The gene/protein map for NC_000964 is currently unavailable.
Definition Bacillus subtilis subsp. subtilis str. 168 chromosome, complete genome.
Accession NC_000964
Length 4,215,606

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The map label for this gene is zwf

Identifier: 255767517

GI number: 255767517

Start: 2479156

End: 2480625

Strand: Direct

Name: zwf

Synonym: BSU23850

Alternate gene names: 255767517

Gene position: 2479156-2480625 (Clockwise)

Preceding gene: 16079440

Following gene: 50812265

Centisome position: 58.81

GC content: 42.52

Gene sequence:

>1470_bases
GTGAAAACAAACCAACAACCAAAAGCAGTAATTGTCATATTCGGTGCAACTGGAGATTTAGCAAAACGAAAATTGTATCC
GTCTATTCACCGTTTATATCAAAACGGACAAATCGGAGAAGAGTTTGCAGTGGTAGGAGTTGGAAGAAGACCTTGGTCTA
ATGAGGATCTTCGCCAAACTGTTAAAACATCCATTTCCTCATCTGCAGATAAGCATATAGATGATTTCACGTCTCATTTT
TACTATCACCCGTTTGACGTGACAAACCCTGGTTCTTATCAAGAGCTAAACGTATTGCTTAACCAGCTGGAAGATACATA
TCAAATTCCTAACAACAGAATGTTCTACTTGGCAATGGCTCCTGAATTCTTCGGAACGATTGCAAAAACATTAAAATCAG
AGGGTGTAACAGCTACAACCGGCTGGTCCCGCCTTGTCATCGAAAAACCGTTCGGCCATGATCTGCCAAGCGCACAGGCA
TTGAATAAAGAAATCCGCGAAGCATTTACGGAAGATCAAATTTACAGAATCGACCATTATCTAGGCAAACAAATGGTTCA
GAACATTGAAGTGATTCGATTTGCCAATGCGATTTTCGAACCGCTTTGGACAAACCGCTACATTTCAAACATTCAAATCA
CATCTAGCGAATCACTAGGCGTTGAAGACCGCGCAAGATATTACGAAAAATCAGGCGCCCTTCGCGACATGGTGCAAAAC
CATATTATGCAGATGGTTGCCCTTCTTGCAATGGAGCCGCCTATCAAATTGAACACAGAAGAAATCCGCAGCGAGAAAGT
GAAGGTGCTGAGAGCACTGCGTCCTATTGCAAAAGACGAAGTGGATGAATACTTTGTGCGCGGACAATATCATGCTGGTG
AAATTGACGGTGTACCGGTTCCTGCTTATACAGATGAAGATAATGTCGCTCCTGACTCCAATACAGAAACCTTTGTTGCC
GGCAAGCTCTTGATCGACAACTTCAGATGGGCTGGTGTTCCATTCTACATCAGAACCGGAAAACGAATGAAAGAAAAGTC
CACAAAAATTGTCGTTCAATTTAAGGACATTCCGATGAACCTGTACTACGGTAATGAAAACAACATGAATCCGAACTTGC
TTGTCATTCATATTCAGCCTGACGAAGGCATTACGCTTTACTTAAATGCTAAAAAGCTTGGCGGAGCAGCACACGCACAG
CCAATCAAACTCGATTATTGCAGCAATTGCAATGACGAGTTGAACACCCCTGAAGCATATGAAAAACTAATTCACGACTG
TCTTCTTGGCGATGCAACAAACTTTGCACACTGGGATGAAGTTGCCCTTTCTTGGAGCTTTGTCGACTCTATTTCTGAAA
CATGGGCAGCAAACAAAACCTTATCTCCTAACTACGAATCAGGCTCAATGGGACCGAAAGAATCTGATGATCTTTTGGTG
AAAGACGGCTTACACTGGTGGAACATATAA

Upstream 100 bases:

>100_bases
AAGGGCTTAAATGTTTGCTTTCGTTGAATTTTAGATTTAAAATGAAGGAAATATACGGGGTGTACTAAAATAAAGCTTCG
AATAAAGTGAGGTACTTTTA

Downstream 100 bases:

>100_bases
TAAGAAGAAAAAAGCCGAAATAGTTTACTAAGCATTTTCGGTCTTTTTTACGCTGAACAAAGGTATAACAATCTCCTTAA
TAACAAAACCCCCAAAGCTT

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD; Vegetative protein 11; VEG11

Number of amino acids: Translated: 489; Mature: 489

Protein sequence:

>489_residues
MKTNQQPKAVIVIFGATGDLAKRKLYPSIHRLYQNGQIGEEFAVVGVGRRPWSNEDLRQTVKTSISSSADKHIDDFTSHF
YYHPFDVTNPGSYQELNVLLNQLEDTYQIPNNRMFYLAMAPEFFGTIAKTLKSEGVTATTGWSRLVIEKPFGHDLPSAQA
LNKEIREAFTEDQIYRIDHYLGKQMVQNIEVIRFANAIFEPLWTNRYISNIQITSSESLGVEDRARYYEKSGALRDMVQN
HIMQMVALLAMEPPIKLNTEEIRSEKVKVLRALRPIAKDEVDEYFVRGQYHAGEIDGVPVPAYTDEDNVAPDSNTETFVA
GKLLIDNFRWAGVPFYIRTGKRMKEKSTKIVVQFKDIPMNLYYGNENNMNPNLLVIHIQPDEGITLYLNAKKLGGAAHAQ
PIKLDYCSNCNDELNTPEAYEKLIHDCLLGDATNFAHWDEVALSWSFVDSISETWAANKTLSPNYESGSMGPKESDDLLV
KDGLHWWNI

Sequences:

>Translated_489_residues
MKTNQQPKAVIVIFGATGDLAKRKLYPSIHRLYQNGQIGEEFAVVGVGRRPWSNEDLRQTVKTSISSSADKHIDDFTSHF
YYHPFDVTNPGSYQELNVLLNQLEDTYQIPNNRMFYLAMAPEFFGTIAKTLKSEGVTATTGWSRLVIEKPFGHDLPSAQA
LNKEIREAFTEDQIYRIDHYLGKQMVQNIEVIRFANAIFEPLWTNRYISNIQITSSESLGVEDRARYYEKSGALRDMVQN
HIMQMVALLAMEPPIKLNTEEIRSEKVKVLRALRPIAKDEVDEYFVRGQYHAGEIDGVPVPAYTDEDNVAPDSNTETFVA
GKLLIDNFRWAGVPFYIRTGKRMKEKSTKIVVQFKDIPMNLYYGNENNMNPNLLVIHIQPDEGITLYLNAKKLGGAAHAQ
PIKLDYCSNCNDELNTPEAYEKLIHDCLLGDATNFAHWDEVALSWSFVDSISETWAANKTLSPNYESGSMGPKESDDLLV
KDGLHWWNI
>Mature_489_residues
MKTNQQPKAVIVIFGATGDLAKRKLYPSIHRLYQNGQIGEEFAVVGVGRRPWSNEDLRQTVKTSISSSADKHIDDFTSHF
YYHPFDVTNPGSYQELNVLLNQLEDTYQIPNNRMFYLAMAPEFFGTIAKTLKSEGVTATTGWSRLVIEKPFGHDLPSAQA
LNKEIREAFTEDQIYRIDHYLGKQMVQNIEVIRFANAIFEPLWTNRYISNIQITSSESLGVEDRARYYEKSGALRDMVQN
HIMQMVALLAMEPPIKLNTEEIRSEKVKVLRALRPIAKDEVDEYFVRGQYHAGEIDGVPVPAYTDEDNVAPDSNTETFVA
GKLLIDNFRWAGVPFYIRTGKRMKEKSTKIVVQFKDIPMNLYYGNENNMNPNLLVIHIQPDEGITLYLNAKKLGGAAHAQ
PIKLDYCSNCNDELNTPEAYEKLIHDCLLGDATNFAHWDEVALSWSFVDSISETWAANKTLSPNYESGSMGPKESDDLLV
KDGLHWWNI

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family

Homologues:

Organism=Homo sapiens, GI109389365, Length=487, Percent_Identity=35.523613963039, Blast_Score=313, Evalue=3e-85,
Organism=Homo sapiens, GI108773793, Length=487, Percent_Identity=35.523613963039, Blast_Score=313, Evalue=3e-85,
Organism=Homo sapiens, GI52145310, Length=396, Percent_Identity=31.3131313131313, Blast_Score=176, Evalue=4e-44,
Organism=Escherichia coli, GI1788158, Length=498, Percent_Identity=39.3574297188755, Blast_Score=367, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI17538218, Length=481, Percent_Identity=35.966735966736, Blast_Score=317, Evalue=9e-87,
Organism=Saccharomyces cerevisiae, GI6324088, Length=474, Percent_Identity=38.3966244725738, Blast_Score=308, Evalue=1e-84,
Organism=Drosophila melanogaster, GI24643352, Length=474, Percent_Identity=34.8101265822785, Blast_Score=284, Evalue=9e-77,
Organism=Drosophila melanogaster, GI24643350, Length=474, Percent_Identity=34.8101265822785, Blast_Score=284, Evalue=1e-76,
Organism=Drosophila melanogaster, GI221513548, Length=474, Percent_Identity=28.2700421940928, Blast_Score=208, Evalue=5e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): G6PD_BACSU (P54547)

Other databases:

- EMBL:   D84432
- EMBL:   AL009126
- PIR:   B69964
- RefSeq:   NP_390266.2
- ProteinModelPortal:   P54547
- SMR:   P54547
- EnsemblBacteria:   EBBACT00000000675
- GeneID:   938690
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU23850
- NMPDR:   fig|224308.1.peg.2390
- GenoList:   BSU23850
- GeneTree:   EBGT00050000002988
- HOGENOM:   HBG322449
- PhylomeDB:   P54547
- ProtClustDB:   PRK05722
- BioCyc:   BSUB:BSU23850-MONOMER
- BRENDA:   1.1.1.49
- GO:   GO:0005488
- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PANTHER:   PTHR23429
- PIRSF:   PIRSF000110
- PRINTS:   PR00079
- TIGRFAMs:   TIGR00871

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N

EC number: =1.1.1.49

Molecular weight: Translated: 55632; Mature: 55632

Theoretical pI: Translated: 5.36; Mature: 5.36

Prosite motif: PS00069 G6P_DEHYDROGENASE

Important sites: ACT_SITE 241-241 BINDING 17-17 BINDING 49-49 BINDING 179-179 BINDING 183-183 BINDING 346-346

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure: 

>Translated Secondary Structure
MKTNQQPKAVIVIFGATGDLAKRKLYPSIHRLYQNGQIGEEFAVVGVGRRPWSNEDLRQT
CCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCHHHHHH
VKTSISSSADKHIDDFTSHFYYHPFDVTNPGSYQELNVLLNQLEDTYQIPNNRMFYLAMA
HHHHHHCCHHHHHHHHHHCCEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEEC
PEFFGTIAKTLKSEGVTATTGWSRLVIEKPFGHDLPSAQALNKEIREAFTEDQIYRIDHY
HHHHHHHHHHHHHCCCEEECCCCEEEEECCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHH
LGKQMVQNIEVIRFANAIFEPLWTNRYISNIQITSSESLGVEDRARYYEKSGALRDMVQN
HHHHHHHHHHHHHHHHHHHHHHHCCCEECEEEEECCCCCCCHHHHHHHHHCCHHHHHHHH
HIMQMVALLAMEPPIKLNTEEIRSEKVKVLRALRPIAKDEVDEYFVRGQYHAGEIDGVPV
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
PAYTDEDNVAPDSNTETFVAGKLLIDNFRWAGVPFYIRTGKRMKEKSTKIVVQFKDIPMN
CCCCCCCCCCCCCCCCEEEEEEEEEECCEECCCCEEEECCCHHHCCCCEEEEEEECCCEE
LYYGNENNMNPNLLVIHIQPDEGITLYLNAKKLGGAAHAQPIKLDYCSNCNDELNTPEAY
EEECCCCCCCCCEEEEEEECCCCEEEEEECHHCCCCCCCCCEEEECCCCCCCCCCCHHHH
EKLIHDCLLGDATNFAHWDEVALSWSFVDSISETWAANKTLSPNYESGSMGPKESDDLLV
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEE
KDGLHWWNI
ECCCHHCCC
>Mature Secondary Structure
MKTNQQPKAVIVIFGATGDLAKRKLYPSIHRLYQNGQIGEEFAVVGVGRRPWSNEDLRQT
CCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCHHHHHH
VKTSISSSADKHIDDFTSHFYYHPFDVTNPGSYQELNVLLNQLEDTYQIPNNRMFYLAMA
HHHHHHCCHHHHHHHHHHCCEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEEC
PEFFGTIAKTLKSEGVTATTGWSRLVIEKPFGHDLPSAQALNKEIREAFTEDQIYRIDHY
HHHHHHHHHHHHHCCCEEECCCCEEEEECCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHH
LGKQMVQNIEVIRFANAIFEPLWTNRYISNIQITSSESLGVEDRARYYEKSGALRDMVQN
HHHHHHHHHHHHHHHHHHHHHHHCCCEECEEEEECCCCCCCHHHHHHHHHCCHHHHHHHH
HIMQMVALLAMEPPIKLNTEEIRSEKVKVLRALRPIAKDEVDEYFVRGQYHAGEIDGVPV
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
PAYTDEDNVAPDSNTETFVAGKLLIDNFRWAGVPFYIRTGKRMKEKSTKIVVQFKDIPMN
CCCCCCCCCCCCCCCCEEEEEEEEEECCEECCCCEEEECCCHHHCCCCEEEEEEECCCEE
LYYGNENNMNPNLLVIHIQPDEGITLYLNAKKLGGAAHAQPIKLDYCSNCNDELNTPEAY
EEECCCCCCCCCEEEEEEECCCCEEEEEECHHCCCCCCCCCEEEECCCCCCCCCCCHHHH
EKLIHDCLLGDATNFAHWDEVALSWSFVDSISETWAANKTLSPNYESGSMGPKESDDLLV
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEE
KDGLHWWNI
ECCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377; 9298659