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The map label for this gene is pepP [H]

Identifier: 15594413

GI number: 15594413

Start: 61254

End: 63032

Strand: Reverse

Name: pepP [H]

Synonym: BB0067

Alternate gene names: 15594413

Gene position: 63032-61254 (Counterclockwise)

Preceding gene: 15594428

Following gene: 15594412

Centisome position: 6.92

GC content: 30.93

Gene sequence:

>1779_bases
TTGGATATTAATAAAAGATTAGCTTTGCTTAGAGATCATATGAGAGATAATGGGGTTGATGCTTATTTGGTAGCAGGCTA
TGATCCTCATTTTAGTGAATATTCTCATGAAAGATATAGCACTCGTAAGTTTATTACAGGTTTTTCTGGTAGCTTTGGTA
CGGTAATTATAACATTATCAAAAGCTGTTCTTTTTACAGATGGTAGGTATTTTTTACAGGCCGAGCAAGAGCTTAAGGGA
ACTGAAATTGCATTAATAAAGCTTGGAGTAAAAGGATCTCCTGATATTTTTACGTATATAAATTTGAATCTTAAAGAATC
AAAGCTTGGAATTTATTCAGATGAGATTAGTATAAAGTTTTATAAAGAGTTGTCTGAAAAATGTAAAAATACACATATCA
AGGCTTTAAATCAAGATCTAATTGATTTAATTTGGAAATCTAGACCCCAGCTTGAGTTTAGCCATGTATTTGAATTGGCT
GATGCTGAGAAGAATAACAAAAGAGCTGAAAAAATCAAATCTATTTATTTGATCTTAGAAAAGAATTTGGCAGATTTTTA
TGTTATTACTGCTCTTGATGAGATTGCTTGGGTGCTGAATTTAAGAGGGGCAGATGTTGAAGAATCAGCATTATTTTATT
CGTTTCTTTTAATATCTAGGAATAAAAATCGAAAAAATGTTCTTTTTGTTGACAYAAAAAAACTTGATTCGGGTGTTAAA
GAAGCACTTGAAATGGAAAATTTTGAAATAGAGTCTTACAGCAATTTTTACTGTTTTTTGGACAAAATAAAGCACGAAGG
TAAATTTTTTGTTTCATTTTATGCCAATGTTAGGGTTTTAAAAGTTCTTGGTGAGACTAATATCATTTTGGGAGAGAGTA
TTATAAGTAGTCTTAAGGCATTAAAAACCGATTATGAACTTCTTAAGATGAAAGAAGCGCATATTATTGATGCTATTGCA
TTGATTAAATTTTTACGTAAATTTAAAAGTCTTAGCAAGGTTGAATTGTCTGAATTAGATGAAATAGATGTTGCTGATAT
GCTTTTGCATTTTAGAAAATTGAATAAAGATTTTTTTAGTTCTAGCTTTGACTCAATAGTTGGTTTTAGAGAAAATGGAG
CTCTTCCGCATTATAAGCCCAAAAGAGGTAGAAAAATAAATACCAATGGTCTTCTTTTGATTGATTCTGGGGGTTCATAT
TTTGGACTTGGTACGACAGACGTTACAAGAGTTTTTTTAATAGGTGATGCCTCTGATGAAGAAAAGCGCGACTATACTTT
GGTTCTTAAGGCTTTCATTGGCCTTTCTTCTTTAAAGTTTCCATATGGATCTTCCGGAGCTTTTCTTGATGGAATTTGTA
GATTACCGCTTTTAAAAAATGAATTGAATTTTATTCATGGCACTGGGCATGGTGTTGGGTTTTTTCTTAATGTTCATGAA
CTTCCAGTTTCTATTAGTCCTAATTCTAGTTATCTTTTTAAAGGATCTGAGGTAGTTTCAATTGAGCCTGGTCTTTATAG
AACATTTAGTCACGGAATAAGAATTGAGAATTTAGTTTTTGTAAGGCAAGCTTTTACAAATGACTTTGGAGCTTTTTTAG
AGTTTGAGAATTTAACCCTTGTTCCTTTTGAAAAGGAATTGATAGTAAAAGAAATGCTCTCAGAAGATGAGTTAAATTAT
ATCAATGATTATCATGAATGTGTATTTTTAACATTAAAAGAGCGCTTTGATAATGAAGGAGAGTTGGAATTTTTAGCAAA
GCTAACAAGTAAAATATGA

Upstream 100 bases:

>100_bases
GAGTTAATTTCAAGCTAAATTATATCAAATAATTTTTTTTTTTTAAATTGATAATTATTTGGTATACTAATATTAGTAAG
GTTGTATAAAGGGGATTTTT

Downstream 100 bases:

>100_bases
GATTTATAATTGCATTTTTAATGATTTTAAATCAAGGATTTTCAAATTTGTTTTCTTTGCCTCCGGAAGATATTATTTTT
GAGAGTTCTTATGAGGTTGC

Product: peptidase

Products: NA

Alternate protein names: X-Pro aminopeptidase; Aminoacylproline aminopeptidase; Aminopeptidase P; APP [H]

Number of amino acids: Translated: 592; Mature: 592

Protein sequence:

>592_residues
MDINKRLALLRDHMRDNGVDAYLVAGYDPHFSEYSHERYSTRKFITGFSGSFGTVIITLSKAVLFTDGRYFLQAEQELKG
TEIALIKLGVKGSPDIFTYINLNLKESKLGIYSDEISIKFYKELSEKCKNTHIKALNQDLIDLIWKSRPQLEFSHVFELA
DAEKNNKRAEKIKSIYLILEKNLADFYVITALDEIAWVLNLRGADVEESALFYSFLLISRNKNRKNVLFVDXKKLDSGVK
EALEMENFEIESYSNFYCFLDKIKHEGKFFVSFYANVRVLKVLGETNIILGESIISSLKALKTDYELLKMKEAHIIDAIA
LIKFLRKFKSLSKVELSELDEIDVADMLLHFRKLNKDFFSSSFDSIVGFRENGALPHYKPKRGRKINTNGLLLIDSGGSY
FGLGTTDVTRVFLIGDASDEEKRDYTLVLKAFIGLSSLKFPYGSSGAFLDGICRLPLLKNELNFIHGTGHGVGFFLNVHE
LPVSISPNSSYLFKGSEVVSIEPGLYRTFSHGIRIENLVFVRQAFTNDFGAFLEFENLTLVPFEKELIVKEMLSEDELNY
INDYHECVFLTLKERFDNEGELEFLAKLTSKI

Sequences:

>Translated_592_residues
MDINKRLALLRDHMRDNGVDAYLVAGYDPHFSEYSHERYSTRKFITGFSGSFGTVIITLSKAVLFTDGRYFLQAEQELKG
TEIALIKLGVKGSPDIFTYINLNLKESKLGIYSDEISIKFYKELSEKCKNTHIKALNQDLIDLIWKSRPQLEFSHVFELA
DAEKNNKRAEKIKSIYLILEKNLADFYVITALDEIAWVLNLRGADVEESALFYSFLLISRNKNRKNVLFVDXKKLDSGVK
EALEMENFEIESYSNFYCFLDKIKHEGKFFVSFYANVRVLKVLGETNIILGESIISSLKALKTDYELLKMKEAHIIDAIA
LIKFLRKFKSLSKVELSELDEIDVADMLLHFRKLNKDFFSSSFDSIVGFRENGALPHYKPKRGRKINTNGLLLIDSGGSY
FGLGTTDVTRVFLIGDASDEEKRDYTLVLKAFIGLSSLKFPYGSSGAFLDGICRLPLLKNELNFIHGTGHGVGFFLNVHE
LPVSISPNSSYLFKGSEVVSIEPGLYRTFSHGIRIENLVFVRQAFTNDFGAFLEFENLTLVPFEKELIVKEMLSEDELNY
INDYHECVFLTLKERFDNEGELEFLAKLTSKI
>Mature_592_residues
MDINKRLALLRDHMRDNGVDAYLVAGYDPHFSEYSHERYSTRKFITGFSGSFGTVIITLSKAVLFTDGRYFLQAEQELKG
TEIALIKLGVKGSPDIFTYINLNLKESKLGIYSDEISIKFYKELSEKCKNTHIKALNQDLIDLIWKSRPQLEFSHVFELA
DAEKNNKRAEKIKSIYLILEKNLADFYVITALDEIAWVLNLRGADVEESALFYSFLLISRNKNRKNVLFVDXKKLDSGVK
EALEMENFEIESYSNFYCFLDKIKHEGKFFVSFYANVRVLKVLGETNIILGESIISSLKALKTDYELLKMKEAHIIDAIA
LIKFLRKFKSLSKVELSELDEIDVADMLLHFRKLNKDFFSSSFDSIVGFRENGALPHYKPKRGRKINTNGLLLIDSGGSY
FGLGTTDVTRVFLIGDASDEEKRDYTLVLKAFIGLSSLKFPYGSSGAFLDGICRLPLLKNELNFIHGTGHGVGFFLNVHE
LPVSISPNSSYLFKGSEVVSIEPGLYRTFSHGIRIENLVFVRQAFTNDFGAFLEFENLTLVPFEKELIVKEMLSEDELNY
INDYHECVFLTLKERFDNEGELEFLAKLTSKI

Specific function: Unknown

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family [H]

Homologues:

Organism=Homo sapiens, GI264681563, Length=619, Percent_Identity=33.9256865912762, Blast_Score=303, Evalue=3e-82,
Organism=Homo sapiens, GI264681565, Length=617, Percent_Identity=32.7390599675851, Blast_Score=283, Evalue=3e-76,
Organism=Homo sapiens, GI93141226, Length=615, Percent_Identity=31.0569105691057, Blast_Score=276, Evalue=4e-74,
Organism=Caenorhabditis elegans, GI17509539, Length=600, Percent_Identity=34.5, Blast_Score=311, Evalue=5e-85,
Organism=Caenorhabditis elegans, GI25149105, Length=572, Percent_Identity=27.6223776223776, Blast_Score=201, Evalue=7e-52,
Organism=Saccharomyces cerevisiae, GI6322999, Length=642, Percent_Identity=30.2180685358255, Blast_Score=258, Evalue=2e-69,
Organism=Drosophila melanogaster, GI17137632, Length=611, Percent_Identity=33.2242225859247, Blast_Score=275, Evalue=5e-74,
Organism=Drosophila melanogaster, GI161078230, Length=593, Percent_Identity=27.4873524451939, Blast_Score=197, Evalue=2e-50,
Organism=Drosophila melanogaster, GI21357287, Length=593, Percent_Identity=27.4873524451939, Blast_Score=197, Evalue=2e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000587
- InterPro:   IPR000994
- InterPro:   IPR001131 [H]

Pfam domain/function: PF01321 Creatinase_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.11.9 [H]

Molecular weight: Translated: 67571; Mature: 67571

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDINKRLALLRDHMRDNGVDAYLVAGYDPHFSEYSHERYSTRKFITGFSGSFGTVIITLS
CCCHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHEECCCCCCCEEEEEEE
KAVLFTDGRYFLQAEQELKGTEIALIKLGVKGSPDIFTYINLNLKESKLGIYSDEISIKF
EEEEEECCEEEEEECCCCCCCEEEEEEECCCCCCCEEEEEEEEEECCCCCEEECCEEHHH
YKELSEKCKNTHIKALNQDLIDLIWKSRPQLEFSHVFELADAEKNNKRAEKIKSIYLILE
HHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCHHHHHHHHEEEEEE
KNLADFYVITALDEIAWVLNLRGADVEESALFYSFLLISRNKNRKNVLFVDXKKLDSGVK
CCCCCEEEEHHHHHHHHHHCCCCCCCCHHHHHHEEEEEECCCCCCEEEEEEHHHHHHHHH
EALEMENFEIESYSNFYCFLDKIKHEGKFFVSFYANVRVLKVLGETNIILGESIISSLKA
HHHHHCCCEECCCCCEEEEEEHHCCCCEEEEEEECCEEEEEEECCCCEEECHHHHHHHHH
LKTDYELLKMKEAHIIDAIALIKFLRKFKSLSKVELSELDEIDVADMLLHFRKLNKDFFS
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCHHHHHHHHHHHCHHHHC
SSFDSIVGFRENGALPHYKPKRGRKINTNGLLLIDSGGSYFGLGTTDVTRVFLIGDASDE
CCHHHHHEECCCCCCCCCCCCCCCEECCCCEEEEECCCCEEECCCCCEEEEEEEECCCCC
EKRDYTLVLKAFIGLSSLKFPYGSSGAFLDGICRLPLLKNELNFIHGTGHGVGFFLNVHE
CCCHHHHHHHHHHCHHHCCCCCCCCCCHHHHHHCCCCCCCCCCEEEECCCCEEEEEEEEE
LPVSISPNSSYLFKGSEVVSIEPGLYRTFSHGIRIENLVFVRQAFTNDFGAFLEFENLTL
CEEEECCCCCEEEECCEEEEECCCHHHHHHCCCEEHHHHHHHHHHCCCCCCEEEECCEEE
VPFEKELIVKEMLSEDELNYINDYHECVFLTLKERFDNEGELEFLAKLTSKI
ECCHHHHHHHHHHCCCCHHHHHHHHHHEEEEEHHHCCCCCHHHHHHHHHHCC
>Mature Secondary Structure
MDINKRLALLRDHMRDNGVDAYLVAGYDPHFSEYSHERYSTRKFITGFSGSFGTVIITLS
CCCHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHEECCCCCCCEEEEEEE
KAVLFTDGRYFLQAEQELKGTEIALIKLGVKGSPDIFTYINLNLKESKLGIYSDEISIKF
EEEEEECCEEEEEECCCCCCCEEEEEEECCCCCCCEEEEEEEEEECCCCCEEECCEEHHH
YKELSEKCKNTHIKALNQDLIDLIWKSRPQLEFSHVFELADAEKNNKRAEKIKSIYLILE
HHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCHHHHHHHHEEEEEE
KNLADFYVITALDEIAWVLNLRGADVEESALFYSFLLISRNKNRKNVLFVDXKKLDSGVK
CCCCCEEEEHHHHHHHHHHCCCCCCCCHHHHHHEEEEEECCCCCCEEEEEEHHHHHHHHH
EALEMENFEIESYSNFYCFLDKIKHEGKFFVSFYANVRVLKVLGETNIILGESIISSLKA
HHHHHCCCEECCCCCEEEEEEHHCCCCEEEEEEECCEEEEEEECCCCEEECHHHHHHHHH
LKTDYELLKMKEAHIIDAIALIKFLRKFKSLSKVELSELDEIDVADMLLHFRKLNKDFFS
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCHHHHHHHHHHHCHHHHC
SSFDSIVGFRENGALPHYKPKRGRKINTNGLLLIDSGGSYFGLGTTDVTRVFLIGDASDE
CCHHHHHEECCCCCCCCCCCCCCCEECCCCEEEEECCCCEEECCCCCEEEEEEEECCCCC
EKRDYTLVLKAFIGLSSLKFPYGSSGAFLDGICRLPLLKNELNFIHGTGHGVGFFLNVHE
CCCHHHHHHHHHHCHHHCCCCCCCCCCHHHHHHCCCCCCCCCCEEEECCCCEEEEEEEEE
LPVSISPNSSYLFKGSEVVSIEPGLYRTFSHGIRIENLVFVRQAFTNDFGAFLEFENLTL
CEEEECCCCCEEEECCEEEEECCCHHHHHHCCCEEHHHHHHHHHHCCCCCCEEEECCEEE
VPFEKELIVKEMLSEDELNYINDYHECVFLTLKERFDNEGELEFLAKLTSKI
ECCHHHHHHHHHHCCCCHHHHHHHHHHEEEEEHHHCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8948633 [H]