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The map label for this gene is degP [C]

Identifier: 15594450

GI number: 15594450

Start: 101525

End: 102976

Strand: Reverse

Name: degP [C]

Synonym: BB0104

Alternate gene names: 15594450

Gene position: 102976-101525 (Counterclockwise)

Preceding gene: 15594451

Following gene: 15594449

Centisome position: 11.31

GC content: 33.61

Gene sequence:

>1452_bases
TTGAGTAATTATGTGGAGGTTATAAAAGTGGAAAAAAAGTTTTTTTCTGGATTTCTTCTTAGTTTTTTGGCTTTGAGTAT
TGGATTTTTTATTGGGATGCATTATTTAGCTTCTAATAGAAGCAACATTGTTTTTGCAGAAGAAAAGGACAATACCGTAC
GAGCCTTACAAGATTCTTTTAGAGAGGTTTCCAAGAAAATTTTACCATCATCTGTGGAAGTTCATGCAACAGGGGTAATC
AAGCAGAGTTTTCCTATTCCATTTTTCTTTTTTGATATGCCAGAATTTGATTCTGAGAGAAAAAGCAATTGGGCGGGGTC
TGGAGTAATAATTGGTAGAGATTCTCAAAAAAAATCATTATTTTATGTGGTTACGAATAGTCATGTGGTAGATAAGGCAA
CTGAACTTGAAGTTGTATCTTATGATAAAAAAAAGCACAAGGCTAAGTTAATTGGCAAAGATGAAAAAAAGGATATTGCC
CTTATTAGCTTTGAAAGTGATGACGCAACTATTAAAGTAGCTGATCTTGGAGATAGTGATAAGCTTGAAATAGGTGATTG
GGTTATGGCAGTGGGCAGCCCTTTTCAATTTAGTTTTACAGTTACAGCAGGTATTGTAAGTGGATTGCAACGTTCTGCAA
ATCCTAATTTGCAATCAAGGAATCTGTTTATTCAAACCGATGCTGCAATCAACAGGGGTAATTCAGGTGGTCCTCTTGTA
AATATAAAGGGCGAGGTTATTGGAATTAATGCTTGGATAGCTTCAAATTCTGGCGGAAATATTGGGTTGGGTTTTGCAAT
TCCTGTTAACAATATTAAAAGCACTGTAGATTTTTTCCTTAAAGGTAAAAAAATTGAATCGGCTTGGCTTGGAATTTCTT
TTTATCCGCTAAAGACAAGAGATTCTGAGGTGCTAAAAAGCTTAGGGGTTGAAAGTAATGATGTTTCAGCTGCAATTATT
GCTTCTCTTTATCCGGGTTCACCCGCTGTTAAATCAGGGCTTAGGGCAGGGGATATTATTATGAAGGTTAATGGGGTTTC
CATGAGCGTTTTTCAAGATGTTACATCATATATTAGTGATTTTTATGCTGGTGAGAAAGTAAATGTAGAAATCTTAAGAG
GCAATGTCAAAAAAAATATTGAGATTGTTCTTGCTGTTAGACCTAAGGATAAAGAGCTTTCTTCTTCAAAGATGCTTCCA
GGCTTTGTTGTGTATCCATTGGTTGAGGATATTAAAGCTCAGCTTAATTTAAGAAATTGGATTAAAGGTGTTGTTGTTGA
TTATATTGATAAAAATTTAGCATCAAATATTAAAATGAAATCAGGAGATGTAATTCTTTCTGTAAATTCAAAAAGTGTTT
CTAATTTAAGAGAATTTTATGATGCTCTTGAGGTTGGAAAAAATACTTATAAAATTTTGAGAGGAAACGATTCTTTTAAA
ATTACATTTTAG

Upstream 100 bases:

>100_bases
ACATTTTGAACATACTGTTGCTGTTGTTGATGGATTGCCTTTAATTTTAAGTGAAGTTTAAATTTTAAATTAATCAAATA
TTTAAATATTATTTATAAAA

Downstream 100 bases:

>100_bases
TAAATTTTAGTTTTGGGTTAAGAGTTGATCTTAGCCCTTTTTTGTTTTACATATAATTGTAAAGCTTTTAGATTGTAATG
ATTTTATTTTATGCAAATAT

Product: periplasmic serine protease DO

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 483; Mature: 482

Protein sequence:

>483_residues
MSNYVEVIKVEKKFFSGFLLSFLALSIGFFIGMHYLASNRSNIVFAEEKDNTVRALQDSFREVSKKILPSSVEVHATGVI
KQSFPIPFFFFDMPEFDSERKSNWAGSGVIIGRDSQKKSLFYVVTNSHVVDKATELEVVSYDKKKHKAKLIGKDEKKDIA
LISFESDDATIKVADLGDSDKLEIGDWVMAVGSPFQFSFTVTAGIVSGLQRSANPNLQSRNLFIQTDAAINRGNSGGPLV
NIKGEVIGINAWIASNSGGNIGLGFAIPVNNIKSTVDFFLKGKKIESAWLGISFYPLKTRDSEVLKSLGVESNDVSAAII
ASLYPGSPAVKSGLRAGDIIMKVNGVSMSVFQDVTSYISDFYAGEKVNVEILRGNVKKNIEIVLAVRPKDKELSSSKMLP
GFVVYPLVEDIKAQLNLRNWIKGVVVDYIDKNLASNIKMKSGDVILSVNSKSVSNLREFYDALEVGKNTYKILRGNDSFK
ITF

Sequences:

>Translated_483_residues
MSNYVEVIKVEKKFFSGFLLSFLALSIGFFIGMHYLASNRSNIVFAEEKDNTVRALQDSFREVSKKILPSSVEVHATGVI
KQSFPIPFFFFDMPEFDSERKSNWAGSGVIIGRDSQKKSLFYVVTNSHVVDKATELEVVSYDKKKHKAKLIGKDEKKDIA
LISFESDDATIKVADLGDSDKLEIGDWVMAVGSPFQFSFTVTAGIVSGLQRSANPNLQSRNLFIQTDAAINRGNSGGPLV
NIKGEVIGINAWIASNSGGNIGLGFAIPVNNIKSTVDFFLKGKKIESAWLGISFYPLKTRDSEVLKSLGVESNDVSAAII
ASLYPGSPAVKSGLRAGDIIMKVNGVSMSVFQDVTSYISDFYAGEKVNVEILRGNVKKNIEIVLAVRPKDKELSSSKMLP
GFVVYPLVEDIKAQLNLRNWIKGVVVDYIDKNLASNIKMKSGDVILSVNSKSVSNLREFYDALEVGKNTYKILRGNDSFK
ITF
>Mature_482_residues
SNYVEVIKVEKKFFSGFLLSFLALSIGFFIGMHYLASNRSNIVFAEEKDNTVRALQDSFREVSKKILPSSVEVHATGVIK
QSFPIPFFFFDMPEFDSERKSNWAGSGVIIGRDSQKKSLFYVVTNSHVVDKATELEVVSYDKKKHKAKLIGKDEKKDIAL
ISFESDDATIKVADLGDSDKLEIGDWVMAVGSPFQFSFTVTAGIVSGLQRSANPNLQSRNLFIQTDAAINRGNSGGPLVN
IKGEVIGINAWIASNSGGNIGLGFAIPVNNIKSTVDFFLKGKKIESAWLGISFYPLKTRDSEVLKSLGVESNDVSAAIIA
SLYPGSPAVKSGLRAGDIIMKVNGVSMSVFQDVTSYISDFYAGEKVNVEILRGNVKKNIEIVLAVRPKDKELSSSKMLPG
FVVYPLVEDIKAQLNLRNWIKGVVVDYIDKNLASNIKMKSGDVILSVNSKSVSNLREFYDALEVGKNTYKILRGNDSFKI
TF

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=338, Percent_Identity=35.207100591716, Blast_Score=146, Evalue=3e-35,
Organism=Homo sapiens, GI24308541, Length=279, Percent_Identity=34.0501792114695, Blast_Score=132, Evalue=7e-31,
Organism=Homo sapiens, GI22129776, Length=360, Percent_Identity=31.3888888888889, Blast_Score=119, Evalue=9e-27,
Organism=Homo sapiens, GI7019477, Length=285, Percent_Identity=31.9298245614035, Blast_Score=109, Evalue=7e-24,
Organism=Escherichia coli, GI1786356, Length=447, Percent_Identity=34.675615212528, Blast_Score=219, Evalue=3e-58,
Organism=Escherichia coli, GI1789629, Length=470, Percent_Identity=33.4042553191489, Blast_Score=218, Evalue=9e-58,
Organism=Escherichia coli, GI1789630, Length=290, Percent_Identity=28.9655172413793, Blast_Score=118, Evalue=6e-28,
Organism=Drosophila melanogaster, GI24646839, Length=302, Percent_Identity=32.1192052980132, Blast_Score=127, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.-

Molecular weight: Translated: 53105; Mature: 52973

Theoretical pI: Translated: 9.65; Mature: 9.65

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNYVEVIKVEKKFFSGFLLSFLALSIGFFIGMHYLASNRSNIVFAEEKDNTVRALQDSF
CCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHH
REVSKKILPSSVEVHATGVIKQSFPIPFFFFDMPEFDSERKSNWAGSGVIIGRDSQKKSL
HHHHHHHCCCCEEEEEEEEEECCCCCCEEEECCCCCCCCHHCCCCCCEEEEECCCCCCEE
FYVVTNSHVVDKATELEVVSYDKKKHKAKLIGKDEKKDIALISFESDDATIKVADLGDSD
EEEEECCEEECCCCCEEEEECCCHHHHHHCCCCCCCCCEEEEEECCCCCEEEEEECCCCC
KLEIGDWVMAVGSPFQFSFTVTAGIVSGLQRSANPNLQSRNLFIQTDAAINRGNSGGPLV
CEEECCEEEECCCCEEEEEEEHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCCCEE
NIKGEVIGINAWIASNSGGNIGLGFAIPVNNIKSTVDFFLKGKKIESAWLGISFYPLKTR
EECCEEEEEEEEEEECCCCCEEEEEEEECCHHHHHHHHHEECCEECEEEEEEEEEEECCC
DSEVLKSLGVESNDVSAAIIASLYPGSPAVKSGLRAGDIIMKVNGVSMSVFQDVTSYISD
HHHHHHHCCCCCCCCCEEEEEEECCCCHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHH
FYAGEKVNVEILRGNVKKNIEIVLAVRPKDKELSSSKMLPGFVVYPLVEDIKAQLNLRNW
HHCCCEEEEEEEECCCCCCEEEEEEECCCCCCCCCCCCCCCEEEHHHHHHHHHHHCHHHH
IKGVVVDYIDKNLASNIKMKSGDVILSVNSKSVSNLREFYDALEVGKNTYKILRGNDSFK
HHHHHHHHHHHHHHHCCEEECCCEEEEECCHHHHHHHHHHHHHHHCCCEEEEEECCCCEE
ITF
EEC
>Mature Secondary Structure 
SNYVEVIKVEKKFFSGFLLSFLALSIGFFIGMHYLASNRSNIVFAEEKDNTVRALQDSF
CCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHH
REVSKKILPSSVEVHATGVIKQSFPIPFFFFDMPEFDSERKSNWAGSGVIIGRDSQKKSL
HHHHHHHCCCCEEEEEEEEEECCCCCCEEEECCCCCCCCHHCCCCCCEEEEECCCCCCEE
FYVVTNSHVVDKATELEVVSYDKKKHKAKLIGKDEKKDIALISFESDDATIKVADLGDSD
EEEEECCEEECCCCCEEEEECCCHHHHHHCCCCCCCCCEEEEEECCCCCEEEEEECCCCC
KLEIGDWVMAVGSPFQFSFTVTAGIVSGLQRSANPNLQSRNLFIQTDAAINRGNSGGPLV
CEEECCEEEECCCCEEEEEEEHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCCCEE
NIKGEVIGINAWIASNSGGNIGLGFAIPVNNIKSTVDFFLKGKKIESAWLGISFYPLKTR
EECCEEEEEEEEEEECCCCCEEEEEEEECCHHHHHHHHHEECCEECEEEEEEEEEEECCC
DSEVLKSLGVESNDVSAAIIASLYPGSPAVKSGLRAGDIIMKVNGVSMSVFQDVTSYISD
HHHHHHHCCCCCCCCCEEEEEEECCCCHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHH
FYAGEKVNVEILRGNVKKNIEIVLAVRPKDKELSSSKMLPGFVVYPLVEDIKAQLNLRNW
HHCCCEEEEEEEECCCCCCEEEEEEECCCCCCCCCCCCCCCEEEHHHHHHHHHHHCHHHH
IKGVVVDYIDKNLASNIKMKSGDVILSVNSKSVSNLREFYDALEVGKNTYKILRGNDSFK
HHHHHHHHHHHHHHHCCEEECCCEEEEECCHHHHHHHHHHHHHHHCCCEEEEEECCCCEE
ITF
EEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]