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The map label for this gene is resA

Identifier: 255767500

GI number: 255767500

Start: 2420804

End: 2421343

Strand: Reverse

Name: resA

Synonym: BSU23150

Alternate gene names: 255767500

Gene position: 2421343-2420804 (Counterclockwise)

Preceding gene: 255767501

Following gene: 16079371

Centisome position: 57.44

GC content: 42.59

Gene sequence:

>540_bases
ATGAAGAAAAAAAGGCGTTTATTCATTCGGACCGGCATCCTTCTCGTTTTAATCTGCGCACTCGGCTATACCATTTACAA
CGCTGTATTTGCCGGCAAAGAGAGTATATCCGAAGGGTCCGACGCACCGAATTTTGTCCTAGAGGATACGAATGGGAAAC
GTATCGAGCTCAGTGACTTAAAAGGGAAAGGTGTTTTTTTGAATTTCTGGGGTACATGGTGTGAACCGTGCAAAAAAGAG
TTTCCTTATATGGCAAACCAATATAAGCATTTTAAAAGCCAAGGTGTTGAAATTGTCGCTGTAAATGTTGGGGAGTCAAA
GATAGCAGTACATAATTTTATGAAATCCTACGGAGTCAATTTCCCGGTTGTTCTGGATACAGATCGCCAAGTGCTTGATG
CCTATGACGTATCTCCGCTTCCGACAACCTTTTTGATCAATCCGGAAGGAAAAGTTGTCAAGGTGGTGACCGGCACTATG
ACAGAAAGCATGATACACGATTATATGAATCTCATAAAACCCGGAGAGACTTCGGGATGA

Upstream 100 bases:

>100_bases
TTCTAAATTTCACATAACCTTCAAAAAGTAAGAAATGTGAAATGAACGTGCAATGATATAATTGAATGGATCTGCAATAG
GGGGAAGGGGGCAGTGGACA

Downstream 100 bases:

>100_bases
AGCAAGTCAAATGTGAATGCGGACATATAAACCCGGTCGGAACCGTTTTATGCGAATCGTGCGGAAGAGCTCTTCAGGAA
ACTCAACCTCCGCTCGCTGA

Product: thiol-disulfide oxidoreductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 179; Mature: 179

Protein sequence:

>179_residues
MKKKRRLFIRTGILLVLICALGYTIYNAVFAGKESISEGSDAPNFVLEDTNGKRIELSDLKGKGVFLNFWGTWCEPCKKE
FPYMANQYKHFKSQGVEIVAVNVGESKIAVHNFMKSYGVNFPVVLDTDRQVLDAYDVSPLPTTFLINPEGKVVKVVTGTM
TESMIHDYMNLIKPGETSG

Sequences:

>Translated_179_residues
MKKKRRLFIRTGILLVLICALGYTIYNAVFAGKESISEGSDAPNFVLEDTNGKRIELSDLKGKGVFLNFWGTWCEPCKKE
FPYMANQYKHFKSQGVEIVAVNVGESKIAVHNFMKSYGVNFPVVLDTDRQVLDAYDVSPLPTTFLINPEGKVVKVVTGTM
TESMIHDYMNLIKPGETSG
>Mature_179_residues
MKKKRRLFIRTGILLVLICALGYTIYNAVFAGKESISEGSDAPNFVLEDTNGKRIELSDLKGKGVFLNFWGTWCEPCKKE
FPYMANQYKHFKSQGVEIVAVNVGESKIAVHNFMKSYGVNFPVVLDTDRQVLDAYDVSPLPTTFLINPEGKVVKVVTGTM
TESMIHDYMNLIKPGETSG

Specific function: Thiol-disulfide oxidoreductase which is required in disulfide reduction during c-type cytochrome synthesis. May accept reducing equivalents from CcdA, leading to breakage of disulfide bonds in apocytochrome c; following this reduction heme can be covalent

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cell membrane; Single-pass type II membrane protein. Note=The thioredoxin-like motif is exposed on the outside of the membrane

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RESA_BACSU (P35160)

Other databases:

- EMBL:   L09228
- EMBL:   AL009126
- PIR:   S45556
- RefSeq:   NP_390196.2
- PDB:   1ST9
- PDB:   1SU9
- PDB:   2F9S
- PDB:   2H19
- PDB:   2H1A
- PDB:   2H1B
- PDB:   2H1D
- PDB:   2H1G
- PDB:   3C71
- PDB:   3C73
- PDBsum:   1ST9
- PDBsum:   1SU9
- PDBsum:   2F9S
- PDBsum:   2H19
- PDBsum:   2H1A
- PDBsum:   2H1B
- PDBsum:   2H1D
- PDBsum:   2H1G
- PDBsum:   3C71
- PDBsum:   3C73
- ProteinModelPortal:   P35160
- SMR:   P35160
- EnsemblBacteria:   EBBACT00000000253
- GeneID:   938958
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU23150
- GenoList:   BSU23150
- GeneTree:   EBGT00050000000761
- HOGENOM:   HBG493509
- ProtClustDB:   PRK03147
- BioCyc:   BSUB:BSU23150-MONOMER
- HAMAP:   MF_01319
- InterPro:   IPR000866
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR012335
- Gene3D:   G3DSA:3.40.30.10

Pfam domain/function: PF00578 AhpC-TSA; SSF52833 Thiordxn-like_fd

EC number: NA

Molecular weight: Translated: 20008; Mature: 20008

Theoretical pI: Translated: 8.44; Mature: 8.44

Prosite motif: PS00194 THIOREDOXIN_1; PS51352 THIOREDOXIN_2

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xfd62a70)-;

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKKRRLFIRTGILLVLICALGYTIYNAVFAGKESISEGSDAPNFVLEDTNGKRIELSDL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCEEEECCCCCEEEEECC
KGKGVFLNFWGTWCEPCKKEFPYMANQYKHFKSQGVEIVAVNVGESKIAVHNFMKSYGVN
CCCEEEEEECCHHHHHHHHHCCHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHCCC
FPVVLDTDRQVLDAYDVSPLPTTFLINPEGKVVKVVTGTMTESMIHDYMNLIKPGETSG
CCEEECCCHHHHHHCCCCCCCEEEEECCCCCEEEEEECHHHHHHHHHHHHHCCCCCCCH
>Mature Secondary Structure
MKKKRRLFIRTGILLVLICALGYTIYNAVFAGKESISEGSDAPNFVLEDTNGKRIELSDL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCEEEECCCCCEEEEECC
KGKGVFLNFWGTWCEPCKKEFPYMANQYKHFKSQGVEIVAVNVGESKIAVHNFMKSYGVN
CCCEEEEEECCHHHHHHHHHCCHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHCCC
FPVVLDTDRQVLDAYDVSPLPTTFLINPEGKVVKVVTGTMTESMIHDYMNLIKPGETSG
CCEEECCCHHHHHHCCCCCCCEEEEECCCCCEEEEEECHHHHHHHHHHHHHCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7934829; 9384377; 8631715; 12637552