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The map label for this gene is mutL [H]

Identifier: 15594556

GI number: 15594556

Start: 215427

End: 217259

Strand: Direct

Name: mutL [H]

Synonym: BB0211

Alternate gene names: 15594556

Gene position: 215427-217259 (Clockwise)

Preceding gene: 15594555

Following gene: 15594557

Centisome position: 23.65

GC content: 27.22

Gene sequence:

>1833_bases
ATGAACAAAATAAGATTCTTAGATAAATACTTGGTTCAAAAAATAGCAGCAGGAGAATCAATAGACAGGCCATGTTCAAT
ATTAAGGGAACTACTAGACAATTCAATAGATTCTGGAGCTACTAAAATTGAGGTTTTTCTTGAAGAAGGGGGAATTCAAA
AAATCTTAATAATAGATAATGGAAGCGGAATAAGTAAAGAAGATTTAAAAATCTGCTATCTACCACACACTACTTCAAAA
ATATCATCGGAAGAAGATTTAAGAAAAATAGAAACTCTAGGCTTTAGGGGAGAGGCTCTCTCTAGTATTGCAATTTGCTC
CAACATTTCAATAACAAGCTCAACAACTAGCAATGAAAGCTATCAAATAGAAGTAGAAAATGGAATTGAAAAATGCTTTA
AAAAACAACCCGCCATAAACGGAACAATAGTAGATGTCACAAAAATATTTCACAACTTCCCAGCAAGGAAAAGATTCTTA
AAGCAAGAACCCATTGAAACAAAAATGTGTCTAAAAGTTTTAGAAGAAAAAATAATAACCCACCCCGAAATCAATTTCGA
AATTAATTTAAATCAAAAGCTAAGAAAAATTTACTTTAAAGAATCGTTAATTGACAGGGTTCAAAATGTATATGGAAATG
TAATAGAAAATAATAAATTTAGGGTCTTAAAAAAAGAACATGACAATATAAAAATAGAAATATTTTTAGCACCAGATAAC
TTTTCTAAAAAAAGTAAAAGACATATTAAAACATTTGTCAACAGAAGACCTATCGATCAAAAAGATCTCTTAGAAGCAAT
AACTAATGGACACAGCAGAATACTTTCTCCTGGCAACTTCCCAATATGTTATTTATTTTTAGAAATAAACCCTGAATATA
TTGACTTTAATGTACACCCTCAAAAAAAAGAAGTAAGATTTTACAATCTTCCATTTTTATTTAAACTAATATCTGACAAT
ATTAATAATTTTTTTGATAAAAATATAAATAACTACCAAGACATAATAATAAAAAGACAATTAACAGAAGATGATCATTT
AATAGAAATGACAAACCAACCAGAAAACTTTAATAAAATCAACACATATGATATACCACAAAACAATAATTTAGAAACAG
AAGATGTAAACGAGCCAAACAAAAACACAACACAAAGCAATATTGACCTTAGAAGGTATAATTCAATTATACAAAATAGA
CCAACACTCAGGGAAAACATTGGAAACATTTTCTCTGACAATTTTTTAGAATTTGAAGAACCTCCAAATAAAAATGAAAA
AGAAGAAATAAAATTTAACTATATTGGACAAATATTCTCTGAATTTTTAATCGTTGAAAAAATAAATGAAATTTACTTCA
TAGACCAACACGCAGTTCACGAAAAAATAATATATGAAAAACTTAGAAATTCAAAAAAAAATGTTCAAAAACTTCTAGTA
CCAATTGAATTCACAGTAGTTGATAAAAACATAGAAGAAATTATAGATAGTGAGATTGAAGAATACAAACAAATGGACAT
TATAATCTCTAAAATAGGCCCTAAAAAATATCAACTTGAATCTATTCCTAATATTTGTAGTCAATATGAAAATACTCTTA
TTAACTTTTTTCAATCAAGAAGAAGTAGGACAATAAATTCTCTTGAATCTGACTTATACGCAACTATTGCCTGTAGAAAG
GCTGTCAAAAGAAATGACATGCTAAGCGCTGAATTTAGTAAATTTTTAATAAATGAATTTTTTAAACTAGAAATCAAACA
TTGTCCTCATGGACGAAAAATTTATTACAAAATATCTAAATTTGAACTTGAAAAAAAAGTTGACAGAGCATAA

Upstream 100 bases:

>100_bases
TGAAAATAACAATGATCAAACACTAAGAGAACTTATAAAAAAATTTCCAAATTACAAAAAAAATGAAAATATTAAAAAAA
TAATAGGAATATAAATTTCA

Downstream 100 bases:

>100_bases
AATAAAACCAGAGTTCCCATGATGAAAAAAATCAAATCAGAAATCAACTTGTTAAAGATAGAAAAAGACAAAAATTTAAT
TGAGCTTGGAAAAATATTAA

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 610; Mature: 610

Protein sequence:

>610_residues
MNKIRFLDKYLVQKIAAGESIDRPCSILRELLDNSIDSGATKIEVFLEEGGIQKILIIDNGSGISKEDLKICYLPHTTSK
ISSEEDLRKIETLGFRGEALSSIAICSNISITSSTTSNESYQIEVENGIEKCFKKQPAINGTIVDVTKIFHNFPARKRFL
KQEPIETKMCLKVLEEKIITHPEINFEINLNQKLRKIYFKESLIDRVQNVYGNVIENNKFRVLKKEHDNIKIEIFLAPDN
FSKKSKRHIKTFVNRRPIDQKDLLEAITNGHSRILSPGNFPICYLFLEINPEYIDFNVHPQKKEVRFYNLPFLFKLISDN
INNFFDKNINNYQDIIIKRQLTEDDHLIEMTNQPENFNKINTYDIPQNNNLETEDVNEPNKNTTQSNIDLRRYNSIIQNR
PTLRENIGNIFSDNFLEFEEPPNKNEKEEIKFNYIGQIFSEFLIVEKINEIYFIDQHAVHEKIIYEKLRNSKKNVQKLLV
PIEFTVVDKNIEEIIDSEIEEYKQMDIIISKIGPKKYQLESIPNICSQYENTLINFFQSRRSRTINSLESDLYATIACRK
AVKRNDMLSAEFSKFLINEFFKLEIKHCPHGRKIYYKISKFELEKKVDRA

Sequences:

>Translated_610_residues
MNKIRFLDKYLVQKIAAGESIDRPCSILRELLDNSIDSGATKIEVFLEEGGIQKILIIDNGSGISKEDLKICYLPHTTSK
ISSEEDLRKIETLGFRGEALSSIAICSNISITSSTTSNESYQIEVENGIEKCFKKQPAINGTIVDVTKIFHNFPARKRFL
KQEPIETKMCLKVLEEKIITHPEINFEINLNQKLRKIYFKESLIDRVQNVYGNVIENNKFRVLKKEHDNIKIEIFLAPDN
FSKKSKRHIKTFVNRRPIDQKDLLEAITNGHSRILSPGNFPICYLFLEINPEYIDFNVHPQKKEVRFYNLPFLFKLISDN
INNFFDKNINNYQDIIIKRQLTEDDHLIEMTNQPENFNKINTYDIPQNNNLETEDVNEPNKNTTQSNIDLRRYNSIIQNR
PTLRENIGNIFSDNFLEFEEPPNKNEKEEIKFNYIGQIFSEFLIVEKINEIYFIDQHAVHEKIIYEKLRNSKKNVQKLLV
PIEFTVVDKNIEEIIDSEIEEYKQMDIIISKIGPKKYQLESIPNICSQYENTLINFFQSRRSRTINSLESDLYATIACRK
AVKRNDMLSAEFSKFLINEFFKLEIKHCPHGRKIYYKISKFELEKKVDRA
>Mature_610_residues
MNKIRFLDKYLVQKIAAGESIDRPCSILRELLDNSIDSGATKIEVFLEEGGIQKILIIDNGSGISKEDLKICYLPHTTSK
ISSEEDLRKIETLGFRGEALSSIAICSNISITSSTTSNESYQIEVENGIEKCFKKQPAINGTIVDVTKIFHNFPARKRFL
KQEPIETKMCLKVLEEKIITHPEINFEINLNQKLRKIYFKESLIDRVQNVYGNVIENNKFRVLKKEHDNIKIEIFLAPDN
FSKKSKRHIKTFVNRRPIDQKDLLEAITNGHSRILSPGNFPICYLFLEINPEYIDFNVHPQKKEVRFYNLPFLFKLISDN
INNFFDKNINNYQDIIIKRQLTEDDHLIEMTNQPENFNKINTYDIPQNNNLETEDVNEPNKNTTQSNIDLRRYNSIIQNR
PTLRENIGNIFSDNFLEFEEPPNKNEKEEIKFNYIGQIFSEFLIVEKINEIYFIDQHAVHEKIIYEKLRNSKKNVQKLLV
PIEFTVVDKNIEEIIDSEIEEYKQMDIIISKIGPKKYQLESIPNICSQYENTLINFFQSRRSRTINSLESDLYATIACRK
AVKRNDMLSAEFSKFLINEFFKLEIKHCPHGRKIYYKISKFELEKKVDRA

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family [H]

Homologues:

Organism=Homo sapiens, GI4557757, Length=310, Percent_Identity=34.5161290322581, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI189458898, Length=410, Percent_Identity=27.0731707317073, Blast_Score=126, Evalue=6e-29,
Organism=Homo sapiens, GI4505911, Length=410, Percent_Identity=27.0731707317073, Blast_Score=126, Evalue=8e-29,
Organism=Homo sapiens, GI189458896, Length=402, Percent_Identity=26.3681592039801, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI4505913, Length=355, Percent_Identity=25.9154929577465, Blast_Score=112, Evalue=1e-24,
Organism=Homo sapiens, GI310128478, Length=355, Percent_Identity=25.9154929577465, Blast_Score=112, Evalue=1e-24,
Organism=Homo sapiens, GI310128480, Length=312, Percent_Identity=25, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI263191589, Length=216, Percent_Identity=27.3148148148148, Blast_Score=77, Evalue=6e-14,
Organism=Escherichia coli, GI1790612, Length=333, Percent_Identity=31.2312312312312, Blast_Score=170, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI71991825, Length=322, Percent_Identity=30.4347826086957, Blast_Score=132, Evalue=6e-31,
Organism=Caenorhabditis elegans, GI17562796, Length=431, Percent_Identity=24.5939675174014, Blast_Score=115, Evalue=6e-26,
Organism=Saccharomyces cerevisiae, GI6323819, Length=317, Percent_Identity=35.6466876971609, Blast_Score=164, Evalue=3e-41,
Organism=Saccharomyces cerevisiae, GI6324247, Length=427, Percent_Identity=27.1662763466042, Blast_Score=134, Evalue=4e-32,
Organism=Saccharomyces cerevisiae, GI6325093, Length=289, Percent_Identity=27.3356401384083, Blast_Score=87, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6323063, Length=165, Percent_Identity=35.7575757575758, Blast_Score=78, Evalue=5e-15,
Organism=Drosophila melanogaster, GI17136968, Length=313, Percent_Identity=33.5463258785943, Blast_Score=163, Evalue=4e-40,
Organism=Drosophila melanogaster, GI17136970, Length=174, Percent_Identity=36.2068965517241, Blast_Score=96, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C [H]

EC number: NA

Molecular weight: Translated: 71544; Mature: 71544

Theoretical pI: Translated: 7.31; Mature: 7.31

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKIRFLDKYLVQKIAAGESIDRPCSILRELLDNSIDSGATKIEVFLEEGGIQKILIIDN
CCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCEEEEEEEECCCCEEEEEEEC
GSGISKEDLKICYLPHTTSKISSEEDLRKIETLGFRGEALSSIAICSNISITSSTTSNES
CCCCCCCCCEEEECCCCCHHCCCHHHHHHHHHCCCCCHHHHHHHHHCCCEEECCCCCCCE
YQIEVENGIEKCFKKQPAINGTIVDVTKIFHNFPARKRFLKQEPIETKMCLKVLEEKIIT
EEEEHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCHHHHHHHCCCCHHHHHHHHHHHHHCC
HPEINFEINLNQKLRKIYFKESLIDRVQNVYGNVIENNKFRVLKKEHDNIKIEIFLAPDN
CCCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCHHCCCCEEEEEECCCCEEEEEEECCCC
FSKKSKRHIKTFVNRRPIDQKDLLEAITNGHSRILSPGNFPICYLFLEINPEYIDFNVHP
CCHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCEECCCCCCCEEEEEEEECCCEEEEECCC
QKKEVRFYNLPFLFKLISDNINNFFDKNINNYQDIIIKRQLTEDDHLIEMTNQPENFNKI
CCCCCEEECCHHHHHHHHHHHHHHHHCCCCCHHHHHEECCCCCCCCEEEECCCCCCCCCC
NTYDIPQNNNLETEDVNEPNKNTTQSNIDLRRYNSIIQNRPTLRENIGNIFSDNFLEFEE
CCEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHCCCCEECCC
PPNKNEKEEIKFNYIGQIFSEFLIVEKINEIYFIDQHAVHEKIIYEKLRNSKKNVQKLLV
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEECHHHHHHHHHHHHHHCHHHHHHHHEE
PIEFTVVDKNIEEIIDSEIEEYKQMDIIISKIGPKKYQLESIPNICSQYENTLINFFQSR
EEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHH
RSRTINSLESDLYATIACRKAVKRNDMLSAEFSKFLINEFFKLEIKHCPHGRKIYYKISK
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHEEHHCCCCCCEEEEEEHH
FELEKKVDRA
HHHHHHHCCC
>Mature Secondary Structure
MNKIRFLDKYLVQKIAAGESIDRPCSILRELLDNSIDSGATKIEVFLEEGGIQKILIIDN
CCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCEEEEEEEECCCCEEEEEEEC
GSGISKEDLKICYLPHTTSKISSEEDLRKIETLGFRGEALSSIAICSNISITSSTTSNES
CCCCCCCCCEEEECCCCCHHCCCHHHHHHHHHCCCCCHHHHHHHHHCCCEEECCCCCCCE
YQIEVENGIEKCFKKQPAINGTIVDVTKIFHNFPARKRFLKQEPIETKMCLKVLEEKIIT
EEEEHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCHHHHHHHCCCCHHHHHHHHHHHHHCC
HPEINFEINLNQKLRKIYFKESLIDRVQNVYGNVIENNKFRVLKKEHDNIKIEIFLAPDN
CCCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCHHCCCCEEEEEECCCCEEEEEEECCCC
FSKKSKRHIKTFVNRRPIDQKDLLEAITNGHSRILSPGNFPICYLFLEINPEYIDFNVHP
CCHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCEECCCCCCCEEEEEEEECCCEEEEECCC
QKKEVRFYNLPFLFKLISDNINNFFDKNINNYQDIIIKRQLTEDDHLIEMTNQPENFNKI
CCCCCEEECCHHHHHHHHHHHHHHHHCCCCCHHHHHEECCCCCCCCEEEECCCCCCCCCC
NTYDIPQNNNLETEDVNEPNKNTTQSNIDLRRYNSIIQNRPTLRENIGNIFSDNFLEFEE
CCEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHCCCCEECCC
PPNKNEKEEIKFNYIGQIFSEFLIVEKINEIYFIDQHAVHEKIIYEKLRNSKKNVQKLLV
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEECHHHHHHHHHHHHHHCHHHHHHHHEE
PIEFTVVDKNIEEIIDSEIEEYKQMDIIISKIGPKKYQLESIPNICSQYENTLINFFQSR
EEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHH
RSRTINSLESDLYATIACRKAVKRNDMLSAEFSKFLINEFFKLEIKHCPHGRKIYYKISK
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHEEHHCCCCCCEEEEEEHH
FELEKKVDRA
HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA