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The map label for this gene is dnaC

Identifier: 255767872

GI number: 255767872

Start: 4157471

End: 4158835

Strand: Reverse

Name: dnaC

Synonym: BSU40440

Alternate gene names: 255767872

Gene position: 4158835-4157471 (Counterclockwise)

Preceding gene: 16081098

Following gene: 16081095

Centisome position: 98.65

GC content: 48.35

Gene sequence:

>1365_bases
ATGACAGACCTTCTGAATGACCGGCTTCCTCCGCAAAATATAGAAGCCGAACAAGCCGTGTTAGGCGCTATTTTTTTACA
GCCGTCTGCTTTAACACTGGCTTCAGAAGTATTGATTCCAGATGATTTCTATAGAATGTCCCACCAAAAAATCTATAATG
CGATGCTGGTGCTCGGTGACCGAGGTGAACCGGTTGATCTGGTGACAGTTACATCAGAGCTTGCGAACACAGACCTGCTG
GAAGAAGTAGGCGGTATTTCATATTTGACAGATATCGCAAACTCGGTGCCGACAGCGGCTAACATAGAATATTACGCGAA
AATCGTTGAGGAAAAATCGATTCTTCGCCGATTAATCAGAACTGCGACAACGATTGCTCAAGACGGGTATACCCGTGAGG
ATGAGGTCGAGGATTTACTCAGTGAAGCGGAAAAAACGATTATGGAAGTGGCACAGCGCAAAAACACGAGTGCCTTCCAA
AATATTAAGGACGTCCTTGTCCAGACCTATGATAATATCGAACAGCTTCACAATCGAAAAGGTGATATCACGGGAATTCC
AACAGGGTTTACGGAGCTTGACCGGATGACTGCGGGTTTCCAGCGCAACGACTTGATCATTGTGGCTGCCCGTCCTTCAG
TAGGGAAAACAGCCTTTGCCCTGAACATCGCACAAAACGTGGCGACGAAGACCGATGAGAGCGTAGCGATTTTCAGTCTT
GAGATGGGTGCCGAGCAGCTCGTTATGCGTATGCTCTGTGCCGAGGGAAATATCAATGCCCAGAATCTCCGTACAGGTAA
CCTGACCGAAGAGGATTGGGGCAAGCTGACGATGGCAATGGGAAGCCTATCGAACAGCGGGATTTACATCGATGATACAC
CGGGTATTCGAGTGAGTGAAATCCGTGCCAAGTGCCGCCGCTTGAAGCAGGAAAGCGGGCTGGGCATGATTTTGATCGAT
TACCTGCAATTGATTCAGGGAAGCGGTCGTTCAAAGGACAACCGTCAGCAGGAAGTATCTGAAATTTCCCGTGAACTGAA
GTCGATTGCGAGGGAGCTGCAAGTCCCTGTTATCGCGCTTTCTCAGCTTTCCAGGGGTGTTGAGCAGCGTCAGGATAAAC
GTCCGATGATGTCTGATATCCGGGAATCAGGAAGTATCGAGCAGGACGCGGATATTGTCGCGTTCCTTTATCGTGATGAC
TACTATGACAAAGAAACCGAGAATAAAAATATTATCGAAATTATTATCGCCAAACAGCGTAACGGCCCGGTAGGAACCGT
GTCTCTTGCGTTCGTAAAAGAATACAACAAATTCGTCAACCTGGAACGGCGTTTTGATGACGCAGGCGTTCCGCCCGGCG
CATAA

Upstream 100 bases:

>100_bases
TAACTGAAAAAAACAGGAAACAGACAATTTTTCTATTTTTTTTCTGTAGAAATGGTAGAATGGAGGTTGGAGATTTTTTA
ATGAGAGGACGGTGCTTAGC

Downstream 100 bases:

>100_bases
GCCCCAAGAGCTGCTCTTGGGGTTTTTTTCATTCGAAAGATGGAAGAAATGACGTTCGCTCAGCGGATGAAAAATTGAAA
GCGTTTTAATAAAATGGTGC

Product: replicative DNA helicase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 454; Mature: 453

Protein sequence:

>454_residues
MTDLLNDRLPPQNIEAEQAVLGAIFLQPSALTLASEVLIPDDFYRMSHQKIYNAMLVLGDRGEPVDLVTVTSELANTDLL
EEVGGISYLTDIANSVPTAANIEYYAKIVEEKSILRRLIRTATTIAQDGYTREDEVEDLLSEAEKTIMEVAQRKNTSAFQ
NIKDVLVQTYDNIEQLHNRKGDITGIPTGFTELDRMTAGFQRNDLIIVAARPSVGKTAFALNIAQNVATKTDESVAIFSL
EMGAEQLVMRMLCAEGNINAQNLRTGNLTEEDWGKLTMAMGSLSNSGIYIDDTPGIRVSEIRAKCRRLKQESGLGMILID
YLQLIQGSGRSKDNRQQEVSEISRELKSIARELQVPVIALSQLSRGVEQRQDKRPMMSDIRESGSIEQDADIVAFLYRDD
YYDKETENKNIIEIIIAKQRNGPVGTVSLAFVKEYNKFVNLERRFDDAGVPPGA

Sequences:

>Translated_454_residues
MTDLLNDRLPPQNIEAEQAVLGAIFLQPSALTLASEVLIPDDFYRMSHQKIYNAMLVLGDRGEPVDLVTVTSELANTDLL
EEVGGISYLTDIANSVPTAANIEYYAKIVEEKSILRRLIRTATTIAQDGYTREDEVEDLLSEAEKTIMEVAQRKNTSAFQ
NIKDVLVQTYDNIEQLHNRKGDITGIPTGFTELDRMTAGFQRNDLIIVAARPSVGKTAFALNIAQNVATKTDESVAIFSL
EMGAEQLVMRMLCAEGNINAQNLRTGNLTEEDWGKLTMAMGSLSNSGIYIDDTPGIRVSEIRAKCRRLKQESGLGMILID
YLQLIQGSGRSKDNRQQEVSEISRELKSIARELQVPVIALSQLSRGVEQRQDKRPMMSDIRESGSIEQDADIVAFLYRDD
YYDKETENKNIIEIIIAKQRNGPVGTVSLAFVKEYNKFVNLERRFDDAGVPPGA
>Mature_453_residues
TDLLNDRLPPQNIEAEQAVLGAIFLQPSALTLASEVLIPDDFYRMSHQKIYNAMLVLGDRGEPVDLVTVTSELANTDLLE
EVGGISYLTDIANSVPTAANIEYYAKIVEEKSILRRLIRTATTIAQDGYTREDEVEDLLSEAEKTIMEVAQRKNTSAFQN
IKDVLVQTYDNIEQLHNRKGDITGIPTGFTELDRMTAGFQRNDLIIVAARPSVGKTAFALNIAQNVATKTDESVAIFSLE
MGAEQLVMRMLCAEGNINAQNLRTGNLTEEDWGKLTMAMGSLSNSGIYIDDTPGIRVSEIRAKCRRLKQESGLGMILIDY
LQLIQGSGRSKDNRQQEVSEISRELKSIARELQVPVIALSQLSRGVEQRQDKRPMMSDIRESGSIEQDADIVAFLYRDDY
YDKETENKNIIEIIIAKQRNGPVGTVSLAFVKEYNKFVNLERRFDDAGVPPGA

Specific function: Participates In Initiation And Elongation During Chromosome Replication; It Exhibits DNA-Dependent ATPase Activity And Contains Distinct Active Sites For ATP Binding, DNA Binding, And Interaction With DNAc Protein, Primase, And Other Prepriming Proteins.

COG id: COG0305

COG function: function code L; Replicative DNA helicase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 SF4 helicase domain

Homologues:

Organism=Escherichia coli, GI1790486, Length=439, Percent_Identity=46.2414578587699, Blast_Score=395, Evalue=1e-111,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DNAC_BACSU (P37469)

Other databases:

- EMBL:   D26185
- EMBL:   AL009126
- EMBL:   M83690
- PIR:   S65970
- RefSeq:   NP_391924.2
- ProteinModelPortal:   P37469
- SMR:   P37469
- EnsemblBacteria:   EBBACT00000002275
- GeneID:   937810
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU40440
- NMPDR:   fig|224308.1.peg.4050
- GenoList:   BSU40440
- GeneTree:   EBGT00050000002184
- HOGENOM:   HBG734566
- PhylomeDB:   P37469
- ProtClustDB:   PRK05748
- BioCyc:   BSUB:BSU40440-MONOMER
- InterPro:   IPR003593
- InterPro:   IPR007692
- InterPro:   IPR007694
- InterPro:   IPR007693
- InterPro:   IPR016136
- Gene3D:   G3DSA:1.10.860.10
- SMART:   SM00382
- TIGRFAMs:   TIGR00665

Pfam domain/function: PF00772 DnaB; PF03796 DnaB_C; SSF48024 DNA_helicase_DnaB-like_N

EC number: =3.6.4.12

Molecular weight: Translated: 50577; Mature: 50446

Theoretical pI: Translated: 4.50; Mature: 4.50

Prosite motif: PS51199 SF4_HELICASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDLLNDRLPPQNIEAEQAVLGAIFLQPSALTLASEVLIPDDFYRMSHQKIYNAMLVLGD
CCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHEEECC
RGEPVDLVTVTSELANTDLLEEVGGISYLTDIANSVPTAANIEYYAKIVEEKSILRRLIR
CCCCEEEEEECHHHHCHHHHHHHCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHH
TATTIAQDGYTREDEVEDLLSEAEKTIMEVAQRKNTSAFQNIKDVLVQTYDNIEQLHNRK
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCC
GDITGIPTGFTELDRMTAGFQRNDLIIVAARPSVGKTAFALNIAQNVATKTDESVAIFSL
CCCCCCCCCHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCEEEEEE
EMGAEQLVMRMLCAEGNINAQNLRTGNLTEEDWGKLTMAMGSLSNSGIYIDDTPGIRVSE
CCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEECCCCCCHHH
IRAKCRRLKQESGLGMILIDYLQLIQGSGRSKDNRQQEVSEISRELKSIARELQVPVIAL
HHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHH
SQLSRGVEQRQDKRPMMSDIRESGSIEQDADIVAFLYRDDYYDKETENKNIIEIIIAKQR
HHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEEEEEECC
NGPVGTVSLAFVKEYNKFVNLERRFDDAGVPPGA
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
TDLLNDRLPPQNIEAEQAVLGAIFLQPSALTLASEVLIPDDFYRMSHQKIYNAMLVLGD
CCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHEEECC
RGEPVDLVTVTSELANTDLLEEVGGISYLTDIANSVPTAANIEYYAKIVEEKSILRRLIR
CCCCEEEEEECHHHHCHHHHHHHCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHH
TATTIAQDGYTREDEVEDLLSEAEKTIMEVAQRKNTSAFQNIKDVLVQTYDNIEQLHNRK
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCC
GDITGIPTGFTELDRMTAGFQRNDLIIVAARPSVGKTAFALNIAQNVATKTDESVAIFSL
CCCCCCCCCHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCEEEEEE
EMGAEQLVMRMLCAEGNINAQNLRTGNLTEEDWGKLTMAMGSLSNSGIYIDDTPGIRVSE
CCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEECCCCCCHHH
IRAKCRRLKQESGLGMILIDYLQLIQGSGRSKDNRQQEVSEISRELKSIARELQVPVIAL
HHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHH
SQLSRGVEQRQDKRPMMSDIRESGSIEQDADIVAFLYRDDYYDKETENKNIIEIIIAKQR
HHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEEEEEECC
NGPVGTVSLAFVKEYNKFVNLERRFDDAGVPPGA
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7584024; 9384377; 1312531