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The map label for this gene is mutSB

Identifier: 15594444

GI number: 15594444

Start: 94611

End: 96953

Strand: Reverse

Name: mutSB

Synonym: BB0098

Alternate gene names: 15594444

Gene position: 96953-94611 (Counterclockwise)

Preceding gene: 15594445

Following gene: 15594443

Centisome position: 10.65

GC content: 26.63

Gene sequence:

>2343_bases
ATGCAAGATGAACAAGATAAATATTTAAAAAATATTGACTTTTATGAAATTTTATCTTTAGTATCTAAATACGTTTCTAA
TCCGGATACTGTTAATTTACTAAGTAATCAAAAAATATTAAAAACAAAAGAAAGTTTAGAGAAAATATTCTCCTTTGTAA
GTCTGATTAGAATGCTTTTTGAAAGTTGCAAAGGATATCCAAATTCTTTTATAAATAGTTTAAAATATCCCATTTCATTA
TTATTAAAAGAAAATTCAAGAGTTTCTATTGAAAATTTGAGAGATATTATAGTGTTTTTAGATGAGGTTTTAAGAATAAA
TTTATTTTTGCATAAAAATAGTGATATCAAGCATCTTAATGTTCAGATTTTATCTGATTTATTATTTTTAAACCCAGAGC
TAAAAAATTTGCTTAATGAATTGAAAGAACATATAGATGTTGATGCTCTTGAATTGAAAAGTGGTGTTGTAAAAGAATAT
GATTCGATTGAATTTGAAATTAAAAATTTAAATAGACGAGTTGAAAATCAGATAAAAAAAATAATTAGTTTGAACGCAGA
ATATTTGACTTCTAATTTTGTTTGTTATAAATCGAATAAATATACCCTTGCTCTTAAGTCTAATTTTAAAGGCAAAATTA
AGGGTAATATTATTTCTATTTCGTCATCAGGTGAAACATTTTATATTGAGCCAAACGATATTGTAAATGCTAACAACAGG
TTAAATTATTTGAGCTTAGAAAAAGAAAGAATAATTTTAAAAATTTTACGAAATCTTTCTGCTAAAGTTCATAGCAACAT
TGTTCTTTTAGATAACCTTTATAATAATTTTTTGTATTATGATTCTTTAAAAGCTCGAGCGATTTATGGAATCAAAACTA
AAGGGGTATTTCCCGAGATTTCAAATGTATTAAATATTTTTGATGCACACCATCCTTTGTTAAAGGATTCAAAGGCAATA
ACTTTTACTCCTGCTGAGAATCGTGTTGTAATTATTACTGGTCCTAATGCTGGTGGAAAAACGGTAACTTTAAAGACAAT
TGGACTACTTAGTGCAATGTTTCAATTTGGGATCCCTATTGTTGTTGGTGAGTCTAGCACTTTTAAAATTTTTGATAACA
TTTTTATTGACATTGGTGATGAGCAGTCAATTTCTAATTCTCTTTCAACTTTTTCAAGCCATATGAGCAATATTTCTTAT
ATTTTAAAACATACTACAAAAGATAGCCTTGTAATATTTGATGAATTTTGCTCAGGAACAGACATTGATCAAGGTCAGGC
GCTTGCTATTTCAATTCTTGAATATTTGATCAATATTAATTCTTATGTTTTAATATCAACTCATTATAATGCTCTTAAAT
ATTTTGCATATACCCATGAAGGTGTTGTTAATGCTTCTATGCGGATGGATTTAGAGACAATGCAGCCCAATTATAATTTA
ATTTTTTCCATTCCTGGTGAAAGTTATGCGTTTAATGTTGCTAGCAAGGCTTTGATTGACAGGAGCATAGTAATTCGTGC
TAATGAAATTTATTCATCTCAAAAAACAGAAATTAATGAAATTTTAGAAAAATTAATAGAAAAAGAAAAAGATTTGCTTT
TAATTAAAGAAAGTATGGATAAGAAATTAATCCAAATAGAATTGCAAGAAAAAGAGCTAGAAAATTTTTATCAAGATCTT
TTATTAAGGGAAAAAAATATTGAGACAAAGCTTTTAAATGAGCAGAATGAATTTTTAAAAAATTCAAGAAAAGTTTTAGA
AAATTTGGTTAGAGAAATAAAAGAGGGCAATATTAATGTTGCAAAGAATAAAGCTTTTATATCAGATTTGGAAAAAAATG
TAGACCTCAAGACAAATAAAGTGAATTCTCTTAACAATAAGAGAAATGTAGTTGCAGATTTTAAAATAGGAGACAAGGTT
AGAATAGTTAATTCTAATGCAAAAGGAAAAATAGTCGGGATCTCAAAAAAGAAGATCACCGTTAATGTAGGTGCTTTTAA
TGTTAGTGTTTCTAGCTCAGAGATATCTTTGGAAAACTTTAAAGAAAAAAAAGAGAATGGAAAAAATTTTAACTTTTCAA
TTGATTATAATAAGGAAAATTTATTAAGCTTTACCATTGATATTAGGGGTATGAGGTCTGTTGATGCTCTAGACTTTTTG
AATAAGAAAATAGATAATATTATATTAAATGGTATTAATAAATTTGAGATCATTCATGGAAAAGGGGAGGGCCATCTTAT
GAGAGAAGTTCACAATTTATTAAAAGAATTGAAGTTTATTAGAAAATATTATTTTGCTCACCCTAGTGATGGAGGGTCTG
GAAAAACCATAGTTGAGATTTAA

Upstream 100 bases:

>100_bases
CCTTATTGTTCTGTTACAAGTTCTTTGGATAATGGAATTTCTAAACTTAGATACGAAAGCTATTTAAAGATTTTGTCAGA
GCTTAAAAATTATAAAAATT

Downstream 100 bases:

>100_bases
TTTAAGTGAATATATCGAAATTTAATGAATTTGAAAATGTATTGTTTCACATTTGCCTTGATGTTGATTTTGTGCTTGAG
AATGAATTTGGCAATTCTTA

Product: recombination and DNA strand exchange inhibitor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 780; Mature: 780

Protein sequence:

>780_residues
MQDEQDKYLKNIDFYEILSLVSKYVSNPDTVNLLSNQKILKTKESLEKIFSFVSLIRMLFESCKGYPNSFINSLKYPISL
LLKENSRVSIENLRDIIVFLDEVLRINLFLHKNSDIKHLNVQILSDLLFLNPELKNLLNELKEHIDVDALELKSGVVKEY
DSIEFEIKNLNRRVENQIKKIISLNAEYLTSNFVCYKSNKYTLALKSNFKGKIKGNIISISSSGETFYIEPNDIVNANNR
LNYLSLEKERIILKILRNLSAKVHSNIVLLDNLYNNFLYYDSLKARAIYGIKTKGVFPEISNVLNIFDAHHPLLKDSKAI
TFTPAENRVVIITGPNAGGKTVTLKTIGLLSAMFQFGIPIVVGESSTFKIFDNIFIDIGDEQSISNSLSTFSSHMSNISY
ILKHTTKDSLVIFDEFCSGTDIDQGQALAISILEYLININSYVLISTHYNALKYFAYTHEGVVNASMRMDLETMQPNYNL
IFSIPGESYAFNVASKALIDRSIVIRANEIYSSQKTEINEILEKLIEKEKDLLLIKESMDKKLIQIELQEKELENFYQDL
LLREKNIETKLLNEQNEFLKNSRKVLENLVREIKEGNINVAKNKAFISDLEKNVDLKTNKVNSLNNKRNVVADFKIGDKV
RIVNSNAKGKIVGISKKKITVNVGAFNVSVSSSEISLENFKEKKENGKNFNFSIDYNKENLLSFTIDIRGMRSVDALDFL
NKKIDNIILNGINKFEIIHGKGEGHLMREVHNLLKELKFIRKYYFAHPSDGGSGKTIVEI

Sequences:

>Translated_780_residues
MQDEQDKYLKNIDFYEILSLVSKYVSNPDTVNLLSNQKILKTKESLEKIFSFVSLIRMLFESCKGYPNSFINSLKYPISL
LLKENSRVSIENLRDIIVFLDEVLRINLFLHKNSDIKHLNVQILSDLLFLNPELKNLLNELKEHIDVDALELKSGVVKEY
DSIEFEIKNLNRRVENQIKKIISLNAEYLTSNFVCYKSNKYTLALKSNFKGKIKGNIISISSSGETFYIEPNDIVNANNR
LNYLSLEKERIILKILRNLSAKVHSNIVLLDNLYNNFLYYDSLKARAIYGIKTKGVFPEISNVLNIFDAHHPLLKDSKAI
TFTPAENRVVIITGPNAGGKTVTLKTIGLLSAMFQFGIPIVVGESSTFKIFDNIFIDIGDEQSISNSLSTFSSHMSNISY
ILKHTTKDSLVIFDEFCSGTDIDQGQALAISILEYLININSYVLISTHYNALKYFAYTHEGVVNASMRMDLETMQPNYNL
IFSIPGESYAFNVASKALIDRSIVIRANEIYSSQKTEINEILEKLIEKEKDLLLIKESMDKKLIQIELQEKELENFYQDL
LLREKNIETKLLNEQNEFLKNSRKVLENLVREIKEGNINVAKNKAFISDLEKNVDLKTNKVNSLNNKRNVVADFKIGDKV
RIVNSNAKGKIVGISKKKITVNVGAFNVSVSSSEISLENFKEKKENGKNFNFSIDYNKENLLSFTIDIRGMRSVDALDFL
NKKIDNIILNGINKFEIIHGKGEGHLMREVHNLLKELKFIRKYYFAHPSDGGSGKTIVEI
>Mature_780_residues
MQDEQDKYLKNIDFYEILSLVSKYVSNPDTVNLLSNQKILKTKESLEKIFSFVSLIRMLFESCKGYPNSFINSLKYPISL
LLKENSRVSIENLRDIIVFLDEVLRINLFLHKNSDIKHLNVQILSDLLFLNPELKNLLNELKEHIDVDALELKSGVVKEY
DSIEFEIKNLNRRVENQIKKIISLNAEYLTSNFVCYKSNKYTLALKSNFKGKIKGNIISISSSGETFYIEPNDIVNANNR
LNYLSLEKERIILKILRNLSAKVHSNIVLLDNLYNNFLYYDSLKARAIYGIKTKGVFPEISNVLNIFDAHHPLLKDSKAI
TFTPAENRVVIITGPNAGGKTVTLKTIGLLSAMFQFGIPIVVGESSTFKIFDNIFIDIGDEQSISNSLSTFSSHMSNISY
ILKHTTKDSLVIFDEFCSGTDIDQGQALAISILEYLININSYVLISTHYNALKYFAYTHEGVVNASMRMDLETMQPNYNL
IFSIPGESYAFNVASKALIDRSIVIRANEIYSSQKTEINEILEKLIEKEKDLLLIKESMDKKLIQIELQEKELENFYQDL
LLREKNIETKLLNEQNEFLKNSRKVLENLVREIKEGNINVAKNKAFISDLEKNVDLKTNKVNSLNNKRNVVADFKIGDKV
RIVNSNAKGKIVGISKKKITVNVGAFNVSVSSSEISLENFKEKKENGKNFNFSIDYNKENLLSFTIDIRGMRSVDALDFL
NKKIDNIILNGINKFEIIHGKGEGHLMREVHNLLKELKFIRKYYFAHPSDGGSGKTIVEI

Specific function: This Protein Is Involved In The Repair Of Mismatches In DNA. It Is Possible That It Carries Out The Mismatch Recognition Step. This Protein Has A Weak Atpase Activity. [C]

COG id: COG1193

COG function: function code L; Mismatch repair ATPase (MutS family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Smr domain

Homologues:

Organism=Homo sapiens, GI36949366, Length=274, Percent_Identity=27.7372262773723, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI284813531, Length=199, Percent_Identity=33.6683417085427, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI26638666, Length=238, Percent_Identity=28.5714285714286, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI4505253, Length=238, Percent_Identity=28.5714285714286, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI4557761, Length=294, Percent_Identity=27.5510204081633, Blast_Score=88, Evalue=3e-17,
Organism=Homo sapiens, GI26638664, Length=239, Percent_Identity=28.4518828451883, Blast_Score=84, Evalue=5e-16,
Organism=Homo sapiens, GI4504191, Length=190, Percent_Identity=30.5263157894737, Blast_Score=84, Evalue=6e-16,
Organism=Homo sapiens, GI262231786, Length=205, Percent_Identity=29.7560975609756, Blast_Score=77, Evalue=5e-14,
Organism=Escherichia coli, GI1789089, Length=228, Percent_Identity=29.3859649122807, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17508445, Length=284, Percent_Identity=25, Blast_Score=92, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17534743, Length=175, Percent_Identity=31.4285714285714, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17539736, Length=293, Percent_Identity=26.2798634812287, Blast_Score=79, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17508447, Length=200, Percent_Identity=29, Blast_Score=75, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6319935, Length=223, Percent_Identity=32.2869955156951, Blast_Score=92, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6324482, Length=156, Percent_Identity=32.0512820512821, Blast_Score=84, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6321912, Length=184, Percent_Identity=29.8913043478261, Blast_Score=82, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6321109, Length=162, Percent_Identity=30.2469135802469, Blast_Score=78, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24664545, Length=240, Percent_Identity=30.8333333333333, Blast_Score=101, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24584320, Length=236, Percent_Identity=29.6610169491525, Blast_Score=91, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MUTS2_BORBU (O51125)

Other databases:

- EMBL:   AE000783
- PIR:   B70112
- RefSeq:   NP_212232.1
- ProteinModelPortal:   O51125
- SMR:   O51125
- EnsemblBacteria:   EBBORT00000008494
- GeneID:   1194934
- GenomeReviews:   AE000783_GR
- KEGG:   bbu:BB0098
- NMPDR:   fig|224326.1.peg.482
- TIGR:   BB_0098
- GeneTree:   EBGT00050000006774
- HOGENOM:   HBG354518
- OMA:   PGLVHDQ
- ProtClustDB:   CLSK507352
- BioCyc:   BBUR224326:BB_0098-MONOMER
- HAMAP:   MF_00092
- InterPro:   IPR005747
- InterPro:   IPR000432
- InterPro:   IPR007696
- InterPro:   IPR002625
- PANTHER:   PTHR11361
- PIRSF:   PIRSF005814
- SMART:   SM00534
- SMART:   SM00533
- SMART:   SM00463
- TIGRFAMs:   TIGR01069

Pfam domain/function: PF00488 MutS_V; PF01713 Smr; SSF48334 DNA_repair_MutS_domIII

EC number: NA

Molecular weight: Translated: 89053; Mature: 89053

Theoretical pI: Translated: 8.85; Mature: 8.85

Prosite motif: PS00486 DNA_MISMATCH_REPAIR_2; PS50828 SMR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQDEQDKYLKNIDFYEILSLVSKYVSNPDTVNLLSNQKILKTKESLEKIFSFVSLIRMLF
CCCCHHHHHHCCCHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHH
ESCKGYPNSFINSLKYPISLLLKENSRVSIENLRDIIVFLDEVLRINLFLHKNSDIKHLN
HHCCCCCHHHHHHHCCCEEEEEECCCCEEHHHHHHHHHHHHHHHEEEEEEECCCCCCEEH
VQILSDLLFLNPELKNLLNELKEHIDVDALELKSGVVKEYDSIEFEIKNLNRRVENQIKK
HHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHCCHHHHHCCCEEEHHHHHHHHHHHHHH
IISLNAEYLTSNFVCYKSNKYTLALKSNFKGKIKGNIISISSSGETFYIEPNDIVNANNR
HHHCCHHHHHCCEEEEECCEEEEEEECCCCCEEECEEEEEECCCCEEEECCCCEECCCCC
LNYLSLEKERIILKILRNLSAKVHSNIVLLDNLYNNFLYYDSLKARAIYGIKTKGVFPEI
EEEEEEHHHHHHHHHHHHHHHHHHCCEEEEECHHCCEEEEECCCEEEEEEEECCCCCHHH
SNVLNIFDAHHPLLKDSKAITFTPAENRVVIITGPNAGGKTVTLKTIGLLSAMFQFGIPI
HHHHHHHHCCCCCCCCCCEEEECCCCCEEEEEECCCCCCCEEEEHHHHHHHHHHHCCCCE
VVGESSTFKIFDNIFIDIGDEQSISNSLSTFSSHMSNISYILKHTTKDSLVIFDEFCSGT
EEECCCCEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCC
DIDQGQALAISILEYLININSYVLISTHYNALKYFAYTHEGVVNASMRMDLETMQPNYNL
CCCCCCHHHHHHHHHHHCCCCEEEEEECCCCEEEEEEECCCEEECHHEEEHHHCCCCCEE
IFSIPGESYAFNVASKALIDRSIVIRANEIYSSQKTEINEILEKLIEKEKDLLLIKESMD
EEECCCCCEEEHHHHHHHHCCEEEEEEHHHHCCCCHHHHHHHHHHHHCCCCEEEEHHHCC
KKLIQIELQEKELENFYQDLLLREKNIETKLLNEQNEFLKNSRKVLENLVREIKEGNINV
CEEEEEEEHHHHHHHHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCEE
AKNKAFISDLEKNVDLKTNKVNSLNNKRNVVADFKIGDKVRIVNSNAKGKIVGISKKKIT
ECCHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCEEEEEECCCCEEEEEEECEEEE
VNVGAFNVSVSSSEISLENFKEKKENGKNFNFSIDYNKENLLSFTIDIRGMRSVDALDFL
EEEEEEEEEECCCCCCHHHHHHHHHCCCCEEEEEEECCCCEEEEEEEECCCCCHHHHHHH
NKKIDNIILNGINKFEIIHGKGEGHLMREVHNLLKELKFIRKYYFAHPSDGGSGKTIVEI
HHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEC
>Mature Secondary Structure
MQDEQDKYLKNIDFYEILSLVSKYVSNPDTVNLLSNQKILKTKESLEKIFSFVSLIRMLF
CCCCHHHHHHCCCHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHH
ESCKGYPNSFINSLKYPISLLLKENSRVSIENLRDIIVFLDEVLRINLFLHKNSDIKHLN
HHCCCCCHHHHHHHCCCEEEEEECCCCEEHHHHHHHHHHHHHHHEEEEEEECCCCCCEEH
VQILSDLLFLNPELKNLLNELKEHIDVDALELKSGVVKEYDSIEFEIKNLNRRVENQIKK
HHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHCCHHHHHCCCEEEHHHHHHHHHHHHHH
IISLNAEYLTSNFVCYKSNKYTLALKSNFKGKIKGNIISISSSGETFYIEPNDIVNANNR
HHHCCHHHHHCCEEEEECCEEEEEEECCCCCEEECEEEEEECCCCEEEECCCCEECCCCC
LNYLSLEKERIILKILRNLSAKVHSNIVLLDNLYNNFLYYDSLKARAIYGIKTKGVFPEI
EEEEEEHHHHHHHHHHHHHHHHHHCCEEEEECHHCCEEEEECCCEEEEEEEECCCCCHHH
SNVLNIFDAHHPLLKDSKAITFTPAENRVVIITGPNAGGKTVTLKTIGLLSAMFQFGIPI
HHHHHHHHCCCCCCCCCCEEEECCCCCEEEEEECCCCCCCEEEEHHHHHHHHHHHCCCCE
VVGESSTFKIFDNIFIDIGDEQSISNSLSTFSSHMSNISYILKHTTKDSLVIFDEFCSGT
EEECCCCEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCC
DIDQGQALAISILEYLININSYVLISTHYNALKYFAYTHEGVVNASMRMDLETMQPNYNL
CCCCCCHHHHHHHHHHHCCCCEEEEEECCCCEEEEEEECCCEEECHHEEEHHHCCCCCEE
IFSIPGESYAFNVASKALIDRSIVIRANEIYSSQKTEINEILEKLIEKEKDLLLIKESMD
EEECCCCCEEEHHHHHHHHCCEEEEEEHHHHCCCCHHHHHHHHHHHHCCCCEEEEHHHCC
KKLIQIELQEKELENFYQDLLLREKNIETKLLNEQNEFLKNSRKVLENLVREIKEGNINV
CEEEEEEEHHHHHHHHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCEE
AKNKAFISDLEKNVDLKTNKVNSLNNKRNVVADFKIGDKVRIVNSNAKGKIVGISKKKIT
ECCHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCEEEEEECCCCEEEEEEECEEEE
VNVGAFNVSVSSSEISLENFKEKKENGKNFNFSIDYNKENLLSFTIDIRGMRSVDALDFL
EEEEEEEEEECCCCCCHHHHHHHHHCCCCEEEEEEECCCCEEEEEEEECCCCCHHHHHHH
NKKIDNIILNGINKFEIIHGKGEGHLMREVHNLLKELKFIRKYYFAHPSDGGSGKTIVEI
HHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9403685