDFIDIRDKFIYIVSRYV
QTLVHSGEVAIDDNVLYYKVFSEFEYNELQNYKGEIRSEFYKEFPNLSIVFQKNFKNLEKDFEKLETVKNIFGASEVLEG

Sequences:

>Translated_560_residues
MASSRGTALKKRPRDFNSLEGQDFVVETLKHSIEKNKIANAYIFSGPRGVGKTSSARAFARCLNCRNGPTVMPCGECSNC
KSIENDSSLDVVEIDGASNTSVQDIRQIKEEIMFPPAISKYRIYIIDEVHMLSNSAFNALLKTIEEPPNYIVFIFATTES
HKLPETIKSRCQHFSFKLLSLDKIYNMLKKVCLEDDIKYEDEALKWIAYKSSGSVRDAYTLFDQIVSFTDSNIKLDQIRS
KMGLTNDEFLEKLSVSILGEDVKELICVLDSIFLSGVSYEQFLLDSIEFFREALFLKIGIKNFEFIGIKSEDLRKKLIEF
DLNYLERIIVVLLETYRDLQFSVNPRYELEINFIKILRLKSYVPNHVLIKQIQNLEDNLLENIATDSNNFDVLSNNKSED
DLAFIPSKSSLKCEFPEIKSLEKEEADRDENLSTKIDKNILETNSIDEIDEIFIEDDNASNSNDFIDIRDKFIYIVSRYV
QTLVHSGEVAIDDNVLYYKVFSEFEYNELQNYKGEIRSEFYKEFPNLSIVFQKNFKNLEKDFEKLETVKNIFGASEVLEG
>Mature_559_residues
ASSRGTALKKRPRDFNSLEGQDFVVETLKHSIEKNKIANAYIFSGPRGVGKTSSARAFARCLNCRNGPTVMPCGECSNCK
SIENDSSLDVVEIDGASNTSVQDIRQIKEEIMFPPAISKYRIYIIDEVHMLSNSAFNALLKTIEEPPNYIVFIFATTESH
KLPETIKSRCQHFSFKLLSLDKIYNMLKKVCLEDDIKYEDEALKWIAYKSSGSVRDAYTLFDQIVSFTDSNIKLDQIRSK
MGLTNDEFLEKLSVSILGEDVKELICVLDSIFLSGVSYEQFLLDSIEFFREALFLKIGIKNFEFIGIKSEDLRKKLIEFD
LNYLERIIVVLLETYRDLQFSVNPRYELEINFIKILRLKSYVPNHVLIKQIQNLEDNLLENIATDSNNFDVLSNNKSEDD
LAFIPSKSSLKCEFPEIKSLEKEEADRDENLSTKIDKNILETNSIDEIDEIFIEDDNASNSNDFIDIRDKFIYIVSRYVQ
TLVHSGEVAIDDNVLYYKVFSEFEYNELQNYKGEIRSEFYKEFPNLSIVFQKNFKNLEKDFEKLETVKNIFGASEVLEG

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4506491, Length=230, Percent_Identity=27.8260869565217, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI31881687, Length=230, Percent_Identity=27.8260869565217, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI31563534, Length=209, Percent_Identity=27.7511961722488, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1786676, Length=361, Percent_Identity=32.1329639889197, Blast_Score=241, Evalue=1e-64,
Organism=Caenorhabditis elegans, GI17554730, Length=288, Percent_Identity=25.3472222222222, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17541988, Length=214, Percent_Identity=25.2336448598131, Blast_Score=74, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6324039, Length=209, Percent_Identity=26.7942583732057, Blast_Score=74, Evalue=9e-14,
Organism=Saccharomyces cerevisiae, GI6324478, Length=214, Percent_Identity=26.6355140186916, Blast_Score=73, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6322528, Length=275, Percent_Identity=24, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI18859927, Length=217, Percent_Identity=28.110599078341, Blast_Score=76, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR001270
- InterPro:   IPR008921
- InterPro:   IPR022754
- InterPro:   IPR012763 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 64552; Mature: 64421

Theoretical pI: Translated: 4.60; Mature: 4.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASSRGTALKKRPRDFNSLEGQDFVVETLKHSIEKNKIANAYIFSGPRGVGKTSSARAFA
CCCCCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCHHHHHHH
RCLNCRNGPTVMPCGECSNCKSIENDSSLDVVEIDGASNTSVQDIRQIKEEIMFPPAISK
HHHCCCCCCCEECCCCCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCCCCC
YRIYIIDEVHMLSNSAFNALLKTIEEPPNYIVFIFATTESHKLPETIKSRCQHFSFKLLS
EEEEEEEHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHH
LDKIYNMLKKVCLEDDIKYEDEALKWIAYKSSGSVRDAYTLFDQIVSFTDSNIKLDQIRS
HHHHHHHHHHHHHCCCCCCCHHHEEEEEEECCCCCHHHHHHHHHHHHHCCCCEEHHHHHH
KMGLTNDEFLEKLSVSILGEDVKELICVLDSIFLSGVSYEQFLLDSIEFFREALFLKIGI
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCC
KNFEFIGIKSEDLRKKLIEFDLNYLERIIVVLLETYRDLQFSVNPRYELEINFIKILRLK
CCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCEEEEEHHHHHHHHH
SYVPNHVLIKQIQNLEDNLLENIATDSNNFDVLSNNKSEDDLAFIPSKSSLKCEFPEIKS
HHCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCEEECCCCCCCEECCCHHHC
LEKEEADRDENLSTKIDKNILETNSIDEIDEIFIEDDNASNSNDFIDIRDKFIYIVSRYV
CCHHHCCCCCCCHHHHHHHHHCCCCCCHHHHHEEECCCCCCCCCEEEHHHHHHHHHHHHH
QTLVHSGEVAIDDNVLYYKVFSEFEYNELQNYKGEIRSEFYKEFPNLSIVFQKNFKNLEK
HHHHHCCCEEECCCEEEEEEHHHCCHHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHH
DFEKLETVKNIFGASEVLEG
HHHHHHHHHHHHCHHHHHCC
>Mature Secondary Structure 
ASSRGTALKKRPRDFNSLEGQDFVVETLKHSIEKNKIANAYIFSGPRGVGKTSSARAFA
CCCCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCHHHHHHH
RCLNCRNGPTVMPCGECSNCKSIENDSSLDVVEIDGASNTSVQDIRQIKEEIMFPPAISK
HHHCCCCCCCEECCCCCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCCCCC
YRIYIIDEVHMLSNSAFNALLKTIEEPPNYIVFIFATTESHKLPETIKSRCQHFSFKLLS
EEEEEEEHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHH
LDKIYNMLKKVCLEDDIKYEDEALKWIAYKSSGSVRDAYTLFDQIVSFTDSNIKLDQIRS
HHHHHHHHHHHHHCCCCCCCHHHEEEEEEECCCCCHHHHHHHHHHHHHCCCCEEHHHHHH
KMGLTNDEFLEKLSVSILGEDVKELICVLDSIFLSGVSYEQFLLDSIEFFREALFLKIGI
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCC
KNFEFIGIKSEDLRKKLIEFDLNYLERIIVVLLETYRDLQFSVNPRYELEINFIKILRLK
CCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCEEEEEHHHHHHHHH
SYVPNHVLIKQIQNLEDNLLENIATDSNNFDVLSNNKSEDDLAFIPSKSSLKCEFPEIKS
HHCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCEEECCCCCCCEECCCHHHC
LEKEEADRDENLSTKIDKNILETNSIDEIDEIFIEDDNASNSNDFIDIRDKFIYIVSRYV
CCHHHCCCCCCCHHHHHHHHHCCCCCCHHHHHEEECCCCCCCCCEEEHHHHHHHHHHHHH
QTLVHSGEVAIDDNVLYYKVFSEFEYNELQNYKGEIRSEFYKEFPNLSIVFQKNFKNLEK
HHHHHCCCEEECCCEEEEEEHHHCCHHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHH
DFEKLETVKNIFGASEVLEG
HHHHHHHHHHHHCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2124672; 7584024; 9384377; 2452406; 2468993; 1698458 [H]