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The map label for this gene is fur

Identifier: 255767511

GI number: 255767511

Start: 2449841

End: 2450290

Strand: Reverse

Name: fur

Synonym: BSU23520

Alternate gene names: 255767511

Gene position: 2450290-2449841 (Counterclockwise)

Preceding gene: 16079410

Following gene: 255767510

Centisome position: 58.12

GC content: 42.0

Gene sequence:

>450_bases
ATGGAAAACCGTATTGATCGTATTAAGAAACAACTGCACTCATCCAGCTATAAACTTACGCCACAGCGTGAAGCGACAGT
AAGAGTGCTGCTTGAAAACGAAGAAGACCATTTAAGCGCAGAAGATGTATACCTCCTCGTAAAAGAGAAATCTCCTGAGA
TCGGTCTCGCTACAGTATACCGTACGCTTGAATTATTAACTGAATTAAAAGTCGTAGATAAAATTAACTTTGGAGACGGT
GTGTCCCGTTACGACCTTCGGAAAGAGGGCGCAGCTCACTTTCATCACCACTTGGTGTGCATGGAGTGCGGAGCCGTTGA
TGAAATTGAAGAAGATTTGCTTGAAGACGTGGAAGAAATCATTGAACGTGATTGGAAATTTAAGATTAAAGATCATAGAT
TGACGTTTCACGGCATTTGCCACCGCTGTAACGGAAAAGAAACTGAATAG

Upstream 100 bases:

>100_bases
AAGAAAACCATTTTATTTATCAGTTTATAATAATTATAGTTGGAACTCTGCGCGTATTTTGTTATAATGAGTCATGGAAT
GCGGCGTAGGAGGGAAAGAC

Downstream 100 bases:

>100_bases
ACGGTGCCGAGCGCGAACCTTTTCTCATGGGGAAAGGGTTTTTTGCTGTTTCTATGTATAAAACCTTTCTGATTTGGCAT
ATGGTTTATATAACTGGAAC

Product: transcriptional regulator for iron transport and metabolism

Products: NA

Alternate protein names: Ferric uptake regulator

Number of amino acids: Translated: 149; Mature: 149

Protein sequence:

>149_residues
MENRIDRIKKQLHSSSYKLTPQREATVRVLLENEEDHLSAEDVYLLVKEKSPEIGLATVYRTLELLTELKVVDKINFGDG
VSRYDLRKEGAAHFHHHLVCMECGAVDEIEEDLLEDVEEIIERDWKFKIKDHRLTFHGICHRCNGKETE

Sequences:

>Translated_149_residues
MENRIDRIKKQLHSSSYKLTPQREATVRVLLENEEDHLSAEDVYLLVKEKSPEIGLATVYRTLELLTELKVVDKINFGDG
VSRYDLRKEGAAHFHHHLVCMECGAVDEIEEDLLEDVEEIIERDWKFKIKDHRLTFHGICHRCNGKETE
>Mature_149_residues
MENRIDRIKKQLHSSSYKLTPQREATVRVLLENEEDHLSAEDVYLLVKEKSPEIGLATVYRTLELLTELKVVDKINFGDG
VSRYDLRKEGAAHFHHHLVCMECGAVDEIEEDLLEDVEEIIERDWKFKIKDHRLTFHGICHRCNGKETE

Specific function: Iron uptake repressor. Acts on the transcription of ferri-siderophore uptake genes

COG id: COG0735

COG function: function code P; Fe2+/Zn2+ uptake regulation proteins

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Fur family

Homologues:

Organism=Escherichia coli, GI1786899, Length=138, Percent_Identity=34.0579710144928, Blast_Score=79, Evalue=1e-16,

Paralogues:

None

Copy number: 3432 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): FUR_BACSU (P54574)

Other databases:

- EMBL:   D84432
- EMBL:   AL009126
- PIR:   E69967
- RefSeq:   NP_390233.2
- ProteinModelPortal:   P54574
- SMR:   P54574
- EnsemblBacteria:   EBBACT00000003049
- GeneID:   938727
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU23520
- NMPDR:   fig|224308.1.peg.2357
- GenoList:   BSU23520
- GeneTree:   EBGT00050000001212
- HOGENOM:   HBG731501
- PhylomeDB:   P54574
- ProtClustDB:   CLSK2765293
- BioCyc:   BSUB:BSU23520-MONOMER
- GO:   GO:0005737
- InterPro:   IPR002481

Pfam domain/function: PF01475 FUR

EC number: NA

Molecular weight: Translated: 17428; Mature: 17428

Theoretical pI: Translated: 5.33; Mature: 5.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENRIDRIKKQLHSSSYKLTPQREATVRVLLENEEDHLSAEDVYLLVKEKSPEIGLATVY
CCHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCCCCCCEEEEEECCCCCCHHHHHH
RTLELLTELKVVDKINFGDGVSRYDLRKEGAAHFHHHLVCMECGAVDEIEEDLLEDVEEI
HHHHHHHHHHHHHCCCCCCCCCHHHHHHCCHHHHHHHHHHEECCCHHHHHHHHHHHHHHH
IERDWKFKIKDHRLTFHGICHRCNGKETE
HHCCCCEEEECCEEHHHHHHHHCCCCCCC
>Mature Secondary Structure
MENRIDRIKKQLHSSSYKLTPQREATVRVLLENEEDHLSAEDVYLLVKEKSPEIGLATVY
CCHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCCCCCCEEEEEECCCCCCHHHHHH
RTLELLTELKVVDKINFGDGVSRYDLRKEGAAHFHHHLVCMECGAVDEIEEDLLEDVEEI
HHHHHHHHHHHHHCCCCCCCCCHHHHHHCCHHHHHHHHHHEECCCHHHHHHHHHHHHHHH
IERDWKFKIKDHRLTFHGICHRCNGKETE
HHCCCCEEEECCEEHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377; 9701813