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The map label for this gene is parC

Identifier: 255767425

GI number: 255767425

Start: 1935448

End: 1937868

Strand: Direct

Name: parC

Synonym: BSU18100

Alternate gene names: 255767425

Gene position: 1935448-1937868 (Clockwise)

Preceding gene: 50812242

Following gene: 16078873

Centisome position: 45.91

GC content: 43.04

Gene sequence:

>2421_bases
TTGTCACAGCCAGAATTATTTCATGATTTACCATTAGAAGAGGTGATCGGCGACCGTTTTGGACGCTACAGTAAATATAT
TATTCAAGACAGGGCGCTGCCCGATGCGAGAGACGGATTAAAGCCGGTACAGCGCAGAATTCTGTATGCAATGCATACAG
ATGGAAACACGTTTGATAAAAACTTCAGAAAAGCGGCCAAAACGGTCGGTAACGTCATCGGTAACTATCATCCGCACGGT
GACAGCTCGGTTTATGAAGCAATGGTGCGGATGAGCCAGGATTGGAAAGTTCGTAATGTGTTAATCGAAATGCATGGAAA
CAATGGAAGCATCGACGGAGATCCCCCGGCAGCCATGCGTTATACAGAGGCACGATTATCTCCGATAGCATCTGAGCTTC
TTCGGGATATTGACAAAAACACGGTTGAATTTGTGCCGAACTTCGATGATACAAGCAAGGAGCCTGTCGTACTCCCGGCG
ATGTTTCCTAACCTATTGGTCAACGGATCTACCGGGATTTCAGCAGGATACGCGACCGACATTCCCCCTCATCATCTGGG
AGAAGTCATTGATGCTGTCATTAAGCGTATTCAAATGCCTTCTTGCTCTGTTGACGAACTCATGGAAGTTATTAAAGGGC
CTGATTTTCCGACAGGCGGTATTATTCAGGGCGTTGACGGGATAAGAAAAGCTTACGAAACCGGAAAAGGAAAAATCATT
ATCCGCGGAAAGGCTGAAATTGAAACAATCAGAGGCGGACGAGAACAAATTGTCATTACTGAAATTCCATTTGAAGTAAA
TAAAGCAAACCTTGTAAAAAAAATGGACGAGTTCCGTATTGATAAAAAGGTTGAAGGCATCTCAGAGGTTCGTGATGAAA
CGGATCGAACAGGGCTGAGAGTGGTCATTGAACTGAAAAAAGAAGCTGATGCCAAAGGCATTTTGAATTTCTTATATAAA
AATACTGATTTGCAGATCACATATAACTTCAATATGGTGGCTATCCATAACCGCCGTCCGATGCTGATGAGCCTGCCGTC
TATTTTGGATGCATATATCGGACACCAAAAGGAAGTTGTCACAAACCGGTCCGTTTACGAGCTTCAAAAAGCAAAAGACA
GACATCATATCGTAGAAGGGCTCATGAAAGCTTTGTCTATTTTGGATGAAGTGATTGCAACAATCCGTTCTTCTAGCGAT
AAACGTGACGCTAAAAACAATTTGATCGCGAAATATGAATTTACAGAGCCTCAGGCTGAAGCCATCGTGTCATTGCAGCT
ATATCGTTTAACCAATACCGATATCACAGCGCTTAAGGAAGAGGCAGAAGAGCTCGGTAAAAAAATTGAAGAGCTCGAAT
CTATTCTGAGCAATGATAAAAAACTGCTAAAAGTGATTACAAACAGCTTAAAAGCACTGAAAAAGAAATATGCAGATACG
AGACGCTCCGTGATTGAAGAAAAAATTGAAGAAATTAAAATCAATCTCGAAGTCATGGTTGCATCTGAGGATGTATATGT
AACCGTTACGAAGGATGGTTACCTAAAACGGACGAGCCAGCGCTCATTTGCCGCTTCCAACGGTCAGGACTTCGGAATGA
AAGATACGGACAGGATGCTGCATCAGTTTGAAATGAATACGACAGACGTGCTGCTGCTCTTTACGAACAAAGGAAGCTAC
ATCTATTGTCCTGTTCACCAGCTGCCTGATATCAGATGGAAGGACATGGGCCAGCATTTTTCAAATCTAATCACTATTGA
CCGTGATGAAACGATTGTAAAGGCTATACCGATAAAAGAATTTGATCCGTCGGCATATCTTCTATTCTTTACGAAAAACG
GTATGGTGAAAAAGACAGAGCTCACTCATTATAAAGCACAGCGTTATTCTAAGGCACTTGTAGCCTTAAATCTGAAGGGT
GAAGATGAACTGATTGATGTACATGTAACAAATGGGGAAAGCCAGATCTTTATGGCCACTCACTTAGGGTATGGTCTATG
GTTTGGAGAAGACGAAGTGAATGTAGTTGGCGCGCGTGCGGCAGGTGTCAAAGGGATTAACTTAAAAGAGGATGACTTTG
TTGTCTCCGGTGAGATTCTTCAGCAATCTGATTCAATTGTCTTGTTCACACAGCGGGGAGCGGTTAAACGCATGAGTCTT
TCTGAGTTCGAGAAGACATCCCGTGCAAAACGCGGTGTCGTAATGCTAAGGGAACTGAAAAAGAATCCTCACCGTGTTGT
AGCACTGTTCGCTTGCGGTCTTGAACAGCGACTAATGGCAGAAACAGAAAAAGGCGACAGAAAAGAACTGCAGACAAAAG
AGTTGCGGACAAACGACAGATACAGCAATGGCTCTTTCTTTTTTGATGAAGAGGAATCAGGCAAGGTTACAGCTGTTTGG
CGCCTTCATACAGAACAATAA

Upstream 100 bases:

>100_bases
GCGCAGAAAGTGGATTGAGAAAAACGTCGCTTTCGGCTTAGATGAAGAAAGCAATATTTTAGAAAATGAAAACTTATCGG
TCGCTGAGGAGGTTTAATGA

Downstream 100 bases:

>100_bases
TAAAAAACCCGCTCATACTATATGAGCGGGTTTCGTTTGTTTTTTATCAGCTTTCATGGTTGGTGAATAGATCTGTTACA
GCATGAATGACTTCAATCCC

Product: DNA topoisomerase IV subunit A

Products: NA

Alternate protein names: Topoisomerase IV subunit A

Number of amino acids: Translated: 806; Mature: 805

Protein sequence:

>806_residues
MSQPELFHDLPLEEVIGDRFGRYSKYIIQDRALPDARDGLKPVQRRILYAMHTDGNTFDKNFRKAAKTVGNVIGNYHPHG
DSSVYEAMVRMSQDWKVRNVLIEMHGNNGSIDGDPPAAMRYTEARLSPIASELLRDIDKNTVEFVPNFDDTSKEPVVLPA
MFPNLLVNGSTGISAGYATDIPPHHLGEVIDAVIKRIQMPSCSVDELMEVIKGPDFPTGGIIQGVDGIRKAYETGKGKII
IRGKAEIETIRGGREQIVITEIPFEVNKANLVKKMDEFRIDKKVEGISEVRDETDRTGLRVVIELKKEADAKGILNFLYK
NTDLQITYNFNMVAIHNRRPMLMSLPSILDAYIGHQKEVVTNRSVYELQKAKDRHHIVEGLMKALSILDEVIATIRSSSD
KRDAKNNLIAKYEFTEPQAEAIVSLQLYRLTNTDITALKEEAEELGKKIEELESILSNDKKLLKVITNSLKALKKKYADT
RRSVIEEKIEEIKINLEVMVASEDVYVTVTKDGYLKRTSQRSFAASNGQDFGMKDTDRMLHQFEMNTTDVLLLFTNKGSY
IYCPVHQLPDIRWKDMGQHFSNLITIDRDETIVKAIPIKEFDPSAYLLFFTKNGMVKKTELTHYKAQRYSKALVALNLKG
EDELIDVHVTNGESQIFMATHLGYGLWFGEDEVNVVGARAAGVKGINLKEDDFVVSGEILQQSDSIVLFTQRGAVKRMSL
SEFEKTSRAKRGVVMLRELKKNPHRVVALFACGLEQRLMAETEKGDRKELQTKELRTNDRYSNGSFFFDEEESGKVTAVW
RLHTEQ

Sequences:

>Translated_806_residues
MSQPELFHDLPLEEVIGDRFGRYSKYIIQDRALPDARDGLKPVQRRILYAMHTDGNTFDKNFRKAAKTVGNVIGNYHPHG
DSSVYEAMVRMSQDWKVRNVLIEMHGNNGSIDGDPPAAMRYTEARLSPIASELLRDIDKNTVEFVPNFDDTSKEPVVLPA
MFPNLLVNGSTGISAGYATDIPPHHLGEVIDAVIKRIQMPSCSVDELMEVIKGPDFPTGGIIQGVDGIRKAYETGKGKII
IRGKAEIETIRGGREQIVITEIPFEVNKANLVKKMDEFRIDKKVEGISEVRDETDRTGLRVVIELKKEADAKGILNFLYK
NTDLQITYNFNMVAIHNRRPMLMSLPSILDAYIGHQKEVVTNRSVYELQKAKDRHHIVEGLMKALSILDEVIATIRSSSD
KRDAKNNLIAKYEFTEPQAEAIVSLQLYRLTNTDITALKEEAEELGKKIEELESILSNDKKLLKVITNSLKALKKKYADT
RRSVIEEKIEEIKINLEVMVASEDVYVTVTKDGYLKRTSQRSFAASNGQDFGMKDTDRMLHQFEMNTTDVLLLFTNKGSY
IYCPVHQLPDIRWKDMGQHFSNLITIDRDETIVKAIPIKEFDPSAYLLFFTKNGMVKKTELTHYKAQRYSKALVALNLKG
EDELIDVHVTNGESQIFMATHLGYGLWFGEDEVNVVGARAAGVKGINLKEDDFVVSGEILQQSDSIVLFTQRGAVKRMSL
SEFEKTSRAKRGVVMLRELKKNPHRVVALFACGLEQRLMAETEKGDRKELQTKELRTNDRYSNGSFFFDEEESGKVTAVW
RLHTEQ
>Mature_805_residues
SQPELFHDLPLEEVIGDRFGRYSKYIIQDRALPDARDGLKPVQRRILYAMHTDGNTFDKNFRKAAKTVGNVIGNYHPHGD
SSVYEAMVRMSQDWKVRNVLIEMHGNNGSIDGDPPAAMRYTEARLSPIASELLRDIDKNTVEFVPNFDDTSKEPVVLPAM
FPNLLVNGSTGISAGYATDIPPHHLGEVIDAVIKRIQMPSCSVDELMEVIKGPDFPTGGIIQGVDGIRKAYETGKGKIII
RGKAEIETIRGGREQIVITEIPFEVNKANLVKKMDEFRIDKKVEGISEVRDETDRTGLRVVIELKKEADAKGILNFLYKN
TDLQITYNFNMVAIHNRRPMLMSLPSILDAYIGHQKEVVTNRSVYELQKAKDRHHIVEGLMKALSILDEVIATIRSSSDK
RDAKNNLIAKYEFTEPQAEAIVSLQLYRLTNTDITALKEEAEELGKKIEELESILSNDKKLLKVITNSLKALKKKYADTR
RSVIEEKIEEIKINLEVMVASEDVYVTVTKDGYLKRTSQRSFAASNGQDFGMKDTDRMLHQFEMNTTDVLLLFTNKGSYI
YCPVHQLPDIRWKDMGQHFSNLITIDRDETIVKAIPIKEFDPSAYLLFFTKNGMVKKTELTHYKAQRYSKALVALNLKGE
DELIDVHVTNGESQIFMATHLGYGLWFGEDEVNVVGARAAGVKGINLKEDDFVVSGEILQQSDSIVLFTQRGAVKRMSLS
EFEKTSRAKRGVVMLRELKKNPHRVVALFACGLEQRLMAETEKGDRKELQTKELRTNDRYSNGSFFFDEEESGKVTAVWR
LHTEQ

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm. Note=Bipolarly localized

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family

Homologues:

Organism=Homo sapiens, GI19913408, Length=351, Percent_Identity=25.6410256410256, Blast_Score=76, Evalue=1e-13,
Organism=Homo sapiens, GI19913406, Length=177, Percent_Identity=28.8135593220339, Blast_Score=70, Evalue=6e-12,
Organism=Escherichia coli, GI1788562, Length=831, Percent_Identity=39.4705174488568, Blast_Score=582, Evalue=1e-167,
Organism=Escherichia coli, GI1789396, Length=590, Percent_Identity=36.4406779661017, Blast_Score=357, Evalue=2e-99,
Organism=Caenorhabditis elegans, GI17535065, Length=175, Percent_Identity=32.5714285714286, Blast_Score=75, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI115534553, Length=171, Percent_Identity=29.8245614035088, Blast_Score=71, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6324241, Length=172, Percent_Identity=27.906976744186, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI17136538, Length=339, Percent_Identity=25.6637168141593, Blast_Score=68, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PARC_BACSU (Q45066)

Other databases:

- EMBL:   Z73234
- EMBL:   AF024713
- EMBL:   AL009126
- PIR:   B69637
- RefSeq:   NP_389692.2
- ProteinModelPortal:   Q45066
- EnsemblBacteria:   EBBACT00000001040
- GeneID:   937107
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU18100
- NMPDR:   fig|224308.1.peg.1813
- GenoList:   BSU18100
- GeneTree:   EBGT00050000002933
- HOGENOM:   HBG635183
- ProtClustDB:   PRK05561
- BioCyc:   BSUB:BSU18100-MONOMER
- GO:   GO:0005694
- GO:   GO:0005737
- InterPro:   IPR020899
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013760
- InterPro:   IPR005741
- Gene3D:   G3DSA:3.30.1360.40
- Gene3D:   G3DSA:3.90.199.10
- SMART:   SM00434
- TIGRFAMs:   TIGR01061

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV; SSF56719 Topo_IIA_cen

EC number: 5.99.1.-

Molecular weight: Translated: 91322; Mature: 91191

Theoretical pI: Translated: 6.75; Mature: 6.75

Prosite motif: NA

Important sites: ACT_SITE 121-121

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQPELFHDLPLEEVIGDRFGRYSKYIIQDRALPDARDGLKPVQRRILYAMHTDGNTFDK
CCCCCCHHCCCHHHHHHHHHHHHHHHHHHCCCCCCHHCCHHHHHHHEEEEEECCCCCHHH
NFRKAAKTVGNVIGNYHPHGDSSVYEAMVRMSQDWKVRNVLIEMHGNNGSIDGDPPAAMR
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCEEEEEEEEEECCCCCCCCCCCHHHH
YTEARLSPIASELLRDIDKNTVEFVPNFDDTSKEPVVLPAMFPNLLVNGSTGISAGYATD
HHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCEEEHHHCCHHEECCCCCCCCCCCCC
IPPHHLGEVIDAVIKRIQMPSCSVDELMEVIKGPDFPTGGIIQGVDGIRKAYETGKGKII
CCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCHHHCHHHHHHHHHCCCCEEE
IRGKAEIETIRGGREQIVITEIPFEVNKANLVKKMDEFRIDKKVEGISEVRDETDRTGLR
EECCCHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
VVIELKKEADAKGILNFLYKNTDLQITYNFNMVAIHNRRPMLMSLPSILDAYIGHQKEVV
EEEEECCCCCHHHHHHHHHCCCCEEEEEEEEEEEEECCCCHHHHHHHHHHHHHCCCHHHH
TNRSVYELQKAKDRHHIVEGLMKALSILDEVIATIRSSSDKRDAKNNLIAKYEFTEPQAE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCEEEEEECCCCHHH
AIVSLQLYRLTNTDITALKEEAEELGKKIEELESILSNDKKLLKVITNSLKALKKKYADT
HEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHH
RRSVIEEKIEEIKINLEVMVASEDVYVTVTKDGYLKRTSQRSFAASNGQDFGMKDTDRML
HHHHHHHHHHHEEEEEEEEEECCCEEEEEECCCCEECCCCCCCCCCCCCCCCCCHHHHHH
HQFEMNTTDVLLLFTNKGSYIYCPVHQLPDIRWKDMGQHFSNLITIDRDETIVKAIPIKE
HHHCCCCCEEEEEEECCCCEEEEEHHHCCCCCHHHHHHHHHHCEEECCCCEEEEEECCCC
FDPSAYLLFFTKNGMVKKTELTHYKAQRYSKALVALNLKGEDELIDVHVTNGESQIFMAT
CCCCEEEEEEECCCCEEEHHHHHHHHHHHCCEEEEEEECCCCCEEEEEEECCCCEEEEEE
HLGYGLWFGEDEVNVVGARAAGVKGINLKEDDFVVSGEILQQSDSIVLFTQRGAVKRMSL
ECCCEEEECCCCCEEEEECCCCCCCCCCCCCCEEEECHHHCCCCCEEEEECCCCHHHHHH
SEFEKTSRAKRGVVMLRELKKNPHRVVALFACGLEQRLMAETEKGDRKELQTKELRTNDR
HHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHCHHHHHHHHCCCCCHHHHHHHHHHCCCC
YSNGSFFFDEEESGKVTAVWRLHTEQ
CCCCCEEECCCCCCCEEEEEEEECCC
>Mature Secondary Structure 
SQPELFHDLPLEEVIGDRFGRYSKYIIQDRALPDARDGLKPVQRRILYAMHTDGNTFDK
CCCCCHHCCCHHHHHHHHHHHHHHHHHHCCCCCCHHCCHHHHHHHEEEEEECCCCCHHH
NFRKAAKTVGNVIGNYHPHGDSSVYEAMVRMSQDWKVRNVLIEMHGNNGSIDGDPPAAMR
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCEEEEEEEEEECCCCCCCCCCCHHHH
YTEARLSPIASELLRDIDKNTVEFVPNFDDTSKEPVVLPAMFPNLLVNGSTGISAGYATD
HHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCEEEHHHCCHHEECCCCCCCCCCCCC
IPPHHLGEVIDAVIKRIQMPSCSVDELMEVIKGPDFPTGGIIQGVDGIRKAYETGKGKII
CCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCHHHCHHHHHHHHHCCCCEEE
IRGKAEIETIRGGREQIVITEIPFEVNKANLVKKMDEFRIDKKVEGISEVRDETDRTGLR
EECCCHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
VVIELKKEADAKGILNFLYKNTDLQITYNFNMVAIHNRRPMLMSLPSILDAYIGHQKEVV
EEEEECCCCCHHHHHHHHHCCCCEEEEEEEEEEEEECCCCHHHHHHHHHHHHHCCCHHHH
TNRSVYELQKAKDRHHIVEGLMKALSILDEVIATIRSSSDKRDAKNNLIAKYEFTEPQAE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCEEEEEECCCCHHH
AIVSLQLYRLTNTDITALKEEAEELGKKIEELESILSNDKKLLKVITNSLKALKKKYADT
HEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHH
RRSVIEEKIEEIKINLEVMVASEDVYVTVTKDGYLKRTSQRSFAASNGQDFGMKDTDRML
HHHHHHHHHHHEEEEEEEEEECCCEEEEEECCCCEECCCCCCCCCCCCCCCCCCHHHHHH
HQFEMNTTDVLLLFTNKGSYIYCPVHQLPDIRWKDMGQHFSNLITIDRDETIVKAIPIKE
HHHCCCCCEEEEEEECCCCEEEEEHHHCCCCCHHHHHHHHHHCEEECCCCEEEEEECCCC
FDPSAYLLFFTKNGMVKKTELTHYKAQRYSKALVALNLKGEDELIDVHVTNGESQIFMAT
CCCCEEEEEEECCCCEEEHHHHHHHHHHHCCEEEEEEECCCCCEEEEEEECCCCEEEEEE
HLGYGLWFGEDEVNVVGARAAGVKGINLKEDDFVVSGEILQQSDSIVLFTQRGAVKRMSL
ECCCEEEECCCCCEEEEECCCCCCCCCCCCCCEEEECHHHCCCCCEEEEECCCCHHHHHH
SEFEKTSRAKRGVVMLRELKKNPHRVVALFACGLEQRLMAETEKGDRKELQTKELRTNDR
HHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHCHHHHHHHHCCCCCHHHHHHHHHHCCCC
YSNGSFFFDEEESGKVTAVWRLHTEQ
CCCCCEEECCCCCCCEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969507; 9539793; 9384377